Product Name

  • Name

    4-Methoxybenzyl bromide

  • EINECS 608-101-7
  • CAS No. 2746-25-0
  • Article Data168
  • CAS DataBase
  • Density 1.406 g/cm3
  • Solubility
  • Melting Point 240 °C
  • Formula C8H9BrO
  • Boiling Point 241.6 °C at 760 mmHg
  • Molecular Weight 201.063
  • Flash Point 95.6 °C
  • Transport Information UN 3265 8/PG 2
  • Appearance
  • Safety 26-36/37/39-45
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 2746-25-0 (4-Methoxybenzyl bromide)
  • Hazard Symbols CorrosiveC
  • Synonyms (4-Methoxyphenyl)methyl bromide;1,4-Methoxybromomethylbenzene;(4-Bromomethylphenoxy)methane;Anisole,p-(bromomethyl)- (6CI,7CI,8CI);1-(Bromomethyl)-4-methoxybenzene;4-(Bromomethyl)anisole;4-Methoxy-1-(bromomethyl)benzene;p-(Bromomethyl)anisole;p-Methoxybenzyl bromide;
  • PSA 9.23000
  • LogP 2.59010

Synthetic route

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With hydrogen bromide In benzene at 78℃; for 1h; Bromination;100%
With hydrogen bromide In benzene at 78℃; for 1h;100%
With phosphorus tribromide In diethyl ether at 0℃; for 2h;100%
4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

A

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With dihydrogen peroxide; methyltrioxorhenium(VII); sodium bromide In acetic acid for 10h; Ambient temperature;A 99%
B 1%
4-Methylanisole
104-93-8

4-Methylanisole

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In Diethyl carbonate for 0.25h; Reflux; Microwave irradiation;98%
With sodium bromate; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; sodium bromide In dichloromethane; water Reflux;92%
With N-Bromosuccinimide; trityl tetrafluoroborate In dichloromethane; benzene at 20℃; Irradiation; Inert atmosphere; chemoselective reaction;75%
4-Methylanisole
104-93-8

4-Methylanisole

A

2-bromo-4-methylanisole
22002-45-5

2-bromo-4-methylanisole

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In various solvent(s) at 90 - 95℃; for 1h; Wohl-Ziegler bromination;A 95%
B 5%
2-(4-methoxy-benzyloxy)-tetrahydro-pyran
18494-82-1

2-(4-methoxy-benzyloxy)-tetrahydro-pyran

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With 4-aminophenyl diphenylphosphinite; bromine In dichloromethane at 20℃; for 0.5h;95%
trimethyl(4-methoxybenzyloxy)silane
14629-56-2

trimethyl(4-methoxybenzyloxy)silane

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With 4-aminophenyl diphenylphosphinite; bromine In dichloromethane at 20℃;95%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With bromine; trimethylamine borane In chloroform at 0 - 5℃; for 0.0333333h;86%
With chloro-trimethyl-silane; 1,1,3,3-Tetramethyldisiloxane; lithium bromide; zinc(II) chloride In acetonitrile at 80℃; for 0.25h;84%
With Dichloromethylsilane; phosphorus tribromide; iron(III) chloride In acetonitrile for 4h; Heating;55%
ammonium acetate
631-61-8

ammonium acetate

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

A

p-methoxybenzyl acetate
104-21-2

p-methoxybenzyl acetate

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide; triphenylphosphine In acetonitrile at 20℃; for 1.9h; Cooling with ice;A 86%
B 6%
4-methoxy-1-(methoxymethoxy)methyl benzene
92565-78-1

4-methoxy-1-(methoxymethoxy)methyl benzene

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With tetrabutylammomium bromide; 1-(n-butyl)-3-methylimidazolium tetrachloroindate at 135 - 140℃; for 0.0916667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;81%
tert-butyl((4-methoxybenzyl)oxy)dimethylsilane
101803-60-5

tert-butyl((4-methoxybenzyl)oxy)dimethylsilane

dibromotriphenylphosphorane
1034-39-5

dibromotriphenylphosphorane

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
In dichloromethane for 15h; Ambient temperature;80%
4-methoxy-1-[(ethoxymethoxy)methyl]benzene
1058649-04-9

