4-ETHYLANILINE supplier | CasNO.589-16-2

Name
4-Ethylaniline
EINECS 209-637-0
CAS No. 589-16-2
Article Data202
CAS DataBase
Density 0.975
Solubility Immiscible with water
Melting Point -5 ºC
Formula C8H11 N
Boiling Point 217.5 °C at 760 mmHg
Molecular Weight 121.182
Flash Point 85 ºC
Transport Information
Appearance red-brown liquid
Safety 36/37/39-45-36/37-28A
Risk Codes R23/24/25;R33
Molecular Structure
Hazard Symbols
Synonyms Aniline,p-ethyl- (8CI); 4-Aminoethylbenzene; 4-Ethylaniline; 4-Ethylbenzenamine;4-Ethylphenylamine; NSC 62015; p-Ethylaminobenzene; p-Ethylaniline
PSA 26.02000
LogP 2.41240

Synthetic route

: 100-13-0
4-nitrostyrene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With potassium fluoride; polymethylhydrosiloxane; palladium diacetate In tetrahydrofuran at 20℃; for 0.5h;	100%
With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 4h;	99%
With 5% Pd/C; hydrogen In ethanol at 20℃; for 0.333333h; chemoselective reaction;	98%

: 371153-68-3
4-benzyloxycarbonylaminophenylacetylene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen In methanol at 20℃; for 3.5h;	100%
With hydrogen In methanol at 40℃; under 760.051 Torr; for 24h; Reagent/catalyst; chemoselective reaction;	100%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 24h;	98%
With hydrogen In methanol at 40℃; for 24h; chemoselective reaction;	89%
With palladium 10% on activated carbon; hydrogen at 20℃; for 24h; Neat (no solvent);	84%

: 14235-81-5
4-Ethynylaniline

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 75℃; under 750.075 Torr; Reagent/catalyst; Pressure; Flow reactor;	100%
With hydrogen In methanol at 20℃; for 5h; chemoselective reaction;	94%
With [Fe(nacnac)dippCH2SiMe3]; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In benzene-d6 at 20℃; for 0.5h; Sealed tube; Inert atmosphere; Schlenk technique; Glovebox;	50%

: 371153-68-3
4-benzyloxycarbonylaminophenylacetylene

A: 93008-63-0
N-(benzyloxycarbonyl)-4-ethylaniline

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 24h; chemoselective reaction;	A 100% B n/a
With palladium 10% on activated carbon; hydrogen In methanol at 25℃; under 750.075 Torr; Flow reactor;
With hydrogen In methanol at 20℃; under 760.051 Torr; for 24h; Reagent/catalyst; chemoselective reaction;

: 100-12-9
4-ethylnitrobenzene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrazine hydrate In ethanol at 20℃; for 12h; Schlenk technique;	99%
With borane-ammonia complex In methanol; water at 49.84℃; for 0.1h; Catalytic behavior;	99%
With hydrogen In ethanol at 90℃; under 7500.75 Torr; for 2h; Autoclave;	99%

: 100-19-6
(4-nitrophenyl)ethanone

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; water; hydrazine hydrate In ethanol at 100℃; for 24h; Reagent/catalyst;	99%
With triethylsilane; palladium dichloride In ethanol for 1h; Inert atmosphere; Reflux;	94%
Stage #1: (4-nitrophenyl)ethanone With hydrazine hydrate at 135℃; for 3h; Stage #2: With potassium hydroxide at 135℃; for 24h;	76%
With palladium on carbon; hydrogen In ethanol at 25℃; under 5171.62 Torr; Reagent/catalyst; Sealed tube;	99 %Chromat.
With chlorobenzene In methanol at 40℃; for 16h; Sealed tube; Green chemistry; chemoselective reaction;	91 %Spectr.

