4-Chlorobenzyl alcohol supplier

Name
4-Chlorobenzyl alcohol
EINECS 212-852-2
CAS No. 873-76-7
Article Data477
CAS DataBase
Density 1.237 g/cm³
Solubility Soluble in water (2.5 mg/ml at 20°C), and methanol.
Melting Point 68-71 °C(lit.)
Formula C₇H₇ClO
Boiling Point 234.069 °C at 760 mmHg
Molecular Weight 142.585
Flash Point 95.362 °C
Transport Information
Appearance white crystalline powder
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Benzenemethanol, 4-chloro- (9CI);(4-Chlorophenyl)methanol;Benzyl alcohol, p-chloro-;4-Chlorobenzenemethanol;Benzenemethanol, 4-chloro-;p-Chlorobenzylalcohol;
PSA 20.23000
LogP 1.83230

Synthetic route

: 104-88-1
4-chlorobenzaldehyde

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%
With diisopropoxytitanium(III) tetrahydroborate In dichloromethane at -20℃; for 0.133333h;	100%
With zirconium dioxide hydrate; isopropyl alcohol at 60℃; for 0.133333h; Meerwein-Ponndorf-Verley Reduction;	100%

: 74-11-3
para-chlorobenzoic acid

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere;	100%
With samarium diiodide; benzaldehyde; samarium(III) trifluoromethanesulfonate In tetrahydrofuran; methanol; water at 20℃; for 0.0166667h; Reduction;	99%
With samarium diiodide; phosphoric acid In tetrahydrofuran for 0.000833333h; Ambient temperature;	94%

: 1126-46-1
Methyl 4-chlorobenzoate

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With C39H39N6ORu(1+)*Br(1-); potassium methanolate; hydrogen In tetrahydrofuran at 70℃; under 37503.8 Torr; for 4h; Reagent/catalyst;	100%
With C56H70Cl3N10Ru2(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran; dodecane at 70℃; under 37503.8 Torr; for 16h; Inert atmosphere; Glovebox; Autoclave;	100%
With C13H34BFeNOP2; hydrogen In tetrahydrofuran at 60℃; under 22502.3 Torr; for 18h; Autoclave; Inert atmosphere;	99%

: 122-01-0
4-chloro-benzoyl chloride

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran at 20℃; for 1.16667h;	100%
With Zr(BH4)2Cl2(dabco)2 In tetrahydrofuran for 1.7h; Heating;	98%
With sodium tetrahydroborate; lithium perchlorate In acetonitrile for 0.666667h;	95%

: 790-41-0
4-chlorobenzoic anhydride

A: 873-76-7
para-Chlorobenzyl alcohol

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; Ambient temperature;	A 94% B 100%

: sodium tetrakis(4-chlorobenzyloxy)borate

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With water	100%

: 18484-03-2
2-(4-chlorobenzyloxy)tetrahydro-2H-pyran

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
silica-supported prop-1-ylsulfonic acid In methanol	99.4%
With sulfuric acid; silica gel In methanol at 20℃; for 0.5h;	98%
With lithium borohydride In methanol at 20℃; for 0.416667h;	96%

: 619-56-7
4-chlorobenzamide

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With samarium diiodide; water In tetrahydrofuran for 0.00277778h; Ambient temperature;	99%
With C24H20ClN2OPRu; potassium tert-butylate; hydrogen In tetrahydrofuran at 110℃; under 10640.7 Torr; for 36h; Inert atmosphere; Schlenk technique;	85%
With [fac-8-(2-diphenylphosphinoethyl)aminotrihydroquinoline]RuH(η1-BH4)(CO); hydrogen In isopropyl alcohol at 140℃; under 37503.8 Torr; for 24h; Autoclave;	62 %Chromat.

