Product Name

  • Name

    3-Cyanomethylthiophene

  • EINECS 237-433-1
  • CAS No. 13781-53-8
  • Article Data12
  • CAS DataBase
  • Density 1.171 g/cm3
  • Solubility
  • Melting Point
  • Formula C6H5NS
  • Boiling Point 243.7 °C at 760 mmHg
  • Molecular Weight 123.178
  • Flash Point 92.4 °C
  • Transport Information UN 3276 6.1/PG 2
  • Appearance clear yellow to brown liquid
  • Safety 26-36/37-45-36/37/39
  • Risk Codes 20/21/22-36/37/38-23/24/25
  • Molecular Structure Molecular Structure of 13781-53-8 (3-Cyanomethylthiophene)
  • Hazard Symbols HarmfulXn, ToxicT
  • Synonyms 3-Cyanomethylthiophene;3-Thienylacetonitrile;
  • PSA 52.03000
  • LogP 1.81418

Synthetic route

3-chlorothiophene
17249-80-8

3-chlorothiophene

sodium cyanoacetate
1071-36-9

sodium cyanoacetate

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(η3-allyl-μ-chloropalladium(II)) In 1,3,5-trimethyl-benzene at 20 - 140℃; for 5.16667h; Inert atmosphere; Sealed tube; chemoselective reaction;78%
Thien-3-ylboronic acid
6165-69-1

Thien-3-ylboronic acid

chloroacetonitrile
107-14-2

chloroacetonitrile

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate In 1,4-dioxane; water at 100℃; for 12h; Inert atmosphere; Sealed tube;53%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate In 1,4-dioxane; water at 60℃; for 12h; Inert atmosphere; Sealed tube;
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

sodium cyanide
143-33-9

sodium cyanide

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
tetrabutylammomium bromide In dichloromethane; water Heating / reflux;44%
With ethanol
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

potassium cyanide

potassium cyanide

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water28%
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

potassium cyanide
151-50-8

potassium cyanide

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With ethanol
3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2, 36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With potassium tert-butylate 1.) THF, -20 deg C, 30 min, 2.) THF, -20 deg C, 30 min; Yield given. Multistep reaction;
Methyl 2-cyano-2-(3-thienyl)acetate
81344-59-4

Methyl 2-cyano-2-(3-thienyl)acetate

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With water; triethylamine Product distribution;
3-Methylthiophene
616-44-4

3-Methylthiophene

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / Reflux
2: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide
2: N-benzyl-N,N,N-triethylammonium chloride / water
View Scheme
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; acetonitrile at 0 - 20℃; Inert atmosphere;4.06 g
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

(Z)-3-Dimethylamino-2-thiophen-3-yl-acrylonitrile

(Z)-3-Dimethylamino-2-thiophen-3-yl-acrylonitrile

Conditions
ConditionsYield
With 2,4-dichlorophenoxyacetic acid dimethylamine In toluene Heating;100%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

methanol
67-56-1

methanol

2-Thiophen-3-yl-acetimidic acid methyl ester; hydrochloride

2-Thiophen-3-yl-acetimidic acid methyl ester; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 0 - 5℃;99%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

3-(3'-Thienyl)-2-(2''-tolyl)propenenitrile

3-(3'-Thienyl)-2-(2''-tolyl)propenenitrile

Conditions
ConditionsYield
With sodium ethanolate In ethanol98%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-(3-thienyl)ethylamine
59311-67-0

2-(3-thienyl)ethylamine

Conditions
ConditionsYield
With indium(III) chloride; sodium tetrahydroborate In tetrahydrofuran at 25℃; for 4h; Inert atmosphere;97%
With diisobutylaluminum borohydride In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;71%
With indium(III) chloride; sodium tetrahydroborate In tetrahydrofuran at 25℃; for 16h; Inert atmosphere;67%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

2-((thiophen-3-yl)methyl)benzo[d]thiazole
1427180-57-1

2-((thiophen-3-yl)methyl)benzo[d]thiazole

Conditions
ConditionsYield
With copper diacetate; triethylamine In ethanol at 70℃; for 6h;97%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

(Z)-3-Thiophen-2-yl-2-thiophen-3-yl-acrylonitrile
13781-61-8

(Z)-3-Thiophen-2-yl-2-thiophen-3-yl-acrylonitrile

Conditions
ConditionsYield
With sodium methylate In methanol at 30℃; Kinetics; Thermodynamic data; ΔE*, Σ*, A;95%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

benzaldehyde
100-52-7

benzaldehyde

(E)-3-phenyl-2-(3-thienyl)acrylonitrile
13781-54-9

(E)-3-phenyl-2-(3-thienyl)acrylonitrile

Conditions
ConditionsYield
With sodium methylate In methanol at 30℃; Kinetics; Thermodynamic data; ΔE*, Σ*, A;95%
With sodium ethanolate In ethanol94%
With potassium tert-butylate In ethanol Heating;60%
With potassium tert-butylate In ethanol at 20℃; Knoevenagel condensation;60%
With sodium ethanolate In ethanol at 4℃; for 8h;51%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

