4-Chlorocinnamic acid supplier

Name
4-Chlorocinnamic acid
EINECS 216-564-8
CAS No. 1615-02-7
Article Data246
CAS DataBase
Density 1.332 g/cm³
Solubility
Melting Point 248-250 °C(lit.)
Formula C₉H₇ClO₂
Boiling Point 325.3 °C at 760 mmHg
Molecular Weight 182.606
Flash Point 150.5 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 36-28A-26
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Cinnamicacid, p-chloro- (6CI,8CI);3-(4-Chlorophenyl)-2-propenoic acid;3-(4-Chlorophenyl)acrylic acid;3-(4-Chlorophenyl)propenoic acid;3-(p-Chlorophenyl)acrylic acid;NSC 1509;NSC 2756;p-Chlorocinnamic acid;p-chloro-cinnamic aci;2-Propenoicacid, 3-(4-chlorophenyl)-;
PSA 37.30000
LogP 2.43780

Synthetic route

: 141-82-2
malonic acid

: 104-88-1
4-chlorobenzaldehyde

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With piperidine; pyridine at 22℃; for 3h; ultrasound;	99%
With piperidine In pyridine for 5h; Reflux;	99%
With aluminum oxide; lithium chloride for 0.1h; Doebner condensation; microwave irradiation;	97%

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; water at 20℃; for 2h;	98%

: 24653-99-4, 31357-32-1
(2RS,3SR)-2,3-dibromo-3-(4-chlorophenyl)propanoic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With zinc In acetic acid for 0.0166667h; microwave irradiation;	97%

: 79-10-7
acrylic acid

: 4-(chloro)benzenediazonium benzo[d][1,3,2]dithiazol-2-ide-1,1,3,3-tetraoxide

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With calcium carbonate; palladium diacetate In tetrahydrofuran at 60℃; for 4.5h; Heck arylation;	96%

: 637-87-6
1-Chloro-4-iodobenzene

: 79-10-7
acrylic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium hydroxide; PS-PEG-NH-C(O)C6H4PPh2-PdCl(η3-C3H5) at 25℃; Heck reaction;	95%
With tributyl-amine; silica-supported bidentate arsine palladium(0) In para-xylene at 100℃; for 6h; Heck arylation;	95%
With tributyl-amine; Si-SH-Pd(0) In xylene at 100℃; for 6h;	94%

: 558-13-4
carbon tetrabromide

: 101671-01-6
1-nitro-2-(4-chlorophenyl)ethylene

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; water; diisopropylamine In acetonitrile at 20℃; for 10h; Inert atmosphere; Irradiation; stereoselective reaction;	94%

: 106-39-8
bromochlorobenzene

: 79-10-7
acrylic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 0.416667h; Heck Reaction;	91%
With tributyl-amine; silica-supported bidentate arsine palladium(0); triphenylphosphine In para-xylene at 140℃; for 12h; Heck arylation;	55%

: 141-82-2
malonic acid

: 46175-04-6
sodium (4-chlorophenyl)(hydroxy)methanesulfonate

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With piperazine In ethylene glycol for 0.108333h; Knoevenagel condensation; microwave irradiation;	90%

: 64-18-6
formic acid

: 2-iodo-1-(4-chlorophenyl)ethylene

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 100℃; for 20h; Inert atmosphere; Sealed tube;	89%

: 104-88-1
4-chlorobenzaldehyde

: 64-19-7
acetic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With pyridine; dmap; sodium tetraborate decahydrate; N-benzyl-N,N,N-triethylammonium chloride In 1-methyl-pyrrolidin-2-one at 185 - 190℃; for 8h;	86%
With pyridine; dmap; lithium chloride In 1-methyl-pyrrolidin-2-one at 185 - 190℃; for 10h;	83%

: 108-31-6
maleic anhydride

: 637-87-6
1-Chloro-4-iodobenzene

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 125℃; chemoselective reaction;	85%