: 7335-27-5
ethyl 4-chlorobenzoate

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate; hafnium tetrachloride In tetrahydrofuran at 20℃; for 5.6h; Inert atmosphere; Cooling with ice;	98%
With phenylsilane; potassium tert-butylate; water; sodium triethylborohydride; cobalt(II) chloride In 1,4-dioxane; toluene at 60℃; for 15h; Inert atmosphere; Glovebox; Schlenk technique;	98%
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave;	96%

: 5406-33-7
4-chlorobenzyl acetate

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With methanol; potassium permanganate at 25℃; chemoselective reaction;	98%
With methanol; [Dy2((2-hydroxy-3-methoxyphenyl)methylene benzohydrazide)2(triflate)2(H2O)4] for 40h; Reflux; Inert atmosphere; chemoselective reaction;	81%
With water In acetonitrile for 0.166667h; Quantum yield; Irradiation;

: 14856-74-7
4-chlorobenzyltrimethylsilyl ether

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With poly (ethylene glycol)-sulfonated sodium montmorillonite nanocomposite In methanol at 20℃; for 0.0333333h;	98%
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	96%
With rice husk ash supported on anatase-phase titania nanoparticles nanocomposite In methanol at 20℃; for 0.05h;	96%

: 104-88-1
4-chlorobenzaldehyde

: 103-67-3
benzyl-methyl-amine

A: 19048-85-2
(4'-chlorobenzyl) 4-chlorobenzoate

B: 137374-28-8
N-benzyl-4-chloro-N-methylbenzamide

C: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
tris(bis(trimethylsilyl)amido)lanthanum(III) In benzene-d6 at 25℃; for 24h;	A n/a B 98% C n/a

...Expand

: 1200-16-4
1-chloro-4-[(methoxymethoxy)methyl]benzene

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0166667h; Microwave irradiation; chemoselective reaction;	97%
phosphotungstic acid In ethanol for 4.5h; Heating;	87%

: 104-88-1
4-chlorobenzaldehyde

: 62-53-3
aniline

A: 6833-15-4
4-chlorobenzanilide

B: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
Stage #1: aniline With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere; Stage #2: 4-chlorobenzaldehyde With yttrium(III) chloride In toluene at 20℃; for 48h; Cannizzaro reaction; Inert atmosphere; Stage #3: With hydrogenchloride In water; toluene at 20℃; Inert atmosphere;	A 97% B n/a

...Expand

: 104-88-1
4-chlorobenzaldehyde

: 67-63-0
isopropyl alcohol

A: 67-64-1
acetone

B: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With titanium(IV) oxide at 24.84℃; Meerwein-Ponndorf-Verley Reduction; Sealed tube; UV-irradiation; Inert atmosphere; Green chemistry; chemoselective reaction;	A 96% B 87%

...Expand

: C13H13ClOSi

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With sodium hydroxide In water Schlenk technique; Inert atmosphere;	96%
With water; sodium hydroxide In benzene-d6 at 20℃; Glovebox; Inert atmosphere;
With sodium hydroxide In methanol for 2h;
With sodium hydroxide In water

: 104-88-1
4-chlorobenzaldehyde

A: 873-76-7
para-Chlorobenzyl alcohol

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water Green chemistry;	A 95% B 95%
With sodium hydroxide In water at 20℃; for 3.5h; Cannizzaro Reaction;	A n/a B 89%
With TEA; magnesium bromide In dichloromethane at 20℃; for 48h; Cannizzaro reaction;	A 88% B n/a

: 1202-68-2
4-chloro-1-[(ethoxymethoxy)methyl]benzene

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0166667h; Microwave irradiation; chemoselective reaction;	95%
phosphotungstic acid In ethanol for 4.5h; Heating;	87%

: 14642-79-6
benzyloxy-trimethylsilane

: 1202-68-2
4-chloro-1-[(ethoxymethoxy)methyl]benzene

A: 873-76-7
para-Chlorobenzyl alcohol

B: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0166667h; Microwave irradiation; chemoselective reaction;	A 95% B 10%

...Expand

: 140-11-4
Benzyl acetate

: 1202-68-2
4-chloro-1-[(ethoxymethoxy)methyl]benzene

A: 873-76-7
para-Chlorobenzyl alcohol

B: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.0166667h; Microwave irradiation; chemoselective reaction;	A 95% B 20%

