4-Chloroaniline supplier | CasNO.106-47-8

Name
4-Chloroaniline
EINECS 203-401-0
CAS No. 106-47-8
Article Data770
CAS DataBase
Density 1.23 g/cm³
Solubility soluble in hot water
Melting Point 67-70 °C(lit.)
Formula C₆H₆ClN
Boiling Point 174.1 °C at 760 mmHg
Molecular Weight 127.573
Flash Point 60.7 °C
Transport Information UN 2018 6.1/PG 2
Appearance Clear amber liquid
Safety 53-45-60-61-36/37-16-7
Risk Codes 45-23/24/25-43-50/53-52/53-39/23/24/25-11
Molecular Structure
Hazard Symbols T，N，F
Synonyms NSC 36941;p-Aminochlorobenzene;p-Chloroaniline;p-Chlorophenylamine;Aniline,p-chloro- (8CI);1-Amino-4-chlorobenzene;4-Amino-1-chlorobenzene;4-Aminochlorobenzene;4-Chloro-1-aminobenzene;4-Chlorobenzenamine;4-Chlorophenylamine;
PSA 26.02000
LogP 2.50340

Synthetic route

: 100-00-5
4-chlorobenzonitrile

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With sodium hydroxide; dodecacarbonyl-triangulo-triruthenium; 2-methoxy-ethanol; carbon monoxide; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 3h; Ambient temperature;	100%
With carbon monoxide; water; [Ru(cyclo-octa-1,5-diene)(pyridine)4][BPh4]2 In tetrahydrofuran at 170℃; for 20h;	100%
With copper(I) chloride; potassium borohydride In methanol for 0.25h; Ambient temperature;	100%

: 3296-05-7
1-azido-4-chlorobenzene

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With tetracarbonylhydridoferrate In ethanol for 12h; Ambient temperature;	100%
With sodium hydrogen telluride In diethyl ether; ethanol for 0.25h; Ambient temperature;	100%
With methyltriphenylphosphonium tetrahydroborate In dichloromethane for 3h; Reduction; Heating;	99%

: 539-03-7
N-(4-chlorophenyl)acetamide

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With 40% potassium fluoride/alumina at 85℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);	99%
With ammonium bromide; ethylenediamine at 70℃; for 5h; Microwave irradiation; Inert atmosphere; neat (no solvent);	99%
Stage #1: N-(4-chlorophenyl)acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere;	92%

: 18437-66-6
N-(t-butoxycarbonyl)-4-chloroaniline

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With water at 100℃; for 10h;	99%
With Montmorillonite K10 In dichloromethane for 1.5h; deacylation; Heating;	98%
With H-β zeolite In dichloromethane for 5h; Heating;	98%

: 823-86-9
N-(4-chlorophenyl)hydroxylamine

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With hydrogen; sodium fluoride In methanol at 39.84℃; for 2.5h;	99%
With mackinawite; iron(II) at 23℃; pH=7.2; Kinetics; Further Variations:; Reagents;
With potassium borohydride; TPGS-750-M In water at 20℃; Inert atmosphere;	100 %Chromat.

: 100-00-5
4-chlorobenzonitrile

A: 106-47-8
4-chloro-aniline

B: 62-53-3
aniline

Conditions

Conditions	Yield
With hydrazine hydrate In toluene at 20℃; for 3h; Inert atmosphere;	A 95% B n/a
With hydrogen In ethyl acetate under 760.051 Torr; for 2h; Heating; Flow reactor; Green chemistry;	A 91% B 6%
With sodium tetrahydroborate In tetrahydrofuran; water at 25℃; for 1.5h;	A 90% B 10%

: 100-00-5
4-chlorobenzonitrile

12percent nickel/Al-SBA-15 fiber: 12percent nickel/Al-SBA-15 fiber

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With hydrogen In ethanol at 109.84℃; under 18751.9 Torr; for 7.5h; Autoclave; Green chemistry; chemoselective reaction;	95%

