Conditions | Yield |
---|---|
With N-chloro-N-(benzenesulfonyl)benzenesulfonamide In acetonitrile at 20 - 25℃; for 0.0833333h; Green chemistry; | 99.2% |
With copper dichloride; 1-hexyl-3-methylimidazol-1-ium chloride at 40℃; for 16h; regioselective reaction; | 85% |
With N-chloro-succinimide In acetonitrile for 10h; Heating; | 57% |
Multi-step reaction with 2 steps 1: diethyl ether; hypochlorous acid / 20 °C 2: hydrochloric acid; diethyl ether / -20 °C View Scheme |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol; water at 20℃; for 4h; Green chemistry; | 90% |
Conditions | Yield |
---|---|
With nickel ammonium sulfate; nitric acid In chloroform; water at 20℃; for 3h; | 92% |
Multi-step reaction with 3 steps 1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 3: conc. sulfuric acid / 0.25 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane 2: nitric acid; acetic anhydride / dichloromethane 3: hydrogenchloride / water / Reflux View Scheme |
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
Stage #1: N-(4-chloro-2-nitrophenyl) pyrimidin-2-amine With triethylsilane; trifluoroacetic acid at 50℃; Inert atmosphere; Stage #2: With acetic acid; hydrazine In methanol at 20℃; Inert atmosphere; regioselective reaction; | 80% |
Conditions | Yield |
---|---|
With nitric acid In sulfuric acid; acetic acid at 20 - 25℃; for 10.5h; Temperature; |
3-Chloronitrobenzene
A
2-chloro-6-nitroaniline
B
4-Chloro-2-nitroaniline
C
2-Chloro-4-nitroaniline
Conditions | Yield |
---|---|
With 2,4,6-trichlorosulfenamide; potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.333333h; | A 26% B 7% C 38% |
With O-Methylhydroxylamin; potassium tert-butylate; copper(l) chloride In N,N-dimethyl-formamide for 1h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With potassium tert-butylate; N,N,N-trimethylhydrazinium iodide In dimethyl sulfoxide Ambient temperature; Yield given. Yields of byproduct given; | |
With O-Methylhydroxylamin; potassium tert-butylate; copper(l) chloride In N,N-dimethyl-formamide at 20℃; Substitution; Amination; Title compound not separated from byproducts; |
N-(2-nitro-4-chlorophenyl)benzamide
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 20℃; for 12h; | 99% |
Conditions | Yield |
---|---|
With sulfuric acid | |
With hydrogenchloride | |
With sodium methylate |
o-azidonitrobenzene
A
2-chloro-6-nitroaniline
B
2-nitro-aniline
C
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With boron trichloride In benzene Ambient temperature; | A 17% B 3% C 64% |
With boron trichloride In benzene at 50℃; for 6h; | A 3% B 3% C 64% |
With boron trichloride In benzene at 50℃; for 6h; | A 17% B 3% C 64% |
Conditions | Yield |
---|---|
With nitric acid Kochen des Reaktionsproduktes mit Natronlauge; | |
With nitric acid at -10℃; durch Erwaermen des Reaktionsprodukts mit etwas konz. Schwefelsaeure auf 100grad; | |
Multi-step reaction with 2 steps 1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C View Scheme |
Conditions | Yield |
---|---|
With trichloroisocyanuric acid; brilliant green carbocation In acetonitrile at 20℃; for 1.5h; Irradiation; Overall yield = 94 %; Overall yield = 81.1 mg; regioselective reaction; |
2-(4-chloro-2-nitrophenylamino)ethanol
methanesulfonyl chloride
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
In pyridine; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate |
Conditions | Yield |
---|---|
With ammonia; water at 175℃; im Eisen-Autoklaven; | |
With ethanol; ammonia at 165℃; | |
With ethanol; ammonia at 200 - 220℃; | |
With NH2 |
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: palladium diacetate; silver(I) nitrite; dipotassium peroxodisulfate; acetic acid / 1,2-dichloro-ethane / 80 °C / Inert atmosphere 2.1: trifluoroacetic acid; triethylsilane / 50 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme |
4-Chloro-1,2-phenylenediamine
A
5-chloro-2-nitroaniline
B
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With 1,9-diperoxynonanedioic acid In acetonitrile at 50℃; for 0.5h; Overall yield = 93 %; | A 49 %Chromat. B 51 %Chromat. |
1-azido-4-methyl-2-nitrobenzene
A
