Product Name

  • Name

    3-Fluorobenzaldehyde

  • EINECS 207-266-9
  • CAS No. 456-48-4
  • Article Data144
  • CAS DataBase
  • Density 1.178 g/cm3
  • Solubility
  • Melting Point 173 °C
  • Formula C7H5FO
  • Boiling Point 173.2 °C at 760 mmHg
  • Molecular Weight 124.115
  • Flash Point 56.7 °C
  • Transport Information UN 1989 3/PG 3
  • Appearance clear colorless to yellow liquid
  • Safety 24/25-37/39-26-36/37/39-27
  • Risk Codes 37/38-36/37/38
  • Molecular Structure Molecular Structure of 456-48-4 (3-Fluorobenzaldehyde)
  • Hazard Symbols IrritantXi，FlammableF
  • Synonyms Benzaldehyde,m-fluoro- (6CI,7CI,8CI);3-Fluorobenzenecarboxaldehyde;3-Fluorophenylcarboxaldehyde;NSC 66830;m-Fluorobenzaldehyde;
  • PSA 17.07000
  • LogP 1.63820

Synthetic route

3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With tert.-butylhydroperoxide; zircornium(IV) n-propoxide In dichloromethane at 20℃; for 5h; molecular sieves;98%
With ammonium nitrate; hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In water; acetonitrile at 60℃; for 6h; Green chemistry;95%
With dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(I) triflate; 5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole In acetonitrile at 25℃; for 1.5h; Catalytic behavior; chemoselective reaction;95%
1-dichloromethyl-3-fluoro-benzene
402-64-2

1-dichloromethyl-3-fluoro-benzene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With dimethyl sulfoxide at 100℃; for 10h;93%
With dimethyl amine at 60℃; for 1h;80%
With calcium carbonate
3-fluorostyrene
350-51-6

3-fluorostyrene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen In 1,2-dichloro-ethane at 70℃; under 760.051 Torr; for 6h; Green chemistry; chemoselective reaction;93%
With tetrafluoroboric acid; iodobenzene; 3-chloro-benzenecarboperoxoic acid In water; toluene at 35℃;71 %Spectr.
1-(dibromomethyl)-3-fluorobenzene
455-34-5

1-(dibromomethyl)-3-fluorobenzene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With dimethyl sulfoxide at 120℃; for 12h;92%
With N,N-dimethyl-formamide at 120℃; for 7h;90%
1-(dibromomethyl)-3-fluorobenzene
455-34-5

1-(dibromomethyl)-3-fluorobenzene

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
at 100 - 120℃; for 10 - 12h;92%
carbon monoxide
201230-82-2

carbon monoxide

1-Fluoro-3-iodobenzene
1121-86-4

1-Fluoro-3-iodobenzene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With triethylsilane; palladium diacetate; sodium hydrogencarbonate; sodium carbonate at 20℃; under 760.051 Torr; for 48h;92%
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; under 7500.75 Torr; for 12h; Autoclave;82%
(3-fluorophenyl)acetic acid
331-25-9

(3-fluorophenyl)acetic acid

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With 1H-imidazole; C17H16ClMnN2O2; tetrabutylammonium periodite In chloroform at 20℃; for 0.333333h;91%
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.3h; Microwave irradiation;90%
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;65%
With 1H-imidazole; [bis(acetoxy)iodo]benzene; Co(AAOPD) In acetonitrile at 20℃;
m-fluorobenzyl chloride
456-42-8

m-fluorobenzyl chloride

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 0.0833333h; Microwave irradiation;87%
With (NH4)4[ZnMo6O18(OH)6]; oxygen In water; acetonitrile at 60℃; under 760.051 Torr; for 12h;84%
With 4Na(1+)*6H(1+)*NiMo6O24(10-)=Na4H6NiMo6O24; oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 12h; Irradiation;81%
With ethanol; carbon dioxide; hexamethylenetetramine
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 3-fluorobromobenzene With n-butyllithium; isopropylmagnesium chloride In tetrahydrofuran; hexane at 0 - 5℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 1h; Further stages.;		81%
carbon dioxide
124-38-9

carbon dioxide

1-Fluoro-3-iodobenzene
1121-86-4

1-Fluoro-3-iodobenzene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With rhodium(III) iodide; hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;80%
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

carbon dioxide
124-38-9

carbon dioxide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With rhodium(III) iodide; dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;80%
(3-fluorophenyl)methanethiol
40096-23-9

