Product Name

  • Name

    4-Bromomethyl-5-methyl-1,3-dioxol-2-one

  • EINECS 807-002-8
  • CAS No. 80715-22-6
  • Article Data31
  • CAS DataBase
  • Density 1.742 g/cm3
  • Solubility
  • Melting Point 188-190°C(lit.)
  • Formula C5H5BrO3
  • Boiling Point 180.518 °C at 760 mmHg
  • Molecular Weight 192.997
  • Flash Point 62.976 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes R36/37/38
  • Molecular Structure Molecular Structure of 80715-22-6 (4-Bromomethyl-5-methyl-1,3-dioxol-2-one)
  • Hazard Symbols Xi
  • Synonyms (5-Methyl-2-oxo-1,3-dioxol-4-yl)methylbromide;5-(Bromomethyl)-4-methyl-2-oxo-1,3-dioxole;
  • PSA 43.35000
  • LogP 1.43610

Synthetic route

4,5-Dimethyl-1,3-dioxole-2-one
37830-90-3

4,5-Dimethyl-1,3-dioxole-2-one

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 85℃; for 16h; Inert atmosphere;95%
With N-Bromosuccinimide In chloroform Reflux; Large scale;93.8%
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 77℃; for 6h;92%
4,5-Dimethyl-1,3-dioxole-2-one
37830-90-3

4,5-Dimethyl-1,3-dioxole-2-one

a,a-azobisisobutyronitrile (AIBN)

a,a-azobisisobutyronitrile (AIBN)

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane90%
4-chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7

4-chloromethyl-5-methyl-1,3-dioxol-2-one

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

Conditions
ConditionsYield
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1h;75%
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1h;
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1.5h;
With sodium bromide In N,N-dimethyl-formamide; acetone at 40 - 45℃; for 5h; Product distribution / selectivity;
4,5-Dimethyl-1,3-dioxole-2-one
37830-90-3

4,5-Dimethyl-1,3-dioxole-2-one

azobisisobutyronitrile
34241-39-9

azobisisobutyronitrile

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane48%
With N-Bromosuccinimide In tetrachloromethane
N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

4,5-Dimethyl-1,3-dioxole-2-one
37830-90-3

4,5-Dimethyl-1,3-dioxole-2-one

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

Conditions
ConditionsYield
2,2'-azobis(isobutyronitrile) In benzene at 20℃; for 0.5h; Heating / reflux;
5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole

5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

trityl olmesartan medoxomil
144690-92-6

trityl olmesartan medoxomil

Conditions
ConditionsYield
Stage #1: 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With tert-butylamine hydrobromide; potassium carbonate In acetone at 0 - 55℃; for 32h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one With potassium carbonate; potassium iodide In acetone at 20 - 55℃; for 3h;		98.5%
...Expand
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

ulifloxacin
112984-60-8

ulifloxacin

prulifloxacin
123447-62-1

prulifloxacin

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 0℃; for 5h; Large scale;95.4%
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 5h; Ambient temperature;62%
Stage #1: ulifloxacin With potassium hydrogencarbonate In acetonitrile at 25 - 30℃;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one at 15 - 30℃; for 27 - 28.25h;
Stage #1: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one; ulifloxacin With potassium hydrogencarbonate In N,N-dimethyl-formamide at 0 - 28℃; for 3 - 4h;
Stage #2: With hydrogenchloride In chloroform; water for 0.25h; pH=0.8 - 1.0;
Stage #1: ulifloxacin With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.166667h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one In acetonitrile at 10 - 30℃; for 21h; Product distribution / selectivity;
(2S,3S)-3-((2-(2-chloro-5-trityl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid

(2S,3S)-3-((2-(2-chloro-5-trityl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

(2S,3S)-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 3-((2-(2-chloro-5-trityl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylate

(2S,3S)-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 3-((2-(2-chloro-5-trityl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-5-fluoro-6-(thiophen-2-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;95%
carbon dioxide
124-38-9

carbon dioxide

L-phenylalanine
63-91-2

L-phenylalanine

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

(S)-2-(5-Methyl-2-oxo-[1,3]dioxol-4-ylmethoxycarbonylamino)-3-phenyl-propionic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

(S)-2-(5-Methyl-2-oxo-[1,3]dioxol-4-ylmethoxycarbonylamino)-3-phenyl-propionic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide Ambient temperature;94%
...Expand
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide
80841-79-8

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide

Conditions
ConditionsYield
With potassium iodide In acetone Ambient temperature;92%
carbon dioxide
124-38-9

carbon dioxide

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

Benzyl-methyl-carbamic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Benzyl-methyl-carbamic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide Ambient temperature;90%
...Expand
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
881381-50-6

2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

C33H44ClN7O5SSi
881381-64-2

C33H44ClN7O5SSi

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;89%
6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-androsta-1,4-diene-17β-carbothioic acid
80474-38-0

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-androsta-1,4-diene-17β-carbothioic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

6α,9α-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-(5-methyl-2-oxo-1,3-dioxol4-ylmethyl) ester

6α,9α-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-(5-methyl-2-oxo-1,3-dioxol4-ylmethyl) ester

Conditions
ConditionsYield
With potassium carbonate In water; ethyl acetate; N,N-dimethyl-formamide85%
4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylic acid
1040405-55-7

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylic acid-5-methyl-2-oxo-[1,3]-dioxolene-4-yl-methyl ester
1040405-56-8