...Expand

: 19350-69-7
4-chlorobenzaldehyde p-toluenesulfonylhydrazone

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With water; potassium carbonate at 130℃; for 0.166667h; Microwave irradiation;	95%

: C15H22BClO

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With sodium hydroxide In water Inert atmosphere;	95%

: 1143018-85-2
2-((4-chlorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With silica gel at 25℃; Inert atmosphere; Glovebox;	95%
With silica gel In methanol for 4h; Reflux;	94%
With silica gel In hexane; ethyl acetate	92%

: 256521-85-4
4-[(chlorophenyl)methoxy](1,1-dimethylethyl)dimethylsilane

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 7h;	95%
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 7h;	95%
With methanol at 20℃; for 2.33333h;	95%

: 21368-28-5
4-chlorobenzoyl azide

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In 1,2-dimethoxyethane for 5.5h; Ambient temperature;	94%
With Ca(BH2S3)2 In tetrahydrofuran for 2h; Heating;	87%

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With N-chloro-succinimide; copper(l) chloride In acetonitrile at 80℃; for 12h;	94%
With N-chloro-succinimide In acetonitrile at 80℃; for 16h;	93%

: 104-88-1
4-chlorobenzaldehyde

: 766-97-2
4-n-methylphenylacetylene

A: 1-(4-chlorophenyl)-3-(4-methylphenyl)prop-2-yn-1-one

B: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With triethylamine; zinc(II) iodide In toluene at 80℃; for 12h; Schlenk technique; Inert atmosphere;	A 94% B n/a

...Expand

: 4-chlorobenzyl β-(trimethylsilyl)ethoxymethyl ether

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With carbon tetrabromide In isopropyl alcohol for 2h; Heating;	93%

: 104-88-1
4-chlorobenzaldehyde

A: 37580-81-7, 67111-67-5, 69483-09-6, 116262-76-1, 38152-44-2
1,2-bis(4-chlorophenyl)-1,2-ethandiol

B: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With vanadium(II) chloride In ethanol; water at 16 - 22℃; for 0.416667h; sonication;	A 92% B 2%
With ammonium chloride; magnesium Ambient temperature;	A 90% B 7%
With zinc(II) chloride; zinc In tetrahydrofuran; water for 3h; Ambient temperature;	A 16% B 82%

: 98-86-2
acetophenone

: 873-76-7
para-Chlorobenzyl alcohol

: 5739-39-9
3-(4-chlorophenyl)-1-phenylpropan-1-one

Conditions

Conditions	Yield
With titanium(IV) oxide; potassium hydroxide In toluene at 100℃; for 10h; Sealed tube; Irradiation;	100%
With C27H24Cl3F6IrN2; potassium hydroxide In toluene at 130℃; for 2h;	94%
With C16H14IrN2O3; caesium carbonate In tert-Amyl alcohol for 6h; Reflux;	91%

: 873-76-7
para-Chlorobenzyl alcohol

: 104-88-1
4-chlorobenzaldehyde

Conditions

Conditions	Yield
With oxygen; perruthenate modified mesoporous silicate MCM-41 In toluene at 80℃; for 1h; Oxidation;	100%
With n-butyltriphenylphosphonium permanganate In acetonitrile at 20℃; for 0.25h;	100%
With butyltriphenylphosphonium chlorochromate In acetonitrile for 0.75h; Heating;	100%

: 873-76-7
para-Chlorobenzyl alcohol

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

Conditions

Conditions	Yield
With tetrachloromethane; cross-linked polymer (containing 2.50 mmol of phosphine/g) for 3h; Heating;	100%
With ziconium(IV) oxychloride octahydrate; lithium chloride In ethanol; water at 90℃; for 1.5h;	95%
With 1,3,5-trichloro-2,4,6-triazine; dimethyl sulfoxide at 20℃; for 0.25h; chemoselective reaction;	94%

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 873-76-7
para-Chlorobenzyl alcohol