: 128654-33-1
1-azido-4-ethylbenzene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen In methanol at 25℃; for 3h; Reagent/catalyst; chemoselective reaction;	99%
With hydrogen In methanol at 25℃; for 6h; Reagent/catalyst; chemoselective reaction;	97%

: 937-31-5
(4-Nitrophenyl)acetylene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 7h;	98%
With sodium tetrahydroborate; copper In tetrahydrofuran; water at 50℃; for 2h;	90%
With platinum(IV) oxide; hydrogen In ethanol for 2h;	46%
With hydrogen In toluene at 20℃; under 7757.43 Torr; for 6h; Catalytic behavior;
With PdCd0.53; hydrogen In N,N-dimethyl-formamide at 60℃; under 750.075 Torr; Catalytic behavior; Reagent/catalyst; Sealed tube;

: 1520-21-4
4-vinyl benzylamine

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With iron(III) chloride; lithium aluminium tetrahydride; hydrogen In tetrahydrofuran at 18℃; under 7500.75 Torr; for 20h; Inert atmosphere; Sealed tube;	97%
With oxygen; hydrazine hydrate In propan-1-ol at 100℃; under 15001.5 Torr;	95%
With oxygen; hydrazine hydrate In propan-1-ol at 100℃; under 15001.5 Torr; for 0.166667h; Flow reactor;	95%

: 14235-81-5
4-Ethynylaniline

A: 1520-21-4
4-vinyl benzylamine

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen In hexane; toluene at 30℃; under 760.051 Torr; for 8h;	A 95% B 5%
With hydrogen In 1,4-dioxane at 20℃; for 24h; chemoselective reaction;
With hydrogen In 1,4-dioxane at 85℃; under 4500.45 Torr; for 14h; chemoselective reaction;	A 24 %Chromat. B n/a
With carbon monoxide; hydrogen In tetrahydrofuran at 70℃; under 7757.43 Torr; for 6h; Autoclave;

: 100-19-6
(4-nitrophenyl)ethanone

A: 99-92-3
4-Aminoacetophenone

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen In glycerol at 100℃; for 2h;	A 95% B n/a
With methanesulfonic acid; palladium, 5% on calcium carbonate, poisoned with lead; hydrogen In ethanol at 30℃; under 2585.81 Torr; for 22h; Reagent/catalyst; Sealed tube;	A 66 %Chromat. B 26 %Chromat.

: 99-92-3
4-Aminoacetophenone

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With sodium tetrahydroborate; aluminium trichloride In tetrahydrofuran for 2h; Heating;	94%
With sodium hypophosphite monohydrate; 5%-palladium/activated carbon; hypophosphorous acid In water at 20℃; Temperature; Sonication;	86%
With hydrogenchloride; amalgamated zinc

: 93453-80-6, 14572-89-5
1-(4-aminophenyl)ethanol

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
Stage #1: 1-(4-aminophenyl)ethanol With ammonium formate In ethanol; water at 22℃; for 0.166667h; Stage #2: With formic acid In ethanol; water at 22℃; for 1h; chemoselective reaction;	93%
With indium; ammonium chloride In ethanol Heating;	31%
With formic acid; 5%-palladium/activated carbon; ammonium formate In methanol; water at 80℃;	96 %Spectr.

: 100-13-0
4-nitrostyrene

A: 1520-21-4
4-vinyl benzylamine

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With borane-ammonia complex In ethanol at 20℃; for 0.25h; Reagent/catalyst; Schlenk technique;	A 91.53% B 8.47%
With borane-ammonia complex In methanol at 24.84℃; for 2h; Schlenk technique; Inert atmosphere; Irradiation;	A 71% B 29%
With hydrogenchloride; iron In water for 3h; Reflux; Overall yield = 0.25 g;

: 61653-33-6
bis-(4-ethyl-phenyl)-diazene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With perchloric acid In isopropyl alcohol; acetonitrile at 25℃; for 0.7h; pH=2; Inert atmosphere; Irradiation;	90%

: 1220120-57-9
tert-butyl N-(4-ethylphenyl)carbamate

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; pyrographite; palladium dichloride In 1,2-dimethoxyethane at 25 - 40℃; for 6h;	90%

: 227778-64-5
N-benzyloxycarbonyl-4-aminostyrene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; ethylenediamine In tetrahydrofuran at 20℃; under 760 Torr; for 16h; Hydrogenation;	89%

