4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl- supplier

Name
7,8-DIHYDROXYFLAVONE
EINECS 253-812-4
CAS No. 38183-03-8
Article Data21
CAS DataBase
Density 1.443 g/cm³
Solubility
Melting Point 243-246°C
Formula C₁₅H₁₀O₄
Boiling Point 494.4 °C at 760 mmHg
Molecular Weight 254.242
Flash Point 193.5 °C
Transport Information
Appearance
Safety 24/25
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Flavone,7,8-dihydroxy- (6CI);7,8-Dihydroxy-2-phenyl-4H-chromen-4-one;7,8-Dihydroxyflavone;
PSA 70.67000
LogP 2.87120

Synthetic route

: 6665-86-7
7-hydroxyflavone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 80℃; for 24h;	98%
With dipotassium peroxodisulfate; alkaline solution Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;
Multi-step reaction with 2 steps 1: aluminium chloride / 160 °C 2: aq. NaOH solution; aqueous hydrogen peroxide View Scheme
With cytochromes P450 in human liver microsomes Kinetics; Enzymatic reaction;

: 500866-00-2
C29H22O4

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 40℃; under 4560.31 - 6080.41 Torr;	90.5%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; for 3h;	83%

: 110865-10-6
C29H18O6

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With sodium methylate In ethanol; dichloromethane	63%
With water; sodium hydroxide In 1,4-dioxane; methanol at 20℃;

: 42345-27-7
8-acetyl-7-hydroxy-2-phenyl-chromen-4-one

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide

: 856084-77-0
1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With sodium acetate; acetic acid Erwaermen des Reaktionsprodukts mit methanol. Kalilauge;

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 87-66-1
2-hydroxyresorcinol

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With diphenylether

: 856084-77-0
1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

: 127-09-3
sodium acetate

: 64-19-7
acetic acid

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
anschliessend Erhitzen mit wss.-methanol. Kalilauge;

...Expand

: 87-66-1
2-hydroxyresorcinol

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With aluminium trichloride; nitrobenzene Behandeln der Reaktionsloesung mit Phenylpropioloylchlorid und Benzol;
Multi-step reaction with 6 steps 1: boron trifluoride diethyl etherate / 50 - 100 °C / Inert atmosphere; Large scale 2: potassium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 90 - 110 °C / Inert atmosphere; Large scale 3: hydrogenchloride; acetic acid / water / 3 h / 20 °C 4: potassium hydroxide / water; ethanol / 20 - 30 °C 5: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere 6: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr View Scheme

Yield

With aluminium trichloride; nitrobenzene Behandeln der Reaktionsloesung mit Phenylpropioloylchlorid und Benzol;

Multi-step reaction with 6 steps
1: boron trifluoride diethyl etherate / 50 - 100 °C / Inert atmosphere; Large scale
2: potassium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 90 - 110 °C / Inert atmosphere; Large scale
3: hydrogenchloride; acetic acid / water / 3 h / 20 °C
4: potassium hydroxide / water; ethanol / 20 - 30 °C
5: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere
6: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr
View Scheme

: 131944-43-9
1-Phenyl-3-(2,3,4-trihydroxy-phenyl)-propane-1,3-dione

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With sulfuric acid In acetic acid at 95 - 100℃; Yield given;

: 93-97-0
benzoic acid anhydride

2.3.4-trioxy-acetophenone: 2.3.4-trioxy-acetophenone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With sodium benzoate at 180 - 185℃; Kochen des Reaktionsprodukts mit waessrig-alkoholischer Kalilauge;

7.8-dimethoxy-flavone: 7.8-dimethoxy-flavone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With hydrogen iodide

: 6665-86-7
7-hydroxyflavone

aqueous alkaline solution: aqueous alkaline solution

potassium peroxo disulfate: potassium peroxo disulfate

A: 38183-03-8
7,8-dihydroxyflavone

B: 7-hydroxy-2-phenyl-8-sulfooxy-chromen-4-one

...Expand

: 528-21-2
2',3',4'-trihydroxyacetophenone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) lithium bis(trimethyl)silyl amide (LiHMDS) / 1) THF, a) -78 deg C, b) -10 deg C, 2) THF, a) -78 deg C, b) room temp. 2: H2SO4 / acetic acid / 95 - 100 °C View Scheme
Multi-step reaction with 2 steps 1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 120 - 140 °C 2: water; sodium hydroxide / 1,4-dioxane; methanol / 20 °C View Scheme
Multi-step reaction with 5 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 50 °C 2.1: trifluoroacetic acid / toluene / 2 h / 20 °C 3.1: potassium hydroxide / ethanol; water / 36 h / 20 °C 3.2: pH Ca. 5 / Cooling with ice 4.1: iodine; dimethyl sulfoxide / 12 h / 110 °C 5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1: potassium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 90 - 110 °C / Inert atmosphere; Large scale 2: hydrogenchloride; acetic acid / water / 3 h / 20 °C 3: potassium hydroxide / water; ethanol / 20 - 30 °C 4: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere 5: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr View Scheme

