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Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

7,8-DIHYDROXYFLAVONE

Cas:38183-03-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou MyLand Pharm&Nutrition Inc.

Product name 7,8-Dihydroxyflavone Other name 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-p

Manufacturer Supplies supplement high-quality 7,8-Dihydroxyflavone powder 98% purity min.

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $3400.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

7,8-dihydroxyflavone

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

7,8-Dihydroxyflavone manufacturer/supplier manufacturer/supplier

Cas:38183-03-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% 7,8-DIHYDROXYFLAVONE 38183-03-8 HACCP Manufacturer

Cas:38183-03-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring member of the flavonoid family. Studies have shown that 7,8-DHF can cross the blood-brain barrier, effectively mimic brain derived neurotrophin (BDNF), specifically bind to TrkB receptor, thus i

Top quality 7,8-DHF / 7,8-Dihydroxyflavone CAS 38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $3400.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7,8-Dihydroxyflavone

Cas:38183-03-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

We guarantee that 100% of your parcel passes through the United States, Britain, Australia, Canada, Mexico, France, Germany, Spain, Belgium, Sweden, Poland, and Russia. We have large stocks in warehouses in the United States, Canada, Germany, and

CAS: 38183-03-8 7 8-Dihydroxyflavone

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $1050.0 / 1100.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name:7, 8-dihydroxyflavone The alias:7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;DIHYDROXYFLAVONE,7,8-(RG);7,8-Dihydroxyflavonehydrate;7,8-dihydroxy-2-phenyl-1-benzopyran-4-one;8-Dihydroxyflavone;7,8-DIHYDROXYFLAVONE7,8-DIHYDROXYFLAVO

7, 8-dihydroxyflavone/CAS:38183-03-8/ made in China

Cas:38183-03-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

7,8-Dihydroxyflavone

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 38183-03-8 with best quality

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

7,8-DIHYDROXYFLAVONE CAS38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We specializing in the production of research and development of pharmaceutical intermediates, this kind of products with high quality price concessions, welcomed

7, 8-Dihydroxyflavone

Cas:38183-03-8

Min.Order:10 Gram

FOB Price: $90.0 / 100.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl- 38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: 7,8-DIHYDROXYFLAVONE Synonyms: 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-1-benzopyran-4-one;8-Dihydroxyflavone;7,8-DIHYDROXYFLAVONE 7,8

7,8-DIHYDROXYFLAVONE

Cas:38183-03-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 7,8-Dihydroxyflavone production plant Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilit

7,8-Dihydroxyflavone production plant

Cas:38183-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-

Cas:38183-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

7,8-dihydroxy Flavones, 7,8-DHF CAS NO.: 38183-03-8

Cas:38183-03-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Nootropics 7,8-DHF as a pro-neurotrophic treatment for neurodevelopmental disorders

Cas:38183-03-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales 7,8-DIHYDROXYFLAVONE CAS 38183-03-8 for 500MT/Year

Cas:38183-03-8

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

7,8-Dihydroxyflavone 38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $0.5

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

7,8-Dihydroxyflavone CAS 38183-03-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assemb

7,8-Dihydroxyflavone CAS 38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Wuhan BJM Pharm Inc.

We have two factories in Dezhou , Shandong and Xianning, Hubei. The factory covers an area of 48,000 square meters with the building area of 26,000 square meters. We are specialized in the manufacture of pharmaceutical intermediates and cosmetic addi

7,8-DIHYDROXYFLAVONE CAS No: 38183-03-8

Cas:38183-03-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

7,8-Dihydroxyflavone CAS 38183-03-8 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a stri

7,8-Dihydroxyflavone CAS 38183-03-8

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7,8-DIHYDROXYFLAVONE

Cas:38183-03-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

7,8-Dihydroxyflavone

Cas:38183-03-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Vegan Tropoflavin / 7,8-Dihydroxyflavone / 7,8-DHF

Cas:38183-03-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

7,8-dihydroxyflavone

Cas:38183-03-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:7,8-Dihydroxyflavon

