3-Bromo-1-propanol supplier

Name
3-Bromo-1-propanol
EINECS 210-986-6
CAS No. 627-18-9
Article Data39
CAS DataBase
Density 1.566 g/cm³
Solubility 167 g/L (20 °C) in water
Melting Point
Formula C₃H₇BrO
Boiling Point 175.3 °C at 760 mmHg
Molecular Weight 138.992
Flash Point 93.9 °C
Transport Information
Appearance colourless liquid
Safety 26-39-37/39
Risk Codes 22-41-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 1-Propanol, 3-bromo-;3-Bromopropan-1-ol;3-Hydroxypropyl bromide;1-Propanol,3-bromo-;4-01-00-01446 (Beilstein Handbook Reference);Trimethylene bromohydrin;4-amino uracil;
PSA 20.23000
LogP 0.76370

Synthetic route

: potassium (3-bromopropyl)trifluoroborate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With Oxone; water In acetone at 20℃; for 0.0333333h;	98%

: 33821-94-2
3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With silica-supported NaHSO4 In methanol at 20℃; for 0.25h;	93%

: 504-63-2
trimethyleneglycol

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With hydrogen bromide In benzene for 20h; Heating;	90%
With hydrogen bromide In water; benzene for 28h; Heating;	79%
With tetrabutylammomium bromide; hydrogen bromide In water for 0.0833333h; Microwave irradiation;	75%

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With Selectfluor In acetonitrile at 150℃; for 0.0833333h; Microwave irradiation;	83%
With methanol; trimethylsilyl bromide at 20℃; for 0.0833333h; chemoselective reaction;	83%

: 3395-91-3
Methyl 3-bromopropionate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In tetrahydrofuran at 67℃; for 2h;	79%

: 503-30-0
trimethylene oxide

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With dimethylboron bromide; triethylamine In dichloromethane at 0℃; for 2h;	78%
With sodium bromide at 50℃; for 18h; Green chemistry;	29%
With diethyl ether; magnesium bromide zuletzt in Benzol bei Siedetemperatur;

: 590-92-1
3-Bromopropionic acid

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In tetrahydrofuran for 6h; Heating;	75%

: 503-30-0
trimethylene oxide

: 925-90-6
ethylmagnesium bromide

A: 71-41-0
pentan-1-ol

B: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 503-30-0
trimethylene oxide

: ethylmagnesium bromide

A: 71-41-0
pentan-1-ol

B: 627-18-9
1-bromo-3-propanol

...Expand

: 4176-55-0
2-oxo-1,3,2-dioxathiane

: 60-29-7
diethyl ether

: phenylmagnesium bromide

A: 92-52-4
biphenyl

B: 945-51-7
1,1'-sulfinylbisbenzene

C: 627-18-9
1-bromo-3-propanol

...Expand

: 15486-96-1
3-Bromopropionyl chloride

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether at -75℃;

: 592-33-6
3-bromopropyl acetate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With methanol

: 539-74-2
Ethyl 3-bromopropionate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In 1,2-dimethoxyethane for 18h; sonication; or with N,N-dimethylaniline, 12 h;

: 107-18-6
allyl alcohol

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; bromine; zirconium(IV) chloride 1.) THF, 30 deg C, 3 h; 2.) THF/benzene, r.t., 1 h; Yield given. Multistep reaction;

: 60-29-7
diethyl ether

: 15486-96-1
3-Bromopropionyl chloride

lithium alanate: lithium alanate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
at -75℃;
at -15℃;
at 35℃;

...Expand

: 7446-70-0
aluminium trichloride

: 60-29-7
diethyl ether

: 15486-96-1
3-Bromopropionyl chloride

lithium alanate: lithium alanate

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
at -75℃;
at -15℃;
at 35℃;

...Expand

: 3395-91-3
Methyl 3-bromopropionate

lithium alanate aluminium chloride: lithium alanate aluminium chloride

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With diethyl ether at -75℃;

: 15486-96-1
3-Bromopropionyl chloride

lithium alanate aluminium chloride: lithium alanate aluminium chloride

: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With diethyl ether at -75℃;

: 10035-10-6, 12258-64-9
hydrogen bromide

: 504-63-2
trimethyleneglycol

A: 109-64-8
1,3-dibromo-propane

B: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
unter verschiedenen Bedingungen;

...Expand

: 7664-93-9
sulfuric acid

: 10035-10-6, 12258-64-9
hydrogen bromide

: 504-63-2
trimethyleneglycol

A: 58929-72-9
bis(3-bromopropyl) ether

B: 109-64-8
1,3-dibromo-propane

C: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
bei der Destillation;

