morpholine
1,3-chlorobromopropane
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
Stage #1: morpholine; 1.3-chlorobromopropane In toluene at 84℃; for 3h; Stage #2: With hydrogenchloride In 1,4-dioxane; toluene | 90% |
Stage #1: morpholine; 1.3-chlorobromopropane In toluene at 84℃; for 3h; Stage #2: With hydrogenchloride In 1,4-dioxane | 90% |
Stage #1: morpholine; 1.3-chlorobromopropane In toluene at 84℃; for 3h; Stage #2: With hydrogenchloride In 1,4-dioxane | 90% |
morpholine
1-iodo-3-chloro-propane
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
Stage #1: morpholine; 1-iodo-3-chloro-propane With potassium carbonate In N,N-dimethyl-formamide for 16h; Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether | 32% |
5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester
N-(3-chloropropyl)morpholine hydrochloride
ethyl 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzoate
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane for 7h; Product distribution / selectivity; Reflux; | 98% |
methyl 2-nitro-4-methoxy-5-hydroxybenzoate
N-(3-chloropropyl)morpholine hydrochloride
4-methoxy-5-(3-morpholinylpropoxy)-2-nitrobenzoic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 2.5h; Reflux; | 87.5% |
With potassium carbonate In acetonitrile for 2.5h; Reflux; |
2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium iodide; sodium hydroxide In methanol; water at 20℃; for 4h; | 87% |
5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol
N-(3-chloropropyl)morpholine hydrochloride
7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 90℃; for 5h; Solvent; Large scale; | 86% |
1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline
N-(3-chloropropyl)morpholine hydrochloride
4-(3-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)propyl)morpholine
Conditions | Yield |
---|---|
With caesium carbonate; potassium iodide In acetonitrile at 20℃; for 3.75h; Reflux; | 83% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide for 6h; Reflux; | 80% |
N-(3-chloropropyl)morpholine hydrochloride
N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}nicotinamide
Conditions | Yield |
---|---|
Stage #1: N-(8-hydroxy-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide bis(trifluoroacetate) With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: N-(3-chloropropyl)morpholine hydrochloride In N,N-dimethyl-formamide at 60℃; for 20h; | 79% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; | 74% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; | 74% |
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-(3-chloropropyl)morpholine hydrochloride
foretinib
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 5h; | 72% |
4-hydroxy-3-phenylcoumarin
N-(3-chloropropyl)morpholine hydrochloride
4-(3-morpholin-4-yl-propoxy)-3-phenyl-chromen-2-one
Conditions | Yield |
---|---|
71% |
4,5-diphenyl-1H-imidazole
N-(3-chloropropyl)morpholine hydrochloride
4-[3-(4,5-diphenylimidazol-1-yl)-propyl]morpholine
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 24h; Heating / reflux; | 68% |
5-nitroguaiacol
N-(3-chloropropyl)morpholine hydrochloride
4-[3-(2-methoxy-5-nitrophenoxy)propyl]morpholine
Conditions | Yield |
---|---|
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 110℃; for 16h; | 61% |
N-(3-chloropropyl)morpholine hydrochloride
3-butyryl-4-(2-methylphenylamino)-8-hydroxyquinoline
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 2.5h; | 58% |
ethyl 3,4-bis(benzyloxy)-5-(dimethylcarbamoyl)-1-(4-hydroxyphenyl)-1H-pyrrole-2-carboxylate
N-(3-chloropropyl)morpholine hydrochloride
ethyl 3,4-bis(benzyloxy)-5-(dimethylcarbamoyl)-1-(4-(3-morpholinopropoxy)phenyl)-1H-pyrrole-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h; | 57% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 16h; | 56% |
5-{[(3-hydroxy-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione
N-(3-chloropropyl)morpholine hydrochloride
5-((3-(3-morpholinopropoxy)-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In DMF (N,N-dimethyl-formamide) at 60℃; for 2h; | 51% |
N-(3-chloropropyl)morpholine hydrochloride
7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
Conditions | Yield |
---|---|
Stage #1: 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol bis(trifluoroacetate) With triethylamine In dichloromethane at 20℃; for 1.5h; Stage #2: N-(3-chloropropyl)morpholine hydrochloride With caesium carbonate In N,N-dimethyl-formamide at 70 - 75℃; for 4.5h; | 44% |
methyl 4-bromo-1H-indazole-6-carboxylate
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With 18-crown-6 ether; sodium hexamethyldisilazane In tetrahydrofuran for 16h; Reflux; Inert atmosphere; | 43% |
N-(3-chloropropyl)morpholine hydrochloride
N-[2-[[(tert-butylamino)carbonyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]acetamide
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 52℃; for 26h; | 41% |
6-(4-hydroxyphenyl)-3,9-dimethoxy-5H-indeno[1,2-c] isoquinoline-5,11(6H)-diketone
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 6-(4-hydroxyphenyl)-3,9-dimethoxy-5H-indeno[1,2-c] isoquinoline-5,11(6H)-diketone; N-(3-chloropropyl)morpholine hydrochloride With tetrabutylammomium bromide In tetrahydrofuran at 20℃; Stage #2: With sodium hydroxide In tetrahydrofuran; water for 4h; Reflux; Inert atmosphere; | 38% |
Conditions | Yield |
---|---|
Stage #1: 3-Bromophenol; N-(3-chloropropyl)morpholine hydrochloride With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40℃; for 88h; Stage #2: formic acid | 38% |
N-(3-chloropropyl)morpholine hydrochloride
(2R,3R)-N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N-(4-fluorophenyl)-2,3-dimethylcyclopropane-1,1-dicarboxamide hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; | 37% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Inert atmosphere; | 37% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium hydrogencarbonate; potassium iodide In 2-ethoxy-ethanol at 110℃; for 2.5h; | 36% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With 4 A molecular sieve In acetone Heating; | 34% |
6-(4-hydroxyphenyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-diketone
N-(3-chloropropyl)morpholine hydrochloride
6-(4-(3-morpholinylpropoxy) phenyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)diketone
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 12h; Reflux; | 32% |
4-((2,4-difluorophenyl)amino)-7-methoxyquinazolin-6-ol
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 30% |
N-(3-chloropropyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Inert atmosphere; | 18% |
The 4-(3-Chloropropyl)morpholine hydrochloride, with the CAS registry number 57616-74-7, is also known as Morpholinopropylchloride hydrochloride. Its EINECS number is 260-851-0. This chemical's molecular formula is C7H14ClNO.HCl and molecular weight is 200.11. What's more, its systematic name is 4-(3-Chloropropyl)morpholin-4-ium chloride.
Physical properties of 4-(3-Chloropropyl)morpholine hydrochloride are: (1)ACD/LogP: 0.656; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.19; (4)ACD/LogD (pH 7.4): 0.37; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 28.11; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 9.23 Å2; (13)Flash Point: 91.2 °C; (14)Enthalpy of Vaporization: 46.37 kJ/mol; (15)Boiling Point: 227.1 °C at 760 mmHg; (16)Vapour Pressure: 0.0789 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].ClCCC[NH+]1CCOCC1
(2)Std. InChI: InChI=1S/C7H14ClNO.ClH/c8-2-1-3-9-4-6-10-7-5-9;/h1-7H2;1H
(3)Std. InChIKey: PQECODMSWJOUAT-UHFFFAOYSA-N
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