3-Methoxy-4-methylbenzaldehyde supplier

Name
3-METHOXY-4-METHYLBENZALDEHYDE
EINECS
CAS No. 24973-22-6
Article Data23
CAS DataBase
Density 1.062 g/cm³
Solubility
Melting Point 40.5-41.5 °C
Formula C₉H₁₀O₂
Boiling Point 246.2 °C at 760 mmHg
Molecular Weight 150.177
Flash Point 105.7 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Anisaldehyde,4-methyl- (7CI,8CI);3-Methoxy-p-tolualdehyde;
PSA 26.30000
LogP 1.81610

Synthetic route

: 4685-50-1
3-methoxy-4-methylbenzyl alcohol

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
With Dess-Martin periodane In dichloromethane at 0℃; for 0.5h;	100%
With manganese(IV) oxide In tetrahydrofuran for 2h;	95%
With manganese(IV) oxide In dichloromethane for 2h; Heating;	90%

: 57295-30-4
3-hydroxy-4-methylbenzaldehyde

: 77-78-1
dimethyl sulfate

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
With potassium hydroxide at 45℃;	91%
With potassium hydroxide	87%

: 57295-30-4
3-hydroxy-4-methylbenzaldehyde

: 74-88-4
methyl iodide

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate	91%
Stage #1: 3-hydroxy-4-methylbenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃;	91%

: 591-31-1
3-methoxy-benzaldehyde

: 74-88-4
methyl iodide

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
Stage #1: 3-methoxy-benzaldehyde With 1-methyl-piperazine; n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #2: With sec.-butyllithium In tetrahydrofuran; hexane; cyclohexane for 0.166667h; Stage #3: methyl iodide In tetrahydrofuran; hexane; cyclohexane at -78 - 20℃; Further stages.;	29%
Yield given. Multistep reaction;

: 123-56-8
Succinimide

: 57295-33-7
(2-Bromo-5-methoxy-4-methyl-phenyl)-methanol

A: 57295-32-6
2-Brom-5-methoxy-4-methylbenzaldehyd

B: 24973-22-6
3-methoxy-4-methylbenzaldehyde

C: 90163-04-5
N-(2-Formyl-4-methoxy-5-methylphenyl)succinimid

Conditions

Conditions	Yield
With copper(l) iodide; sodium hydride 1) dimethylacetamide, 2.,5-3 h, r.t., 2) 6 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
With copper(l) iodide; sodium hydride 1) dimethylacetamide, 2.5-3 h, r.t., 2) 6 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
With copper(l) iodide; sodium hydride 1) dimethylacetamide, 2.5-3 h, r.t., 2) 6 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 50-00-0
formaldehyd

: 16452-01-0
ortho-cresidine

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
(i) aq. NH2OH*HCl, NaOAc, (ii) CuSO4, Na2SO3, aq. NaOAc, (iii) /BRN= 742602/, NaNO2, aq. HCl; Multistep reaction;

: 7151-68-0
3-methoxy-p-toluic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
(i) SOCl2, (ii) Li; Multistep reaction;
Multi-step reaction with 2 steps 1: LiAlH4 / tetrahydrofuran / 20 °C 2: MnO2 / CHCl3 / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 91 percent / acetic acid / diethyl ether 2: 88 percent / LiAlH4 / diethyl ether / 2.5 h / Heating 3: 90 percent / active MnO2 / CH2Cl2 / 2 h / Heating View Scheme

: 3-Methoxybenzaldehyde 2,4-Dimethylpent-3-ylimine

: 74-88-4
methyl iodide

A: 56724-03-9
3-methoxy-2-methyl-benzaldehyde

B: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium 1) ether, cyclohexane, -72 deg C, 1 h; 2) ether, cyclohexane, -72 deg C --> rt; 3) THF, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 586-30-1
3-hydroxy-4-methylbenzoic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: K2CO3 / acetone / 10 h / Heating 2: LiAlH4 / tetrahydrofuran / 20 °C 3: MnO2 / CHCl3 / 3 h / Heating View Scheme

: 31680-07-6
4-methyl-3-nitrobenzaldehyde

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: 91 percent / 33 percent KOH / 45 °C View Scheme

: 104-87-0
4-methyl-benzaldehyde

KOH: KOH

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 91 percent / KNO3 / H2SO4 3: 91 percent / 33 percent KOH / 45 °C View Scheme

: 3556-83-0
methyl 4-methyl-3-methoxybenzoate

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / LiAlH4 / diethyl ether / 2.5 h / Heating 2: 90 percent / active MnO2 / CH2Cl2 / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 25 °C 2: manganese(IV) oxide / tetrahydrofuran / 2 h View Scheme
Multi-step reaction with 2 steps 1: diisobutylaluminium hydride / tetrahydrofuran / 5.5 h / -78 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 2 h / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: diisobutylaluminium hydride / tetrahydrofuran / 5 h / -78 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 2 h / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 2: manganese(IV) oxide / chloroform / 18 h / 20 °C View Scheme