(3-fluorophenyl)methanethiol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With dipotassium peroxodisulfate; tetrakis(pyridine)silver(II) peroxodisulfate; oxygen In N,N-dimethyl-formamide at 23℃; under 760.051 Torr; Irradiation;78%
3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

nitrobenzene
98-95-3

nitrobenzene

A

N-[(3-fluorophenyl)methylidene]aniline
58606-65-8

N-[(3-fluorophenyl)methylidene]aniline

B

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With α,α,α-trifluorotoluene; titanium(IV) oxide In dodecane under 750.075 Torr; for 3h; Darkness; Inert atmosphere; Irradiation;A 72.67%
B n/a
...Expand
N-(benzylidene)-p-methylbenzenesulfonamide
51608-60-7

N-(benzylidene)-p-methylbenzenesulfonamide

C20H16F3NO
1418179-06-2

C20H16F3NO

A

C27H23F3N2O2S

C27H23F3N2O2S

B

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With [Cp*Rh(CH3CN)3][SbF6]2 In tert-butyl alcohol at 90℃; for 3.5h; Schlenk technique; Inert atmosphere;A 71%
B n/a
...Expand
1,2-bis(3-fluorophenyl)-1,2-ethanediol
24133-57-1

1,2-bis(3-fluorophenyl)-1,2-ethanediol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With oxygen; cetyltrimethylammonim bromide In water at 20℃; under 760.051 Torr; for 5h; Irradiation; Green chemistry;67%
2-(3-fluorophenyl)-2-hydroxyacetic acid
32222-47-2, 52923-24-7, 52950-14-8, 395-05-1

2-(3-fluorophenyl)-2-hydroxyacetic acid

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;58%
3-fluorobenzoyl chloride
1711-07-5

3-fluorobenzoyl chloride

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With hydrogen; quinoline; 5% palladium on barium sulfate; sulfur at 80 - 90℃; for 9.5h;57%
With Pd-BaSO4; xylene
m-Fluorotoluene
352-70-5

m-Fluorotoluene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With sodium molybdate; dihydrogen peroxide; cobalt(II) acetate; acetic acid; sodium bromide at 140℃; for 0.5h; Temperature; Concentration;56.1%
With oxygen In water at 150℃; under 30002.4 Torr; for 2h;48%
With carbon disulfide; chromyl chloride Behandeln des Reaktionsprodukts mit kalter wss. SO2-Loesung;
3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

A

3-fluorobenzoic acid
455-38-9

3-fluorobenzoic acid

B

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With picoline; tert.-butylhydroperoxide; chlorophyllin coppered trisodium salt In water at 60℃; for 12h; Temperature; chemoselective reaction;A 35%
B 56%
N-(2-cyanoethyl) N-(3-fluorobenzyl)-4-methylaniline
127598-78-1

N-(2-cyanoethyl) N-(3-fluorobenzyl)-4-methylaniline

A

3-(2-Dimethylaminomethyl-4-methyl-phenylamino)-propionitrile
118072-35-8

3-(2-Dimethylaminomethyl-4-methyl-phenylamino)-propionitrile

B

N-(2-cyanoethyl) N-(3-fluorobenzyl)-2-amino-5-methylbenzaldehyde
127598-86-1

N-(2-cyanoethyl) N-(3-fluorobenzyl)-2-amino-5-methylbenzaldehyde

C

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With water; trichlorophosphate In N,N-dimethyl-formamide Vilsmeier reaction;A 49%
B 13%
C 40%
With water; trichlorophosphate In N,N-dimethyl-formamide Vilsmeier reaction;A n/a
B 13%
C 40%
...Expand
acetic acid
64-19-7