: 20062-24-2
4-azidoacetophenone

A: 93453-80-6, 14572-89-5
1-(4-aminophenyl)ethanol

B: 99-92-3
4-Aminoacetophenone

C: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 25℃; under 760.051 Torr; for 1.5h;	A 5% B 89% C 6%

...Expand

: 109-92-2
ethyl vinyl ether

: 62-53-3
aniline

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With zinc(II) chloride In 1,4-dioxane at 100℃; for 12h; Schlenk technique;	87%

: 103-69-5
N-ethyl-N-phenylamine

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With aluminum oxide; aluminium trichloride for 0.05h; microwave irradiation;	86%
With cobalt(II) bromide at 230℃; unter vermindertem Druck;
With cobalt(II) chloride at 200 - 270℃;

: 937-31-5
(4-Nitrophenyl)acetylene

A: 100-12-9
4-ethylnitrobenzene

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
Stage #1: (4-Nitrophenyl)acetylene With tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,4-dioxane at 20℃; for 0.25h; Inert atmosphere; Stage #2: With formic acid In 1,4-dioxane at 80℃; Inert atmosphere; chemoselective reaction;	A 85% B 7%

: 74-84-0
ethane

: 62-53-3
aniline

A: 578-54-1
ortho-ethylaniline

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
In gaseous matrix at 80℃; Irradiation;	A 82% B 18 % Spectr.
In gaseous matrix at 80℃; Irradiation;	A 82 % Spectr. B n/a

...Expand

: 97-94-9
triethyl borane

: 106-40-1
4-bromo-aniline

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In tetrahydrofuran Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;	82%

: 1585-07-5
1-bromo-4-ethylbenzene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With oxalic acid hydrazide; ammonium hydroxide; tetrabutylammomium bromide; potassium carbonate; 2,5-hexanedione; copper(II) oxide In water at 90℃; for 1.33333h;	78%

: 100-13-0
4-nitrostyrene

A: 100-12-9
4-ethylnitrobenzene

B: 1520-21-4
4-vinyl benzylamine

C: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With borane-ammonia complex In ethanol at 20℃; for 0.25h; Reagent/catalyst; Schlenk technique;	A 10.86% B 76.84% C 12.25%
With 4-methylcyclohexene In methanol at 69.84℃; for 1h; Inert atmosphere;
With platinum doped titanium oxide In toluene at 80℃; under 7500.75 Torr; Autoclave;

...Expand

: 1336-21-6
ammonium hydroxide

: 1585-07-5
1-bromo-4-ethylbenzene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; potassium phosphate tribasic heptahydrate; water; Sucrose In water at 90℃; for 15h; Catalytic behavior; Green chemistry;	75%

: 619-64-7
p-ethylbenzoic acid

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
Stage #1: p-ethylbenzoic acid With trifluorormethanesulfonic acid; trimethylsilylazide In chloroform at 90℃; for 0.0666667h; Schmidt Reaction; Flow reactor; Stage #2: With water In methanol; chloroform at 20℃; Schmidt Reaction; Flow reactor;	69%

: 100-12-9
4-ethylnitrobenzene

A: 93453-80-6, 14572-89-5
1-(4-aminophenyl)ethanol

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With 9,10-dihydro-10-methylacridine; perchloric acid In acetonitrile at 59.9℃; for 0.833333h;	A 40% B 60%

: 34557-54-5
methane

: 62-53-3
aniline

A: 578-54-1
ortho-ethylaniline

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
In gaseous matrix at 80℃; Irradiation;	A 57% B 43 % Spectr.