: 108-48-5
2,6-dimethylpyridine

: 87808-44-4
3-methoxy-4-methylbenzoyl chloride

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
palladium In tetrahydrofuran

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 132980-20-2
3-(3-Methoxy-4-methylphenyl)-2-propenoic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; 3-methoxy-4-methylbenzaldehyde With piperidine; pyridine for 2.5h; Heating / reflux; Stage #2: With hydrogenchloride In water	100%
In piperidine; pyridine for 2.5h; Heating / reflux;	100%
With piperidine; pyridine for 5h; Heating;	99.7%

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 209287-19-4
ferulic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 2.5h; Heating / reflux; Neat (no solvent);	100%
With piperidine; pyridine for 2.5h; Heating / reflux;	100%
With piperidine; pyridine at 100℃; Condensation;

: 141-82-2
malonic acid

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 3-(3-methyl-4-methoxy-phenyl)-acrylic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; 3-methoxy-4-methylbenzaldehyde With piperidine; pyridine for 11h; Heating / reflux; Stage #2: With hydrogenchloride In water	100%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 62-53-3
aniline

: (E)-3-Methoxy-4-methyl-N-phenylbenzaldimin

Conditions

Conditions	Yield
	99%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 4685-50-1
3-methoxy-4-methylbenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol	98.7%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 115928-76-2
C9H14O3

: C18H22O4

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 2h; Knoevenagel Condensation; Dean-Stark; Reflux;	92%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 108-59-8
malonic acid dimethyl ester

: 130921-06-1
Dimethyl 3-Methoxy-4-methylbenzylidenemalonate

Conditions

Conditions	Yield
With piperidine; benzoic acid In benzene Heating;	91%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 126-81-8
dimedone

: 135-19-3
β-naphthol

: 1427548-18-2
C27H26O3

Conditions

Conditions	Yield
With (2,3,4,5,6-pentafluorophenyl)ammonium triflate In toluene at 50℃; for 6h; Green chemistry;	90%

...Expand

: 2942-13-4
6-methoxy-1,3-benzothiazole

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 1361253-14-6
(6-methoxy-1,3-benzothiazol-2-yl)(4-methyl-3-methoxyphenyl)methanol

Conditions

Conditions	Yield
Stage #1: 6-methoxy-1,3-benzothiazole With n-butyllithium In tetrahydrofuran; hexane for 1h; Cooling with acetone-dry ice; Stage #2: 3-methoxy-4-methylbenzaldehyde In tetrahydrofuran; hexane for 2h; Cooling with acetone-dry ice;	89%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 100-06-1
1-(4-methoxyphenyl)ethanone

: (E)-3-(3-methoxy-4-methylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 1-(4-methoxyphenyl)ethanone With lithium hydroxide monohydrate In ethanol at 20℃; for 0.25h; Stage #2: 3-methoxy-4-methylbenzaldehyde In ethanol at 20℃; for 24h;	88%

: 79-24-3
Nitroethane

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 132980-18-8
1-(3-methoxy-4-methylphenyl)-2-nitropropene

Conditions

Conditions	Yield
With ammonium acetate for 2.5h; Heating;	83.5%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 96-34-4
methyl chloroacetate

: 122333-96-4
methyl (3-methoxy-4-methylphenyl)glycidate

Conditions

Conditions	Yield
With sodium methylate In methanol 1) -5 deg C, 2 h, 2) room temperature, 3 h;	80%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 2065-66-9
methyl-triphenylphosphonium iodide

: 501371-37-5
2-methoxy-1-methyl-4-vinylbenzene

Conditions

Conditions	Yield
Stage #1: methyl-triphenylphosphonium iodide With sodium hexamethyldisilazane In tetrahydrofuran at 25℃; for 1h; Inert atmosphere; Stage #2: 3-methoxy-4-methylbenzaldehyde In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	80%

: 67-52-7
BARBITURIC ACID

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 109-77-3
malononitrile

: C16H14N4O4

Conditions

Conditions	Yield
With β‐cyclodextrin In water at 80℃; for 0.633333h;	78.5%

...Expand

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 16640-68-9
cyanomethylene triphenylphosphorane

: 913073-72-0
3-(3-methoxy-4-methylphenyl)acrylonitrile

Conditions

Conditions	Yield
	77%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1096987-59-5
(4-chlorophenyl)(3-methoxy-4-methylphenyl)methanone

Conditions

Conditions	Yield
In tetrahydrofuran for 6h; Reflux;	77%

: 75-52-5
nitromethane

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 1391042-74-2
3-methoxy-4-methyl-1-[(E)-2′-nitrovinyl]benzene