4-Chloro-2-nitroaniline
B
6-chlorobenzo[c][1,2,5]oxadiazole 1-oxide
C
1-(4-Chloro-2-nitro-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With diethyl acetylmalonate; sodium ethanolate In ethanol for 5h; Ambient temperature; | A 35% B 27% C 25% |
N-(4-chlorophenyl)acetamide
A
N-(4-chloro-2-nitrophenyl)-acetamide
B
N-(4-chloro-3-nitrophenyl)acetamide
C
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With sodium nitrate; sulfuric acid for 3h; Ambient temperature; | A 62% B 9% C 21% |
1-azido-4-methyl-2-nitrobenzene
diethyl 1,3-acetonedicarboxylate
A
4-Chloro-2-nitroaniline
B
6-chlorobenzo[c][1,2,5]oxadiazole 1-oxide
C
1-(4-Chloro-2-nitro-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 5h; Ambient temperature; | A 35% B 27% C 25% |
N,N-dichloro-2-nitroaniline
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With hydrogenchloride; diethyl ether at -20℃; |
Conditions | Yield |
---|---|
With basic copper carbonate powder; ethylene glycol at 130 - 140℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid; copper(II) nitrate hydrate; oxygen / acetonitrile; water / 12 h / 100 °C / 760.05 Torr 2: potassium hydroxide / methanol / 12 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at -20℃; |
3,4-dinitro-chlorobenzene
A
5-chloro-2-nitroaniline
B
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With titanium(III) chloride In methanol; water Title compound not separated from byproducts; | A 19.10 % Chromat. B 15.90 % Chromat. |
tert-butylhypochlorite
2-nitro-aniline
A
2-chloro-6-nitroaniline
B
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With tert-butyl alcohol; benzene | |
With acetic acid; benzene | |
With benzene | |
With tert-butyl alcohol | |
With acetic acid |
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔH, ΔS; |
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔS, ΔH; |
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔH, ΔS; |
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔH, ΔS; |
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔH, ΔS; |
methyltrimethicone
B
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
In benzene at 26.9℃; Equilibrium constant; Thermodynamic data; ΔG, ΔH, ΔG; |
4-Chloro-2-nitroaniline
dimethyl sulfate
4-chloro-N-methyl-2-nitroaniline
Conditions | Yield |
---|---|
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 20℃; Methylation; | 100% |
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 20℃; | 94% |
Conditions | Yield |
---|---|
With N-Bromosuccinimide In acetonitrile Reflux; | 100% |
With bromine; acetic acid at 0 - 20℃; for 1h; | 100% |
With bromine; acetic acid at 0 - 20℃; for 1h; Cooling with ice; | 100% |
(3R)-4-[2-chloro-6-(1-methanesulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 80℃; for 1h; Buchwald-Hartwig Coupling; Microwave irradiation; Sealed tube; Inert atmosphere; | 100% |
thiophene boronic acid
4-Chloro-2-nitroaniline
2-nitro-4-thiophen-2-yl-phenylamine
Conditions | Yield |
---|---|
With potassium phosphate; (2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1 ‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate In 1,4-dioxane; water for 20h; Sealed tube; Schlenk technique; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With samarium; 1,1’-di-n-octyl-4,4’-bipyridinium dibromide In methanol at 20℃; for 5.5h; | 99% |
With iron(III)-acetylacetonate; hydrazine hydrate In methanol at 150℃; for 0.133333h; Microwave irradiation; chemoselective reaction; | 98% |
With palladium/alumina; hydrogen In ethanol at 125℃; for 8h; Flow reactor; | 96% |
trimethylsilyl acetate
4-Chloro-2-nitroaniline
N-(4-chloro-2-nitrophenyl)-acetamide
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
trimethylsilyl isobutyrate
4-Chloro-2-nitroaniline
4'-chloro-2-methyl-2'-nitropropananilide
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
trimethylsilyl 2,2-dimethylpropionate
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
3-methylbutyric acid trimethylsilyl ester
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
4-Chloro-2-nitroaniline
β-naphthol
1-(4'-chloro-2'-nitrophenylazo)-2-naphthol
Conditions | Yield |
---|---|