...Expand

: 105-05-5
1,4-diethylbenzene

: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With sodium azide; oxygen; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone at 40℃; for 4h; Sealed tube;	53%

: 82140-87-2
3,3-Diazido-2-cyan-acrylsaeure-methylester

: 589-16-2
4-aminoethylbenzene

A: 130148-86-6
3-Azido-2-cyan-3-(4-ethylanilino)acrylsaeure-methylester

B: C8H11N*HN3

Conditions

Conditions	Yield
In dichloromethane at -30℃; for 16h;	A 100% B n/a

...Expand

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 589-16-2
4-aminoethylbenzene

: 111186-10-8
2-(((4-ethylphenyl)amino)methylene)diethyl malonate

Conditions

Conditions	Yield
at 130℃; for 2h;	100%
With toluene-4-sulfonic acid In pentane Reflux;	96%
at 120℃; for 3h;
In ethanol at 80℃; for 4h;

: 105-39-5
chloroacetic acid ethyl ester

: 38663-85-3
2-methoxyethyl isothiocyanate

: 589-16-2
4-aminoethylbenzene

: (Z)-2-((4-ethylphenyl)imino)-3-(2-methoxyethyl)thiazolidin-4-one

Conditions

Conditions	Yield
Stage #1: 2-methoxyethyl isothiocyanate; 4-aminoethylbenzene In ethanol at 78℃; for 12h; Knoevenagel Condensation; Stage #2: chloroacetic acid ethyl ester With sodium acetate In ethanol at 78℃; for 5h; regioselective reaction;	100%

...Expand

: 1H-indazole-5-sulfonyl chloride

: 589-16-2
4-aminoethylbenzene

: 1H-indazole-5-sulfonic acid (4-ethylphenyl)amide

Conditions

Conditions	Yield
With pyridine at 50℃; for 4h;	100%
With pyridine at 50℃;	98%

: 110-13-4
2,5-hexanedione

: 589-16-2
4-aminoethylbenzene

: 1-(4-ethylphenyl)-2,5-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With montmorillonite K-10 In dichloromethane at 20 - 90℃; for 0.1h; Paal-Knorr Pyrrole Synthesis; Microwave irradiation;	99%
With bentonite In neat (no solvent) at 20℃; for 0.05h; Reagent/catalyst; Paal-Knorr Pyrrole Synthesis; Milling; Green chemistry;	98%
In neat (no solvent) at 20℃; for 24h; Paal-Knorr Pyrrole Synthesis; Green chemistry;	90%

: 118-92-3
anthranilic acid

: 122-51-0
orthoformic acid triethyl ester

: 589-16-2
4-aminoethylbenzene

: 22874-41-5
3-(4-ethylphenyl)quinazolin-4(3H)-one

Conditions

Conditions	Yield
With ytterbium(III) triflate at 60℃; for 0.0333333h;	99%

...Expand

: 286-20-4
cyclohexane-1,2-epoxide

: 589-16-2
4-aminoethylbenzene

: trans-2-(4-ethylanilino)cyclohexan-1-ol

Conditions

Conditions	Yield
With 2CF3O3S(1-)4CH4O2C19H13N3O2(2-)Co(3+)5H2O*Tb(3+) at 20℃; for 4h; Neat (no solvent); Inert atmosphere;	99%
With {Co3+-Zn2+} metal-organic framework at 20℃; for 4h; neat (no solvent);	99%
With sulfated zirconia In neat (no solvent) at 20℃; for 1h; regioselective reaction;	80%

: 7154-66-7
2-bromobenzoic acid chloride

: 589-16-2
4-aminoethylbenzene

: 296273-16-0
2-bromo-N-(4-ethylphenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	99%
With triethylamine In dichloromethane

: 96-09-3
styrene oxide

: 589-16-2
4-aminoethylbenzene

: 1260096-13-6
C16H19NO

Conditions

Conditions	Yield
With 2CF3O3S(1-)4CH4O2C19H13N3O2(2-)Co(3+)5H2O*Tb(3+) at 20℃; for 4h; Neat (no solvent); Inert atmosphere; regioselective reaction;	99%
With {Co3+-Cd2+} metal-organic framework at 20℃; for 4h; neat (no solvent);	99%
With 3Zn(2+)Co(3+)2C21H11N3O6(4-)HO(1-)17H2O In neat (no solvent) at 20℃; for 4h; Reagent/catalyst; regioselective reaction;	> 99 %Chromat.

