Conditions | Yield |
---|---|
With potassium phosphate monohydrate; 4,4'-di-tBu-2,2'-dipyridylpalladium(II) dichloride In methanol; water at 80℃; for 2h; Suzuki-Miyaura Coupling; | 100% |
With potassium carbonate; palladium dichloride In water at 20 - 90℃; Suzuki coupling; Inert atmosphere; | 99% |
With potassium carbonate In water at 90℃; for 0.25h; Suzuki reaction; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 100% B 94% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 94% B 100% |
C22H18N2O5
A
2-methoxy-benzeneacetonitrile
B
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 100% B 95% |
Conditions | Yield |
---|---|
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction; | 100% |
With potassium carbonate; carbapalladacycle complex*periodic mesoporous organosilica for 24h; Suzuki coupling; Heating; | 100% |
With sodium phosphate; palladium on activated charcoal In water; isopropyl alcohol at 20℃; for 3.5h; Suzuki-Miyaura coupling reaction; | 100% |
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; 4-biphenylylmagnesium bromide In tetrahydrofuran at 20℃; under 3000.3 Torr; gas-liquid flow reactor assembly; Stage #2: With polymer-supported sulfonic acid In tetrahydrofuran | 100% |
para-bromoacetophenone
phenylboronic acid
A
biphenyl-4-acetaldehyde
B
4-Bromobenzoic acid
C
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: para-bromoacetophenone; phenylboronic acid; immobilized 4-bromobenzoic acid With potassium carbonate In water; N,N-dimethyl-formamide Stage #2: With potassium hydroxide In ethanol; water | A 100% B 19% C 81% |
Conditions | Yield |
---|---|
With silica-supported Jones reagent In dichloromethane for 0.035h; | 99.5% |
With diethylene glycol dimethyl ether at 70℃; for 0.583333h; Sonication; | 96% |
With sodium tetrahydroborate; 1% Pd/C; water; potassium hydroxide In methanol at 20℃; for 6h; In air; | 89% |
Conditions | Yield |
---|---|
With water; lithium hydroxide In tetrahydrofuran at 0 - 20℃; for 3h; | 99% |
With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 20h; | 99% |
With water In methanol at 30 - 50℃; Rate constant; Thermodynamic data; Kinetics; ΔH(excit), ΔS(excit), log A; |
Conditions | Yield |
---|---|
With potassium hydroxide In water at 80℃; for 2h; Suzuki Coupling; Green chemistry; | 99% |
With glucosamine-based dicyclohexylarylphosphine; sodium carbonate; palladium diacetate In ethanol; water; toluene at 80℃; Suzuki-Miyaura cross coupling reaction; | 97% |
With sodium hydroxide; polyaniline-supported palladium In water at 80℃; for 4h; Suzuki coupling; | 97% |
Conditions | Yield |
---|---|
With dmap; palladium dichloride for 0.333333h; Stille Cross Coupling; Microwave irradiation; | 99% |
Conditions | Yield |
---|---|
With dmap; palladium dichloride for 0.25h; Stille Cross Coupling; Microwave irradiation; | 99% |
Conditions | Yield |
---|---|
With oxovanadium(IV) sulfate; hydrogen bromide; oxygen; acetic acid In water at 100℃; under 750.075 Torr; for 20h; | 98% |
With oxygen; Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Green chemistry; | 92% |
With carbon tetrabromide; oxygen; triphenylphosphine In ethyl acetate for 10h; fluorescent irradiation; | 90% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 98% B 95% |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide In tetrahydrofuran; methanol for 3h; Heating; | 98% |
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate In water; N,N-dimethyl-formamide at 100℃; for 24h; Suzuki Coupling; | 98% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 75% B 97% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 86% B 97% |
Conditions | Yield |
---|---|
With sodium carbonate at 100℃; for 0.583333h; Suzuki-Miyaura Coupling; Sealed tube; | 97% |
With potassium carbonate for 1.5h; Suzuki-Miyaura Coupling; | 96% |
With potassium carbonate at 100℃; for 2h; Catalytic behavior; | 95% |
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In water at 80℃; for 2h; Suzuki-Miyaura Coupling; | 97% |
With palladium diacetate; potassium carbonate In water at 65℃; for 2h; Suzuki-Miyaura cross-coupling; | 96% |
