Product Name

  • Name

    4-Chloropyridine-2-carboxylic acid

  • EINECS -0
  • CAS No. 5470-22-4
  • Article Data32
  • CAS DataBase
  • Density 1.47 g/cm3
  • Solubility
  • Melting Point 181 °C
  • Formula C6H4ClNO2
  • Boiling Point 308 °C at 760 mmHg
  • Molecular Weight 157.556
  • Flash Point 140.1 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 5470-22-4 (4-Chloropyridine-2-carboxylic acid)
  • Hazard Symbols IrritantXi
  • Synonyms Picolinicacid, 4-chloro- (6CI,7CI,8CI);4-Chloro-2-carboxypyridine;4-Chloropicolinicacid;NSC 26285;4-Chloropicolinic acid;
  • PSA 50.19000
  • LogP 1.43320

Synthetic route

4-Chloro-pyridine-2-carboxylic acid methyl ester
24484-93-3

4-Chloro-pyridine-2-carboxylic acid methyl ester

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 1h;87%
Stage #1: 4-Chloro-pyridine-2-carboxylic acid methyl ester With methanol; sodium hydroxide; water at 20℃; for 0.25h;
Stage #2: With hydrogenchloride; water pH=2;
Stage #1: 4-Chloro-pyridine-2-carboxylic acid methyl ester With methanol; sodium hydroxide; water at 0 - 20℃; for 0.25h;
Stage #2: With hydrogenchloride; water pH=2;
4-chloro-pyridine-2-carbonitrile
19235-89-3

4-chloro-pyridine-2-carbonitrile

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With sodium carbonate; sodium sulfite In ice-water; sulfuric acid; water54.9%
2-Picolinic acid
98-98-6

2-Picolinic acid

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
Stage #1: 2-Picolinic acid With thionyl chloride; sodium bromide for 20h; Heating / reflux;
Stage #2: With water at -2 - 2℃;
28%
Multi-step reaction with 2 steps
1: 1) SOCl2, DMF / 1) 40-45 deg C, 45 min; 45->72 deg C, 2 h; 72 deg C, 21 h, 2) toluene, room temperature, 1 h
2: 1) 57percent HI, aq. hypophosphorous acid, 2) aq. NaOH / 1) 107 deg C, 6 h, 2) 95 deg C, 30 min; room temperature, 1 h
View Scheme
With thionyl chloride In N,N-dimethyl-formamide at 95℃; for 12h;
4-chIoro-2-methylpyridine
3678-63-5

4-chIoro-2-methylpyridine

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With potassium permanganate
4-chloro-pyridine-2-carbonyl chloride
53750-66-6

4-chloro-pyridine-2-carbonyl chloride

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With water
With water
4,4'-dichloro-2,2'-bipyridine
1762-41-0

4,4'-dichloro-2,2'-bipyridine

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With potassium permanganate; sulfuric acid; water
2-picolinic acid hydrochloride
636-80-6

2-picolinic acid hydrochloride

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With thionyl chloride; sulfur dioxide Behandeln des Reaktionsprodukts mit H2O;
With thionyl chloride In water at 0℃; Reflux;
methyl 4-chloropyridine-2-carboxylate hydrochloride

methyl 4-chloropyridine-2-carboxylate hydrochloride

A

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

B

4-iodopicolinic acid hemi-hydroiodide

4-iodopicolinic acid hemi-hydroiodide

Conditions
ConditionsYield
With sodium hydroxide; hydrogen iodide; hypophosphorous acid 1) 107 deg C, 6 h, 2) 95 deg C, 30 min; room temperature, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
2-Picolinic acid
98-98-6

2-Picolinic acid

thionyl chloride
7719-09-7

thionyl chloride

A

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

B

4,6-dichloro-2-pyridinecarboxylic acid
88912-25-8

4,6-dichloro-2-pyridinecarboxylic acid

C

4,5,6-trichloropicolinic acid
496849-77-5

4,5,6-trichloropicolinic acid

Conditions
ConditionsYield
Irradiation;
2-Picolinic acid
98-98-6

2-Picolinic acid

A

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

B

4-chloro-6-oxy-picolinic acid

4-chloro-6-oxy-picolinic acid

Conditions
ConditionsYield
With phosphorus pentachloride at 250 - 270℃; im Rohr; Behandeln des Reaktionsprodukts mit Schwefelsaeure;
4-chloro-aniline
106-47-8