...Expand

: 109-64-8
1,3-dibromo-propane

A: 5703-46-8
1,2-dioxacyclohexane

B: 106-95-6
allyl bromide

C: 504-63-2
trimethyleneglycol

D: 627-18-9
1-bromo-3-propanol

Conditions

Conditions	Yield
With metal oxide; water at 150℃; under 5931.67 Torr; for 1h;

...Expand

: 21867-69-6
1-(4-methoxybenzyl)piperazine

: 627-18-9
1-bromo-3-propanol

: 79837-50-6
3-[4-(4-Methoxy-benzyl)-piperazin-1-yl]-propan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In butanone Heating;	100%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 627-18-9
1-bromo-3-propanol

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.5h;	100%
With 1H-imidazole In tetrahydrofuran at 20℃; for 24h;	100%
With dmap; triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;	100%

: 627-18-9
1-bromo-3-propanol

: 100502-66-7
3-(nitrooxy)propan-1-ol

Conditions

Conditions	Yield
With silver nitrate In acetonitrile for 24h; Ambient temperature;	100%
With silver nitrate In acetonitrile at 20℃; for 24h;	86%
With silver nitrate In acetonitrile Heating;	78.3%

: 10240-08-1
4-methyl-1-naphthol

: 627-18-9
1-bromo-3-propanol

: 222161-54-8
1-(3-hydroxypropoxy)-4-methylnaphthalene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4h; Heating;	100%

: 106-41-2
4-bromo-phenol

: 627-18-9
1-bromo-3-propanol

: 67900-64-5
3-(4-Bromophenoxy)-1-propanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	93%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h;	83%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 627-18-9
1-bromo-3-propanol

: 177338-13-5
3-(tert-butyldiphenylsilyloxy)propyl bromide

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane for 21h; Inert atmosphere;	100%
In dichloromethane at 0℃;	99%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 9h;	97%

: 13154-24-0
triisopropylsilyl chloride

: 627-18-9
1-bromo-3-propanol

: 215650-24-1
(3-bromopropoxy)triisopropylsilane

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane for 18h;	100%
With 1H-imidazole In dichloromethane for 20h;	100%
With 1H-imidazole In dichloromethane at 20℃; for 60h;	100%

: 100-83-4
meta-hydroxybenzaldehyde

: 627-18-9
1-bromo-3-propanol

: 245510-06-9
3-(3-hydroxy-propoxy)-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 3h; Reflux;	100%
Stage #1: meta-hydroxybenzaldehyde With potassium carbonate In DMF (N,N-dimethyl-formamide) for 0.166667h; Stage #2: 1-bromo-3-propanol In DMF (N,N-dimethyl-formamide) for 2h; Heating / reflux;	95%
With potassium carbonate In acetonitrile for 48h; Heating;	90%
With potassium carbonate In acetonitrile for 48h; Heating / reflux;	90%
With potassium carbonate In acetonitrile for 5h; Heating / reflux;

: 890532-75-9
C21H23BrN4O2

: 627-18-9
1-bromo-3-propanol

: 890532-85-1
C24H28Br2N4O2

Conditions

Conditions	Yield
With bis(1-methylethyl) ester diazenedicarboxylic acid; triphenylphosphine In tetrahydrofuran at 20℃; for 1h;	100%

: 879205-96-6
tert-butyl (2S)-2-(4-hydroxyphenyl)morpholine-4-carboxylate

: 627-18-9
1-bromo-3-propanol

: 879205-97-7
tert-butyl (2S)-2-(4-(3-bromopropyloxy)phenyl)morpholine-4-carboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 20℃; for 10h;	100%

: 86176-56-9
5-(5-chloro-2-hydroxylphenyl)isoxazole

: 627-18-9
1-bromo-3-propanol

: 1233227-88-7
5-[2-(3-Bromo-propoxy)-5-chloro-phenyl]-isoxazole

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	100%

: 438634-98-1
2-oxo-2,3-dihydro-1,3-benzothiazole-6-carbaldehyde

: 627-18-9
1-bromo-3-propanol

: 1435516-79-2
3-(3-hydroxypropyl)-2-oxo-2,3-dihydro-1,3-benzothiazole-6-carbaldehyde

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h;	100%
With potassium carbonate; potassium iodide In acetonitrile at 65℃; for 48h;
With potassium carbonate; potassium iodide In acetonitrile at 65℃; for 48h;