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; water at 25℃; for 24h;	81%
With potassium hydroxide In ethanol at 20℃; for 2h;
With water; lithium hydroxide In methanol at 20℃; for 16h;
With sodium hydroxide In ethanol; water at 60℃;
With lithium hydroxide In tetrahydrofuran; ethanol; water at 20℃; for 4h;

: 124-38-9
carbon dioxide

: 154230-29-2
(E)-4-chlorostyrylboronic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 70℃; under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	80%

: 24583-70-8
(E)-3-(p-chlorophenyl)prop-2-en-1-ol

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium phosphate; carbon dioxide; CrH6Mo6O24(3-)3H3N3H(1+) In dimethyl sulfoxide at 80℃; under 750.075 Torr; for 24h; Green chemistry;	80%

: (E)-3-(4-Chloro-phenyl)-acrylic acid 4-nitro-benzyl ester

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With zinc In tetrahydrofuran for 2h; Ambient temperature;	77%

: 201230-82-2
carbon monoxide

: 66482-29-9, 66482-30-2, 125428-11-7
1-(2-bromovinyl)-4-chlorobenzene

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With [bmim]PF6; triethylamine; bis-triphenylphosphine-palladium(II) chloride In water at 100℃; under 15001.2 Torr; for 20h;	76%

: 108-31-6
maleic anhydride

: 106-39-8
bromochlorobenzene

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 130℃; chemoselective reaction;	74%

: 65946-59-0
(trimethylsilyl)ketene bis(trimethylsilyl) acetal

: 104-88-1
4-chlorobenzaldehyde

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With sodium fluoride In N,N-dimethyl-formamide for 5.5h;	73%

: 2019-34-3
3-(4-chlorophenyl)propanoic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
Stage #1: 3-(4-chlorophenyl)propanoic acid With Zn(2,2,6,6-tetramethylpiperidine)2*2LiCl In tetrahydrofuran at -40℃; for 1.5h; Inert atmosphere; Sealed tube; Stage #2: With bis(η3-allyl-μ-chloropalladium(II)); Allyl acetate In tetrahydrofuran at -40 - 60℃; for 3h; Inert atmosphere; Sealed tube; diastereoselective reaction;	66%

: 141-82-2
malonic acid

: 104-88-1
4-chlorobenzaldehyde

A: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

B: 3-amino-3-(4-chlorophenyl)propionic acid hydrochloride

Conditions

Conditions	Yield
Stage #1: malonic acid; 4-chlorobenzaldehyde With ammonium acetate In ethanol for 7h; Heating; Stage #2: With hydrogenchloride	A n/a B 65%

...Expand

: 1073-67-2
4-vinylbenzyl chloride

: 558-13-4
carbon tetrabromide

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With Eosin Y; dimethyl sulfoxide; cobalt(II) iodide at 50℃; for 15h; Inert atmosphere; UV-irradiation;	60%

: 30626-03-0
(3E)-4-(4-chlorophenyl)-3-buten-2-one

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With copper(l) iodide; hydroxylamine hydrochloride; oxygen In dimethyl sulfoxide at 100℃; for 12h;	51%

: 141-97-9
ethyl acetoacetate

: 104-88-1
4-chlorobenzaldehyde

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzaldehyde With hydrogenchloride; sodium azide; sodium nitrite In water at 0 - 20℃; for 2h; Stage #2: ethyl acetoacetate With triethylamine In N,N-dimethyl-formamide at 20℃; Stage #3: With palladium on activated charcoal; hydrogen In ethyl acetate at 20℃; for 2h;	51%

: 3095-95-2
diethylphosphonoacetic acid

: 104-88-1
4-chlorobenzaldehyde

A: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

B: 125951-04-4
(E)-diethyl (4-chlorostyryl)phosphonate

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Heating;	A 21% B 48%

...Expand

: 17449-02-4
p-chlorobenzylidenepropane-1,3-dioic acid

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 108-24-7
acetic anhydride

: 104-88-1
4-chlorobenzaldehyde

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With potassium acetate at 150 - 190℃;
With sodium acetate at 180 - 200℃;

