Conditions | Yield |
---|---|
With laccase from Coriolus versicolor MTCC-138; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt In 1,4-dioxane for 1h; pH=4.5; Green chemistry; Enzymatic reaction; | 100% |
With laccase at 20℃; Reagent/catalyst; Green chemistry; Enzymatic reaction; | 100% |
With laccase of Pleurotus ostreatus MTCC-1801; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt In 1,4-dioxane at 20℃; pH=4.5; Enzymatic reaction; | 98% |
1,1-diacetoxy-1-(3-nitrophenyl)methane
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With [NO(1+)*18-crown-6*H(NO3)2(1-)]; silica gel In dichloromethane at 20℃; for 0.0833333h; | 100% |
With beta zeolite modified with chlorosulphonic acid (28 wtpercent) In ethanol at 50℃; for 0.5h; | 100% |
With Montmorillonite K10 In benzene for 0.333333h; Heating; | 98% |
Conditions | Yield |
---|---|
With Montmorillonite K10; ferric nitrate In hexane at 60℃; for 3h; | 99% |
With tert.-butylhydroperoxide; V/SiO2 In decane; tert-butyl alcohol at 25℃; for 3h; | 99.8% |
With 4-methyl-morpholine; chromium(VI) oxide; hydrogenchloride In diethyl ether; chloroform at 65℃; for 0.0833333h; microwave irradiation; | 99% |
Conditions | Yield |
---|---|
With 1-benzyl-4-aza-1-azoniabiyclo<2.2.2>octane peroxodisulfate In acetonitrile for 0.25h; Oxidation; Heating; | 98% |
With silica gel; chromic acid In dichloromethane | 98% |
With 1,4-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane chlorochromate In acetonitrile for 0.25h; Heating; | 97% |
Conditions | Yield |
---|---|
With water; acetone; mesoporous aluminosilicate at 55℃; for 2h; | 98% |
perchloric acid In methanol; water at 25 - 30℃; for 0.416667h; | 92% |
With water In methanol at 25 - 30℃; for 0.416667h; | 92% |
3-nitrophenyl-1,3-dithiolane
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With silica gel In neat (no solvent) at 20℃; for 0.0333333h; | 98% |
With sodium nitrate; sulfuric acid; silica gel In dichloromethane at 20℃; for 0.25h; | 90% |
With tert.-butylhydroperoxide In methanol; water Heating; | 77% |
Conditions | Yield |
---|---|
With water; silica gel; bis(trimethylsilyl)chromate In chloroform for 0.416667h; Heating; | 97% |
With potassium permanganate; montmorillonite K-10 for 0.333333h; | 94% |
With 3-carboxypyridinium chlorochromate In acetonitrile for 4h; Heating; | 80% |
With sulfuric acid; silica gel In hexane for 5h; | |
Multi-step reaction with 2 steps 1: 73 percent / O2 / 0.5 h / 2585.7 Torr 2: BzSPh (C13H12S) View Scheme |
Conditions | Yield |
---|---|
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate for 0.00972222h; | 97% |
With ammonium cerium(IV) nitrate In methanol; water at 20℃; for 0.166667h; Ring cleavage; | 96% |
potassium ferrate(VI); montmorillonite K-10 In dichloromethane for 0.25h; Heating; | 92% |
Conditions | Yield |
---|---|
With water; sodium hydroxide at 20℃; for 0.0666667h; Microwave irradiation; | 96% |
With trihexyl (tetradecyl) phosphonium tetrafluoroborate; dihydrogen peroxide In water at 50℃; for 1h; Inert atmosphere; | 87% |
With pyridine N-oxide; silver(l) oxide In acetonitrile at 50℃; | 86% |
Conditions | Yield |
---|---|
With sulfuric acid; water; nitric acid at 68℃; Concentration; Temperature; Flow reactor; | 96% |
1-Methyl-2-[2-(3-nitro-phenyl)-[1,3]dioxan-5-yl]-pyridinium; iodide
A
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 25℃; var.: K2CO3, 60 deg C; | A 95% B n/a |
With sodium hydroxide In ethanol at 25℃; Product distribution; var.: K2CO3, 60 deg C; | A 95% B n/a |
trimethyl(3-nitrobenzyloxy)silane
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In acetonitrile for 2.5h; Heating; | 95% |
With aluminum oxide; potassium permanganate for 0.333333h; Product distribution; Further Variations:; Reagents; reaction times; | 95% |
With aluminium trichloride; benzyltriphenylphosphonium chlorochromate In acetonitrile for 2.5h; Heating; | 95% |
2-(3-nitrophenyl)-1,3-dithiane
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With mercury(II) nitrate at 20℃; for 0.0333333h; | 95% |