4-chloro-aniline

A

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

B

4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

C

bis-(4-chloro-phenyl)-diazene
1602-00-2

bis-(4-chloro-phenyl)-diazene

D

n,n'-dichloroazobenzene

n,n'-dichloroazobenzene

Conditions
ConditionsYield
With phosphate buffer; ozone In water for 0.416667h; pH=8; Formation of xenobiotics; Title compound not separated from byproducts;
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aqueous H2O2; acetic acid
2: fuming H2SO4; aqueous HNO3
3: PCl3 / 60 °C
4: H2O; KMnO4; H2SO4
View Scheme
[2,2']bipyridinyl 1,1'-dioxide
7275-43-6

[2,2']bipyridinyl 1,1'-dioxide

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: fuming H2SO4; aqueous HNO3
2: PCl3 / 60 °C
3: H2O; KMnO4; H2SO4
View Scheme
4,4'-dinitro-2,2'-bipyridyl-N,N'-dioxide
51595-55-2

4,4'-dinitro-2,2'-bipyridyl-N,N'-dioxide

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: PCl3 / 60 °C
2: H2O; KMnO4; H2SO4
View Scheme
4-chloro-2-pyridinecarbaldehyde
63071-13-6

4-chloro-2-pyridinecarbaldehyde

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With potassium permanganate In water; acetonitrile
4-hydroxypyridine-2-carboxylic acid
22468-26-4

4-hydroxypyridine-2-carboxylic acid

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide at 120℃; for 6h;
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

dimethyl amine
124-40-3

dimethyl amine

3-(dimethylamino)picolinic acid

3-(dimethylamino)picolinic acid

Conditions
ConditionsYield
In water at 150℃; for 2h; Sealed tube;99%
In water at 100℃; for 5h; Sealed tube;95%
In water for 2h; Sealed tube; Heating;90%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4-chloropicolinamide
99586-65-9

4-chloropicolinamide

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid In thionyl chloride at 80℃; for 2h;
Stage #2: With ammonia In methanol; thionyl chloride at 0 - 20℃; for 3.25h;
96%
Stage #1: 4-chloropicolinic acid With thionyl chloride at 80℃; for 2h;
Stage #2: With ammonia In methanol at 0 - 20℃; for 3.25h;
96%
Stage #1: 4-chloropicolinic acid With thionyl chloride In toluene at 80℃; for 6h;
Stage #2: With ammonium hydroxide In toluene at 20℃; for 1h; Cooling with ice;
94%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

4-Chloro-pyridine-2-carboxylic acid methyl ester
24484-93-3

4-Chloro-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid; diazomethyl-trimethyl-silane With methanol In tetrahydrofuran at 0 - 20℃;
Stage #2: With acetic acid In tetrahydrofuran; methanol; water
96%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

4-chloropyridine-2-carboxylic acid N-methoxy-N-methylamide
757251-62-0

4-chloropyridine-2-carboxylic acid N-methoxy-N-methylamide

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 4-chloropicolinic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;
96%
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;46%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 4-chloropyridin-2-ylcarbamate
1073372-14-1

benzyl 4-chloropyridin-2-ylcarbamate

Conditions
ConditionsYield
With trimethylsilylazide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In tetrahydrofuran Curtius rearrangement; Reflux;94%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

ethanol
64-17-5

ethanol

Ethyl 4-ethoxypicolinate
71777-70-3

Ethyl 4-ethoxypicolinate

Conditions
ConditionsYield
sulfuric acid for 48h; Heating / reflux;93%
Stage #1: 4-chloropicolinic acid; ethanol With sulfuric acid for 48h; Reflux;
Stage #2: With sodium hydroxide In ethanol pH=8 - 9;
93%
With sulfuric acid at 85℃; for 16h;69%
methanol
67-56-1

methanol

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4-Chloro-pyridine-2-carboxylic acid methyl ester
24484-93-3

4-Chloro-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃;
Stage #2: methanol at 20℃; for 0.5h;
92%
Stage #1: 4-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1.5h;
Stage #2: methanol at 20℃; for 0.5h;
90%
Stage #1: 4-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: methanol at 20℃; for 16h;
74%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4-Amino-1-cyclohexyl-3-methyl-1H-pyrazole-5-carboxamide
553671-80-0

4-Amino-1-cyclohexyl-3-methyl-1H-pyrazole-5-carboxamide

N-[5-(aminocarbonyl)-1-cyclohexyl-3-methyl-1H-pyrazol-4-yl]-4-chloro-2-pyridinecarboxamide
553671-89-9