: 104-88-1
4-chlorobenzaldehyde

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With sodium acetate; acetic anhydride
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C 2: water; lithium hydroxide / methanol / 16 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 60 °C 2: sodium hydroxide / ethanol; water / 60 °C View Scheme

: 106-47-8
4-chloro-aniline

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With hydrogenchloride Diazotization.Eintragen in ein Gemisch von Maleinsaeure (oder Acrylsaeure), Kupfer(II)-chlorid, Natriumacetat und Wasser;

: 51978-97-3
(E)-5-(4-chlorostyryl)-3-methyl-4-nitroisoxazole

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 6h; Heating;	67 % Turnov.

: 61556-61-4
-α-<<3-(4-chlorophenyl)-1-oxo-2-propenyl>oxy>benzenepropanoic acid

A: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

B: 20312-36-1
L-3-phenyllactic acid

Conditions

Conditions	Yield
carboxypeptidase A In water at 25℃; Rate constant; Equilibrium constant; pH 7.5, ionic strength 0.55;

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 35086-79-4, 95602-71-4
cinnamoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With thionyl chloride In N,N-dimethyl-formamide for 4h; Reflux;	100%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide Reflux; Inert atmosphere;	100%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: C9H7(2)H2ClO2

Conditions

Conditions	Yield
With aluminum oxide; rhodium(III) chloride; potassium deuteroformate for 0.05h; microwave irradiation;	100%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 100-46-9
benzylamine

: (E)-N-benzyl-3-(4-chlorophenyl)acrylamide

Conditions

Conditions	Yield
With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine In tetrahydrofuran; dichloromethane at 60℃; for 6h; Inert atmosphere;	99%

: 186581-53-3, 908094-01-9
diazomethane

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

Conditions

Conditions	Yield
In methanol; diethyl ether at 20℃; for 0.25h; Inert atmosphere;	98%
In diethyl ether

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 15687-27-1
ibuprofen

: 683-18-1
dibutyltin chloride

: (E,Z)-dibutyl((2-(4-isobutylphenyl)propanoyl)oxy)stannyl 3-(4-chlorophenyl)acrylate

Conditions

Conditions	Yield
With triethylamine In toluene at 80 - 110℃; for 18h;	98%

...Expand

: 64-17-5
ethanol

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 24h; Fischer esterification; Heating;	97%
With sulfuric acid for 30h; Reflux;	70%
With sulfuric acid for 5h; Heating;	64%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 31357-32-1, 24653-99-4
α,β-dibromo-p-chlorohydrocinnamic acid

Conditions

Conditions	Yield
With bromine In acetic acid at 0 - 20℃; for 3.5h;	97%
With bromine In tetrachloromethane	94%
With bromine In various solvent(s) at 95℃; for 2h;	77%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 101671-01-6
1-nitro-2-(4-chlorophenyl)ethylene

Conditions

Conditions	Yield
With chloro-trimethyl-silane; copper(II) nitrate trihydrate In acetonitrile at 100℃; for 2h; stereoselective reaction;	97%
With ferric nitrate for 1h; Milling;	86%
With quinoline; dipotassium peroxodisulfate; tert.-butylnitrite In acetonitrile at 85℃; for 5h;	85%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

Conditions

Conditions	Yield
With sulfuric acid In ethanol; benzene	97%

oxone: oxone

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5
disodium ethylenediaminetetraacetic acid

: 56010-48-1, 114380-31-3
trans-β-(p-Chlorophenyl)glycidic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydrogencarbonate In water; ethyl acetate; acetone	97%

...Expand

: 67-56-1
methanol

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Reflux;	96%
Dowex H+ resin Heating;	95%
With Dowex-WX4 In various solvent(s) Heating;	95%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 74710-09-1
o-phenylenediamine sulphate