With aluminium trichloride; 1-benzyl-1-aza-4-azoniabicyclo<2.2.2>octane periodate at 20℃; for 0.333333h; | 95% |
With potassium permanganate; tungstate sulfuric acid In dichloromethane at 20℃; for 1h; | 95% |
3-nitrobenzaldehyde N-[-(3-nitrophenyl)methylidene]hydrazone
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With selenium(IV) oxide In N,N-dimethyl-formamide at 100℃; for 4h; | 94% |
With ammonium cerium(IV) nitrate In acetonitrile for 1.5h; Heating; |
3-nitro-benzaldehyde semicarbazone
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With potassium permanganate; montmorillonite K-10 for 0.333333h; | 94% |
With magnesium hydrogen sulfate; water; silica gel In hexane at 20℃; for 0.25h; | 92% |
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃; for 0.0138889h; | 91% |
(3-Nitro-phenyl)-phenylamino-methanesulfonic acid; compound with methylamine
A
3-nitro-benzaldehyde
B
α-Anilino-m-nitro-toluolsulfonsaeure-aniliniumsalz
Conditions | Yield |
---|---|
With hydrogenchloride for 24h; | A n/a B 93% |
3,6,6-Trimethyl-4-{[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid dimethyl ester
A
3-nitro-benzaldehyde
B
3-nitrobenzonitrile
Conditions | Yield |
---|---|
With sodium methylate In ethanol for 3h; Product distribution; Heating; | A 4% B 93% |
Conditions | Yield |
---|---|
With copper(l) iodide; oxygen In dimethyl sulfoxide at 120℃; for 6h; chemoselective reaction; | 93% |
Conditions | Yield |
---|---|
With Vilsmeier reagent; potassium nitrate In neat (no solvent) at 100℃; under 1500.15 Torr; Reagent/catalyst; Temperature; Microwave irradiation; | 92% |
With nitric acid; sodium dodecyl-sulfate In acetonitrile at 24.84℃; for 3h; Micellar solution; regioselective reaction; | 86% |
With nitric acid; manganese(III) acetylacetonate In dichloromethane; water at 20℃; for 2.5h; regioselective reaction; | 85% |
Conditions | Yield |
---|---|
With N-acetoxyphthalimide; cobalt(II) acetate; manganese(II) acetate In acetic acid at 130℃; under 7600 Torr; for 14h; | A 5% B 92% |
With Coprinus sp. peroxidase; tartaric acid buffer; dihydrogen peroxide In water; acetone at 20℃; pH=5; |
2-(3-nitrophenyl)-1,3-oxathiolane
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With copper(II) nitrate monohydrate at 90℃; for 0.15h; | 92% |
With Montmorillonite K10 In benzene for 3.5h; Heating; | 85% |
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; β‐cyclodextrin In water; acetone at 20℃; for 0.333333h; | 85% |
With eosin Y disodium salt In acetonitrile at 20℃; for 3h; Irradiation; | 74% |
2-<3-Nitro-benzyloxy>-tetrahydro-pyran
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
With ammonium cerium(IV) nitrate; nitric acid; silica gel for 0.0666667h; microwave irradiation; | 91% |
With aluminium trichloride; silver bromate In acetonitrile for 2h; Heating; | 90% |
With potassium dichromate; aluminium trichloride for 0.5h; | 75% |
With aluminum oxide; [bis(acetoxy)iodo]benzene In acetonitrile for 1h; Oxidation; Heating; | 60% |
With trichloroisocyanuric acid In acetonitrile Reflux; |
Conditions | Yield |
---|---|
With (1,4-diazabicyclo{2.2.2}-octane)zinc(II) tetrahydoborate In hexane; dichloromethane for 0.25h; Ambient temperature; | 90% |
With diethylene glycol dimethyl ether; lithium tri-t-butoxyaluminum hydride | |
Multi-step reaction with 2 steps 1: 75 percent / pyridine / 0 °C 2: anhydrous potassium carbonate, hydrazine hydrate, copper (II) sulphate / methanol / 0.92 h / Heating View Scheme | |
Stage #1: m-nitrobenzoic acid chloride With morpholine; diisobutylaluminium hydride In tetrahydrofuran; hexane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With diisobutylaluminium hydride In tetrahydrofuran; hexane at 0℃; for 0.166667h; | 96 %Chromat. |
Conditions | Yield |
---|---|
With [(NO3)3Ce]3.H2IO6 In acetonitrile for 1.16667h; Heating; | 90% |
With ammonium dichromate(VI); water; silica gel; zirconium(IV) chloride at 80℃; for 0.416667h; | 90% |