N-[5-(aminocarbonyl)-1-cyclohexyl-3-methyl-1H-pyrazol-4-yl]-4-chloro-2-pyridinecarboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 3h;91%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4,5-difluoroindoline hydrochloride
1158918-84-3

4,5-difluoroindoline hydrochloride

(4-chloro-pyridin-2-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone
1159010-09-9

(4-chloro-pyridin-2-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃;91%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

methyl-d3-amine hydrochloride
7436-22-8

methyl-d3-amine hydrochloride

4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide)
1189858-48-7

4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 16h;91%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

ethanol
64-17-5

ethanol

ethyl 4-chloropyridine-2-carboxylate
64064-56-8

ethyl 4-chloropyridine-2-carboxylate

Conditions
ConditionsYield
With sulfuric acid90%
Stage #1: 4-chloropicolinic acid With thionyl chloride at 100℃; for 6h;
Stage #2: ethanol at 20℃; for 20h;
89%
Stage #1: 4-chloropicolinic acid With thionyl chloride at 100℃; for 6h;
Stage #2: ethanol at 0 - 20℃; for 8h;
85%
Stage #1: 4-chloropicolinic acid With thionyl chloride at 100℃; for 6h; Inert atmosphere;
Stage #2: ethanol at 20℃; for 25.5h; Cooling with ice;
Stage #3: With sodium hydrogencarbonate In water
83.6%
With sulfuric acid for 2h; Inert atmosphere; Reflux;55.7%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

(S)-tert-leucinol
112245-13-3

(S)-tert-leucinol

C12H17ClN2O2
1257527-15-3

C12H17ClN2O2

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: (S)-tert-leucinol With 4-methyl-morpholine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;
90%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl 4-chloropicolinate
874786-49-9

isopropyl 4-chloropicolinate

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1.5h;
Stage #2: isopropyl alcohol In dichloromethane
Stage #3: With sodium hydrogencarbonate In dichloromethane
87%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

zinc(II) acetate tetrahydrate

zinc(II) acetate tetrahydrate

zinc 4-chloropicolinate

zinc 4-chloropicolinate

Conditions
ConditionsYield
In water86.4%
1,4-dioxane
123-91-1

1,4-dioxane

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4–chloro–2–(2–(2–chloroethoxy)ethoxy)pyridine

4–chloro–2–(2–(2–chloroethoxy)ethoxy)pyridine

Conditions
ConditionsYield
With tert-butylhypochlorite; chloranil at 110℃; for 12h; Inert atmosphere;86%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

5-fluoroindoline
2343-22-8

5-fluoroindoline

(4-chloropyridin-2-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
1159009-70-7

(4-chloropyridin-2-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃;85%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4-(3,5-dichlorophenoxy)-2-(piperazin-1-yl)pyrimidine

4-(3,5-dichlorophenoxy)-2-(piperazin-1-yl)pyrimidine

(4-chloropyridin-2-yl)(4-(4-(3,5-dichlorophenoxy)pyrimidin-2-yl)piperazin-1-yl)methanone

(4-chloropyridin-2-yl)(4-(4-(3,5-dichlorophenoxy)pyrimidin-2-yl)piperazin-1-yl)methanone

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 10h;85%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

3-Trifluoromethylphenol
98-17-9

3-Trifluoromethylphenol

4-(3-(trifluoromethyl)phenoxy)-2-pyridinecarboxylic acid

4-(3-(trifluoromethyl)phenoxy)-2-pyridinecarboxylic acid

Conditions
ConditionsYield
With sodium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 140℃; for 8h;84.5%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

aniline
62-53-3

aniline

4-chloro-N-phenylpyridine-2-carboxamide
133928-61-7

4-chloro-N-phenylpyridine-2-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;84%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 4h;69%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

(4-chloro-2-pyridyl)-(4-methylpiperazin-1-yl)methanone

(4-chloro-2-pyridyl)-(4-methylpiperazin-1-yl)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;83%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate

cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate

allyl alcohol
107-18-6

allyl alcohol

[RuCp(η3-C3H5)(4-Cl-PA)]PF6, PA=picolinic acid

[RuCp(η3-C3H5)(4-Cl-PA)]PF6, PA=picolinic acid

Conditions
ConditionsYield
In acetone at 20℃; Inert atmosphere; Schlenk technique;82%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

1-amino-naphthalene
134-32-7

1-amino-naphthalene

4-chloro-N-(naphth-1-yl)pyridine-2-amide

4-chloro-N-(naphth-1-yl)pyridine-2-amide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Inert atmosphere; Sealed tube;81%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