acetic acid

propionaldehyde
123-38-6

propionaldehyde

(+/-)-1-(3'-fluorophenyl)but-3-en-1-ol
215320-36-8

(+/-)-1-(3'-fluorophenyl)but-3-en-1-ol

A

4β-acetoxy-2β,6β-diethyl-tetrahydropyran

4β-acetoxy-2β,6β-diethyl-tetrahydropyran

4β-acetoxy-6β-ethyl-2β-(3'-fluorophenyl)-tetrahydropyran

4β-acetoxy-6β-ethyl-2β-(3'-fluorophenyl)-tetrahydropyran

C

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With trimethylsilyl acetate; boron trifluoride diethyl etherate In cyclohexane at 20℃; for 3h; Prins cyclization;A 9%
B 46%
C 9%
...Expand
N-benzenesulfonyl-N'-(3-fluoro-benzoyl)-hydrazine
360-22-5

N-benzenesulfonyl-N'-(3-fluoro-benzoyl)-hydrazine

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With sodium carbonate; ethylene glycol
3-fluorobenzaldehyde-1,1-diacetate
1479-26-1

3-fluorobenzaldehyde-1,1-diacetate

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With sulfuric acid In ethanol
(3-fluorophenyl)methanamine
100-82-3

(3-fluorophenyl)methanamine

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With N-chloro-succinimide In water at 24.9℃; Kinetics; Thermodynamic data; pH 10.6; ΔH(excit.), ΔS(excit.);
With N-bromoacetamide In water at 14.9 - 34.9℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.);
3-Fluorocinnamic acid
20595-30-6

3-Fluorocinnamic acid

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With oxalic acid; pyridinium chlorochromate In water at 35℃; Rate constant; Kinetics; Thermodynamic data; further temperatures, ΔH(act.), ΔS(act.);
With chloroamine-T; oxalic acid In water at 35℃; Rate constant; Kinetics; Thermodynamic data; furhter temperatures, ΔH(act.), ΔS(act.);
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride In sulfolane; toluene at 210℃; for 5h;7 % Chromat.
benzaldehyde
100-52-7

benzaldehyde

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With fluorine In trichlorofluoromethane at -78℃; Product distribution; addition of BCl3;
4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid
108133-60-4

4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid

A

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

B

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With borate buffer; water In methanol at 25℃; Rate constant; Kinetics; Mechanism; ΔG(activ.), ΔH(activ.), ΔS(activ.);
C13H10FNO

C13H10FNO

A

Nitrosobenzene
586-96-9

Nitrosobenzene

B

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

Conditions
ConditionsYield
With perchloric acid; water; chloramine-B In N,N-dimethyl-formamide at 30℃; Rate constant; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.); var. temperature;
With perchloric acid; N-bromobenzenesulphonamide; acetic acid at 30℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.); other temp.;
1-amino-3-(dimethylamino)propane
109-55-7

1-amino-3-(dimethylamino)propane

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

N-(3-fluorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

N-(3-fluorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions
ConditionsYield
In ethanol Heating;100%
In benzene Heating;
methylamine
74-89-5

methylamine

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

1-(3-fluorophenyl)-N-methylmethanimine

1-(3-fluorophenyl)-N-methylmethanimine

Conditions
ConditionsYield
at 20℃; for 12h;100%
at 80℃; for 1h;
at 20℃; for 1h;
In methanol; water at 20℃; for 0.333333h;
at 20℃; for 1h;
2,2-dimethoxyethylamine
22483-09-6

2,2-dimethoxyethylamine

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine
73261-94-6

N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine

Conditions
ConditionsYield
In toluene for 1.5h; Heating;100%
for 0.333333h; Heating;
In benzene Reflux;
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2-(3-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile
100948-28-5, 82128-93-6