4-Octyne
1942-45-6

4-Octyne

(Z)-2-propyl-3-(3-thienylmethyl)-2-hexenenitrile
1180490-30-5

(Z)-2-propyl-3-(3-thienylmethyl)-2-hexenenitrile

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel(0); dimethylaluminum chloride; 2-dicyclohexylphosphino-2',4',6'-trimethylbiphenyl In hexane; toluene at 80℃; for 2h; Inert atmosphere; stereoselective reaction;95%
With bis(1,5-cyclooctadiene)nickel (0); dimethylaluminum chloride; 2-dicyclohexylphosphino-2',4',6'-trimethylbiphenyl In hexane; tetradecane; toluene at 80℃; for 2h; Inert atmosphere; regioselective reaction;95%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-(thiophen-3-yl) ethanamine hydrochloride
34843-84-0

2-(thiophen-3-yl) ethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With borane-dimethyl sulfide complex In tetrahydrofuran for 16h; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 0.333333h;
94%
Stage #1: (thiophen-3-yl)acetonitrile With dimethylsulfide borane complex In tetrahydrofuran for 16h; Heating / reflux;
Stage #2: With methanol In tetrahydrofuran
94%
Stage #1: (thiophen-3-yl)acetonitrile With dimethylsulfide borane complex In tetrahydrofuran for 16h; Heating / reflux;
Stage #2: With hydrogenchloride; methanol at 20℃; for 0.333333h;
94%
Stage #1: (thiophen-3-yl)acetonitrile With dimethylsulfide borane complex In tetrahydrofuran for 12h; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran for 0.5h;
78.5%
Stage #1: (thiophen-3-yl)acetonitrile With borane-THF In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;
Stage #2: With methanol In tetrahydrofuran
Stage #3: With hydrogenchloride In 1,4-dioxane; methanol
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

5-(thiophen-3-ylmethyl)-1H-1,2,3,4-tetrazole

5-(thiophen-3-ylmethyl)-1H-1,2,3,4-tetrazole

Conditions
ConditionsYield
With sodium azide; triethylamine hydrochloride In toluene at 110℃; for 16h; Inert atmosphere;93%
With aluminium trichloride; sodium azide In tetrahydrofuran for 48h; Heating;61%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

4,4-bis(methylthio)but-3-en-2-one
17649-86-4

4,4-bis(methylthio)but-3-en-2-one

(E)-3-Methylsulfanyl-5-oxo-2-thiophen-3-yl-hex-3-enenitrile

(E)-3-Methylsulfanyl-5-oxo-2-thiophen-3-yl-hex-3-enenitrile

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With sodium hydride In N,N-dimethyl-formamide; benzene for 0.25h; Metallation;
Stage #2: 4,4-bis(methylthio)but-3-en-2-one In N,N-dimethyl-formamide at 20℃; Substitution;
93%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

ethanol
64-17-5

ethanol

ethyl 2-(thiophen-3-yl)acetimidate hydrochloride

ethyl 2-(thiophen-3-yl)acetimidate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 0℃; Pinner reaction;93%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

bis(acetonitrile)diiodotricarbonyltungsten(II)
113350-36-0, 102382-37-6

bis(acetonitrile)diiodotricarbonyltungsten(II)

triphenylphosphine
603-35-0

triphenylphosphine

WI2(CO)3(thiophene-3-acetonitrile)(PPh3)
211744-19-3

WI2(CO)3(thiophene-3-acetonitrile)(PPh3)

Conditions
ConditionsYield
In dichloromethane N2-atmosphere; stirring W-complex with equimolar amt. of PPh3 for 3 min,filtration into equimolar amt. of ligand soln., stirring for 30 min; solvent removal (vac.); elem. anal.;93%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-(2,5-diiodothiophen-3-yl)acetonitrile

2-(2,5-diiodothiophen-3-yl)acetonitrile

Conditions
ConditionsYield
With N-iodo-succinimide; toluene-4-sulfonic acid In ethanol at 50℃; for 0.166667h; Green chemistry; regioselective reaction;93%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