: 206982-69-6
(E)-2-(4-chlorostyryl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
In ethylene glycol for 3h; Heating;	96%

: 288-13-1
NH-pyrazole

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: (E)-3-(4-chlorophenyl)-1-(1H-pyrazol-1-yl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: NH-pyrazole With thionyl chloride In dichloromethane at 0 - 25℃; for 1h; Stage #2: 3-(4-chlorophenyl)prop-2-enoic acid In dichloromethane for 3h;	96%
Stage #1: NH-pyrazole With thionyl chloride In dichloromethane at 0 - 20℃; for 1h; Stage #2: 3-(4-chlorophenyl)prop-2-enoic acid In dichloromethane for 3h;	96%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 771557-40-5
(E)-3-(4-chlorophenyl)-N-methoxy-N-methylacrylamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	96%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

Conditions

Conditions	Yield
With sulfuric acid In methanol	95%
With hydrogenchloride; methanol
Multi-step reaction with 2 steps 1: SOCl2 2: methanol View Scheme
With sulfuric acid In methanol
Multi-step reaction with 2 steps 1: thionyl chloride / 1 h / 20 °C 2: dichloromethane / 0.5 h / 20 °C View Scheme

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 24653-99-4, 31357-32-1
(2RS,3SR)-2,3-dibromo-3-(4-chlorophenyl)propanoic acid

Conditions

Conditions	Yield
With copper(II) nitrate trihydrate; trimethylsilyl bromide In acetonitrile at 50℃; for 2h;	95%
With selenium(IV) oxide; hydrogen bromide In diethyl ether Ambient temperature;	35%
With chloroform; bromine at 20℃;

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 83421-78-7
(E)-3-(4-Chloro-phenyl)-acryloyl azide

Conditions

Conditions	Yield
With sodium azide; N,N-dimethyl-formamide; trichlorophosphate at 10 - 15℃; for 3h;	95%
With diphenyl phosphoryl azide; triethylamine In toluene at 20℃; Inert atmosphere;	80%
With thionyl chloride; sodium azide 1) 1 h, reflux, 2) 1 h, acetone, water; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: triethylamine / acetone / 1 h / 0 °C 2: sodium azide / acetone; H2O / 16 h / 20 °C View Scheme
With diphenyl phosphoryl azide; triethylamine In toluene at 20℃; for 3h; Cooling with ice;

: 1185654-13-0
(3S,5S)-3-(2-tert-butoxycarbonylaminoethyl)-5-(aminomethyl)-1-(2-ethylbutyl)-1,4-diazepan-2-one

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 1185652-50-9
(E)-N-(((3S,5S)-3-(2-aminoethyl)-1-(2-ethylbutyl)-2-oxo-1,4-diazepan-5-yl)methyl)-3-(4-chlorophenyl)acrylamide

Conditions

Conditions	Yield
Stage #1: (3S,5S)-3-(2-tert-butoxycarbonylaminoethyl)-5-(aminomethyl)-1-(2-ethylbutyl)-1,4-diazepan-2-one; 3-(4-chlorophenyl)prop-2-enoic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;	95%
Stage #1: (3S,5S)-3-(2-tert-butoxycarbonylaminoethyl)-5-(aminomethyl)-1-(2-ethylbutyl)-1,4-diazepan-2-one; 3-(4-chlorophenyl)prop-2-enoic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;	95%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 100-66-3
methoxybenzene

: 6552-68-7, 30925-57-6, 41564-68-5
4'-methoxy-4-chlorochalcone

Conditions

Conditions	Yield
With phosphoric acid; trifluoroacetic acid at 20℃; for 3h;	95%

: 106-44-5
p-cresol

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 4-(4-chlorophenyl)-6-methylchroman-2-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 125℃; for 3h;	94%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 73789-56-7
N-isocyaniminotriphenylphosphorane

