4,6-Dichloropyrimidine supplier

Name
4,6-Dichloropyrimidine
EINECS 214-770-2
CAS No. 1193-21-1
Article Data40
CAS DataBase
Density 1.493 g/cm³
Solubility
Melting Point 65-67 °C(lit.)
Formula C₄H₂Cl₂N₂
Boiling Point 176 °C at 760 mmHg
Molecular Weight 148.979
Flash Point 105.1 °C
Transport Information UN 3263 8/PG 2
Appearance Yellow Solid
Safety 26-36/37/39-45-27
Risk Codes 34-20/21/22-36/37
Molecular Structure
Hazard Symbols C
Synonyms 4,6-Dichloro Pyrimidine;Pyrimidine, 4,6-dichloro-;
PSA 25.78000
LogP 1.78340

Synthetic route

: 104-90-5
5-ethyl-2-methyl-pyridine

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate	100%
With trichlorophosphate	98%

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate at 40 - 105℃; for 2h;	99.1%
With chlorine; magnesium chloride; phosphorus trichloride In trichlorophosphate at 66℃; under 750.075 Torr; for 3.5h; Reagent/catalyst; Temperature; Pressure; Solvent;	99.83%
With bis(trichloromethyl) carbonate; sulfuric acid In N,N-dimethyl-formamide; 1,2-dichloro-benzene at 80℃; for 4.2h; Temperature; Solvent; Industrial scale;	97%

: 2434-56-2
4,6-diaminopyrimidine

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: 4,6-diaminopyrimidine With hydrogenchloride; sodium nitrite In water at -5℃; for 2h; Stage #2: With hydrogenchloride; copper(l) chloride In water at 45℃; for 2h;	86.4%

: 75-44-5
phosgene

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With 2,3-Dimethylaniline In dichloromethane; water	80%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile

: 89283-48-7
4-chloro-6-methylsulfanylpyrimidine

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With sulfuryl dichloride In dichloromethane; acetonitrile at 0℃; for 0.5h;	76%

: 75-44-5
phosgene

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 75-05-8
acetonitrile

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
at 20 - 140℃; under 982.607 - 20686.5 Torr; for 3h; the Parr Reactor (17328-33);	62.21%
at 105℃; under 5999.08 - 8378.02 Torr; for 3h;
With hydrogenchloride In chlorobenzene at 105℃; under 11739.6 Torr; for 23.5h;

...Expand

: 25286-58-2
1H-pyrimidine-4,6-dione

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With pyridine; trichlorophosphate
With N,N-dimethyl-aniline; trichlorophosphate

: C6(2)H6*C4H2Cl2N2

A: 1193-21-1
4,6-dichloropyrimidine

B: 1076-43-3
benzene-d6

Conditions

Conditions	Yield
In tetrachloromethane at 34.9℃; Equilibrium constant;

: 60-35-5
acetamide

: 75-44-5
phosgene

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In chlorobenzene at 75 - 105℃; under 4913.04 - 17583.5 Torr; for 1.66667 - 23.1667h;

...Expand

: 75-44-5
phosgene

: 623-49-4
ethyl cyanoformate

: 75-05-8
acetonitrile

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With hydrogenchloride at 52 - 74℃;

...Expand

: 75-44-5
phosgene

: 25600-32-2
aminoketone hydrochloride

: 13507-15-8
acetamide hydrochloride

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In chlorobenzene at 105℃; under 14997.7 Torr; for 90h;

...Expand

: 26452-81-3
4-chloro-6-methoxy-pyrimidine

: 1193-21-1
4,6-dichloropyrimidine

: 75-44-5
phosgene

: 1193-24-4
4,6-pyrimidinediol

: 791-28-6
Triphenylphosphine oxide

: 2526-64-9
dichlorotriphenylphosphorane

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In chlorobenzene

...Expand

: 75-44-5
phosgene

: 1122-58-3
dmap

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In water; acetonitrile

...Expand

: 288-32-4
1H-imidazole

: 75-44-5
phosgene

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In acetonitrile

...Expand

: 1193-21-1
4,6-dichloropyrimidine

: 7422-78-8
allylhydrazine

: 4,6-bis[1-(prop-2-enyl)hydrazino]pyrimidine

Conditions

Conditions	Yield
for 3h; Heating;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 60-34-4
methylhydrazine

: 618428-20-9
4,6-bis(1-methylhydrazino)pyrimidine

Conditions

Conditions	Yield
for 2h; Heating;	100%
for 2h; Inert atmosphere; Reflux;	86%
Reflux; Inert atmosphere;