Conditions

Conditions	Yield
With ammonium acetate In toluene for 18h; Inert atmosphere; Reflux;	73%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 134058-08-5
3-(3-methoxy-4-methylphenyl)-2-propenoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran Inert atmosphere; Stage #2: 3-methoxy-4-methylbenzaldehyde In tetrahydrofuran at 20℃; for 20h; Inert atmosphere;	63%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; hexane for 0.416667h; Inert atmosphere; Stage #2: 3-methoxy-4-methylbenzaldehyde In tetrahydrofuran; hexane at 20℃; for 20.5h;	63%
With sodium hydride 1.) toluene, 0 deg C, 1 h, 2.) toluene, THF, RT, 20 h; Yield given. Multistep reaction;

: 21938-30-7
N-(5,6-Dihydro-4H-cyclopentathiazol-2-yl)-N'-isopropylidene-hydrazine

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 82814-17-3
N-(5,6-Dihydro-4H-cyclopentathiazol-2-yl)-N'-[1-(3-methoxy-4-methyl-phenyl)-meth-(E)-ylidene]-hydrazine

Conditions

Conditions	Yield
In acetic acid for 0.5h; Heating;	61%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 113296-73-4
1,4-diacetyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

: 113321-18-9
(Z)-1-acetyl-3-(3-methoxy-4-methylphenylmethylene)-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide; tert-butyl alcohol for 24h; Ambient temperature;	58%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 6882-68-4
sophoridine

: 14-(3-methoxy-4-methylphenylmethylene)sophoridine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 37℃; for 13h; Reflux;	49%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 57295-30-4
3-hydroxy-4-methylbenzaldehyde

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -10 - 20℃; for 6h;	41.4%
With boron tribromide In dichloromethane at 20℃; for 5h; Cooling with ice;	41.4%

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 109-77-3
malononitrile

: 2-(3-methoxy-4-methylbenzylidene)malononitrile

Conditions

Conditions	Yield
With L-proline In ethanol at 20℃; for 3h; Knoevenagel Condensation; Inert atmosphere;	32%

: N-cyclopropylguanidine hydrochloride

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 945001-76-3
C16H16N4O2

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 75℃; for 18h;	29%

...Expand

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 74516-54-4
2-hydroxy-4-methyl-5-methoxybenzaldehyde

Conditions

Conditions	Yield
With palladium diacetate; toluene-4-sulfonic acid; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; acetic acid; 2-Amino-4-chlorobenzoic acid at 90℃; for 24h; Sealed tube;	28%

: 141-84-4
2-thioxo-4-thiazolidinone

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 58264-65-6
5-(3-methoxy-4-methyl-benzylidene)-2-thioxo-thiazolidin-4-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid Heating;

3-Methoxy-4-methylbenzaldehyde Chemical Properties

Product Name: Benzaldehyde,3-methoxy-4-methyl- (CAS NO.24973-22-6)

Molecular Formula: C₉H₁₀O₂
Molecular Weight: 150.17g/mol
Mol File: 24973-22-6.mol
Melting Point: 40.5-41.5
Index of Refraction: 1.542
Molar Refractivity: 44.5 cm³
Molar Volume: 141.3 cm³
Surface Tension 36.1 dyne/cm
Density: 1.062 g/cm³
Flash Point: 105.7 °C
Enthalpy of Vaporization: 48.33 kJ/mol
Boiling Point: 246.2 °C at 760 mmHg
Vapour Pressure: 0.0276 mmHg at 25°C
XLogP3-AA: 2.3
H-Bond Donor: 0
H-Bond Acceptor: 2
Structure Descriptors of Benzaldehyde,3-methoxy-4-methyl- (CAS NO.24973-22-6):
IUPAC Name: 3-methoxy-4-methylbenzaldehyde
Canonical SMILES: CC1=C(C=C(C=C1)C=O)OC
InChI: InChI=1S/C9H10O2/c1-7-3-4-8(6-10)5-9(7)11-2/h3-6H,1-2H3
InChIKey: TVDHPUFLDYYBPO-UHFFFAOYSA-N
Product Categories: FINE Chemical & INTERMEDIATES; Aromatic Aldehydes & Derivatives (substituted); Aldehydes; Phenyls & Phenyl-Het; Benzaldehyde; Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates; Phenyls & Phenyl-Het

3-Methoxy-4-methylbenzaldehyde Safety Profile

Safety Information of Benzaldehyde,3-methoxy-4-methyl- (CAS NO.24973-22-6):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

3-Methoxy-4-methylbenzaldehyde Specification

Benzaldehyde,3-methoxy-4-methyl- , its CAS NO. is 24973-22-6, the synonym is 3-Methoxy-4-methylbenzaldehyde .

Product Name

3-METHOXY-4-METHYLBENZALDEHYDE

Synthetic route

3-Methoxy-4-methylbenzaldehyde Chemical Properties

3-Methoxy-4-methylbenzaldehyde Safety Profile

3-Methoxy-4-methylbenzaldehyde Specification

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