2-(3-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile

Conditions
ConditionsYield
With triethylamine at 20℃; for 24h;100%
With C32H39Br2MgN2(1-)*C16H32LiO4(1+) In chloroform-d1 at 20℃; for 1h; Inert atmosphere; Glovebox;99%
With zinc(II) iodide at 5 - 20℃; for 0.333333h; Yield given;
3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

Conditions
ConditionsYield
With hydrogen; Et4N In 1,2-dimethoxyethane at 100℃; under 38000 Torr; for 13h;100%
With triethylamine; isopropyl alcohol; lithium bromide at 20℃; for 48h; Meerwein-Ponndorf-Verley reaction;98%
With Candida boidinii formate dehydrogenase; Geobacillus stearothermophilus ε‐deaminating L‐lysine dehydrogenase variant 24; nicotinamide adenine dinucleotide In aq. buffer at 30℃; for 24h; pH=7; Reagent/catalyst; Enzymatic reaction;94%
(R)-2-amino-3-methylbutanol
4276-09-9

(R)-2-amino-3-methylbutanol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2-[(3-fluoro-benzylidene)-amino]-3-methyl-butan-1-ol
860805-86-3

2-[(3-fluoro-benzylidene)-amino]-3-methyl-butan-1-ol

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 0 - 20℃; for 16h;100%
In dichloromethane at 0 - 20℃; for 16h; drying with MgSO4;100%
With magnesium sulfate In dichloromethane at 0 - 20℃;
(R)-2-amino-3-methylbutanol
4276-09-9

(R)-2-amino-3-methylbutanol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

C12H16FNO
562103-08-6

C12H16FNO

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 0 - 20℃; for 16h;100%
With magnesium sulfate In dichloromethane at 0 - 20℃; for 16h;100%
In dichloromethane
3-(2,3-dihydroxy-propylsulfanylmethyl)-N-[2-hydrazinocarbonyl-4,5-bis-(2-methoxy-ethoxy)-phenyl]-benzamide
773071-71-9

3-(2,3-dihydroxy-propylsulfanylmethyl)-N-[2-hydrazinocarbonyl-4,5-bis-(2-methoxy-ethoxy)-phenyl]-benzamide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

3-(2,3-Dihydroxy-propylsulfanylmethyl)-N-[2-(3-fluorobenzylidene-hydrazinocarbonyl)-4,5-bis-(2-methoxy-ethoxy)-phenyl]-benzamide

3-(2,3-Dihydroxy-propylsulfanylmethyl)-N-[2-(3-fluorobenzylidene-hydrazinocarbonyl)-4,5-bis-(2-methoxy-ethoxy)-phenyl]-benzamide

Conditions
ConditionsYield
In toluene at 20℃; for 1h;100%
carbon tetrabromide
558-13-4

carbon tetrabromide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

1-(2,2-Dibromo-vinyl)-3-fluoro-benzene
221148-37-4

1-(2,2-Dibromo-vinyl)-3-fluoro-benzene

Conditions
ConditionsYield
With triphenylphosphine In dichloromethane100%
Stage #1: carbon tetrabromide With triphenylphosphine In dichloromethane at 0 - 10℃; for 1h;
Stage #2: 3-Fluorobenzaldehyde In dichloromethane at 0℃; for 1h;		100%
Stage #1: carbon tetrabromide With triphenylphosphine In dichloromethane at 0 - 10℃; for 1.05h;
Stage #2: 3-Fluorobenzaldehyde In dichloromethane at 0℃; for 1h;		100%
cis, trans-1,3-dimethylaminocyclohexane
2579-20-6

cis, trans-1,3-dimethylaminocyclohexane

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

C22H24F2N2
1217527-05-3

C22H24F2N2

Conditions
ConditionsYield
In methanol at 20℃; Molecular sieve;100%
In methanol at 20℃; Molecular sieve;
3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(E)-2-(3-fluorobenzylideneamino)-N-phenylbenzamide
1201652-24-5