: 98-88-4
benzoyl chloride

O5-benzoyl-O1,O2-isopropyliden-β-D-arabinofuranose: O5-benzoyl-O1,O2-isopropyliden-β-D-arabinofuranose

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) lithium bis(trimethyl)silyl amide (LiHMDS) / 1) THF, a) -78 deg C, b) -10 deg C, 2) THF, a) -78 deg C, b) room temp. 2: H2SO4 / acetic acid / 95 - 100 °C View Scheme

: 72994-98-0
4-oxo-2-phenyl-4H-chromen-7-yl acetate

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminium chloride / 60 °C 2: aq. NaOH solution; aqueous hydrogen peroxide View Scheme

: 93827-33-9
C29H24O4

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iodine; dimethyl sulfoxide / 12 h / 110 °C 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme

: 50439-63-9
1-(2,3,4-tris(benzyloxy)phenyl)ethanone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: trifluoroacetic acid / toluene / 2 h / 20 °C 2.1: potassium hydroxide / ethanol; water / 36 h / 20 °C 2.2: pH Ca. 5 / Cooling with ice 3.1: iodine; dimethyl sulfoxide / 12 h / 110 °C 4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride; acetic acid / water / 3 h / 20 °C 2: potassium hydroxide / water; ethanol / 20 - 30 °C 3: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere 4: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr View Scheme

: 2652-27-9
1-(3,4-bis(benzyloxy)-2-hydroxyphenyl)ethanone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium hydroxide / ethanol; water / 36 h / 20 °C 1.2: pH Ca. 5 / Cooling with ice 2.1: iodine; dimethyl sulfoxide / 12 h / 110 °C 3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: potassium hydroxide / water; ethanol / 20 - 30 °C 2: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere 3: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr View Scheme

: 528-21-2
2',3',4'-trihydroxyacetophenone

: 98-88-4
benzoyl chloride

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Stage #1: 2',3',4'-trihydroxyacetophenone; benzoyl chloride With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene for 8h; Reflux; Stage #2: With sodium hydroxide In 1,4-dioxane; methanol
Stage #1: 2',3',4'-trihydroxyacetophenone; benzoyl chloride With potassium carbonate In acetone for 12.1667h; Baker-Venkataraman Rearrangement; Inert atmosphere; Reflux; Stage #2: In methanol; water for 3h; Inert atmosphere; Reflux;

: 5396-18-9
2'-hydroxy-3',4'-dimethoxyacetophenone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: pyridine / 1 h / 75 °C 2.1: pyridine; potassium hydroxide / 2 h / 50 - 75 °C 3.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C 3.2: 0.5 h / 0 - 20 °C 4.1: boron tribromide / dichloromethane / Heating View Scheme

: 65548-54-1
7,8-dimethoxyflavone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With boron tribromide In dichloromethane Heating;

: 1-(2-benzoyloxy-3,4-dimethoxy-phenyl)-ethanone

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: pyridine; potassium hydroxide / 2 h / 50 - 75 °C 2.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C 2.2: 0.5 h / 0 - 20 °C 3.1: boron tribromide / dichloromethane / Heating View Scheme

: 169788-03-8
1-(2-hydroxy-3,4-dimethoxy-phenyl)-3-phenyl-propane-1,3-dione

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C 1.2: 0.5 h / 0 - 20 °C 2.1: boron tribromide / dichloromethane / Heating View Scheme

: 6665-86-7
7-hydroxyflavone

A: 2196-14-7
7,4'-Dihydroxyflavon

B: 38183-04-9
6,7-dihydroxyflavone

C: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
With cytochromes P450 in human liver microsomes Kinetics; Enzymatic reaction;

...Expand

: 525-82-6
FLAVONE

A: 2196-14-7
7,4'-Dihydroxyflavon

B: 38183-04-9
6,7-dihydroxyflavone

C: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: cytochromes P450 in human liver microsomes / Enzymatic reaction 2: cytochromes P450 in human liver microsomes / Enzymatic reaction View Scheme