: [(1S,3aR,5aS,6R,11bR,11cS)-10-[(t-butyldimethylsilyl)oxy]-1,2,3a,4,5,6,7,11c-octahydro-3H-6,11b-(epiminoethano)-1,5a-methanonaphtho[1,2-e]indol-3-yl] (phenyl)methanone

: 627-18-9
1-bromo-3-propanol

: [(1S,3aR,5aS,6R,11bR,11cS)-10-[(t-butyldimethylsilyl)oxy]-14-(3-hydroxypropyl)-1,2,3a,4,5,6,7,11c-octahydro-3H-6,11b-(epiminoethano)-1,5a-methanonaphtho[1,2-e]indol-3-yl](phenyl)methanone

Conditions

Conditions	Yield
Stage #1: [(1S,3aR,5aS,6R,11bR,11cS)-10-[(t-butyldimethylsilyl)oxy]-1,2,3a,4,5,6,7,11c-octahydro-3H-6,11b-(epiminoethano)-1,5a-methanonaphtho[1,2-e]indol-3-yl] (phenyl)methanone; 1-bromo-3-propanol With potassium carbonate; potassium iodide In acetonitrile for 20h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride	100%

: 2-bromo-3-chloro-4-(4-ethoxybenzyl)-6-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenol

: 627-18-9
1-bromo-3-propanol

: 3-(2-bromo-3-chloro-4-(4-ethoxybenzyl)-6-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenoxy)propan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In acetone at 55℃; for 15h;	100%

: 4-(benzyloxy)-2-bromo-3,5-dimethoxyphenol

: 627-18-9
1-bromo-3-propanol

: 3-(4-(benzyloxy)-2-bromo-3,5-dimethoxyphenoxy)propan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 21h; Inert atmosphere;	100%

: 1790-74-5
8-mercapto-1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione

: 627-18-9
1-bromo-3-propanol

: C11H16N4O3S

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: 3-benzyl-6-bromo-2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)phenol

: 627-18-9
1-bromo-3-propanol

: C49H48BrClO7

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20 - 50℃; for 12h;	100%

: 6-bromo-3-(1-hydroxy-2-methylpropan-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

: 627-18-9
1-bromo-3-propanol

: 6-bromo-3-(1-hydroxy-2-methylpropan-2-yl)-1-(3 -hydroxypropyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h;	100%

: 110-87-2
3,4-dihydro-2H-pyran

: 627-18-9
1-bromo-3-propanol

: 33821-94-2
3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane for 5h;	99%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 5h;	98%
With toluene-4-sulfonic acid In dichloromethane at 20℃; Inert atmosphere;	97.4%

: 627-18-9
1-bromo-3-propanol

: 72320-38-8
3-azidopropan-1-ol

Conditions

Conditions	Yield
With sodium azide In water at 60℃;	99%
With sodium azide In water at 80℃; for 72h; Inert atmosphere; Schlenk technique;	98%
With sodium azide In N,N-dimethyl-formamide at 90℃;	97%

: 603-35-0
triphenylphosphine

: 627-18-9
1-bromo-3-propanol

: 51860-45-8
3-hydroxypropyltriphenylphosphonium bromide

Conditions

Conditions	Yield
In toluene for 16h; Reflux;	99%
In toluene at 110℃; for 16h;	99%
In toluene at 110℃; for 16h;	99%

: 2873-29-2
D-glucal triacetate

: 627-18-9
1-bromo-3-propanol

: 142631-67-2
3'-bromopropyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane for 0.0833333h; Ambient temperature;	99%
With boron trifluoride diethyl etherate In dichloromethane at 20℃; Ferrrier rearrangement;	85%
With erbium(III) triflate In nitromethane at 20℃; for 0.166667h; Ferrier rearrangement;	75%

: 596-43-0
bromo-triphenyl-methane

: 627-18-9
1-bromo-3-propanol

: 76504-33-1
((3-bromopropoxy)methanetrityl)tribenzene

Conditions

Conditions	Yield
With dmap; triethylamine In N,N-dimethyl-formamide for 24h; Ambient temperature;	99%
With dmap; triethylamine In dichloromethane for 4h; Ambient temperature;	95%
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;	85%

: 69739-34-0
t-butyldimethylsiyl triflate

: 627-18-9
1-bromo-3-propanol

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-propanol With 2,6-dimethylpyridine; calcium hydride In dichloromethane at 0℃; Inert atmosphere; Stage #2: t-butyldimethylsiyl triflate In dichloromethane at 20℃; for 2h; Inert atmosphere;	99%
In dichloromethane at 0℃; for 4h;	85%