With potassium carbonate; palladium diacetate In methanol for 2h; Suzuki reaction; Heating; | 96% |
With {2,6-bis[(di-1-piperidinylphosphino)amino]phenyl}palladium(II) chloride; potassium carbonate In 1,4-dioxane; water; butan-1-ol at 100℃; for 2h; Suzuki-Miyaura reaction; | 59% |
With Na2[Pd(BuHSS)]; caesium carbonate In water at 80℃; for 1h; Suzuki-Miyaura Coupling; Sealed tube; |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide In tetrahydrofuran; methanol for 3h; Heating; | 97% |
carbon dioxide
2-([1,1'-biphenyl]-4-yl)-5,5-dimethyl-1,3,2-dioxaborinane
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h; | 97% |
With (1,3-bis(2,6-diisopropyl-4-(morpholinomethyl)phenyl)imidazolidin-2-ylidene)copper(I) bromide; potassium tert-butylate In tetrahydrofuran under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry; | 91% |
Stage #1: carbon dioxide; 2-([1,1'-biphenyl]-4-yl)-5,5-dimethyl-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 80% |
N-methoxy-3-((triisopropylsilyl)ethynyl)-[1,1'-biphenyl]-4-carboxamide
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With tert.-butylnitrite; water at 29℃; for 0.583333h; | 97% |
carbon dioxide
[1,1’-biphenyl]-4-yl sulfurofluoridate
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 20h; Schlenk technique; Inert atmosphere; Glovebox; | 97% |
Conditions | Yield |
---|---|
With ammonium cerium (IV) nitrate; acetic acid at 120℃; for 12h; Inert atmosphere; Schlenk technique; | 96% |
With Iron(III) nitrate nonahydrate; iodine; oxygen; dimethyl sulfoxide at 130℃; under 750.075 Torr; for 12h; Sealed tube; Green chemistry; | 81% |
With Iron(III) nitrate nonahydrate; iodine; oxygen In dimethyl sulfoxide at 130℃; for 12h; Sealed tube; | 81% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 93% B 96% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 94% B 96% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating; | A 96% B 96% |
(cyclohexyl)(difluoro)(phenyl)silane
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride In tetrahydrofuran at 80℃; for 48h; Condensation; | 96% |
(cyclohexyl)(difluoro)(phenyl)silane
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 80℃; for 48h; | 96% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 1h; | 100% |
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)pyridinium trifluoromethanesulfonate; triethylamine In dichloromethane at 20℃; for 1h; | 100% |
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h; | 98% |
Conditions | Yield |
---|---|
100% | |
Stage #1: biphenyl-4-carboxylic acid With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 20℃; for 4h; Cooling with ice; Inert atmosphere; Stage #2: With water In tetrahydrofuran; diethyl ether for 16h; | 99% |
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; | 89% |
biphenyl-4-carboxylic acid
4-biphenyl-carboxylic acid chloride
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide Heating / reflux; | 100% |
With thionyl chloride; N,N-dimethyl-formamide at 85℃; for 16h; Industrial scale; | 100% |
Stage #1: biphenyl-4-carboxylic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h; | 100% |
biphenyl-4-carboxylic acid
α,α-dideuterio-p-phenylbenzyl alcohol
Conditions | Yield |
---|---|
With lithium aluminium deuteride In diethyl ether at 0 - 20℃; for 2h; | 100% |
With lithium aluminium deuteride In diethyl ether for 30h; Heating; | 53% |
With lithium aluminium deuteride In diethyl ether for 1h; Heating; | |
With lithium aluminium deuteride In diethyl ether at 0 - 20℃; |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 18h; | 100% |
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; | 100% |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; | 100% |
(3S,4S,5R,6S)-1-N-benzyloxycarbonyl-3-aminomethyl-4,5-O-isopropylidene-6-methyl-hexahydropyridazine-4,5-diol
biphenyl-4-carboxylic acid
(3S,4S,5R,6S)-1-N-benzyloxycarbonyl-3-(p-phenylbenzoylaminomethyl)-4,5-O-isopropylidene-6-methyl-hexahydropyridazine-4,5-diol
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 72h; | 100% |