4-methoxy-1-[(ethoxymethoxy)methyl]benzene

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With tetrabutylammomium bromide; 1-(n-butyl)-3-methylimidazolium tetrachloroindate at 135 - 140℃; for 0.0916667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;79%
butyraldehyde
123-72-8

butyraldehyde

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

A

p-methoxybenzyl butyrate
6963-56-0

p-methoxybenzyl butyrate

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; bromine; sodium hydrogencarbonate In dichloromethane; waterA 50%
B 27%
C 16%
4-Methylanisole
104-93-8

4-Methylanisole

A

3-bromo-4-methylanisole
36942-56-0

3-bromo-4-methylanisole

B

2-bromo-4-methylanisole
22002-45-5

2-bromo-4-methylanisole

C

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With hydrogen bromide; sodium bromide In chloroform; water at 0 - 2℃; Electrolysis;A 37%
B 39%
C 12%
(4-methoxy-benzyl)-trimethyl-silane
17988-20-4

(4-methoxy-benzyl)-trimethyl-silane

A

4-Methylanisole
104-93-8

4-Methylanisole

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With hydrogen bromide; bromine In acetic acid Quantum yield; Product distribution; Ambient temperature; Irradiation; variation of concentration of Br2 and HBr;A 9.6%
B 1%
tetrachloromethane
56-23-5

tetrachloromethane

N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

4-Methylanisole
104-93-8

4-Methylanisole

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

bromocyane
506-68-3

bromocyane

N-benzyl-1-(4-methoxyphenyl)-N-methylmethanamine
415921-79-8

N-benzyl-1-(4-methoxyphenyl)-N-methylmethanamine

A

N-benzyl-N-methyl cyanamide
34065-04-8

N-benzyl-N-methyl cyanamide

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

bromocyane
506-68-3

bromocyane

N-methyl-N-(4-methyl)benzyl-(4-methoxy)benzylamine
857825-44-6

N-methyl-N-(4-methyl)benzyl-(4-methoxy)benzylamine

A

methyl-(4-methyl-benzyl)-carbamonitrile
52245-36-0

methyl-(4-methyl-benzyl)-carbamonitrile

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

bromocyane
506-68-3

bromocyane

(4-methoxy-benzyl)-methyl-(4-phenyl-benzyl)-amine

(4-methoxy-benzyl)-methyl-(4-phenyl-benzyl)-amine

A

methyl-(4-phenyl-benzyl)-carbamonitrile

methyl-(4-phenyl-benzyl)-carbamonitrile

B

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

4-methoxybenzyl iodide
70887-29-5

4-methoxybenzyl iodide

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With pyridine; tributyltin bromide at 50℃; Thermodynamic data; Δ G;
2-(4-methoxyphenyl)acetic anhydride
3951-10-8

2-(4-methoxyphenyl)acetic anhydride

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
Yield given. Multistep reaction;
(4-methoxy-benzyl)-trimethyl-silane
17988-20-4

(4-methoxy-benzyl)-trimethyl-silane

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With bromine; sodium acetate In acetic acid Irradiation;
4-Methylanisole
104-93-8

4-Methylanisole

Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

A

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In benzene at 70℃; Product distribution; Mechanism; Irradiation; other substituted toluenes, unsubstituted alkylbenzenes and substituted cumenes;
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With pyridine; tributyltin bromide at 50℃; Thermodynamic data; Δ G;
With sodium bromide In N,N-dimethyl-formamide at 25℃; for 2h; Inert atmosphere;
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
With sodium bromide In N,N-dimethyl-formamide at 25℃; for 2h; Inert atmosphere;
4-methoxyphenyl-acetic chloride
4693-91-8

4-methoxyphenyl-acetic chloride

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
Yield given. Multistep reaction;
hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

chloroform
67-66-3

chloroform

bromine
7726-95-6

bromine

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

A

formaldehyd
50-00-0

formaldehyd

B

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

C

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

p-cresol
106-44-5

p-cresol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / tetrahydrofuran / 25 °C
1.2: tetrahydrofuran / 20 °C
2.1: NBS; AIBN / CCl4 / Irradiation
View Scheme
p-cresol
106-44-5

p-cresol

3-nitro-benzene-sulfenic acid-(1)-chloride

3-nitro-benzene-sulfenic acid-(1)-chloride

A

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

B

sodium-compound of 2-ethyl-acetoacetic acid ethyl ester

sodium-compound of 2-ethyl-acetoacetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Na
2: NBS
View Scheme
ice-H2 O

