4-Amino-2,5-dimethylphenol supplier

Name
4-Amino-2,5-dimethylphenol
EINECS 221-449-0
CAS No. 3096-71-7
Article Data39
CAS DataBase
Density 1.118 g/cm³
Solubility
Melting Point 242-243 °C
Formula C₈H₁₁NO
Boiling Point 288.4 °C at 760 mmHg
Molecular Weight 137.181
Flash Point 128.2 °C
Transport Information
Appearance Solid
Safety 26-37/39
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 2,5-Xylenol,4-amino- (6CI,7CI,8CI);(2,5-Dimethyl-4-hydroxyphenyl)amine;2,5-Dimethyl-4-aminophenol;2,5-Dimethyl-4-hydroxyaniline;4-Amino-2,5-dimethylphenol;
PSA 46.25000
LogP 2.17240

Synthetic route

: 2593-53-5
2,5-dimethyl-p-benzoquinone 4-oxime

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In dichloromethane; water for 16h; Reagent/catalyst; Reflux;	81%
With hydrogenchloride; tin
With hydrogen sulfide in ammoniakalischer Loesung;
With hydrogenchloride; tin(ll) chloride In dichloromethane; water for 24h; Reflux;

: 95-87-4
2,5-Dimethylphenol

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With sodium hydroxide; 4-sulfo-benzenediazonium-(1)-salt anschliessend Erwaermen der Reaktionsloesung mit Natriumdithionit;
Multi-step reaction with 3 steps 1: KOH / ethanol 2: HNO3, AcOH 3: H2 / Pd-C / ethanol View Scheme
Multi-step reaction with 2 steps 1: sodium nitrite; hydrogenchloride / ethanol; water / 1 h / 0 °C 2: hydrogenchloride; tin(ll) chloride / water; dichloromethane / 16 h / Reflux View Scheme

: 89-58-7
mononitro-p-xylene

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With sulfuric acid Electrolysis.Reduktion;
With sulfuric acid In ethanol at 90℃; (electrochemical reduction);

: 3096-64-8
N-(2,5-dimethylphenyl)hydroxylamine

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With sulfuric acid In water at 25℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.);
With sulfuric acid in Kohlendioxyd-Atmosphaere;

: 95-68-1
2,4-Xylidine

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With sulfuric acid bei der elektrolytischen Oxydation an Platin-Anoden;

: 3139-05-7
4-nitro-2,5-xylenol

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

: 19499-98-0
2,5-Dimethyl-4-nitro-phenyl-benzylether

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

: 3096-64-8
N-(2,5-dimethylphenyl)hydroxylamine

A: 20782-94-9
4-chloro-2,5-dimethylaniline

B: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With perchloric acid; sodium perchlorate; sodium chloride In water; acetonitrile at 25℃; Rate constant;

: 7664-93-9
sulfuric acid

: 95-68-1
2,4-Xylidine

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
bei der elektrolytischen Oxydation an Platin-Anoden.Electrolysis;

: 64-17-5
ethanol

: 35774-21-1
2,5-dimethylphenyl azide

: 7664-93-9
sulfuric acid

A: 615-90-7
2,5-dimethylhydroquinone

B: 3096-71-7
2,5-dimethyl-4-amino phenol

...Expand

2.5-dimethyl-benzoquinone-(1.4)-mono-<O-methyl oxime >: 2.5-dimethyl-benzoquinone-(1.4)-mono-<O-methyl oxime >

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With titanium(III) chloride; water

2-azido-p-xylene: 2-azido-p-xylene

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With sulfuric acid
With sulfuric acid
With sulfuric acid

4-oxy-2.5-dimethyl-acetophenone oxime: 4-oxy-2.5-dimethyl-acetophenone oxime

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
With hydrogenchloride

: 7647-01-0
hydrogenchloride

: 2593-53-5
2,5-dimethyl-p-benzoquinone 4-oxime

tin: tin

: 3096-71-7
2,5-dimethyl-4-amino phenol

...Expand

: 7664-93-9
sulfuric acid

: 3096-64-8
N-(2,5-dimethylphenyl)hydroxylamine

A: 615-90-7
2,5-dimethylhydroquinone

B: 3096-71-7
2,5-dimethyl-4-amino phenol

...Expand

: 7647-01-0
hydrogenchloride

: 1-(4-hydroxy-2,5-dimethyl-phenyl)-ethanone oxime

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 70853-94-0
N-(2,4-dimethylphenyl)hydroxylamine

hot diluted sulfuric acid: hot diluted sulfuric acid

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 137-18-8
2,5-Dimethyl-1,4-benzoquinone

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: alcohol; hydroxylamine hydrochloride 2: tin; hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; sodium acetate / ethanol / 1.5 h / Reflux 2: hydrogenchloride; tin(ll) chloride / water; dichloromethane / 16 h / Reflux View Scheme

: 835-84-7
2-(benzyloxy)-1,4-dimethylbenzene

: 3096-71-7
2,5-dimethyl-4-amino phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HNO3, AcOH 2: H2 / Pd-C / ethanol View Scheme