Conditions | Yield |
---|---|
With propane-1,3-diyl dinitrite In tetrahydrofuran at 90℃; under 12929 Torr; for 0.166667h; Reagent/catalyst; Time; Flow reactor; | 100% |
With 1,3-(2,2-dimethyl)propanedinitrite In tetrahydrofuran; tert-butyl alcohol at 80℃; for 6h; |
Conditions | Yield |
---|---|
With propane-1,3-diyl dinitrite In 2-methyltetrahydrofuran at 86℃; under 12929 Torr; for 0.333333h; Flow reactor; | 100% |
aniline
biphenyl-4-carboxylic acid
N-phenyl-[1,1'-biphenyl]-4-carboxamide
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h; | 99% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h; | 89% |
With trimethylaluminum In toluene at 90℃; for 1h; | 85% |
With tetrachloromethane; cross-linked polymer (containing 2.00 mmol of phosphine/g) In 1,2-dichloro-ethane for 3h; Heating; | 73% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 1h; | 99% |
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)pyridinium trifluoromethanesulfonate; triethylamine In dichloromethane at 20℃; for 1h; | 99% |
With N-(methylpolystyrene)-4-(methylamino)pyridine; TEA; (2-chloro-1-pyridinio)-(Wang resin) triflate In dichloromethane for 1h; | 92% |
Conditions | Yield |
---|---|
In cyclohexane at 80℃; for 12h; Inert atmosphere; Schlenk technique; | 99% |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1-methyl-pyrrolidin-2-one at 40℃; for 8h; Reagent/catalyst; Solvent; Temperature; Time; Schlenk technique; Inert atmosphere; | 99% |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1-methyl-pyrrolidin-2-one at 40℃; for 8h; Schlenk technique; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h; | 99% |
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; for 2h; | 98.4% |
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; for 2h; | 98.4% |
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; for 2h; | 98.4% |
The IUPAC name of 4-Biphenylcarboxylic acid is 4-phenylbenzoic acid. With the CAS registry number 92-92-2, it is also named as 4-Carboxy-(1,1'-biphenyl); Para phenyl benzoic acid. The product's categories are biphenyl derivatives; organic acids; miscellaneous; absolute configuration determination (Exciton Chirality CD Method); analytical chemistry; enantiomer excess & absolute configuration determination. It is white to light yellow crystal powder which is soluble in alcohol and ether, insoluble in water.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.75; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.43; (4)ACD/LogD (pH 7.4): 0.87; (5)ACD/BCF (pH 5.5): 19.83; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 124.26; (8)ACD/KOC (pH 7.4): 3.47; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.607; (13)Molar Refractivity: 57.77 cm3; (14)Molar Volume: 167.2 cm3; (15)Polarizability: 22.9×10-24 cm3; (16)Surface Tension: 49.1 dyne/cm; (17)Enthalpy of Vaporization: 65.38 kJ/mol; (18)Vapour Pressure: 3.28E-06 mmHg at 25°C; (19)Rotatable Bond Count: 2; (20)Exact Mass: 198.06808; (21)MonoIsotopic Mass: 198.06808; (22)Topological Polar Surface Area: 37.3; (23)Heavy Atom Count: 15; (24)Complexity: 211.
Preparation of 4-Biphenylcarboxylic acid: It can be obtained by 1-biphenyl-4-yl-ethanone with the reagent O2, Mn(NO3)2 and Co(NO3)2 and solvent acetic acid at 100 °C. The reaction time is 6 hours.
Uses of 4-Biphenylcarboxylic acid: It is used as polarographic analytical reagent. And it is also used in organic synthesis. For example: It reacts with N-phenylselanyl-phthalimide to get (4-phenylphenyl)(phenylseleno)methanone. This reaction needs reagent tri-n-butylphosphine and solvent tetrahydrofuran at temperature of 25 °C. The reaction time is 4.0 hours. The yield is 58 %.
When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. And it is also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing and eye/face protection.
People can use the following data to convert to the molecule structure.
1. SMILES: O=C(O)c2ccc(c1ccccc1)cc2;
2. InChI: InChI=1/C13H10O2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H,14,15).
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