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: β-naphthol In water at 60℃; for 1h; | 99% |
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Green chemistry; Stage #2: β-naphthol In water at 60℃; for 1h; Green chemistry; | 99% |
With hydrogenchloride; sodium nitrite 1.) -10 deg C - 0 deg C, 5 min, 2.) EtOH, H2O; Yield given. Multistep reaction; | |
With hydrogenchloride; Amberlite-IR 120 (Na(1+) form); sodium nitrite 1.) 0-5 deg C, 2.) water, ethanol, RT, 30 min; Yield given. Multistep reaction; |
2,5-dimethyl-2,3-dihydrofuran-3-one
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite at 20℃; for 1h; Stage #2: 2,5-dimethyl-2,3-dihydrofuran-3-one In water at 20℃; for 1h; | 99% |
di-tert-butyl dicarbonate
4-Chloro-2-nitroaniline
tert-butyl N-[(tert-butoxy)carbonyl]-N-(4-chloro-2-nitrophenyl)carbamate
Conditions | Yield |
---|---|
dmap In tetrahydrofuran at 90℃; for 1h; | 99% |
With dmap In tetrahydrofuran at 25 - 90℃; for 6h; | 58% |
4-Chloro-2-nitroaniline
isobutyraldehyde
4-chloro-2-nitro-N-(2-methyl-1-propen-1-yl)benzenamine
Conditions | Yield |
---|---|
With 4 A molecular sieve In benzene at 20℃; for 26h; | 99% |
Molecular sieve; | |
With magnesium sulfate In dichloromethane Schlenk technique; Inert atmosphere; Reflux; Sealed tube; |
Conditions | Yield |
---|---|
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: 2'-methoxyacetoacetanilide In water at 60℃; for 1h; | 99% |
Conditions | Yield |
---|---|
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.416667h; Stage #2: 5-acetoacetylamino-2-benzimidazolone In water at 60℃; for 2h; Time; | 99% |
Conditions | Yield |
---|---|
Stage #1: 4-Chloro-2-nitroaniline With hydrogenchloride; sodium nitrite In water for 0.666667h; Stage #2: N-phenylacetoacetamide In water at 20℃; for 0.166667h; | 99% |
trimethylsilyl 2-methylbenzoate
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 98% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 98% |
4-Chloro-2-nitroaniline
ethyl chlorocarbonylacetate
ethyl 3-((4-chloro-2-nitrophenyl)amino)-3-oxopropanoate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 98% |
In toluene for 24h; Heating; | 63% |
1,2-dibromo-1,2-diphenylethane
4-Chloro-2-nitroaniline
2,3-diphenyl-6-chloroquinoxaline
Conditions | Yield |
---|---|
With N-hexylpyridine hexafluorophosphate; cisplatine; 4,7-Dimethyl-1,10-phenanthroline; diisopropanolamine In dimethyl sulfoxide at 80℃; for 12h; Reagent/catalyst; Inert atmosphere; | 97.3% |
4-Chloro-2-nitroaniline
chloroacetyl chloride
N-(4-chloro-2-nitrophenyl)-2-chloroacetamide
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide Cooling with ice; | 97% |
trimethylsilyl ester of hydrocinnamic acid
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 97% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 97% |
4-Chloro-2-nitroaniline
2,6-difluorobenzoylchloride
N,N-bis-(2,6-difluorobenzoyl)-4-chloro-6-nitroaniline
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 20℃; | 97% |
Conditions | Yield |
---|---|
With Hexamethyldisiloxane; MS-5Angstroem; 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 96% |
Conditions | Yield |
---|---|
With tetrahydrofuran; tert.-butylnitrite; dimethyl sulfoxide at 30℃; for 1h; Green chemistry; | 96% |
benzyl bromide
4-Chloro-2-nitroaniline
N-benzyl-4-chloro-2-nitrobenzenamine
Conditions | Yield |
---|---|
In water at 100℃; for 1.5h; | 95% |
In water at 100℃; | 85% |
In water at 100℃; for 2h; Green chemistry; | 85% |
nitratocarbonylbis(triphenylphosphine)rhodium
4-Chloro-2-nitroaniline
Conditions | Yield |
---|---|
With KOH In methanol; acetone to an acetone soln. of Rh complex were added equimolar quantity of nitroaniline (in acetone) and KOH in MeOH; solvents were evpd. in vac., red residue extd. with benzene and filtered from KNO3; solvent removed in vac., crystals pptd. with hexane, filtered, washed with hexane and dried in air; elem. anal.; | 95% |
4-hydroxy-benzaldehyde
4-Chloro-2-nitroaniline
phosphonic acid diethyl ester
diethyl (4-chloro-2-nitrophenylamino)(4-hydroxyphenyl)methylphosphonate
Conditions | Yield |
---|---|
With ethylammonium nitrate at 20℃; for 4h; | 95% |