: 7385-85-5
naphthalen-2-yl tosylate

: 589-16-2
4-aminoethylbenzene

: (4-ethyl-phenyl)-[2]naphthyl-amine

Conditions

Conditions	Yield
With (1,3-bis(2,6-diisopropylphenyl)imidazolidene)Ni(styrene)2; lithium tert-butoxide In 1,4-dioxane for 10h; Inert atmosphere; Heating; Schlenk technique;	99%

: 589-16-2
4-aminoethylbenzene

: 100-51-6
benzyl alcohol

: 109240-32-6
N-benzyl 4-ethylaniline

Conditions

Conditions	Yield
With C55H43ClN5P2Ru(1+)*Cl(1-); potassium hydroxide In toluene at 140℃; for 2h; Sealed tube;	99%
With 2,2':6,2''-terpyridine In toluene at 160℃; for 1h; Microwave irradiation;	96%
With 1,4-diaza-bicyclo[2.2.2]octane; rhodium(III) acetylacetonate; potassium hydroxide In acetonitrile at 110℃; Sealed tube;	92%

: 1275518-55-2
C7H6F3NO3

: 589-16-2
4-aminoethylbenzene

: 3-(4,4,4-trifluoro-3-(4-ethylanilino)butanoyl)oxazolidin-2-one

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 3h; Michael Addition;	99%
In neat (no solvent) at 20℃; for 3h; Michael Addition;	99%

: C11H19N3O4S

: 589-16-2
4-aminoethylbenzene

: C19H30N4O4S

Conditions

Conditions	Yield
In dichloromethane; acetonitrile at 50℃; Inert atmosphere;	99%

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: ethyl 2-(2-ethoxy-2-oxoethyl)-4,5-dimethoxybenzoate

: 589-16-2
4-aminoethylbenzene

: 2-(4-ethylphenyl)-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: tert-Butoxybis(dimethylamino)methane; ethyl 2-(2-ethoxy-2-oxoethyl)-4,5-dimethoxybenzoate at 100℃; for 3h; Stage #2: 4-aminoethylbenzene With acetic acid at 20℃; for 2h; Stage #3: With sodium hydroxide In ethanol at 80℃; for 1h;	99%

...Expand

: 122-79-2
Phenyl acetate

: 589-16-2
4-aminoethylbenzene

: 3663-34-1
N-(4-ethylphenyl)acetamide

Conditions

Conditions	Yield
With cell-free extract containing recombinant PpATaseCH In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 24h; pH=7.5; Time;	99%

: 108-24-7
acetic anhydride

: 589-16-2
4-aminoethylbenzene

: 3663-34-1
N-(4-ethylphenyl)acetamide

Conditions

Conditions	Yield
With cadmium(II) oxide at 80℃; for 0.166667h; Neat (no solvent); Microwave irradiation;	98%
With ZnAl2O4 nanoparticles at 20℃; for 0.0833333h; Neat (no solvent);	96%
In neat (no solvent) at 20℃; for 0.05h;	96%

: 17455-13-9
18-crown-6 ether

: 589-16-2
4-aminoethylbenzene

: 4-ethylanilinium tetrafluoroborate-1,4,7,10,13,16-hexaoxacyclooctadecane (1/1)

Conditions

Conditions	Yield
With tetrafluoroboric acid In methanol at 20℃;	98%

: 98-59-9
p-toluenesulfonyl chloride

: 589-16-2
4-aminoethylbenzene

: 1506-96-3
toluene-4-sulfonic acid-(4-ethyl-anilide)

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 16h;	98%
With pyridine In dichloromethane at 20℃; for 3h; Inert atmosphere;

: 108-86-1
bromobenzene

: 589-16-2
4-aminoethylbenzene

: 32804-22-1
4-ethyl-N-phenylbenzenamine

Conditions

Conditions	Yield
With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; 2,6-bis(diphenylphosphino)pyridine In N,N-dimethyl acetamide at 135℃; for 1h; Catalytic behavior; Buchwald-Hartwig Coupling; Inert atmosphere;	98%
With potassium ethoxide In 1,4-dioxane at 200℃; Reagent/catalyst; Autoclave;	28.6%