2-(4-aminophenyl)benzothiazole
6278-73-5

2-(4-aminophenyl)benzothiazole

(4-benzothiazol-2-yl-phenyl)-pyridin-4-yl-amine

(4-benzothiazol-2-yl-phenyl)-pyridin-4-yl-amine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 160℃; for 3h;80%
In N,N-dimethyl-formamide at 160℃; for 3h;8%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

diethylamine
109-89-7

diethylamine

4-chloro-N,N-diethylpicolinamide
851903-41-8

4-chloro-N,N-diethylpicolinamide

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 0.883333h; Inert atmosphere; Glovebox;
Stage #2: diethylamine In N,N-dimethyl-formamide at 50℃; for 12h; Inert atmosphere; Schlenk technique;
80%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

C17H28N4O4S*C2HF3O2

C17H28N4O4S*C2HF3O2

C23H30ClN5O5S

C23H30ClN5O5S

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Cooling with ice;
Stage #2: C17H28N4O4S*C2HF3O2 With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Cooling with ice;
80%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

sodium cyclopropylsulfinate
910209-21-1

sodium cyclopropylsulfinate

4-(cyclopropylsulfonyl)picolinic acid
1354558-38-5

4-(cyclopropylsulfonyl)picolinic acid

Conditions
ConditionsYield
With quinoline; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 140℃; for 0.166667h; Microwave irradiation;75%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

benzene
71-43-2

benzene

4-chloro-2-phenyl-pyridine
57311-18-9

4-chloro-2-phenyl-pyridine

Conditions
ConditionsYield
With tert-butylhypochlorite; potassium carbonate at 40℃; for 15h; Schlenk technique;75%
With tert-butylhypochlorite; potassium carbonate at 60℃; for 20h;75%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

C14H12N4O

C14H12N4O

N-(3-((1H-indazol-5-yl)carbamoyl)phenyl)-4-chloropicolinamide

N-(3-((1H-indazol-5-yl)carbamoyl)phenyl)-4-chloropicolinamide

Conditions
ConditionsYield
Stage #1: 4-chloropicolinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: C14H12N4O With dmap In N,N-dimethyl-formamide at 20℃; for 18h;
74.5%
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4-Chloro-pyridine-2-carboxylic acid methyl ester
24484-93-3

4-Chloro-pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With oxalyl dichloride In methanol; dichloromethane at 0 - 20℃; for 18h;74%

4-Chloropyridine-2-carboxylic acid Specification

The 4-Chloropyridine-2-carboxylic acid, with the cas register number 5470-22-4, is also known to us as iflab-bb f1926-0017; 4-chloropicolinic acid; 4-chloropyridine-2-carboxylic acid; 4-chloro-2-pyridinecarboxylic acid; chloropicolinicacid; 4-chloropyridine-2-carboxylic; 4-chloropicolinic acid 99%; 4-chloropicolinic acid ,98%.

The physical properties of this chemical are as followings: (1)ACD/LogP: 0.76; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1 ; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 3 ; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 1; (9)Polar Surface Area: 39.19 ; (10)Index of Refraction: 1.59; (11)Molar Refractivity: 36.16 cm3; (12)Molar Volume: 107.1 cm3; (13)Polarizability: 14.33× 10-24 cm3; (14)Surface Tension: 61 dyne/cm; (15)Density: 1.47 g/cm3; (16)Flash Point: 140.1 °C; (17)Enthalpy of Vaporization: 57.93 kJ/mol; (18)Boiling Point: 308 °C at 760 mmHg; (19)Vapour Pressure: 0.000303 mmHg at 25°C.

Being a kind of irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes. So while dealing with this chemical, you'd better take the following instrction. Wear suitable protective clothing, gloves and eye/face protection, and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. When store it, it should be kept in cool storeroom.

This kind of chemical is usually applied in BPC(bulk pharmaceutical chemicals). As to its product categories, there are various, including blocks; carboxes; pyridines; pyridine series; acids and derivatives; heterocycles; pharmacetical; carboxylic acids; pyridine; chloropyridines; halopyridines; carboxylic acids; While its raw materials are hydrochloric acid, acetic acid glacial, nitric acid, sodium carbonate, hydrogen peroxide, potassium permanganate, sulfuric acid, 2-picoline, 2-methyl-4-nitropyridine.

In addition, you could obtain the molecular structure by converting the following datas:
SMILES:Clc1ccnc(C(=O)O)c1
InChI:InChI=1/C6H4ClNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)
InChIKey:NNMYRMGMVLMQAY-UHFFFAOYAQ

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