With water; silica gel; iodic acid for 0.5h; | 85% |
With selenium(IV) oxide In N,N-dimethyl-formamide at 100℃; for 4h; | 79% |
Conditions | Yield |
---|---|
With iron(III) chloride In N,N-dimethyl-formamide at 25℃; for 0.5h; sonication; | 90% |
Conditions | Yield |
---|---|
With hydrogen bromide; dimethyl sulfoxide at 110℃; for 15h; | 89% |
With nitric acid In dichloromethane at 20℃; for 24h; | 78% |
With N-Bromosuccinimide In tetrachloromethane for 1h; Irradiation; Reflux; | 65% |
With sulfuric acid In water; acetonitrile for 6h; Quantum yield; Irradiation; different pH; | |
Multi-step reaction with 2 steps 1: O2 / H2O / Irradiation; neutral medium 2: KI / H2O View Scheme |
3-Methyl-4-{[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid diethyl ester
A
3-nitro-benzaldehyde
B
3-Methyl-4H-cyclopenta-1,2,4-triazin-5,7-dicarbonsaeure-diethylester
C
3-nitrobenzonitrile
Conditions | Yield |
---|---|
With ethanol Heating; | A 56% B 89% C 15% |
In ethanol Product distribution; Heating; | A 56% B 89% C 15% |
Conditions | Yield |
---|---|
With magnesium hydrogen sulfate; water; silica gel In hexane at 20℃; for 1h; | 88% |
Conditions | Yield |
---|---|
With sodium formate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 4h; | 88% |
With sodium formate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 6h; | 87% |
acetic anhydride
3-nitro-benzaldehyde
1,1-diacetoxy-1-(3-nitrophenyl)methane
Conditions | Yield |
---|---|
With poly(4-vinylpyridine)-supported sulfuric acid In dichloromethane at 20℃; for 0.0833333h; Green chemistry; chemoselective reaction; | 100% |
With ytterbium(III) perfluorooctanesulfonate; octadecafluorodecahydronaphthalene (cis+trans) In toluene at 80℃; for 2h; | 99% |
VSO4*5H2O at 20℃; for 0.75h; | 99% |
Conditions | Yield |
---|---|
With piperidine In ethanol | 100% |
With ethanol; zinc(II) chloride |
3-nitro-benzaldehyde
p-toluidine
N-(3-nitrobenzylidene)-4-methylbenzenamine
Conditions | Yield |
---|---|
100% | |
With chitosan In ethanol; water at 20℃; for 0.333333h; | 85% |
With ethanol |
3-nitro-benzaldehyde
dimedone
3,3,6,6-tetramethyl-9-(3-nitrophenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
Conditions | Yield |
---|---|
With poly[(2-acrylamido-2-methylpropane sulfonic acid)-co-(acrylic acid)-co-(vinyl functionalized halloysite clay)] In water at 20℃; for 3h; | 100% |
With N-sulfonic acid poly(4-vinylpyridinium) chloride at 100℃; for 0.133333h; | 98% |
With cobalt (II) nanoparticles(att)SBA-15 In water at 60℃; for 0.5h; Green chemistry; | 98% |
3-nitro-benzaldehyde
ethyl 2-cyanoacetate
(E)-2-cyano-3-(3-nitrophenyl)-2-propenoic acid ethyl ester
Conditions | Yield |
---|---|
With L-proline for 0.1h; Knoevenagel condensation; microwave irradiation; | 100% |
With third generation polystyrene supported poly(amidoamine) dendrimer In ethanol at 50℃; for 0.333333h; Knoevenagel condensation; | 100% |
With polyacrylonitrile fiber functionalized with N,N-dimethyl-1,3-propanediamine In ethanol for 1.5h; Knoevenagel condensation; Reflux; | 99% |
Conditions | Yield |
---|---|
With C7H15N4(1+)*BF4(1-) In water at 20℃; for 0.0166667h; Knoevenagel Condensation; Green chemistry; | 100% |
With sodium sulfide; aluminum oxide In dichloromethane at 20℃; for 0.0833333h; Knoevenagel reaction; | 99% |
With third generation polystyrene supported poly(amidoamine) dendrimer In ethanol at 30℃; for 0.25h; Knoevenagel condensation; | 99% |
Conditions | Yield |
---|---|
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given; | 100% |
With sodium tetrahydroborate In ethanol at 20℃; for 0.5h; Inert atmosphere; | 100% |
With sodium tetrahydroborate In ethanol at 0 - 20℃; | 99% |
Conditions | Yield |
---|---|
With barium permanganate In acetonitrile for 5h; Heating; | 100% |
With potassium bromate; sulfuric acid In acetic acid for 0.25h; Heating; | 99% |
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 5h; Heating; | 99% |
Conditions | Yield |
---|---|