ice-H2 O

diethyl ether
60-29-7

diethyl ether

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

Conditions
ConditionsYield
With hydrogen bromide
pyridine
110-86-1

pyridine

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

N-(4-methoxybenzyl)pyridinium bromide
112503-29-4

N-(4-methoxybenzyl)pyridinium bromide

Conditions
ConditionsYield
In acetone; benzene at 20℃; for 24h;100%
In nitrobenzene at 40℃; Rate constant; Mechanism;
With ethanol
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

triphenylphosphine
603-35-0

triphenylphosphine

((4-methoxyphenyl)methyl)triphenylphosphonium bromide
1530-38-7

((4-methoxyphenyl)methyl)triphenylphosphonium bromide

Conditions
ConditionsYield
In benzene for 24h; Ambient temperature;100%
In toluene at 110℃;99%
In toluene for 10h; Inert atmosphere; Reflux;98%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

2',3'-O-isopropylidene-5-fluorouridine
2797-17-3

2',3'-O-isopropylidene-5-fluorouridine

2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine
129141-66-8

2',3'-O-Isopropylidene-3-(4-methoxybenzyl)-5-fluorouridine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 3h; Ambient temperature;100%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 5h; Ambient temperature; Yield given;
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

1-(azidomethyl)-4-methoxybenzene
70978-37-9

1-(azidomethyl)-4-methoxybenzene

Conditions
ConditionsYield
With sodium azide In tetrahydrofuran; water at 80℃; for 3h; Inert atmosphere;100%
With sodium azide; potassium iodide In acetonitrile for 16h; Reflux; Inert atmosphere;100%
With sodium azide In dimethyl sulfoxide at 80℃;100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

triethyl phosphite
122-52-1

triethyl phosphite

diethyl 4-methoxybenzylphosphonate
1145-93-3

diethyl 4-methoxybenzylphosphonate

Conditions
ConditionsYield
In water at 80℃; for 5h; Inert atmosphere;100%
Reflux;99%
for 5h; Heating;95%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation;100%
With dihydrogen peroxide In ethanol for 4h; Reflux; Green chemistry;96%
With pyridine N-oxide for 0.0111111h; Irradiation; with microwave irradiation;92%
homoalylic alcohol
627-27-0

homoalylic alcohol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

1-(4-methoxybenzyloxy)-3-butene
142860-83-1

1-(4-methoxybenzyloxy)-3-butene

Conditions
ConditionsYield
Stage #1: homoalylic alcohol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.0833333h;
Stage #2: p-Methoxybenzyl bromide In tetrahydrofuran at 0℃; for 1h;
100%
Stage #1: homoalylic alcohol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: p-Methoxybenzyl bromide With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 0 - 20℃; for 17h; Inert atmosphere;
100%
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h;96%
(4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane
87318-96-5

(4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

(S)-4-[(R)-2-(4-Methoxy-benzyloxy)-pent-4-enyl]-2,2-dimethyl-[1,3]dioxolane
397886-48-5

(S)-4-[(R)-2-(4-Methoxy-benzyloxy)-pent-4-enyl]-2,2-dimethyl-[1,3]dioxolane

Conditions
ConditionsYield
Stage #1: (4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
Stage #2: p-Methoxybenzyl bromide In N,N-dimethyl-formamide at 20℃;
100%
Stage #1: (4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
Stage #2: p-Methoxybenzyl bromide In N,N-dimethyl-formamide at 20℃; Further stages.;
100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole
101226-33-9

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

1-(4-methoxybenzyl)-3-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazolium bromide

1-(4-methoxybenzyl)-3-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazolium bromide

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 2h;100%
tetrahydropyran-2-yl 4,6-O-(4-methoxyphenyl)methylidene-5-deoxy-5-thio-α-D-glucopyranoside
865166-82-1

tetrahydropyran-2-yl 4,6-O-(4-methoxyphenyl)methylidene-5-deoxy-5-thio-α-D-glucopyranoside

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

tetrahydropyran-2-yl 2,3-di-O-(4-methoxyphenyl)methyl-4,6-O-(4-methoxyphenyl)methylidene-5-deoxy-5-thio-α-D-glucopyranoside
865166-84-3

tetrahydropyran-2-yl 2,3-di-O-(4-methoxyphenyl)methyl-4,6-O-(4-methoxyphenyl)methylidene-5-deoxy-5-thio-α-D-glucopyranoside