(E)-2-(3-fluorobenzylideneamino)-N-phenylbenzamide

Conditions
ConditionsYield
100%
tert-butyl 2,2-dideuterio-2-(diethoxyphosphoryl)ethanoate

tert-butyl 2,2-dideuterio-2-(diethoxyphosphoryl)ethanoate

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

tert-butyl (E)-2-deuterio-3-(3'-fluorophenyl)propenoate
1332928-88-7

tert-butyl (E)-2-deuterio-3-(3'-fluorophenyl)propenoate

Conditions
ConditionsYield
With water-d2; potassium carbonate at 50℃; for 30h; Horner-Wadsworth-Emmons olefination; Inert atmosphere; optical yield given as %de; diastereoselective reaction;100%
ethyl 2-(2-aminophenyl)indolizine-1-carboxylate

ethyl 2-(2-aminophenyl)indolizine-1-carboxylate

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

ethyl 6-(3-fluorophenyl)indolizino[3,2-c]quinoline-12-carboxylate

ethyl 6-(3-fluorophenyl)indolizino[3,2-c]quinoline-12-carboxylate

Conditions
ConditionsYield
With iron(III) chloride In dichloromethane at 60℃; for 16h; Pictet-Spengler Synthesis;100%
2-aminobenzanilide
4424-17-3

2-aminobenzanilide

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2-(3-fluorobenzylideneamino)-N-phenylbenzamide

2-(3-fluorobenzylideneamino)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol100%
(tert-Butoxycarbonylmethylene)triphenylphosphorane
86302-43-4

(tert-Butoxycarbonylmethylene)triphenylphosphorane

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(E)-3-(3-fluorophenyl)acrylic acid tert-butyl ester
277745-38-7

(E)-3-(3-fluorophenyl)acrylic acid tert-butyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h;100%
3-amino-8-methoxy-2H-chromen-2-iminium chloride

3-amino-8-methoxy-2H-chromen-2-iminium chloride

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

C17H13FN2O2

C17H13FN2O2

Conditions
ConditionsYield
In acetonitrile at 60℃; for 33h;100%
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(2E)-3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
1840-00-2

(2E)-3-(3-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃; Aldol Condensation;99.2%
Stage #1: o-hydroxyacetophenone With potassium hydroxide In ethanol at 0℃; for 0.166667h; Claisen-Schmidt Condensation;
Stage #2: 3-Fluorobenzaldehyde In ethanol at 0 - 20℃; for 8h; Claisen-Schmidt Condensation;		76%
With sodium hydroxide In ethanol; water at 20℃;53%
With sodium hydroxide In ethanol; water at 20℃; for 24h;32%
With sodium hydroxide In ethanol; water at 20℃;
malonic acid
141-82-2

malonic acid

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

3-Fluorocinnamic acid
20595-30-6

3-Fluorocinnamic acid

Conditions
ConditionsYield
Stage #1: malonic acid; 3-Fluorobenzaldehyde With piperidine; pyridine Knoevenagel-Doebner reaction; Reflux;
Stage #2: With hydrogenchloride In water Cooling with ice; optical yield given as %de;		99%
With piperidine In pyridine Heating;80%
With ammonia Erhitzen des Reaktionsprodukts auf 180-190grad;
3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(rac)-1,2-bis(3-fluorophenyl)-2-hydroxyethan-1-one
66659-65-2

(rac)-1,2-bis(3-fluorophenyl)-2-hydroxyethan-1-one

Conditions
ConditionsYield
With 1,3-dimethylbenzimidazolium Iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran for 1h; Heating;99%
With Thiamine hydrochloride; sodium hydroxide In ethanol at 55℃; for 16h; Schlenk technique; Inert atmosphere;81%
With sodium cyanide In ethanol; water for 4h; Reflux;68.4%
naltrexone Hydrochloride
16676-29-2

naltrexone Hydrochloride

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

7(E)-(3-fluorobenzylidene)naltrexone

7(E)-(3-fluorobenzylidene)naltrexone

Conditions
ConditionsYield
With piperidine In methanol at 120℃; Sealed tube;99%
With sodium hydroxide for 24h; Ambient temperature;76%
allyl iodid
556-56-9

allyl iodid

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(+/-)-1-(3'-fluorophenyl)but-3-en-1-ol
215320-36-8