: 99-61-6
3-nitro-benzaldehyde

: 134-81-6
benzil

: 589-16-2
4-aminoethylbenzene

: 1-(4-ethylphenyl)-2-(3-nitrophenyl)-4,5-diphenyl-1H-imidazole

Conditions

Conditions	Yield
With ammonium acetate In neat (no solvent) at 110℃; for 0.666667h; Green chemistry;	98%
With ammonium acetate In neat (no solvent) at 80℃; for 0.416667h; Catalytic behavior; Green chemistry;	98%

...Expand

: 107-31-3
Methyl formate

: 589-16-2
4-aminoethylbenzene

: 69753-59-9
N-(4-ethylphenyl)formamide

Conditions

Conditions	Yield
With calcium(II) bis(trifluoromethanesulfonyl)imide In neat (no solvent) at 115℃; for 1h; Reagent/catalyst; Microwave irradiation; Sealed tube;	98%

: 4744-50-7
2,3-pyrazinedicarboxylic anhydride

: 589-16-2
4-aminoethylbenzene

: 3-[(4-ethylphenyl)carbamoyl]pyrazine-2-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2,3-pyrazinedicarboxylic anhydride; 4-aminoethylbenzene In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water pH=6;	98%

4-ETHYLANILINE Chemical Properties

IUPAC Name: 4-Ethylaniline
Synonyms: P-aminoethylbenzene ; P-ethylaniline ; 1-Amino-4-ethylbenzene ; 4-Aminoethylbenzene ; 4-Ethyl-anilin ; 4-Ethyl-benzenamin ; 4-Ethylbenzenamine ; 4-ethyl-benzenamine
Product Categories: Anilines (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Amines;C8;Nitrogen Compounds
Molecular Structure:
Molecular Formula :C₈H₁₁N
Molecular Weight :121.18
CAS NO: 589-16-2
EINECS :209-637-0
Mol File: 589-16-2.mol
BRN :774319
Density :0.975
Melting point :-5 ºC
Boiling point :216 ºC
Refractive index :1.5532-1.5552
Flash point :85 ºC
Water solubility: 4-Ethylaniline (CAS NO. 589-16-2) is immiscible .
Surface Tension: 38.2 dyne/cm
Density: 0.973 g/cm³
Enthalpy of Vaporization: 45.39 kJ/mol
Vapour Pressure: 0.132 mmHg at 25°C
Appearance: 4-Ethylaniline (CAS NO. 589-16-2) is clear yellow to red-brown liquid.

4-ETHYLANILINE Uses

4-Ethylaniline (CAS NO. 589-16-2) can be used as intermediates of liquid crystal.

4-ETHYLANILINE Toxicity Data With Reference

1.	dns-rat:lvr 100 µmol/L	ENMUDM Environmental Mutagenesis. 5 (1983),803.
2.	orl-mus LD50:500 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 89 (1947),153.
3.	ipr-mus LD50:133 mg/kg	JMCMAR Journal of Medicinal Chemistry. 17 (1974),900.
4.	ivn-mus LD50:56 mg/kg	CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#02908 .
5.	orl-qal LD50:422 mg/kg	AECTCV Archives of Environmental Contamination and Toxicology. 12 (1983),355.
6.	orl-bwd LD50:75 mg/kg	AECTCV Archives of Environmental Contamination and Toxicology. 12 (1983),355.

4-ETHYLANILINE Consensus Reports

Reported in EPA TSCA Inventory.

4-ETHYLANILINE Safety Profile

Hazard Codes Toxic T
Risk Statements 23/24/25-33
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R33:Danger of cumulative effects.
Safety Statements 36/37/39-45-28
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR 1602
WGK Germany 3
RTECS BX9900000
HazardClass 6.1
PackingGroup III
HS Code 29214980

4-ETHYLANILINE Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Product Name

4-Ethylaniline

Synthetic route

4-ETHYLANILINE Chemical Properties

4-ETHYLANILINE Uses

4-ETHYLANILINE Toxicity Data With Reference

4-ETHYLANILINE Consensus Reports

4-ETHYLANILINE Safety Profile

4-ETHYLANILINE Specification

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