...Expand

: 525-82-6
FLAVONE

: 38183-03-8
7,8-dihydroxyflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: cytochromes P450 in human liver microsomes / Enzymatic reaction 2: cytochromes P450 in human liver microsomes / Enzymatic reaction View Scheme

: 38183-03-8
7,8-dihydroxyflavone

: 74-88-4
methyl iodide

: 65548-54-1
7,8-dimethoxyflavone

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h;	94%
With potassium carbonate In acetone at 60℃;

: 38183-03-8
7,8-dihydroxyflavone

: 106-95-6
allyl bromide

: 2-phenyl-7,8-bis(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4h; Inert atmosphere; Reflux;	78%

: 38183-03-8
7,8-dihydroxyflavone

: 7,8-dihydroxy 4-thioflavone

Conditions

Conditions	Yield
With Lawessons reagent In toluene at 40℃; for 0.5h; Substitution;	77%

: 358-23-6
trifluoromethylsulfonic anhydride

: 38183-03-8
7,8-dihydroxyflavone

: 1257063-84-5
4-oxo-2-phenyl-4H-chromene-7,8-diyl Bis(trifluoromethanesulfonate)

Conditions

Conditions	Yield
With pyridine In dichloromethane at -78 - 0℃; Inert atmosphere;	76%
Stage #1: 7,8-dihydroxyflavone With pyridine In dichloromethane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at -78 - 0℃; Inert atmosphere;	76%

: 38183-03-8
7,8-dihydroxyflavone

: 121-44-8
triethylamine

: [Et3NH]2[{(O2)C15H8O2}3Si]

Conditions

Conditions	Yield
With tetraethoxy orthosilicate In acetonitrile at 20℃; for 24h; Inert atmosphere;	70%

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 38183-03-8
7,8-dihydroxyflavone

: 6674-22-2
1,8-diazabicyclo[5.4.0]undec-7-ene

: 786706-00-1
7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one

Conditions

Conditions	Yield
With CuCl2 In acetonitrile	69%

...Expand

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 38183-03-8
7,8-dihydroxyflavone

: 786706-00-1
7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride In acetonitrile at 0 - 20℃;	69%
With copper(l) iodide; potassium carbonate; potassium iodide In acetone at 50℃; for 4h;	62%

: 38183-03-8
7,8-dihydroxyflavone

: 107-15-3
ethylenediamine

: 4-(7-phenyl-2,3-dihydro-1H-1,4-diazepin-5-yl)benzene-1,2,3-triol

Conditions

Conditions	Yield
In ethanol at 100℃;	56%

: 38183-03-8
7,8-dihydroxyflavone

: 108-24-7
acetic anhydride

: 109688-08-6
4-oxo-2-phenyl-4H-chromene-7,8-diyl diacetate

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	53.3%
With potassium carbonate In dichloromethane at 20℃;	53.3%
With sodium acetate

: 38183-03-8
7,8-dihydroxyflavone

: 3674-13-3
2,3-dibromopropionic acid ethyl ester

A: 121869-37-2
7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

B: 121869-36-1
7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 20h; Heating;	A 8% B 44%

...Expand

: 38183-03-8
7,8-dihydroxyflavone

: 3674-13-3
2,3-dibromopropionic acid ethyl ester

1360: 1360

A: 121869-37-2
7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

B: 121869-36-1
7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 20h; Heating;	A 8% B 44%

...Expand

: 4530-20-5
BOC-glycine

: 38183-03-8
7,8-dihydroxyflavone

: 1609067-52-8
C29H32N2O10

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In pyridine for 24h; Cooling with ice;	25%

: 38183-03-8
7,8-dihydroxyflavone

: 108-12-3
isopentanoyl chloride

: 1609067-34-6
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(3-methylbutanoate)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	23.1%
With potassium carbonate In dichloromethane at 20℃;	23.1%

: 38183-03-8
7,8-dihydroxyflavone

: 109-90-0
ethyl isocyanate

: 1609067-38-0
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(ethylcarbamate)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	22.5%
With potassium carbonate In dichloromethane at 20℃;	22.5%

: 458-35-5, 32811-40-8, 69056-21-9
coniferal alcohol

: 38183-03-8
7,8-dihydroxyflavone

: 5-deoxyscutellaprostin-A

Conditions

Conditions	Yield
With silver carbonate In acetone; benzene at 60℃; for 24h;	21%

: 38183-03-8
7,8-dihydroxyflavone

: 3282-30-2
pivaloyl chloride

: 1609067-33-5
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(2,2-dimethylpropanoate)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	20.9%
With potassium carbonate In dichloromethane at 20℃;	20.9%

: 109-01-3
1-methyl-piperazine

: 32315-10-9
bis(trichloromethyl) carbonate

: 38183-03-8
7,8-dihydroxyflavone

: 1609067-46-0
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(4-methylpiperazine-1-carboxylate).