: 1193-21-1
4,6-dichloropyrimidine

: 124-40-3
dimethyl amine

: 31058-83-0
6-chloro-N,N-dimethylpyrimidin-4-amine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol Heating;	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 20℃; for 28h;
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;
With potassium carbonate In tetrahydrofuran; 1,4-dioxane for 14h; Reflux;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethanol at 150℃; for 0.0833333h; Microwave irradiation;

: 1193-21-1
4,6-dichloropyrimidine

: 392338-15-7
tert-butyl [(3R)-pyrrolidin-3-yl]methylcarbamate

: 929716-71-2
tert-butyl (R)-(1-(2-amino-6-chloropyrimidin-4-yl)pyrrolidin-3-yl)(methyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol for 24h; Product distribution / selectivity; Heating / reflux;	100%

: 862270-48-2
(R)-4-[1-(4-fluorophenyl)ethyl]piperazine

: 1193-21-1
4,6-dichloropyrimidine

: 1020064-27-0
4-chloro-6-{4-[(R)-1-(4-fluoro-phenyl)-ethyl]-piperazin-1-yl}-pyrimidine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 70℃; for 6h;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 939986-79-5
tert-butyl 4-((6-chloropyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 120℃; for 0.5h; Microwave irradiation;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 442199-19-1
tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 1h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃; for 2h;	100%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; for 2h;	72%
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃;	59%

: 1193-21-1
4,6-dichloropyrimidine

: 39546-32-2
4-carboxamidopiperidine

: 1242240-92-1
1-(6-chloropyrimidin-4-yl)piperidine-4-carboxamide

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; Microwave irradiation;	100%
With triethylamine In ethanol at 100℃; for 1h; Microwave irradiation;	71%
With triethylamine Microwave irradiation;

: 1193-21-1
4,6-dichloropyrimidine

: 1231749-37-3
6-hydroxy-3,4-dimethyl-3H-benzoxazol-2-one

: 1231749-35-1
6-(6-chloro-pyrimidin-4-yloxy)-3,4-dimethyl-3H-benzoxazol-2-one

Conditions

Conditions	Yield
Stage #1: 6-hydroxy-3,4-dimethyl-3H-benzoxazol-2-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.166667h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 1231750-06-3
(S)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-ol

: 1231750-08-5
(S)-6-(6-chloropyrimidin-4-yloxy)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 101187-40-0
1-Boc-amine-11-amino-3,6,9-trioxaundecane

: tert-butyl {2-[2-(2-{2-[(6-chloropyrimidin-4-yl)amino]ethoxy}ethoxy)ethoxy]ethyl}carbamate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 17h;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 2-(7-(difluoromethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-amine hydrochloride

: 6-chloro-N-(2-(7-(difluoromethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)pyrimidin-4-amine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 95℃; for 2.5h; Inert atmosphere;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 66399-30-2
(S)-1-(4-Fluoro-phenyl)-ethylamine

: (S)-6-chloro-N-(1-(4-fluorophenyl)ethyl)pyrimidin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃; for 5h;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 845252-02-0
(1S)-1-(2,4-difluorophenyl)ethanamine

: C12H10ClF2N3

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 1-(2-chloro-4-fluorophenyl)ethan-1-amine

: C12H10Cl2FN3

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50℃;	100%

: 1193-21-1
4,6-dichloropyrimidine

: 95-54-5
1,2-diamino-benzene

: C10H9ClN4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 150℃; for 0.166667h; Irradiation;	100%

: 1193-21-1
4,6-dichloropyrimidine

: Sodium N-benzylglycinate

: 155670-20-5
6--4-chloropyrimidine

Conditions

Conditions	Yield
In ethanol Heating;	99.2%

: 1193-21-1
4,6-dichloropyrimidine

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1-(6-chloropyrimidin-4-yl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions

Conditions	Yield
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%
Stage #1: 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;	99.2%

: 1193-21-1
4,6-dichloropyrimidine

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1007124-88-0
(1R,2S,3R,5R)-3-[(6-Chloropyrimidin-4-yl)amino]-5-(hydroxymethyl)-cyclopentane-1,2-diol

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 90℃; for 1h; Product distribution / selectivity;	99%
With triethylamine In ethanol at 150℃; for 0.25h; Product distribution / selectivity; Microwave irradiation;	90%