With potassium tert-butylate In toluene Wittig-Horner Reaction; Reflux; Inert atmosphere; | 100% |
With sodium hydride In 1,2-dimethoxyethane | |
Horner-Wadsworth-Emmons Olefination; |
Conditions | Yield |
---|---|
With hydroxylamine In ethanol at 20℃; for 2h; Inert atmosphere; | 100% |
With hydroxylamine hydrochloride; silica gel at 50℃; for 3h; Temperature; Green chemistry; | 97% |
With hydroxylamine hydrochloride; potassium carbonate In water Reflux; | 97% |
Conditions | Yield |
---|---|
With 1-(ferrocenylbutyl)-4-(3-methylimidazolium) tetrafluoroborate; iodine; potassium carbonate at 50 - 60℃; for 24h; Inert atmosphere; | 100% |
With palladium 10% on activated carbon; oxygen; sodium carbonate at 90℃; under 15001.5 Torr; for 2h; Microwave irradiation; Green chemistry; | 98% |
With 3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl-1-(2,4,6-trimethylphenyl)-1H-imidazol-3-ium bis(trifluoromethanesulfonimide) salt; caesium carbonate In toluene at 60℃; for 3h; | 98% |
diethoxyphosphoryl-acetic acid ethyl ester
3-nitro-benzaldehyde
(E)-ethyl 3-(3-nitrophenyl)acrylate
Conditions | Yield |
---|---|
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h; | 100% |
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester; 3-nitro-benzaldehyde With lithium chloride In acetonitrile at 0℃; for 0.0833333h; Horner-Wadsworth-Emmons reaction; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 20℃; | 96% |
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: 3-nitro-benzaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; | 93% |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 0℃; | 100% |
3-nitro-benzaldehyde
5-chloro-1H-indole-2-carbohydrazide
5-Chlor-N'-<(3-nitrophenyl)-methylen>-2-indolcarbohydrazid
Conditions | Yield |
---|---|
In ethanol for 3h; Heating; | 100% |
3-nitro-benzaldehyde
4,6-dimethoxy-2,3-diphenyl-1H-indole
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran for 3h; | 100% |
lithium cyanide
3-nitro-benzaldehyde
benzoyl chloride
benzoyloxy-(3-nitro-phenyl)-acetonitrile
Conditions | Yield |
---|---|
In tetrahydrofuran for 0.166667h; Ambient temperature; | 100% |
3-nitro-benzaldehyde
diethyl 2,4-dioxoimidazolidin-5-yl-phosphonate
5-(3-nitro-benzylidene)-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol Ambient temperature; | 100% |
Conditions | Yield |
---|---|
at 20℃; for 12h; | 100% |
With magnesium sulfate In dichloromethane at 20℃; | 98% |
In methanol; dichloromethane for 18h; Molecular sieve; | 96% |
3-nitro-benzaldehyde
2-hydroxyethanethiol
2-(3-nitrophenyl)-1,3-oxathiolane
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In diethyl ether for 3h; Heating; | 100% |
TiCl4 on montmorillonite In dichloromethane for 0.5h; Heating; | 92% |
With lithium tetrafluoroborate In acetonitrile at 20℃; for 5h; | 87% |
With cation-exchange resin KU-2 In hexane azeotropic distillation of the water; | |
With N-Bromosuccinimide In dichloromethane at 20℃; |
3-nitro-benzaldehyde
acrylonitrile
2-[hydroxy(m-nitrophenyl)methyl]acrylonitrile
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 0.416667h; Morita-Baylis-Hillman reaction; | 100% |
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 0℃; for 0.416667h; Catalytic behavior; Solvent; Time; Temperature; Morita-Baylis-Hillman Alkylation; | 100% |
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 0.416667h; Baylis-Hillman reaction; neat (no solvent); | 99% |
N-(4-methoxyphenyl)ethane-1,2-diamine
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
In methanol at 25℃; for 1h; Condensation; | 100% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 1h; Condensation; | 100% |
3-nitro-benzaldehyde
N-(3-chlorophenyl)-1,2-diaminoethane
Conditions | Yield |
---|---|
In methanol at 25℃; for 1h; Condensation; | 100% |
3-nitro-benzaldehyde
Conditions | Yield |
---|---|
In methanol at 25℃; for 1h; Condensation; | 100% |
Conditions | Yield |
---|---|
at 25 - 30℃; for 1h; Solid phase reaction; condensation; | 100% |
With phosphoric acid In ethanol for 0.166667h; microwave irradiation; | 93% |