Glyoxilic acid
298-12-4

Glyoxilic acid

(2Z)-3-cyano-3-(3-thienyl)acrylic acid
1076169-87-3

(2Z)-3-cyano-3-(3-thienyl)acrylic acid

Conditions
ConditionsYield
With potassium carbonate In methanol for 3h; Knoevenagel Condensation; Reflux;90%
With potassium carbonate In methanol for 3h; Heating / reflux;90%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

methyl iodide
74-88-4

methyl iodide

rac-2-(thiophen-2-yl)propanenitrile
88701-59-1

rac-2-(thiophen-2-yl)propanenitrile

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
90%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

cyclopropyl(4-fluorophenyl)methanone
772-31-6

cyclopropyl(4-fluorophenyl)methanone

9a-(4-fluorophenyl)-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one
1429308-76-8

9a-(4-fluorophenyl)-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one

Conditions
ConditionsYield
With tributylphosphine; boron trifluoride diethyl etherate; copper(I) bromide In nitromethane at 90℃; for 18h; Ritter Amidation;90%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

bis(acetonitrile)diiodotricarbonyltungsten(II)
113350-36-0, 102382-37-6

bis(acetonitrile)diiodotricarbonyltungsten(II)

WI2(CO)3(thiophene-3-acetonitrile)2
211744-17-1

WI2(CO)3(thiophene-3-acetonitrile)2

Conditions
ConditionsYield
In dichloromethane N2-atmosphere; stirring W-complex with 2 equiv. of ligand (warm water bath, 90 min, then room temp., 1 h); filtration, solvent removal (vac.); elem. anal.;89%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

2-(thiophene-3-yl) acetamide
13781-66-3

2-(thiophene-3-yl) acetamide

Conditions
ConditionsYield
With water at 130℃; for 1h; Microwave irradiation;88%
With copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In nitromethane; water at 20 - 100℃; for 3h;75%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

methyl (4-methoxyphenyl)carbodithioate
5874-09-9

methyl (4-methoxyphenyl)carbodithioate

2-(4-methoxyphenyl)thieno[2,3-b]thiophene-3-carbonitrile

2-(4-methoxyphenyl)thieno[2,3-b]thiophene-3-carbonitrile

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With potassium tert-butylate In 1,4-dioxane at 0℃; for 0.166667h;
Stage #2: methyl (4-methoxyphenyl)carbodithioate In 1,4-dioxane at 0 - 20℃; for 1h;
Stage #3: With iodine In 1,4-dioxane at 90℃;
87%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

α,α'-dichloroazo compound
57908-42-6

α,α'-dichloroazo compound

6,7,8,9-tetrahydro-2-(thiophene-3-yl)methyl-5H-[1,2,4]triazolo[1,5-a]azepine

6,7,8,9-tetrahydro-2-(thiophene-3-yl)methyl-5H-[1,2,4]triazolo[1,5-a]azepine

Conditions
ConditionsYield
With antimonypentachloride In dichloromethane at -60 - 23℃; for 2.16667h;86%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

formic acid ethyl ester
109-94-4

formic acid ethyl ester

3-hydroxy-2-(thien-3-yl)acrylonitrile sodium salt

3-hydroxy-2-(thien-3-yl)acrylonitrile sodium salt

Conditions
ConditionsYield
With sodium methylate In methanol for 2h; Heating;85%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

allyl bromide
106-95-6

allyl bromide

2-allyl-2-(thiophen-3-yl)pent-4-enenitrile
62716-51-2

2-allyl-2-(thiophen-3-yl)pent-4-enenitrile

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With sodium hydride In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: allyl bromide In dimethyl sulfoxide at 20℃; for 2h; Inert atmosphere;
85%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

4-chlorophenyl cyclopropyl ketone
6640-25-1

4-chlorophenyl cyclopropyl ketone

9a-(4-chlorophenyl)-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one
1429308-77-9

9a-(4-chlorophenyl)-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one

Conditions
ConditionsYield
With tributylphosphine; boron trifluoride diethyl etherate; copper(I) bromide In nitromethane at 90℃; for 18h; Ritter Amidation;84%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

cyclopropyl phenyl ketone
3481-02-5

cyclopropyl phenyl ketone

9a-phenyl-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one
1429308-75-7

9a-phenyl-7,8,9,9a-tetrahydrothieno[3,2-g]indolizin-5(4H)-one

Conditions
ConditionsYield
With tributylphosphine; boron trifluoride diethyl etherate; copper(I) bromide In nitromethane at 90℃; for 18h; Ritter Amidation;84%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