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; toluene at 20℃; for 2h;100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

2-amino-1-hydroxy-indole-3-carboxylic acid ethyl ester
65547-91-3

2-amino-1-hydroxy-indole-3-carboxylic acid ethyl ester

ethyl 2-amino-1-[(4-methoxybenzyl)oxy]-1H-indole-3-carboxylate

ethyl 2-amino-1-[(4-methoxybenzyl)oxy]-1H-indole-3-carboxylate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃;100%
(S)-3,7-dimethyl-6-octen-1-ol
7540-51-4

(S)-3,7-dimethyl-6-octen-1-ol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

(S)-4-methoxybenzyl 3,7-dimethyl-6-octenyl ether
934704-86-6

(S)-4-methoxybenzyl 3,7-dimethyl-6-octenyl ether

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 48h; Heating;100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

coumarin 2
26078-25-1

coumarin 2

7-[ethyl-(4-methoxy-benzyl)amino]-4,6-dimethyl-chromen-2-one
873795-53-0

7-[ethyl-(4-methoxy-benzyl)amino]-4,6-dimethyl-chromen-2-one

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide Heating;100%
methyl 1-butyl-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-4-carboxylate

methyl 1-butyl-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-4-carboxylate

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

1-butyl-4,5-bis(4-chlorophenyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-4,5-dihydro-1H-imidazolium iodide
1255528-46-1

1-butyl-4,5-bis(4-chlorophenyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-4,5-dihydro-1H-imidazolium iodide

Conditions
ConditionsYield
With sodium iodide In acetone at 20℃; for 18h;100%
2,3-bis(methoxycarbonyl)phenol
36669-02-0

2,3-bis(methoxycarbonyl)phenol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

3-(4-methoxy-benzyloxy)-phthalic acid dimethyl ester
1061606-47-0

3-(4-methoxy-benzyloxy)-phthalic acid dimethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Heating / reflux;100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate
155377-19-8

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

ethyl 1-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)pyrazole-4-carboxylate
1105039-92-6

ethyl 1-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; Inert atmosphere;100%
2-hydroxy-5-formylbenzoic acid
616-76-2

2-hydroxy-5-formylbenzoic acid

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C16H14O5
1251530-68-3

C16H14O5

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 24h;100%
(1R)-N-[(2-benzyloxy)-1-(hydroxymethyl)ethyl]chloromethane sulphonamide
1189331-99-4

(1R)-N-[(2-benzyloxy)-1-(hydroxymethyl)ethyl]chloromethane sulphonamide

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C19H24ClNO5S
1251834-16-8

C19H24ClNO5S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;100%
C19H20N2
946415-03-8

C19H20N2

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C27H29N2O(1+)*I(1-)
1255528-58-5

C27H29N2O(1+)*I(1-)

Conditions
ConditionsYield
With sodium iodide In acetone at 20℃; for 18h;100%
4-cyanobenzenethiol
36801-01-1

4-cyanobenzenethiol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

4-[(4-methoxybenzyl)thio]benzonitrile
1257086-86-4

4-[(4-methoxybenzyl)thio]benzonitrile

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 18h;100%
2-iodo-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
1073143-37-9

2-iodo-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C24H18F6INO3
1073143-41-5

C24H18F6INO3

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide100%
C21H34O5Si
1338989-55-1

C21H34O5Si

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

C29H42O6Si
1338989-56-2

C29H42O6Si

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 0 - 24℃;100%
N-(tert-butoxycarbonyl)-D-tyrosine
70642-86-3

N-(tert-butoxycarbonyl)-D-tyrosine

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

4-methoxybenzyl N-(tert-butoxycarbonyl)-D-tyrosinate
1417188-71-6

4-methoxybenzyl N-(tert-butoxycarbonyl)-D-tyrosinate

Conditions
ConditionsYield
Stage #1: N-(tert-butoxycarbonyl)-D-tyrosine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: p-Methoxybenzyl bromide In N,N-dimethyl-formamide at 20℃;
Stage #3: With acetic acid In water; ethyl acetate; N,N-dimethyl-formamide pH=5;
100%
Stage #1: N-(tert-butoxycarbonyl)-D-tyrosine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: p-Methoxybenzyl bromide In N,N-dimethyl-formamide at 20℃;
100%
2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-hydroxyallyl]hexyl ester
1449522-84-2