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 108-24-7
acetic anhydride

: 3096-93-3
1-Acetoxy-4-acetylamino-2,5-dimethylbenzene

Conditions

Conditions	Yield
With pyridine In ethyl acetate for 1h; Heating / reflux;	95%
With potassium acetate In chloroform at 20℃; Heating / reflux;

: 1121-60-4
pyridine-2-carbaldehyde

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 2,5-Dimethyl-4-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-phenol

Conditions

Conditions	Yield
In toluene	91%

: 24424-99-5
di-tert-butyl dicarbonate

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 185063-84-7
4-hydroxy-2,5-dimethylphenylcarbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	90%
With triethylamine In methanol at 20℃; for 13h;	80%
In tetrahydrofuran for 4h; Heating;
In tetrahydrofuran Reflux;

: 28860-25-5
N-methyl-N-ethylformamide

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1357382-69-4
N-ethyl-N'-(4-hydroxy-2,5-dimethylphenyl)-N-methylimidoformamide hydrochloride

Conditions

Conditions	Yield
With trichlorophosphate In acetonitrile at 60℃; for 1h;	85%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 149-73-5
trimethyl orthoformate

: 1357382-71-8
methyl N-(4-hydroxy-2,5-dimethylphenyl)formimidate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 2h; Reflux;	83.8%
With toluene-4-sulfonic acid for 1h; Reflux;

: 90418-16-9
5-chloro-3-(4-chlorobenzyl)-1,2,4-thiadiazole

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1357382-68-3
4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylaniline

Conditions

Conditions	Yield
Stage #1: 2,5-dimethyl-4-amino phenol With sodium hydroxide In N,N-dimethyl acetamide at 40℃; for 0.5h; Inert atmosphere; Stage #2: 5-chloro-3-(4-chlorobenzyl)-1,2,4-thiadiazole In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere;	83.8%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 21905-46-4
5-chloro-3-phenyl-isothiazole

: 1239257-83-0
2,5-dimethyl-4-[(3-phenylisothiazol-5-yl)oxy]aniline

Conditions

Conditions	Yield
Stage #1: 2,5-dimethyl-4-amino phenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h; Stage #2: 5-chloro-3-phenyl-isothiazole In N,N-dimethyl-formamide; mineral oil at 100℃; for 3h;	80%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 532-55-8
Benzoyl isothiocyanate

: C16H16N2O2S

Conditions

Conditions	Yield
In acetone at 40℃; for 1h;	80%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 98-59-9
p-toluenesulfonyl chloride

: N-(4-hydroxy-2,5-dimethylphenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 5h; Inert atmosphere;	80%
With pyridine at 0 - 20℃; for 24h; Inert atmosphere;
With pyridine at 0 - 25℃; for 12h; Inert atmosphere;

: 1239257-77-2
3-tert-butyl-5-chloroisothiazole-4-carbonitrile

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1239257-75-0
5-(4-amino-2,5-dimethylphenoxy)-3-tert-butylisothiazole-4-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 6h; Reflux;	79%

: 1202783-66-1
3-[1-(4-chloro-phenyl)cyclopropyl]-5-[(4-methylphenyl)sulphonyl]-1,2,4-thiadiazole

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1202783-65-0
4-({3-[1-(4-chlorophenyl)cyclopropyl]-1,2,4-thiadiazol-5-yl}oxy)-2,5-dimethylaniline

Conditions

Conditions	Yield
Stage #1: 2,5-dimethyl-4-amino phenol With potassium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: 3-[1-(4-chloro-phenyl)cyclopropyl]-5-[(4-methylphenyl)sulphonyl]-1,2,4-thiadiazole In acetonitrile at 50℃; for 12h;	76.9%

: 1239257-86-3
4,5-dichloro-3-phenylisothiazole

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1239257-85-2
4-[(4-chloro-3-phenylisothiazol-5-yl)oxy]-2,5-dimethylaniline

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 150℃; for 4h;	72%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 35675-44-6
4-methylphenylacetyl chloride

: 1413925-56-0
N-(4-hydroxy-2,5-dimethylphenyl)-2-(4-methylphenyl)acetamide

Conditions

Conditions	Yield
With sodium acetate; acetic acid In N,N-dimethyl-formamide at 20℃;	72%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 124-63-0
methanesulfonyl chloride

: 321947-91-5
N-(4-hydroxy-2,5-dimethylphenyl)methanesulfonamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 70℃; for 0.5h;	70%

: 1074-86-8
4-formyl indole

: 590-93-2
2-Butynoic acid

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 3096-71-7
2,5-dimethyl-4-amino phenol

: N-(2-(tert-butylamino)-1-(1H-indol-4-yl)-2-oxoethyl)-N-(4-hydroxy-2,5-dimethylphenyl)but-2-ynamide

Conditions

Conditions	Yield
In methanol at 50℃; Ugi Condensation;	70%

...Expand

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 4513-25-1
N-phenylsulfonylbenzimidoyl chloride

: 461672-41-3
N-(4-hydroxy-2,5-dimethylphenyl)-N'-(phenylsulfonyl)benzimidamide

Conditions

Conditions	Yield
With sodium acetate In acetic acid; N,N-dimethyl-formamide	69%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 102-92-1
Cinnamoyl chloride