: 106-40-1
4-bromo-aniline

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With copper(I) oxide; tetramethlyammonium chloride; L-proline In ethanol at 110℃; for 15h; Inert atmosphere;	94%
With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 12h; Finkelstein Reaction; Schlenk technique; Inert atmosphere;	92%
With iron(III) chloride; sodium chloride In acetonitrile for 10h; Inert atmosphere; Green chemistry; regioselective reaction;

: 288-32-4
1H-imidazole

: 123167-91-9
(4-Chloro-phenyl)-carbamic acid 10,10-dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl ester

A: 123168-20-7
1-(10,10-Dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl)-1H-imidazole

B: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
In dichloromethane for 4h; Ambient temperature;	A 93% B 46%

...Expand

: 106018-89-7
2-Trimethylsilanyl-ethanesulfonic acid (4-chloro-phenyl)-amide

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h;	93%

: 2948-37-0
N-(4-chlorophenyl)benzylamine

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With ammonium formate; zinc In ethylene glycol for 0.0416667h; microwave irradiation;	93%
With ammonium formate; magnesium In ethylene glycol for 0.0333333h; microwave irradiation;	93%

: 1679-18-1
4-Chlorophenylboronic acid

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With potassium carbonate; ammonium hydroxide In methanol at 60℃; for 21h;	92%
With copper(ll) sulfate pentahydrate; ammonia; sodium hydroxide In water at 20℃; under 760.051 Torr; for 5h;	90%
With ammonium hydroxide; potassium nitrate In water at 20℃; for 2h; Electrochemical reaction; chemoselective reaction;	80%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In water; acetonitrile at 100℃; for 0.25h; Microwave irradiation;	74%
With copper(I) oxide; ammonium hydroxide In water for 0.0833333h; Microwave irradiation;

: 170300-50-2
4,4,4-Trifluoro-3-(p-chloroanilino)-2-phenyl-2-butenenitrile

A: 106-47-8
4-chloro-aniline

B: 139746-19-3
4,4,4-Trifluoro-3,3-dihydroxy-2-phenyl-butyronitrile

C: 51502-77-3
(4-chlorophenyl)hydrazonophenyl acetonitrile

Conditions

Conditions	Yield
With diazomethane; diethyl ether In diethyl ether Ambient temperature;	A 91% B 68% C 4%

...Expand

: 21650-51-1, 30926-04-6, 1602-00-2
(E)-bis(4-chlorophenyl)diazene

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With nickel; hydrazinium monoformate In methanol for 0.133333h; Heating;	91%

: 100-00-5
4-chlorobenzonitrile

A: 1,2-bis(4-chlorophenyl)diazene oxide

B: 106-47-8
4-chloro-aniline

C: 21650-51-1, 30926-04-6, 1602-00-2
(E)-bis(4-chlorophenyl)diazene

Conditions

Conditions	Yield
With hydrazine hydrate; potassium hydroxide In toluene at 100℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Concentration; Sealed tube;	A 4% B 4% C 91%

...Expand

: 614-26-6
4,4'-bis(chloro)azoxybenzene

A: 106-47-8
4-chloro-aniline

B: 1602-00-2
bis-(4-chloro-phenyl)-diazene

C: 953-14-0
N,N'-bis(4-chlorophenyl)hydrazine

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel boride In methanol for 24h; Ambient temperature;	A 9.9% B 90.4% C 5.3%
With sodium tetrahydroborate; nickel boride In methanol for 0.5h; Ambient temperature;	A 35.6% B 20.6% C 23.8%

...Expand

: 1613-88-3
4-chloro-N-hydroxybenzamide

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 2h; Lossen rearrangement;	90%
With potassium carbonate In dimethyl sulfoxide at 90℃; for 2h; Lossen Rearrangement;	90%
With sodium hydroxide In dimethyl sulfoxide at 80℃; for 1.5h; Lossen rearrangement;

: 110-89-4
piperidine

: 123167-91-9
(4-Chloro-phenyl)-carbamic acid 10,10-dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl ester

A: 123167-92-0
N-<9-(10,10-dioxo-10,10,10,10-tetrahydrothioxanthenyl)methyl>piperidine