Conditions

Conditions	Yield
Stage #1: 1-methyl-piperazine; bis(trichloromethyl) carbonate In tetrahydrofuran at -78℃; for 1h; Stage #2: 7,8-dihydroxyflavone In pyridine; water; acetone at 0 - 20℃;	20.2%

...Expand

: 38183-03-8
7,8-dihydroxyflavone

: 79-03-8
propionyl chloride

: 1609067-36-8
4-oxo-2-phenyl-4H-chromene-7,8-diyl dipropionate

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	17.4%
With potassium carbonate In dichloromethane at 20℃;	17.4%

: 38183-03-8
7,8-dihydroxyflavone

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1609067-35-7
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(dimethylcarbamate)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	15.9%
With potassium carbonate In dichloromethane at 20℃;	15.9%

: 38183-03-8
7,8-dihydroxyflavone

: 541-41-3
chloroformic acid ethyl ester

: 1609067-37-9
diethyl (4-oxo-2-phenyl-4H-chromene-7,8-diyl) bis(carbonate)

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃;	15.9%
With potassium carbonate In dichloromethane at 20℃;	15.9%

: 186581-53-3, 908094-01-9
diazomethane

: 38183-03-8
7,8-dihydroxyflavone

: 65548-54-1
7,8-dimethoxyflavone

Conditions

Conditions	Yield
With diethyl ether

: 20757-83-9
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

: 38183-03-8
7,8-dihydroxyflavone

: 4476-32-8
8-phenyl-[1,3]dioxolo[4,5-h]chromen-6-one

Conditions

Conditions	Yield
With potassium carbonate; acetone

: 38183-03-8
7,8-dihydroxyflavone

: 77-78-1
dimethyl sulfate

: 65548-54-1
7,8-dimethoxyflavone

Conditions

Conditions	Yield
With potassium carbonate; acetone
With alkaline solution

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl- Specification

The 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-, with CAS registry number 38183-03-8, belongs to the following product categories: (1)Di-substituted Flavones; (2)Biochemistry; (3)Flavonoids. It has the systematic name of 7,8-dihydroxy-2-phenyl-4H-chromen-4-one. Its classification code is Mutation data. When use this chemical, avoid contact with skin and eyes. What's more, its EINECS is 253-812-4.

Physical properties of 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-: (1)ACD/LogP: 2.51; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.49; (4)ACD/LogD (pH 7.4): 1.82; (5)ACD/BCF (pH 5.5): 45.16; (6)ACD/BCF (pH 7.4): 9.82; (7)ACD/KOC (pH 5.5): 525.11; (8)ACD/KOC (pH 7.4): 114.21; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 44.76 Å²; (13)Index of Refraction: 1.698; (14)Molar Refractivity: 67.97 cm³; (15)Molar Volume: 176.1 cm³; (16)Polarizability: 26.94×10^-24cm³; (17)Surface Tension: 68.2 dyne/cm; (18)Density: 1.443 g/cm³; (19)Flash Point: 193.5 °C; (20)Enthalpy of Vaporization: 79.07 kJ/mol; (21)Boiling Point: 494.4 °C at 760 mmHg; (22)Vapour Pressure: 2.13E-10 mmHg at 25°C.

Preparation: this chemical can be prepared by C₂₉H₁₈O₆. This reaction will need reagent NaOMe and solvents ethanol, CH₂Cl₂. The yield is about 63%.

Uses of 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-: it can be used to produce 7,8-dihydroxy-2-phenyl-chromene-4-thione. This reaction will need reagent Lawesson's reagent and solvent toluene. The reaction time is 30 min with reaction temperature of 40 ℃. The yield is about 77%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C\1c3c(O/C(=C/1)c2ccccc2)c(O)c(O)cc3
(2)InChI: InChI=1/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
(3)InChIKey: COCYGNDCWFKTMF-UHFFFAOYAA
(4)Std. InChI: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
(5)Std. InChIKey: COCYGNDCWFKTMF-UHFFFAOYSA-N

Product Name

7,8-DIHYDROXYFLAVONE

Synthetic route

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl- Specification

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