: 1413925-72-0
(2E)-N-(4-hydroxy-2,5-dimethylphenyl)-3-phenylprop-2-enamide

Conditions

Conditions	Yield
With sodium acetate; acetic acid In N,N-dimethyl-formamide at 20℃;	66%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 39890-98-7
2,6-dichloro-4-(trifluoromethyl)pyridine

: 4-(2-chlor-4-trifluormethylpyridyl-6-oxy)-2,5-xylidine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 6h;	64%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 103-71-9
phenyl isocyanate

: 218134-92-0
1-(4-hydroxy-2,5-dimethylphenyl)-3-phenylurea

Conditions

Conditions	Yield
In 1,4-dioxane at 100℃;	64%

: 4513-27-3
N-(tolylsulfonyl)benzimidoyl chloride

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 461672-30-0
N-(4-hydroxy-2,5-dimethylphenyl)-N'-(4-methylphenylsulfonyl)benzimidamide

Conditions

Conditions	Yield
With sodium acetate In acetic acid; N,N-dimethyl-formamide	62%

: 13088-17-0
4-nitro-benzenesulfinyl chloride

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 1057963-27-5
N-4-nitrophenylthio-2,5-dimethyl-1,4-benzoquinone imine

Conditions

Conditions	Yield
With triethylamine In diethyl ether	60%

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 186767-23-7
3,4-dichloro-2-ethylpyridine

: 4-(2-ethyl-3-chloropyridyl-4-oxy)-2,5-xylidine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 6h;	59%

: 624-78-2
N-Ethylmethylamine

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 149-73-5
trimethyl orthoformate

: N-ethyl-N'-(4-hydroxy-2,5-dimethylphenyl)-N-methylimidoformamide

Conditions

Conditions	Yield
Stage #1: 2,5-dimethyl-4-amino phenol; trimethyl orthoformate With toluene-4-sulfonic acid for 2h; Heating / reflux; Stage #2: N-Ethylmethylamine In toluene at 50℃; for 20h;	55%

...Expand

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 4513-26-2
N-p-chlorophenylsulfonylbenzimidoyl chloride

: 1332847-25-2
N'-(4-chlorophenylsulfonyl)-N-(4-hydroxy-2,5-dimethylphenyl)benzimidamide

Conditions

Conditions	Yield
With sodium acetate In acetic acid; N,N-dimethyl-formamide	54%

: 13088-17-0
4-nitro-benzenesulfinyl chloride

: 3096-71-7
2,5-dimethyl-4-amino phenol

: N-[(4-nitrophenyl)sulfinyl]-2,5-dimethyl-1,4-benzoquinone imine

Conditions

Conditions	Yield
Stage #1: 4-nitro-benzenesulfinyl chloride; 2,5-dimethyl-4-amino phenol With triethylamine In diethyl ether for 0.166667h; Stage #2: With silver(l) oxide In acetone for 0.5h; Further stages.;	53%

: 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 286371-50-4
4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2,5-dimethylaniline

Conditions

Conditions	Yield
With dimethyl sulfoxide In methanol; water	52%

: 438249-84-4
4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 4-(2,5-Dimethyl-4-hydroxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine hydrochloride

Conditions

Conditions	Yield
	47%

: 438249-85-5
4-chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

: 3096-71-7
2,5-dimethyl-4-amino phenol

: 4-(2,5-Dimethyl-4-hydroxyanilino)-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine hydrochloride

Conditions

Conditions	Yield
	47%

4-Amino-2,5-dimethylphenol Chemical Properties

Empirical Formula: C₈H₁₁NO
Molecular Weight: 137.179 g/mol
EINECS: 221-449-0
Index of Refraction: 1.6
Density: 1.118 g/cm³
Flash Point: 128.2 °C
Enthalpy of Vaporization: 54.88 kJ/mol
Boiling Point: 288.4 °C at 760 mmHg
Vapour Pressure: 0.00135 mmHg at 25 °C
Melting point: 242-243 °C(lit.)
Appearance: Solid
Structure of 4-Amino-2,5-dimethylphenol (CAS NO.3096-71-7):

IUPAC Name: 4-Amino-2,5-dimethylphenol
Product Category of 4-Amino-2,5-dimethylphenol (CAS NO.3096-71-7): Phenoles and thiophenoles;API intermediates

4-Amino-2,5-dimethylphenol Safety Profile

Hazard Codes of 4-Amino-2,5-dimethylphenol (CAS NO.3096-71-7): Harmful Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

4-Amino-2,5-dimethylphenol Specification

4-Amino-2,5-dimethylphenol , its cas register number is 3096-71-7. It also can be called 4-Amino-2,5-xylenol ; and Phenol, 4-amino-2,5-dimethyl- .

Product Name

4-Amino-2,5-dimethylphenol

Synthetic route

4-Amino-2,5-dimethylphenol Chemical Properties

4-Amino-2,5-dimethylphenol Safety Profile

4-Amino-2,5-dimethylphenol Specification

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