B: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
for 0.5h; Ambient temperature;	A 89% B n/a

...Expand

: 956484-63-2
(4-chlorophenyl)-carbamic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl ester

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	89%

: 14933-95-0
N-(4-chlorophenyl)benzenesulfenamide

A: 3372-79-0
2,7-dichloro-phenazine

B: 106-47-8
4-chloro-aniline

C: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene at 25℃; Further byproducts given;	A 34% B 55% C 88%

...Expand

: 108-24-7
acetic anhydride

: 106-47-8
4-chloro-aniline

: 539-03-7
N-(4-chlorophenyl)acetamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; Inert atmosphere;	100%
In chloroform	99%
With aluminum oxide at 25℃; for 0.0833333h;	98%

: 100-52-7
benzaldehyde

: 106-47-8
4-chloro-aniline

: 780-21-2
N-(4-chlorobenzylidene)aniline

Conditions

Conditions	Yield
With acetic acid In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere;	100%
With aqueous extract of pericarp of Sapindus trifoliatus fruits at 20℃; for 0.0333333h;	98%
sodium hydrogen sulfate; silica gel at 62 - 64℃; for 0.0208333h; microwave irradiation;	96%

: 64-18-6
formic acid

: 106-47-8
4-chloro-aniline

: 2617-79-0
N-(4-chlorophenyl)formamide

Conditions

Conditions	Yield
In toluene Reflux;	100%
With sodium formate at 20℃; for 2h; Neat (no solvent);	98%
With TiO2-SO4(2-) In acetonitrile at 20℃; for 6h;	98.3%

: 506-68-3
bromocyane

: 106-47-8
4-chloro-aniline

: 13463-94-0
N-(4-chlorophenyl)cyanamide

Conditions

Conditions	Yield
With trimethylamine Ambient temperature;	100%
With sodium hydrogencarbonate In benzene at 20℃; for 2h;	93%
In methanol	75%

: 1951-11-7
3-chlorobutanoyl chloride

: 106-47-8
4-chloro-aniline

: 307335-67-7
3-chloro-butyric acid-(4-chloro-anilide)

Conditions

Conditions	Yield
In acetone for 1h; Acylation; Heating;	100%
With acetone

: 106-47-8
4-chloro-aniline

: 98-59-9
p-toluenesulfonyl chloride

: 2903-34-6
4-methyl-N-(4-chlorophenyl)benzenesulfonamide

Conditions

Conditions	Yield
In pyridine; acetonitrile at 20℃; for 16h;	100%
In ethanol; water at 25℃; for 0.333333h;	96%
With (Na1752K0.144Ca0365Mg0.065)(Al2044Si2774O96)*19.16H2O In ethanol at 25 - 30℃; for 0.25h; Sonication; Green chemistry;	95%

: 6018-41-3
methyl coumalate

: 106-47-8
4-chloro-aniline

: 89537-90-6
(Z)-4-[1-(4-Chloro-phenylamino)-meth-(Z)-ylidene]-pent-2-enedioic acid 5-methyl ester

Conditions

Conditions	Yield
In methanol at 25℃; for 12h;	100%

: 541-41-3
chloroformic acid ethyl ester

: 106-47-8
4-chloro-aniline

: 2621-80-9
ethyl p-chlorophenylcarbamate

Conditions

Conditions	Yield
With pyridine at 0℃; for 1.5h;	100%
With TEA In tetrahydrofuran for 1h; Heating;	98%
With pyridine at 20℃; for 1h;	86.8%

: 123-08-0
4-hydroxy-benzaldehyde

: 106-47-8
4-chloro-aniline

: 3369-35-5
4-[(4-chloro-phenylimino)-methyl]-phenol

Conditions

Conditions	Yield
for 6h; Ambient temperature;	100%
In ethanol at 70℃;	82%
In methanol at 20℃; for 0.5h;	82%