: 14856-74-7
4-chlorobenzyltrimethylsilyl ether

Conditions

Conditions	Yield
With aluminum potassium sulfate dodecahydrate In acetonitrile at 20℃; for 0.333333h;	100%
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.0166667h; Green chemistry;	100%
With asymmetric salen type di-Schiff base-based zinc complex supported on Fe3O4 nanoparticles at 20℃; for 0.2h;	100%

: 108-24-7
acetic anhydride

: 873-76-7
para-Chlorobenzyl alcohol

: 5406-33-7
4-chlorobenzyl acetate

Conditions

Conditions	Yield
(NH4)8[CeW10O36]*20H2O for 0.0833333h; Heating;	100%
With SBA-15-Ph-Pr-SO3H at 20℃; for 0.333333h;	100%
With tin(IV) tetraphenylporphyrin perchlorate at 20℃; for 0.0833333h;	99%

: 873-76-7
para-Chlorobenzyl alcohol

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With bromine; oxygen In acetonitrile for 10h; Irradiation;	100%
With periodic acid; tripropylammonium fluorochromate (VI) In acetonitrile at 0℃;	99%
With silica-supported Jones reagent In dichloromethane for 0.035h;	99.4%

: 109-87-5
Dimethoxymethane

: 873-76-7
para-Chlorobenzyl alcohol

: 1200-16-4
1-chloro-4-[(methoxymethoxy)methyl]benzene

Conditions

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 1.2h;	100%
With zirconyl triflate at 20℃; for 0.166667h; neat (no solvent); chemoselective reaction;	100%
With 12-tungstophosphoric acid immobilized on [bmim][FeCl4] at 75 - 82℃; for 0.00555556h; Microwave irradiation;	98%

: 873-76-7
para-Chlorobenzyl alcohol

: 623-03-0
4-Cyanochlorobenzene

Conditions

Conditions	Yield
With ammonium hydroxide; oxygen In tert-Amyl alcohol at 130℃; under 3750.38 Torr; for 24h;	100%
Stage #1: para-Chlorobenzyl alcohol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; iodine In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: With ammonia; iodine In dichloromethane; water at 20℃; for 2h; Inert atmosphere;	99%
With ammonia; oxygen In tert-Amyl alcohol; water at 100℃; under 3750.38 Torr; for 5h; Autoclave; High pressure;	99%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 873-76-7
para-Chlorobenzyl alcohol

: 68388-09-0
4-chlorobenzoic acid N-hydroxysuccinimide ester

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; benzoic acid In ethyl acetate for 0.5h; cooling;	100%
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In decane; acetonitrile at 80℃; for 18h; Solvent;	92%
With tert.-butylhydroperoxide; oxygen In acetonitrile for 24h; Irradiation; Sealed tube;	52%

: 873-76-7
para-Chlorobenzyl alcohol

: 693-13-0
diisopropyl-carbodiimide

: C14H21ClN2O

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) at 100℃; for 0.0833333h; Microwave irradiation;	100%

: C14H17N3O3*ClH

: 873-76-7
para-Chlorobenzyl alcohol

: 530-62-1
1,1'-carbonyldiimidazole

: 1144035-02-8
4-chlorobenzyl 4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: para-Chlorobenzyl alcohol; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: C14H17N3O3*ClH In N,N-dimethyl-formamide at 20℃; for 18h;	100%

...Expand

: 98-85-1, 13323-81-4
1-Phenylethanol

: 873-76-7
para-Chlorobenzyl alcohol

: 5739-39-9
3-(4-chlorophenyl)-1-phenylpropan-1-one

Conditions

Conditions	Yield
With Cu-Ag supported on hydrotalcite In o-xylene at 150℃; for 8h; Inert atmosphere;	100%
With C44H35ClO4P2Ru; potassium hydroxide In para-xylene at 130℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Molecular sieve;	95%
With C44H35ClO4P2Ru; sodium sulfate; potassium hydroxide In toluene at 150℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	95%

: 72-18-4
L-valine

: 104-15-4
toluene-4-sulfonic acid

: 873-76-7
para-Chlorobenzyl alcohol

: (S)-1-((4-chlorobenzyl)oxy)-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
In water; toluene for 24h; Reflux; Dean-Stark;	100%