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylic acid-5-methyl-2-oxo-[1,3]-dioxolene-4-yl-methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 20℃; for 5h;84%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

azilsartan
147403-03-0

azilsartan

C35H28N4O11

C35H28N4O11

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h;83%
formic acid
64-18-6

formic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

4-formyloxymethyl-5-methyl-1,3-dioxolen-2-one
91526-17-9

4-formyloxymethyl-5-methyl-1,3-dioxolen-2-one

Conditions
ConditionsYield
With trimethylamine In acetonitrile at 20℃; for 1h;82%
With triethylamine In acetonitrile for 1h; Ambient temperature;80%
With triethylamine In acetonitrile for 2h; Ambient temperature;
3-[[(1S)-1-(dimethylcarbamoyl)propyl]-(trans-4-methylcyclohexanecarbonyl)amino]-5-(3-methylbut-1-ynyl)thiophene-2-carboxylic acid

3-[[(1S)-1-(dimethylcarbamoyl)propyl]-(trans-4-methylcyclohexanecarbonyl)amino]-5-(3-methylbut-1-ynyl)thiophene-2-carboxylic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

C30H40N2O7S

C30H40N2O7S

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 0.333333h; Microwave irradiation;78%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
147403-52-9

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

C31H26N4O8

C31H26N4O8

Conditions
ConditionsYield
Stage #1: methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate With potassium carbonate In N,N-dimethyl-formamide at -10 - 0℃; for 0.5h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one In N,N-dimethyl-formamide at 20℃;		77.5%
5-(3,3-dimethylbut-1-ynyl)-3-[(trans-4-methylcyclohexanecarbonyl)-(2-oxo-2-thiomorpholino-ethyl)amino]thiophene-2-carboxylic acid

5-(3,3-dimethylbut-1-ynyl)-3-[(trans-4-methylcyclohexanecarbonyl)-(2-oxo-2-thiomorpholino-ethyl)amino]thiophene-2-carboxylic acid

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

C30H38N2O8S

C30H38N2O8S

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 0.416667h; Microwave irradiation;75%
5-(3-methylbut-1-ynyl)-3-[(trans-4-methylcyclohexanecarbonyl)-[(1S)-1-(morpholine-4-carbonyl)propyl]amino]thiophene-2-carboxylic acid.

5-(3-methylbut-1-ynyl)-3-[(trans-4-methylcyclohexanecarbonyl)-[(1S)-1-(morpholine-4-carbonyl)propyl]amino]thiophene-2-carboxylic acid.

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

C32H42N2O8S

C32H42N2O8S

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 0.333333h; Microwave irradiation;74%
C28H40NO2P

C28H40NO2P

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

C33H45BrNO5P

C33H45BrNO5P

Conditions
ConditionsYield
In toluene at 130℃; for 21h; Inert atmosphere; Schlenk technique;74%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

prulifloxacin
123447-62-1

prulifloxacin

6-Fluoro-1-methyl-7-[4-(5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl)-piperazin-1-yl]-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

6-Fluoro-1-methyl-7-[4-(5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl)-piperazin-1-yl]-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 39.9℃; for 3h;72%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 24.9℃; Rate constant; also in presence of DIPA and TNBA, var concn. of DMDO-Br and amines;
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

(S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid
649748-09-4

(S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid

(S)-3-(tert-butoxycarbonylamino-methyl)-5-methyl-hexanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
1026789-40-1

(S)-3-(tert-butoxycarbonylamino-methyl)-5-methyl-hexanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
Stage #1: (S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid With caesium carbonate In methanol at 20℃; for 2h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one In ISOPROPYLAMIDE		72%
Stage #1: (S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid With caesium carbonate In methanol at 20℃; for 2h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one In N,N-dimethyl acetamide		72%
carbon dioxide
124-38-9

carbon dioxide

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

benzylamine
100-46-9

benzylamine

Benzyl-carbamic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Benzyl-carbamic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide Ambient temperature;70%
...Expand
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

N-benzyloxycarbonyl NFLX
105439-94-9

N-benzyloxycarbonyl NFLX

N-benzyloxycarbonyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
105439-93-8

N-benzyloxycarbonyl NFLX (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 60℃;69%
5-Propyl-azepane-2-carboxylic acid [2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide

5-Propyl-azepane-2-carboxylic acid [2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran
96042-30-7

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

1-(5-Methyl-2-oxo-[1,3]dioxol-4-ylmethyl)-5-propyl-azepane-2-carboxylic acid [2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide

1-(5-Methyl-2-oxo-[1,3]dioxol-4-ylmethyl)-5-propyl-azepane-2-carboxylic acid [2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide

Conditions
ConditionsYield
With potassium hydrogencarbonate In methanol; N,N-dimethyl-formamide68%
...Expand
tert-butyl 2-(methylamino)ethylcarbamate
122734-32-1

tert-butyl 2-(methylamino)ethylcarbamate

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

tert-butyl (2-(methyl((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)amino)ethyl)carbamate

tert-butyl (2-(methyl((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)amino)ethyl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;67.4%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate
113028-17-4

ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate

ethyl 6-fluoro-1-methyl-7-<4-<(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl>-1-piperazyl>-4-oxo-4H-<1,3>thiazeto<3,2-a>-quinoline-3-carboxylate

ethyl 6-fluoro-1-methyl-7-<4-<(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl>-1-piperazyl>-4-oxo-4H-<1,3>thiazeto<3,2-a>-quinoline-3-carboxylate

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 1h; Ambient temperature;66%
With potassium hydrogencarbonate In N,N-dimethyl-formamide
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin
85195-76-2

N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 5h;66%
potassium bicarbonate

potassium bicarbonate

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin
85195-76-2

N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin

Conditions
ConditionsYield
In N-methyl-acetamide; water66%
...Expand
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

(-)-6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-<1,3>thiazeto<3,2-a>quinoline-3-carboxylic acid

(-)-6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-<1,3>thiazeto<3,2-a>quinoline-3-carboxylic acid

S-(-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
1235993-71-1

S-(-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at -5 - 5℃; for 3h; Product distribution / selectivity;63%

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