: 924-44-7
glyoxylic acid ethyl ester

: 106-47-8
4-chloro-aniline

: 121641-61-0
(4-chloro-phenylimino)-acetic acid ethyl ester

Conditions

Conditions	Yield
With magnesium sulfate In toluene at 25℃; for 0.5h;	100%
With sodium sulfate In toluene at 110℃; for 0.5h;
With sodium sulfate In toluene

: 40657-29-2
1,1,1-trifluoro-4,4-diethoxy-3-buten-2-one

: 106-47-8
4-chloro-aniline

: 128648-66-8
(E)-4-(4-Chloro-phenylamino)-4-ethoxy-1,1,1-trifluoro-but-3-en-2-one

Conditions

Conditions	Yield
In acetonitrile for 18h; Ambient temperature;	100%

: 71105-17-4
phenylene-1,2-diisothiocyanate

: 106-47-8
4-chloro-aniline

: 75644-25-6
1-(4-chloranilino-thiocarbonyl)-benzimidazolidine-2-thione

Conditions

Conditions	Yield
for 1h; Solid phase reaction; cyclization; addition;	100%
In acetonitrile for 0.5h; Ambient temperature;	95%

: 1934-75-4
sodium dicyanamide

: 106-47-8
4-chloro-aniline

: 1482-62-8
1-(4-chlorophenyl)-3-cyanoguanidine

Conditions

Conditions	Yield
oxonium; acetic acid In water at 40℃; Rate constant; Mechanism;	100%
With hydrogenchloride In water at 60℃; for 3h;	87%
Stage #1: sodium dicyanamide; 4-chloro-aniline With hydrogenchloride In water at 50 - 90℃; for 18h; Stage #2: With sodium hydrogencarbonate In water for 0.25h;	78.3%

: 106-47-8
4-chloro-aniline

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 38608-18-3
4-chloro-N-(3,4-dimethoxyphenyl)methylenebenzenamine

Conditions

Conditions	Yield
In toluene Heating;	100%
magnesium(II) perchlorate In 1,2-dichloro-ethane at 20℃; for 8h;	90%
In ethanol for 0.75h; Heating;
With Montmorillonite K10 clay Condensation; microwave irradiation;
In neat (no solvent) Heating;

: 106-47-8
4-chloro-aniline

: 83760-12-7
ethyl 3-dimethylamino-2-(2-tert-butyl-2H-tetrazol-5-yl)acrylate

: 141099-96-9, 141099-97-0
ethyl 2-(2-tert-butyl-2H-tetrazol-5-yl)-3-(4-chloroanilino)acrylate

Conditions

Conditions	Yield
In acetic acid at 50℃; for 2h;	100%

: 106-47-8
4-chloro-aniline

: 147992-99-2
1-dimethylamino-2-nitro-4-(2,4-dichlorophenyl)-4-oxopropene-1

: 137555-40-9
1-(4-chlorophenylamino)-2-nitro-4-(2,4-dichlorophenyl)-4-oxopropene-1

Conditions

Conditions	Yield
In ethanol for 1h; Ambient temperature;	100%

: 106-47-8
4-chloro-aniline

: 106-96-7
propargyl bromide

: 22774-67-0
4-chloro-N-prop-2-ynylaniline

Conditions

Conditions	Yield
With aluminum oxide In diethyl ether at 20℃; for 96h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 5h;	85%
With potassium carbonate In N,N-dimethyl-formamide; toluene at 20℃; Inert atmosphere;	82%

: 106-47-8
4-chloro-aniline

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 16937-03-4
4-nitro-N-(4-chlorophenyl)benzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃;	100%
With pyridine at 20℃;	84%
With sodium acetate In methanol; water at 60℃;	71%

: 106-47-8
4-chloro-aniline

: 147670-94-8
1-phenyl-3-p-toluoyl-4,5-dihydro-4,5-pyrazoledione

: 4-(4-Chloro-phenylamino)-4-hydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one