...Expand

: 110-87-2
3,4-dihydro-2H-pyran

: 873-76-7
para-Chlorobenzyl alcohol

: 18484-03-2
2-(4-chlorobenzyloxy)tetrahydro-2H-pyran

Conditions

Conditions	Yield
silica-supported prop-1-ylsulfonic acid In acetonitrile for 0.166667h;	99.9%
With chloromethylated polystyrene supported tetrakis(p-aminophenyl)porphyrinatotin(IV) trifluoromethanesulfonate In tetrahydrofuran at 20℃; for 0.1h;	99%
With mesoporous p-hydroxybenzenesulphonic acid-formaldehyde polymer resin In neat (no solvent) at 20℃; for 1.15h; chemoselective reaction;	97%

: 63-91-2
L-phenylalanine

: 104-15-4
toluene-4-sulfonic acid

: 873-76-7
para-Chlorobenzyl alcohol

: phenylalanine p-chlorobenzyl ester p-toluenesulfonate

Conditions

Conditions	Yield
In toluene for 5h; Heating;	99.5%

...Expand

: 106-47-8
4-chloro-aniline

: 873-76-7
para-Chlorobenzyl alcohol

: 13159-74-5
4-chloro-N-(4-chlorobenzyl)aniline

Conditions

Conditions	Yield
With sodium hydrogencarbonate In toluene at 110℃; for 48h; Inert atmosphere;	99%
Stage #1: 4-chloro-aniline; para-Chlorobenzyl alcohol With (1,3-bis(2,6-di-iso-propylphenyl)-4,5-dihydroimidazol-2-ylidene) copper chloride; potassium tert-butylate; oxygen In tetrahydrofuran at 20℃; for 6h; Molecular sieve; Stage #2: With (1,3-bis(2,6-di-iso-propylphenyl)-4,5-dihydroimidazol-2-ylidene) copper chloride In tetrahydrofuran at 20℃; for 8h; Molecular sieve;	94%
With C51H40Cl2N2O3P2Ru; potassium hydroxide In toluene at 120℃; for 14h;	84%

: 873-76-7
para-Chlorobenzyl alcohol

: 106-43-4
para-chlorotoluene

Conditions

Conditions	Yield
With hydrazine hydrate; C23H40MnNO2P2; potassium tert-butylate In tert-butyl alcohol at 115℃; for 48h; Wolff-Kishner Reduction; Green chemistry;	99%
With carbon monoxide; hydrogen; benzene at 190℃; under 176522 Torr; Reagens 4: Octacarbonyldikobalt, Reagens 5: Kobaltcarbonat;
With 2,4,6-trimethyl-pyridine; 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine In toluene for 24h; Irradiation;	74 %Chromat.

: 873-76-7
para-Chlorobenzyl alcohol

: 622-95-7
4-chlorobenzyl bromide

Conditions

Conditions	Yield
Stage #1: para-Chlorobenzyl alcohol With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane Stage #2: With potassium bromide In dichloromethane; N,N-dimethyl-formamide for 0.266667h;	99%
With N-Bromosuccinimide; triphenylphosphine for 0.00277778h; microwave irradiation;	98%
With bromine; triphenylphosphine In dichloromethane at -78 - 20℃; for 18h; Inert atmosphere;	97%

: 873-76-7
para-Chlorobenzyl alcohol

: 35424-56-7
1-chloro-4-(iodomethyl)benzene

Conditions

Conditions	Yield
Stage #1: para-Chlorobenzyl alcohol With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane Stage #2: With potassium iodide In dichloromethane; N,N-dimethyl-formamide for 0.0833333h;	99%
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; iodine; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dichloro-ethane at 20℃; under 22502.3 Torr; Autoclave; Schlenk technique;	99%
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen; iodine In toluene at 20℃; under 22502.3 Torr; for 5.5h;	99%

: 873-76-7
para-Chlorobenzyl alcohol

: 194664-25-0
C20H21N3O6S

: 194664-26-1
1-benzyloxycarbonyl-2-tert-butyloxycarbonyl-1-(4-chlorobenzyl)-2-(4-cyanobenzenesulfonyl)-hydrazine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran	99%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;	99%