With trifluoroacetic acid In ethanol Reflux; | 86% |
5-methylisoxazol-3-ylamine
3-nitro-benzaldehyde
(5-Methyl-isoxazol-3-yl)-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amine
Conditions | Yield |
---|---|
Heating; | 100% |
In ethanol; chloroform |
3-nitro-benzaldehyde
1,1-dibromo-3,3,3-trifluoroacetone
2-(3-nitrophenyl)-4-trifluoromethyl-1H-imidazole
Conditions | Yield |
---|---|
Stage #1: 1,1-dibromo-3,3,3-trifluoroacetone With sodium acetate for 0.5h; Heating; Stage #2: 3-nitro-benzaldehyde With ammonia In methanol at 20℃; | 100% |
3-nitro-benzaldehyde
iso-propyl 3-oxo-5-(trimethylsilanyl)pent-4-ynoate
2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-5-trimethylsilanyl-pent-4-ynoic acid isopropyl ester
Conditions | Yield |
---|---|
With piperdinium acetate In toluene Knoevenagel condensation; Heating; | 100% |
The 3-Nitrobenzaldehyde , with the CAS register number 99-61-6, has other names as 3-nitro-benzaldehyd;3 nitrobenzaldehyle;5-nitrobenzaldehyde;benzaldehyde, m-nitro-;benzaldehyde,3-nitro-;m-nitro-benzaldehyd;nitrobenzaldehyde-3;m-nitrobenzaldehyde .
The physical properties of this chemical are as the following:(1)#H bond acceptors: 4 ; (2)#Freely Rotating Bonds: 2 ; (3)Polar Surface Area: 62.89; (4)Index of Refraction: 1.617 ; (5)Molar Refractivity: 39.55 cm3 ; (6)Molar Volume: 112.9 cm3 ; (7)Polarizability: 15.67× 10-24 cm3 ; (8)Surface Tension: 55.1 dyne/cm ; (9)Density: 1.338 g/cm3 ; (10)Flash Point: 128.6 °C ; (11)Enthalpy of Vaporization: 50.24 kJ/mol ; (12)Boiling Point: 264.5 °C at 760 mmHg ; (13)Vapour Pressure: 0.00966 mmHg at 25°C .
It is a kind of yellow crystalline solid and it is acicular while separate out of water. Being sensitive to air, it is soluble in mellow wine, ether, chloroform, and acetone while insoluble in water. As for its usage, it is widely used in many fields. First, it could be as the intermediate of organic synthesis, such as pharmaceutics, dying, and surfactant. Second, it could be used to composing the medicines in the pharmaceutic industry, such as iopanoic acid, Nimodipine, nicardipine, nitrendipine, and so on. As for its products category, they are various, including aromatic aldehydes & derivative;benzaldehyde;nicardipine;aldehydes;c7;carbonyl compounds.
Being an irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes and it will be very harmful if swallowed. Then it is toxic to aquatic organisms and it may cause long-term adverse effects in the aquatic environment. So while dealing with it, we need to very cautious. Wear suitable protective clothing and eye/face protection and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And avoid contacting with skin and eyes. Besides, avoid releasing to the environment and then refer to special instructions/safety data sheet. What's more, do not empty into drains. If you need more safety information, you could refer to the WGK Germany 3.
What's more, there is a simple way to produce the chemical in the lab. Prepare the raw material of benzaldehyde and then have the process of nitration under the existence of vitriol with nitrate of potash, sodium nitrate or hydrogen nitrate, then you could get the 3-Nitrobenzaldehyde, with the productivity of 80%、60% and 75%.
Its preparation products are including 3-Hydroxybenzaldehyde, 3-Chlorobenzaldehyde, Iopanoic acid, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, Nicardipine, 3-(3-Nitrophenyl)propionic acid, Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate , etc. Besides, its raw materials are including Etanol, Ethyl acetate, Sulfuric acid, Dichloromethane, PETROLEUM ETHER, Nitric acid.
Below are the toxicity information of this chemcial:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD | intraperitoneal | > 500mg/kg (500mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 144, 1954. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02435, |
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