N-Hydroxy-2-thiophen-3-yl-acetamidine
925252-85-3, 155601-61-9

N-Hydroxy-2-thiophen-3-yl-acetamidine

Conditions
ConditionsYield
With potassium carbonate; ammonium chloride In methanol at 60℃; for 12h;83%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

bis-(1-chloro-1-methyl-ethyl)-diazene
29540-62-3

bis-(1-chloro-1-methyl-ethyl)-diazene

1,5-dimethyl-3-((thiophene-3-yl)methyl)-1H-1,2,4-triazole

1,5-dimethyl-3-((thiophene-3-yl)methyl)-1H-1,2,4-triazole

Conditions
ConditionsYield
With antimonypentachloride In dichloromethane at -60 - 23℃; for 2.16667h;83%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

methyl 4-bromocrotonate
1117-71-1

methyl 4-bromocrotonate

methyl 5-(dimethylamino)thiophene-2-carbodithioate

methyl 5-(dimethylamino)thiophene-2-carbodithioate

2-(5-(dimethylamino)thiophen-2-yl)-3-(thiophen-3-yl)thieno[3,2-b]pyridin-5(4H)-one

2-(5-(dimethylamino)thiophen-2-yl)-3-(thiophen-3-yl)thieno[3,2-b]pyridin-5(4H)-one

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.166667h;
Stage #2: methyl 5-(dimethylamino)thiophene-2-carbodithioate In tetrahydrofuran at 0℃; for 0.5h;
Stage #3: methyl 4-bromocrotonate In tetrahydrofuran at 0 - 20℃; for 8.5h;
82%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

hexachlorobenzene
118-74-1

hexachlorobenzene

α-(3-Thiophene-yl)-α-(2,3,4,5,6-pentachlorophenyl)acetonitrile

α-(3-Thiophene-yl)-α-(2,3,4,5,6-pentachlorophenyl)acetonitrile

Conditions
ConditionsYield
With n-butyllithium In diethyl ether 1.) -70 deg C, 2 h, 2.) -70 deg C to r.t.; r.t., overnight;80%
(thiophen-3-yl)acetonitrile
13781-53-8

(thiophen-3-yl)acetonitrile

methyl fluorobenzenedithiocarboxylate
5969-47-1

methyl fluorobenzenedithiocarboxylate

2-(4-fluorophenyl)thieno[2,3-b]thiophene-3-carbonitrile

2-(4-fluorophenyl)thieno[2,3-b]thiophene-3-carbonitrile

Conditions
ConditionsYield
Stage #1: (thiophen-3-yl)acetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.166667h;
Stage #2: methyl fluorobenzenedithiocarboxylate In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;
Stage #3: With tetrabutylammomium bromide; copper diacetate; palladium diacetate In N,N-dimethyl-formamide; mineral oil at 90℃;
80%
Stage #1: (thiophen-3-yl)acetonitrile With potassium tert-butylate In 1,4-dioxane at 0℃; for 0.166667h;
Stage #2: methyl fluorobenzenedithiocarboxylate In 1,4-dioxane at 0 - 20℃; for 1h;
Stage #3: With iodine In 1,4-dioxane at 90℃;
77%

3-Thiopheneacetonitrile Chemical Properties

IUPAC Name: 2-thiophen-3-ylacetonitrile
The MF of 3-Thiopheneacetonitrile(13781-53-8): C6H5NS
The MW of 3-Thiopheneacetonitrile(13781-53-8): 123.18
EINECS: 237-433-1
bp: 124-125 °C16 mm Hg(lit.)
density: 1.08 g/mL at 25 °C(lit.)
refractive index: n20/D 1.545(lit.)
Fp: >230 °F
Appearance: Clear brown liquid.
Categories: Aromatic Nitriles;Thiophene&Benzothiophene;Nitriles;Thiophens
Synonyms: THIOPHENE-3-ACETONITRILE;3-Thienylacetonitrile;LABOTEST-BB LT00848266;3-THIOPHENEACETONITRILE;3-Cyanomethylthiophene;thiophen-3-acetonitrile;2,3-thiopheneacetonitrile;THIEN-3-YLACETONITRILE
The Structure of 3-Thiopheneacetonitrile(13781-53-8):

3-Thiopheneacetonitrile Safety Profile

Hazard Codes: Xn,T
Risk Statements: 20/21/22-36/37/38-23/24/25
20/21/22:  Harmful by inhalation, in contact with skin and if swallowed 
36/37/38:  Irritating to eyes, respiratory system and skin 
23/24/25:  Toxic by inhalation, in contact with skin and if swallowed 
Safety Statements: 26-36/37-45-36/37/39
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36/37:  Wear suitable protective clothing and gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
RIDADR: UN 3276 6.1/PG 2
WGK Germany: 3
PackingGroup: III

3-Thiopheneacetonitrile Specification

1. First Aid Measures
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
2. Handling and Storage
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
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