: 1193-21-1
4,6-dichloropyrimidine

: 98-17-9
3-Trifluoromethylphenol

: 4-chloro-6-[(α,α,α-trifluoro-m-tolyl)oxy]pyrimidine

Conditions

Conditions	Yield
With potassium carbonate In acetone	99%
With potassium carbonate In acetone	99%

: 1193-21-1
4,6-dichloropyrimidine

: 61721-07-1
4-fluoro-3-(trifluoromethyl)phenol

: 4-chloro-6-[(α,α,α,4-tetrafluoro-m-tolyl)oxy]pyrimidine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide	99%
With potassium carbonate In N,N-dimethyl-formamide	99%
With sodium hydroxide In water; toluene	70%

: 1193-21-1
4,6-dichloropyrimidine

: 1194-21-4
6-chloroisocytosine

Conditions

Conditions	Yield
With acetic acid In sodium hydroxide	99%

: 1193-21-1
4,6-dichloropyrimidine

: 78-81-9
isobutylamine

: 1220028-08-9
4-isobutylamino-6-chloropyrimidine

Conditions

Conditions	Yield
In methanol at 20℃; for 6.16667h; Cooling with ice;	99%

: 1193-21-1
4,6-dichloropyrimidine

: 92-67-1
4-Aminobiphenyl

: N-([1,1'-biphenyl]-4-yl)-6-chloropyrimidin-4-amine

Conditions

Conditions	Yield
With triethylamine In ethanol at 120℃; for 3h;	99%

: 123-75-1
pyrrolidine

: 1193-21-1
4,6-dichloropyrimidine

: 939986-64-8
4-Chloro-6-(pyrrolidin-1-yl)pyrimidine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol Heating;	98%
With triethylamine In ethanol at 20℃; for 0.25h;	63%
In isopropyl alcohol Reflux;

: 1193-21-1
4,6-dichloropyrimidine

: 870-46-2
t-butoxycarbonylhydrazine

: tert-butyl N-[(6-chloropyrimidin-4-yl)amino]carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Reflux;	98%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 68h; Reflux;	98%
With N-ethyl-N,N-diisopropylamine In ethanol at 120℃; for 1h;

: 1193-21-1
4,6-dichloropyrimidine

: 13033-84-6
D-phenylalanine methyl ester hydrochloride

: 693792-77-7
methyl (2R)-2-[(6-chloropyrimidin-4-yl)amino]-3-phenylpropanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 80℃;	98%

: 1193-21-1
4,6-dichloropyrimidine

: 1298084-34-0
6-(2-methyl-5-nitrophenyl)-1H-indole

: 1298084-35-1
1-(6-chloropyrimidine-4-yl)-6-(2-methyl-5-nitrophenyl)-1H-indole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil	98%

4,6-Dichloropyrimidine Chemical Properties

IUPAC Name: 4,6-Dichloropyrimidine
Synonyms of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): Pyrimidine, 4,6-dichloro-
CAS NO: 1193-21-1
Molecular Formula: C₄H₂Cl₂N₂
Molecular Weight: 148.98
Molecular Structure:
EINECS: 214-770-2
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 25.78 Å²
Index of Refraction: 1.559
Molar Refractivity: 32.22 cm³
Molar Volume: 99.7 cm³
Surface Tension: 51.5 dyne/cm
Density: 1.493 g/cm³
Flash Point: 105.1 °C
Enthalpy of Vaporization: 39.54 kJ/mol
Boiling Point: 176 °C at 760 mmHg
Vapour Pressure: 1.5 mmHg at 25°C
Melting Point: 65-67 °C(lit.)
Appearance:Yellow Solid
Product Categories of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): PYRIMIDINE;FINE Chemical & INTERMEDIATES;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks

4,6-Dichloropyrimidine Uses

4,6-Dichloropyrimidine (CAS NO.1193-21-1) is used as intermediate in the synthesis of pharmaceutical.

4,6-Dichloropyrimidine Safety Profile

Safety Information about 4,6-Dichloropyrimidine (CAS NO.1193-21-1):
Hazard Codes : C
The Risk Statements: 34-20/21/22-36/37
34: Causes burns
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37: Irritating to eyes and respiratory system
The Safety Statements: 26-36/37/39-45-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR:UN 3263 8/PG 2
F:19
WGK Germany:3
Hazard Note : Corrosive
HazardClass :8

4,6-Dichloropyrimidine Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

4,6-Dichloropyrimidine

Synthetic route

4,6-Dichloropyrimidine Chemical Properties

4,6-Dichloropyrimidine Uses

4,6-Dichloropyrimidine Safety Profile

4,6-Dichloropyrimidine Specification

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