(+/-)-1-(3'-fluorophenyl)but-3-en-1-ol

Conditions
ConditionsYield
With indium In water for 48h;99%
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

methyl 2-((3-fluorophenyl)(hydroxy)methyl)acrylate
784144-71-4

methyl 2-((3-fluorophenyl)(hydroxy)methyl)acrylate

Conditions
ConditionsYield
1,4-diaza-bicyclo[2.2.2]octane; tributyl(ethyl)phosphonium tosylate at 20℃; for 24h; Baylis-Hillman reaction;99%
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 6h; Baylis-Hillman Reaction; Inert atmosphere;98%
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 3h; Morita-Baylis-Hillman Alkylation; Inert atmosphere;89%
phenylacetylene
536-74-3

phenylacetylene

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

1-(3-fluorophenyl)-3-phenylprop-2-yn-1-ol

1-(3-fluorophenyl)-3-phenylprop-2-yn-1-ol

Conditions
ConditionsYield
Stage #1: With (1S,2S,5S)-4,6,6-trimethyl-2-[2-{(S)-6-phenylpyridin-2-yl}phenyl]bicyclo-[3.1.1]hept-3-en-2-ol; dimethyl zinc(II) In toluene at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: phenylacetylene In toluene at 20℃; for 0.75h; Inert atmosphere;
Stage #3: 3-Fluorobenzaldehyde In toluene at 0℃; for 72h; Inert atmosphere;		99%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78 - 21℃; for 1h; Inert atmosphere;
Stage #2: 3-Fluorobenzaldehyde In tetrahydrofuran; hexane at -78 - 21℃; for 1h; Inert atmosphere;		96%
Stage #1: phenylacetylene With dimethyl zinc(II) In toluene at 20℃; for 0.5h;
Stage #2: 3-Fluorobenzaldehyde In toluene at 20℃; for 24h;		92%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 3-Fluorobenzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere;
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 3-Fluorobenzaldehyde In tetrahydrofuran at 20℃;
β-naphthol
135-19-3

β-naphthol

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

14-(3-fluorophenyl)-14H-dibenzo[a,j]xanthene
37096-98-3

14-(3-fluorophenyl)-14H-dibenzo[a,j]xanthene

Conditions
ConditionsYield
With para-dodecylbenzenesulfonic acid at 125℃; under 5171.62 Torr; for 0.0666667h; Microwave irradiation; Neat (no solvent);99%
With phospho sulphonic acid In neat (no solvent) at 110℃; for 0.75h; Green chemistry;96%
With aminosulfonic acid for 0.0416667h; microwave irradiation;95%
cyclohexanone
108-94-1

cyclohexanone

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2,6-bis(3-fluorobenzylidene)cyclohexanone
565416-89-9

2,6-bis(3-fluorobenzylidene)cyclohexanone

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃;99%
With 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride at 20℃; for 2h;91%
With potassium hydroxide In ethanol at 20℃; for 4h;90.5%
With sodium hydroxide In ethanol at 5 - 20℃; Claisen Schmidt condensation;
With potassium hydroxide In ethanol at 20℃; Claisen-Schmidt Condensation;
cyclopentanone
120-92-3

cyclopentanone

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2,5-bis(3-fluorobenzylidene)cyclopentanone
892253-13-3

2,5-bis(3-fluorobenzylidene)cyclopentanone

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃;99%
With 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride at 20℃; for 2h;91%
With sodium hydroxide In ethanol at 5 - 20℃; Claisen Schmidt condensation;
diethyl<<(p-chlorophenyl)sulfonyl>methyl>phosphonate
40137-12-0

diethyl<<(p-chlorophenyl)sulfonyl>methyl>phosphonate

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(E)-1-(2-((4-chlorophenyl)sulfonyl)vinyl)-3-fluorobenzene
1554271-57-6