: 431-03-8
dimethylglyoxal

: 1443438-81-0
3-{5-[(E)-2-(4-chlorophenyl)-1-ethenyl]-1,3,4-oxadiazol-2-yl}-3-hydroxy-2-butanone

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.333333h; Aza-Wittig Reaction; Sonication;	94%
In water at 20 - 26℃; for 12h; Green chemistry;	90%
In dichloromethane at 20℃; for 12h; Aza-Wittig Reaction; Neutral conditions;	88%

...Expand

: 68820-12-2
cyclohexyl-N-tosyl aziridine

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 2-((4-Methylphenyl)sulfonamido)cyclohexyl (E)-3-(4-chlorophenyl)acrylate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; Green chemistry;	94%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 106-96-7
propargyl bromide

: prop-2-yn-1-yl (E)-3-(4-chlorophenyl)acrylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; toluene at 20℃; for 48h; Inert atmosphere;	94%

: 1615-02-7
3-(4-chlorophenyl)prop-2-enoic acid

: 40217-17-2, 90719-32-7, 120574-96-1, 102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1000415-73-5
(4R)-4-benzyl-3-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-1,3-oxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: 3-(4-chlorophenyl)prop-2-enoic acid; (R)-4-(phenylmethyl)-2-oxazolidinone With pivaloyl chloride; triethylamine In tetrahydrofuran at -20℃; for 2h; Stage #2: With lithium chloride In tetrahydrofuran at -20℃; for 16h; Further stages.;	93%

4-Chlorocinnamic acid Specification

1. Introduction of 4-Chlorocinnamic acid
4-Chlorocinnamic acid , its cas register number is 1615-02-7. It also can be called p-Chlorocinnamic acid; 3-(p-Chlorophenyl)acrylic acid; trans-3-(4-Chlorophenyl)propenoic acid; and 3-(4-Chlorophenyl)-2-propenoic acid. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.
In addition, 4-Chlorocinnamic acid could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Hydrogen chloride, carbon monoxide, carbon dioxide.

2. Properties of 4-Chlorocinnamic acid
Melting point: 248-250 °C(lit.)
Index of Refraction: 1.627
Molar Refractivity: 48.6 cm³
Molar Volume: 136.9 cm³
Surface Tension: 52 dyne/cm
Density: 1.332 g/cm³
Flash Point: 150.5 °C
Enthalpy of Vaporization: 59.9 kJ/mol
Boiling Point: 325.3 °C at 760 mmHg
Vapour Pressure: 9.47E-05 mmHg at 25 °C
Appearance: White to light yellow crystal powder

3. Structure Descriptors of 4-Chlorocinnamic acid
InChI
InChI=1/C9H7ClO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12)/b6-3+
Smiles
c1(ccc(Cl)cc1)\C=C\C(O)=O
Product Categories: Benzene series;Cinnamic acid;Aromatics Compounds;Acids & Esters;Chlorine Compounds

4. Toxicity of 4-Chlorocinnamic acid
4-Chlorocinnamic acid hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD	intraperitoneal	> 350mg/kg (350mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: REGIDITY	Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987.
mouse	LD50	oral	1622mg/kg (1622mg/kg)		Pharmazie. Vol. 23, Pg. 714, 1968.

5. Safety Information of 4-Chlorocinnamic acid

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36-28A-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS GD8490000
Hazard Note Irritant

6. Preparation of 4-Chlorocinnamic acid
4-Chlorocinnamic acid can be derived by the reaction of right-Chlorobenzaldehyde with Acetic anhydride . Taking Chlorobenzaldehyde , Acetic anhydride and Sodium acetate together at 180 ° C for the reaction 13h.

7. Use of 4-Chlorocinnamic acid
4-Chlorocinnamic acid is used as organic synthesis intermediate for the synthesis of aromatic acid, production of herbicide Mr enemy scattered.

Product Name

4-Chlorocinnamic acid

Synthetic route

4-Chlorocinnamic acid Specification

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