4-Chloro-2-nitroaniline
2.3-butanediol
6-chloro-2,3-dimethyl-quinoxaline
Conditions | Yield |
---|---|
With cesiumhydroxide monohydrate; C17H14Br2CoN4 In toluene at 150℃; for 24h; Sealed tube; Inert atmosphere; | 95% |
With sodium hydroxide In toluene at 120℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry; | 77% |
With dodecacarbonyl-triangulo-triruthenium; cesiumhydroxide monohydrate; 1,3-bis-(diphenylphosphino)propane In tert-Amyl alcohol at 150℃; for 8h; Schlenk technique; Inert atmosphere; | 68% |
With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube; | 64% |
With cobalt supported on N,P co-doped porous carbon In toluene at 140℃; for 12h; Sealed tube; Inert atmosphere; | 81 %Chromat. |
The IUPAC name of Kayaku Fast Red 3GL Base is 4-chloro-2-nitroaniline. With the CAS registry number 89-63-4, it is also named as Azofix Red 3GL Salt. The product's categories are Intermediates of Dyes and Pigments; Anilines, Aromatic Amines and Nitro Compounds; Organics. It is bright orange powder which is insoluble in water, soluble in alcohol, ether and acetic acid, and slightly soluble in crude gasoline. It is also stable, combustible and incompatible with strong oxidizing agents. When heated to decomposition it emits toxic vapors of NOx and Cl−. What's more, this chemical can form explosive products on reaction with nitric acid. So the storage environment should be well-ventilated, low-temperature and dry. Keep Kayaku Fast Red 3GL Base separate from raw materials of food.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.74; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.74; (4)ACD/LogD (pH 7.4): 2.74; (5)ACD/BCF (pH 5.5): 71.65; (6)ACD/BCF (pH 7.4): 71.65; (7)ACD/KOC (pH 5.5): 740.59; (8)ACD/KOC (pH 7.4): 740.59; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.646; (13)Molar Refractivity: 41.92 cm3; (14)Molar Volume: 115.5 cm3; (15)Polarizability: 16.62×10-24 cm3; (16)Surface Tension: 62.2 dyne/cm; (17)Enthalpy of Vaporization: 54.95 kJ/mol; (18)Vapour Pressure: 0.000667 mmHg at 25°C; (19)Exact Mass: 172.003955; (20)MonoIsotopic Mass: 172.003955; (21)Topological Polar Surface Area: 71.8; (22)Heavy Atom Count: 11; (23)Complexity: 159.
Preparation of Kayaku Fast Red 3GL Base: It can be obtained by forcing ammonolysis of 2,5-Dichloronitrobenzene.
Uses of Kayaku Fast Red 3GL Base: It is used in the production of yellow pigment 10G, disperse yellow 211, UV absorber UV-326 and so on. It is not only used in dyeing cotton and printing cotton, but also used for dyeing of viscose fiber, silk and polyester. What's more, it can react with sulfuric acid dimethyl ester to get 4-chloro-N-methyl-2-nitro-aniline. This reaction which is a kind of methylation needs reagents NaOH, Bu4NHSO4 and solvent toluene, H2O at temperature of 20 °C. The yield is 100%.
When you are using this chemical, please be cautious about it as the following:
It is very toxic by inhalation, in contact with skin and if swallowed. And it has danger of cumulative effects. Wha's more, this chemical is also toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. After contact with skin, wash immediately with plenty of soap-suds. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Avoid release to the environment. Refer to special instructions / safety data sheets.
People can use the following data to convert to the molecule structure.
1. SMILES:Clc1cc([N+]([O-])=O)c(N)cc1
2. InChI:InChI=1/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
3. InChIKey:PBGKNXWGYQPUJK-UHFFFAOYAL
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | National Technical Information Service. Vol. OTS0536149, |
mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
mouse | LD50 | intravenous | 63mg/kg (63mg/kg) | "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 139, 1954. | |
mouse | LD50 | oral | 800mg/kg (800mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
rat | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
rat | LD50 | oral | 400mg/kg (400mg/kg) | Office of Toxic Substances Report. Vol. OTS, |
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