: 64-19-7
acetic acid

: 873-76-7
para-Chlorobenzyl alcohol

: 5406-33-7
4-chlorobenzyl acetate

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate at 20℃; for 0.583333h;	99%
With potassium fluoride at 80℃; for 3h;	97%
With 50wtpercent Cs2.5H0.5PW12O40 supported on MCM-41 In acetonitrile at 50℃; for 0.5h;	97%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 873-76-7
para-Chlorobenzyl alcohol

: (S)-2-[(4-Chloro-benzyl)-(2-nitro-benzenesulfonyl)-amino]-propionic acid

Conditions

Conditions	Yield
Multistep reaction;	99%

...Expand

4-Chlorobenzyl alcohol Specification

The 4-Chlorobenzyl alcohol, with the CAS registry number 873-76-7, is also known as Benzenemethanol, 4-chloro-. It belongs to the product categories of Alcohols and Derivatives; Benzhydrols, Benzyl & Special Alcohols; Alcohol; Alcohols; Chlorine Compounds; C7 to C8; Oxygen Compounds. Its EINECS registry number is 212-852-2. This chemical's molecular formula is C₇H₇ClO and molecular weight is 142.58. What's more, both its IUPAC name and systematic name are the same which is called (4-Chlorophenyl)methanol. It should be stored in a cool, dry and well-ventilated place. When you are dealing with this chemical, you should be very careful. The gas can not be breathed. You should avoid contacting with skin and eyes.

Physical properties about 4-Chlorobenzyl alcohol are: (1)ACD/LogP: 1.639; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.64; (4)ACD/LogD (pH 7.4): 1.64; (5)ACD/BCF (pH 5.5): 10.36; (6)ACD/BCF (pH 7.4): 10.36; (7)ACD/KOC (pH 5.5): 185.54; (8)ACD/KOC (pH 7.4): 185.54; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.23 Å²; (13)Index of Refraction: 1.566; (14)Molar Refractivity: 37.599 cm³; (15)Molar Volume: 115.201 cm³; (16)Polarizability: 14.905×10^-24 cm³; (17)Surface Tension: 43.99 dyne/cm; (18)Density: 1.238 g/cm³; (19)Flash Point: 95.362 °C; (20)Enthalpy of Vaporization: 49.756 kJ/mol; (21)Boiling Point: 234.069 °C at 760 mmHg; (22)Vapour Pressure: 0.030 mmHg at 25 °C.

Preparation of 4-Chlorobenzyl alcohol: this chemical can be prepared by 4-Chloro-benzoic acid ethyl ester. This reaction needs reagent Ca(BH₄)₂ and solvents tetrahydrofuran, toluene at temperature of 100 °C. The reaction time is 1 hour. The yield is 95 %.

4-Chlorobenzyl alcohol can be prepared by 4-Chloro-benzoic acid ethyl ester.

Uses of 4-Chlorobenzyl alcohol: (1) it is used as medicine, synthetic organic intermediates; (2) it is used to produce other chemicals. For example, it can react with pyridine-2,3-diamine to get 2-(4-chloro-phenyl)-3H-imidazo[4,5-b]pyridine. The reaction occurs with reagent sulfur at temperature of 185-200 °C. The reaction time is 2 hours. The yield is 61 %.

4-Chlorobenzyl alcohol can react with pyridine-2,3-diamine to get 2-(4-chloro-phenyl)-3H-imidazo[4,5-b]pyridine.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1ccc(cc1)CO
(2) InChI: InChI=1S/C7H7ClO/c8-7-3-1-6(5-9)2-4-7/h1-4,9H,5H2
(3) InChIKey: PTHGDVCPCZKZKR-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	unreported	1800mg/kg (1800mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(5), Pg. 13, 1990.
rat	LD50	unreported	3840mg/kg (3840mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(5), Pg. 13, 1990.

Product Name

4-Chlorobenzyl alcohol

Synthetic route

4-Chlorobenzyl alcohol Specification

Related Products

Hot Products