: 930-69-8
sodium thiophenolate

: 627-18-9
1-bromo-3-propanol

: 24536-40-1
3-phenylthiopropanol

Conditions

Conditions	Yield
In methanol for 0.75h; Ambient temperature;	99%

: 53364-99-1
N,N'-ditoluenesulfonyl-1,3-diaminopropane

: 627-18-9
1-bromo-3-propanol

: 124615-98-1
N4,N8-ditosyl-4,8-diaza-1,11-undecanediol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 24h; Alkylation;	99%

: 540-38-5
4-Iodophenol

: 627-18-9
1-bromo-3-propanol

: 145073-42-3
3-(4-iodophenoxy)propan-1-ol

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide for 6h; Reflux;	99%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	84%
With potassium carbonate In N,N-dimethyl-formamide at 180℃; for 0.5h; Irradiation; microwave irradiation;	75%
Stage #1: p-Iodophenol With potassium hydroxide In ethanol at 20℃; for 1h; deprotonation; Stage #2: 1-bromo-3-propanol In ethanol at 50℃; for 16h; Alkylation;
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide

: 591-20-8
3-Bromophenol

: 627-18-9
1-bromo-3-propanol

: 92584-63-9
3-(3-bromophenoxy)propan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h;	99%
Stage #1: 3-Bromophenol With sodium hydride In N,N-dimethyl-formamide Stage #2: 1-bromo-3-propanol In N,N-dimethyl-formamide
With potassium carbonate In acetonitrile Reflux;

: 98-88-4
benzoyl chloride

: 627-18-9
1-bromo-3-propanol

: 6065-69-6
3-bromopropyl benzoate

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 0 - 20℃; for 9.5h;	99%
With triethylamine In diethyl ether at 0 - 20℃; for 14.5h;	99%
With pyridine In tetrahydrofuran at 20℃;	63%
With pyridine; dmap In 1,2-dichloro-ethane at 60℃; for 2h;

: 6-hydroxy-1-(3-isopropoxy-benzoyl)-7-methoxy-isoquinoline-4-carboxylic acid ethyl ester

: 627-18-9
1-bromo-3-propanol

: 6-(3-hydroxy-propoxy)-hydroxy-1-(3-isopropoxy-benzoyl)-7-methoxy-isoquinoline-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20 - 85℃; for 2h;	99%

3-Bromo-1-propanol Chemical Properties

Product Name: 3-Bromo-1-propanol (CAS NO.627-18-9)

Molecular Formula: C₃H₇BrO
Molar mass:138.99108 g/mol
Density: 1.566 g/cm³
Flash Point: 93.9 °C
Boiling Point: 175.3 °C at 760 mmHg
Index of Refraction:1.48
Vapour Pressure: 0.357 mmHg at 25°C
Water solubility: 167 g/L (20°C)
Storage temp: 2-8°C
Appearance: colourless liquid
XLogP3-AA: 0.7
H-Bond Donor: 1
H-Bond Acceptor: 1
Structure Descriptors of 3-Bromo-1-propanol (CAS NO.627-18-9):
IUPAC Name: 3-bromopropan-1-ol
Canonical SMILES: C(CO)CBr
InChI: InChI=1S/C3H7BrO/c4-2-1-3-5/h5H,1-3H2
InChIKey: RQFUZUMFPRMVDX-UHFFFAOYSA-N
Product Categories: Aliphatics; Halides; omega-Bromoalkanols; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides

3-Bromo-1-propanol Uses

3-Bromo-1-propanol (CAS NO.627-18-9) can be used as a raw material in organic synthesis ,and is an important chemical intermediate.

3-Bromo-1-propanol Toxicity Data With Reference

mmo-sat 177 µg/plate

MUREAV Mutation Research. 57 (1978),381.

3-Bromo-1-propanol Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of Br⁻. See also BROMIDES.
Hazard Codes:Xn,Xi
Risk Statements:
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
41: In case of fire and/or explosion do not breathe fumes
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37: Wear suitable gloves
39: Wear eye/face protection

3-Bromo-1-propanol Specification

3-Bromo-1-propanol , its CAS NO. is 627-18-9, the synonyms are 3-Bromopropan-1-ol ; 3-Hydroxypropyl bromide ; Trimethylene bromohydrin ; 1-Propanol, 3-bromo- ; 1-Bromo-3-propanol .

Product Name

3-Bromo-1-propanol

Synthetic route

3-Bromo-1-propanol Chemical Properties

3-Bromo-1-propanol Uses

3-Bromo-1-propanol Toxicity Data With Reference

3-Bromo-1-propanol Safety Profile

3-Bromo-1-propanol Specification

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