(E)-1-(2-((4-chlorophenyl)sulfonyl)vinyl)-3-fluorobenzene

Conditions
ConditionsYield
Stage #1: diethyl<<(p-chlorophenyl)sulfonyl>methyl>phosphonate With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: 3-Fluorobenzaldehyde In tetrahydrofuran; cyclohexane at -78 - 20℃; for 1h;		99%
3-acetylcoumarin
3949-36-8

3-acetylcoumarin

malononitrile
109-77-3

malononitrile

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

2-amino-6-(2-oxo-2H-chromen-3-yl)-4-(3-fluorophenyl)nicotinonitrile
1421234-48-1

2-amino-6-(2-oxo-2H-chromen-3-yl)-4-(3-fluorophenyl)nicotinonitrile

Conditions
ConditionsYield
With ammonium acetate In neat (no solvent) at 100℃; for 0.25h;99%
With perchloric acid adsorbed on silica gel; ammonium acetate In neat (no solvent) at 60℃; for 1.2h; Green chemistry;94%
...Expand
2,5-dimethoxyaniline
102-56-7

2,5-dimethoxyaniline

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

4-((4-amino-2,5-dimethoxyphenyl)(3-fluorophenyl)methyl)-2,5-dimethoxybenzenamine

4-((4-amino-2,5-dimethoxyphenyl)(3-fluorophenyl)methyl)-2,5-dimethoxybenzenamine

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In nitromethane at 80℃; for 0.166667h; Microwave irradiation; Sealed tube; regioselective reaction;99%
phenylhydrazine
100-63-0

phenylhydrazine

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

1-(3-fluorobenzylidene)-2-phenylhydrazine
351-24-6

1-(3-fluorobenzylidene)-2-phenylhydrazine

Conditions
ConditionsYield
In ethanol for 0.00833333h; Sonication;99%
With Fe(+3)-montmorillonite K10

3-Fluorobenzaldehyde Specification

The m-Fluorobenzaldehyde, with the CAS registry number 456-48-4, is also known as Benzaldehyde, 3-fluoro-. Its molecular formula is C7H5FO and its IUPAC name is 3-fluorobenzaldehyde. This chemical is clear colorless to yellow liquid which should be kept cool and dry. Keep it away from the oxides. Additionally, its product categories are Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Fluorobenzene; Adehydes, Acetals & Ketones; Fluorine Compounds; Aldehydes; C7; Carbonyl Compounds.

Other characteristics of the m-Fluorobenzaldehyde can be summarised as followings: (1)ACD/LogP: 1.89; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.89; (4)ACD/LogD (pH 7.4): 1.89; (5)#H bond acceptors: 1; (6)#H bond donors: 0; (7)#Freely Rotating Bonds: 1; (8)Polar Surface Area: 17.07 Å2; (9)Index of Refraction: 1.539; (10)Molar Refractivity: 32.99 cm3; (11)Molar Volume: 105.3 cm3; (12)Polarizability: 13.08×10-24cm3; (13)Surface Tension: 36.8 dyne/cm; (14)Density: 1.178 g/cm3; (15)Flash Point: 56.7 °C; (16)Enthalpy of Vaporization: 40.96 kJ/mol; (17)Boiling Point: 173.2 °C at 760 mmHg; (18)Vapour Pressure: 1.28 mmHg at 25°C.

Uses of the m-Fluorobenzaldehyde: It could react with malonic acid to obtain the 3-fluoro-trans-cinnamic acid. This reaction needs the reagent of piperidine, and the solvent of pyridine. The yield is 80 %. In addition, this reaction needs the condition of heating.

the m-Fluorobenzaldehyde could react with malonic acid to obtain the 3-fluoro-trans-cinnamic acid

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing, gloves and eye/face protection to avoid contact with skin and eyes. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. 

You can still convert the following datas into molecular structure: 
1.SMILES: O=Cc1cc(F)ccc1
2.InChI: InChI=1/C7H5FO/c8-7-3-1-2-6(4-7)5-9/h1-5H
3.InChIKey: PIKNVEVCWAAOMJ-UHFFFAOYAY

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View