Conditions

Conditions	Yield
In toluene Ambient temperature;	100%

: 106-47-8
4-chloro-aniline

: 556-61-6
methyl thioisocyanate

: 2740-97-8
1-(4-chloro-phenyl)-3-methyl-thiourea

Conditions

Conditions	Yield
at 20℃; for 24h; Addition; solid-phase reaction;	100%
In methanol for 1h; Heating;	80%
In ethanol for 1h; Heating;
In acetonitrile at 40℃;

: 562-46-9
4,4-dimethylcyclohexane-1,3-dione

: 106-47-8
4-chloro-aniline

: 3-((4-chlorophenyl)amino)-6,6-dimethylcyclohex-2-enone

Conditions

Conditions	Yield
at 20℃; for 0.5h; Solid phase reaction; condensation;	100%
With magnesium sulfate In methanol Heating;

4-Chloroaniline Chemical Properties

Product Name: 4-Chloroaniline (CAS NO.106-47-8)
IUPAC Name: 4-chloroaniline

MF: C₆H₆ClN
MW: 127.57
EINECS: 203-401-0
MP: 67-70 °C(lit.)
BP: 232 °C(lit.)
Density: 1,43 g/cm³
Vapor density: 4.4 (vs air)
Vapor pressure: 0.15 mm Hg ( 25 °C)
Refractive index: 1.5546
Fp: 120°C
Storage temp: 2-8°C
Water Solubility: 0.3 g/100 mL (20 °C)
Merck: 14,2118
BRN: 471359
Product Categories: Fluorobenzene; Anilines, Aromatic Amines and Nitro Compounds; 2002/61/EC; Alpha Sort; Aryl Amines MAK III, Category 2Volatiles/ Semivolatiles; C; CAlphabetic; CHMethod Specific; European Community: ISO and DIN; Method Specific; Oeko-Tex Standard 100; Amines; C2 to C6; Nitrogen Compounds; Aryl Amines MAK III, Category 2Pesticides&Metabolites; Aryl Amines MAK III, Category 2Alphabetic; ChloroMore...Close...;Analytical Standards; AromaticsChemical Class; AromaticsMethod Specific; CHChemical Class; Chemical Class; Halogenated

4-Chloroaniline Uses

4-Chloroaniline (CAS NO.106-47-8) is mainly used as dye int, pharmaceuticals and agricultural chemicals.

4-Chloroaniline Toxicity Data With Reference

1.	skn-rbt 500 mg/24H MLD	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96.
2.	eye-rbt 250 µg/24H SEV	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96.
3.	mma-sat 100 µg/plate	ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1.
4.	otr-rat:emb 14,500 ng/plate	JJATDK JAT, Journal of Applied Toxicology. 1 (1981),190.
5.	dns-rat:lvr 5 mg/L	MUREAV Mutation Research. 97 (1982),359.
6.	orl-rat TDLo:9270 mg/kg/2Y-C:CAR	FCTOD7 Food and Chemical Toxicology. 29 (1991),119.
7.	orl-rat LD50:310 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

4-Chloroaniline Consensus Reports

EPA Genetic Toxicology Program. 4-Chloroaniline (CAS NO.106-47-8) is reported in EPA TSCA Inventory.

4-Chloroaniline Safety Profile

Safety Information of 4-Chloroaniline (CAS NO.106-47-8):
Hazard Codes: T Toxic ,N Dangerous ,F Flammable
RIDADR: UN 2018 6.1/PG 2
WGK Germany: 3
RTECS: BX0700000
Hazard Note: Toxic/Possible Carcinogen
HazardClass: 6.1
PackingGroup: II
HS Code: 29214210
Hazardous Substances Data: 106-47-8(Hazardous Substances Data)
Confirmed carcinogen with experimental neoplastigenic and tumorigenic data. Poison by ingestion, inhalation, skin contact, subcutaneous, and intravenous routes. A skin and severe eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.

4-Chloroaniline Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

Product Name

4-Chloroaniline

Synthetic route

4-Chloroaniline Chemical Properties

4-Chloroaniline Uses

4-Chloroaniline Toxicity Data With Reference

4-Chloroaniline Consensus Reports

4-Chloroaniline Safety Profile

4-Chloroaniline Standards and Recommendations

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