2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-hydroxyallyl]hexyl ester

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

(-)-2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester
1449522-85-3

(-)-2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

Conditions
ConditionsYield
With potassium hexamethylsilazane; triethylamine In tetrahydrofuran; toluene at -78 - 20℃; for 1.5h; Inert atmosphere;100%
2-Hydroxybenzophenone
117-99-7

2-Hydroxybenzophenone

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

2'-(4-methoxylbenzyloxy)benzophenone

2'-(4-methoxylbenzyloxy)benzophenone

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 50℃;100%
With caesium carbonate In acetonitrile at 50℃; Inert atmosphere;100%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone at 55℃;65.6%
pyrrolidine
123-75-1

pyrrolidine

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

1-(4-methoxybenzyl)pyrrolidine
122439-15-0

1-(4-methoxybenzyl)pyrrolidine

Conditions
ConditionsYield
In ethyl acetate at 0 - 20℃; for 0.333333h;100%
(2R,3R,4S,5S,6S)-4,5-dibenzyloxy-2-[(tert-butyl(dimethyl)silyl)oxymethyl]-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]tetrahydropyran-3-ol

(2R,3R,4S,5S,6S)-4,5-dibenzyloxy-2-[(tert-butyl(dimethyl)silyl)oxymethyl]-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]tetrahydropyran-3-ol

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

tert-butyl [[(2R,3R,4R,5S,6S)-4,5-dibenzyloxy-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-[(4-methoxyphenyl)methoxy]tetrahydropyran-2-yl]methoxy]dimethylsilane

tert-butyl [[(2R,3R,4R,5S,6S)-4,5-dibenzyloxy-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-[(4-methoxyphenyl)methoxy]tetrahydropyran-2-yl]methoxy]dimethylsilane

Conditions
ConditionsYield
Stage #1: (2R,3R,4S,5S,6S)-4,5-dibenzyloxy-2-[(tert-butyl(dimethyl)silyl)oxymethyl]-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]tetrahydropyran-3-ol With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: p-Methoxybenzyl bromide In tetrahydrofuran at 0 - 20℃; for 3h;
100%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-(4-methoxybenzyl)piperidin-4-yl)carbamate

tert-butyl (1-(4-methoxybenzyl)piperidin-4-yl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;100%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1h;81%
With triethylamine In ethanol
benzhydrylidene aza-glycinyl-D-phenylalanine tert-butyl ester
1392506-40-9

benzhydrylidene aza-glycinyl-D-phenylalanine tert-butyl ester

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

benzhydrylidene-aza-4-methoxyphenylalaninyl-D-phenylalanine tert-butyl ester

benzhydrylidene-aza-4-methoxyphenylalaninyl-D-phenylalanine tert-butyl ester

Conditions
ConditionsYield
Stage #1: benzhydrylidene aza-glycinyl-D-phenylalanine tert-butyl ester With tetraethylammonium hydroxide In tetrahydrofuran; water at 20℃; for 0.5h; Inert atmosphere;
Stage #2: p-Methoxybenzyl bromide In tetrahydrofuran; water at 20℃; Inert atmosphere;
100%

4-Methoxybenzyl bromide Chemical Properties

Product Name: 4-Methoxybenzyl bromide
Synonyms: METHOXYBENZYLBROMIDE(4-);1-(BROMOMETHYL)-4-METHOXYBENZENE;4-METHOXYBENZYL BROMIDE;4-MethoxybenzylBromide4-Methoxybenzylbromide;p-Methoxybenzylbromide;4-Methoxybenzyl bromide ,95%
MF: C8H9BrO
MW: 201.06
bp : 91 °C1 mm Hg(lit.)
density : 1.379 g/mL at 25 °C(lit.)
refractive index : n20/D 1.5780(lit.)
Fp : >230 °F

4-Methoxybenzyl bromide Safety Profile

Risk Statements : 34
Safety Statements : 26-36/37/39-45
Hazard Codes : C
RIDADR : UN 3265 8/PG 2
WGK Germany : 1
Transport Information : UN 3265
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