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-

Cas:38183-03-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

7-hydroxyflavone
6665-86-7

7-hydroxyflavone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 80℃; for 24h;98%
With dipotassium peroxodisulfate; alkaline solution Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;
Multi-step reaction with 2 steps
1: aluminium chloride / 160 °C
2: aq. NaOH solution; aqueous hydrogen peroxide
View Scheme
With cytochromes P450 in human liver microsomes Kinetics; Enzymatic reaction;
C29H22O4
500866-00-2

C29H22O4

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 40℃; under 4560.31 - 6080.41 Torr;90.5%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; for 3h;83%
C29H18O6
110865-10-6

C29H18O6

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With sodium methylate In ethanol; dichloromethane63%
With water; sodium hydroxide In 1,4-dioxane; methanol at 20℃;
8-acetyl-7-hydroxy-2-phenyl-chromen-4-one
42345-27-7

8-acetyl-7-hydroxy-2-phenyl-chromen-4-one

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide
1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione
856084-77-0

1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With sodium acetate; acetic acid Erwaermen des Reaktionsprodukts mit methanol. Kalilauge;
ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

2-hydroxyresorcinol
87-66-1

2-hydroxyresorcinol

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With diphenylether
1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione
856084-77-0

1-(3,4-bis-benzoyloxy-2-hydroxy-phenyl)-3-phenyl-propane-1,3-dione

sodium acetate
127-09-3

sodium acetate

acetic acid
64-19-7

acetic acid

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
anschliessend Erhitzen mit wss.-methanol. Kalilauge;
2-hydroxyresorcinol
87-66-1

2-hydroxyresorcinol

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With aluminium trichloride; nitrobenzene Behandeln der Reaktionsloesung mit Phenylpropioloylchlorid und Benzol;
Multi-step reaction with 6 steps
1: boron trifluoride diethyl etherate / 50 - 100 °C / Inert atmosphere; Large scale
2: potassium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 90 - 110 °C / Inert atmosphere; Large scale
3: hydrogenchloride; acetic acid / water / 3 h / 20 °C
4: potassium hydroxide / water; ethanol / 20 - 30 °C
5: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere
6: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr
View Scheme
1-Phenyl-3-(2,3,4-trihydroxy-phenyl)-propane-1,3-dione
131944-43-9

1-Phenyl-3-(2,3,4-trihydroxy-phenyl)-propane-1,3-dione

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With sulfuric acid In acetic acid at 95 - 100℃; Yield given;
benzoic acid anhydride
93-97-0

benzoic acid anhydride

2.3.4-trioxy-acetophenone

2.3.4-trioxy-acetophenone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With sodium benzoate at 180 - 185℃; Kochen des Reaktionsprodukts mit waessrig-alkoholischer Kalilauge;
7.8-dimethoxy-flavone

7.8-dimethoxy-flavone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With hydrogen iodide
7-hydroxyflavone
6665-86-7

7-hydroxyflavone

aqueous alkaline solution

aqueous alkaline solution

potassium peroxo disulfate

potassium peroxo disulfate

A

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

B

7-hydroxy-2-phenyl-8-sulfooxy-chromen-4-one

7-hydroxy-2-phenyl-8-sulfooxy-chromen-4-one

2',3',4'-trihydroxyacetophenone
528-21-2

2',3',4'-trihydroxyacetophenone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) lithium bis(trimethyl)silyl amide (LiHMDS) / 1) THF, a) -78 deg C, b) -10 deg C, 2) THF, a) -78 deg C, b) room temp.
2: H2SO4 / acetic acid / 95 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 120 - 140 °C
2: water; sodium hydroxide / 1,4-dioxane; methanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 50 °C
2.1: trifluoroacetic acid / toluene / 2 h / 20 °C
3.1: potassium hydroxide / ethanol; water / 36 h / 20 °C
3.2: pH Ca. 5 / Cooling with ice
4.1: iodine; dimethyl sulfoxide / 12 h / 110 °C
5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 90 - 110 °C / Inert atmosphere; Large scale
2: hydrogenchloride; acetic acid / water / 3 h / 20 °C
3: potassium hydroxide / water; ethanol / 20 - 30 °C
4: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere
5: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

O5-benzoyl-O1,O2-isopropyliden-β-D-arabinofuranose

O5-benzoyl-O1,O2-isopropyliden-β-D-arabinofuranose

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) lithium bis(trimethyl)silyl amide (LiHMDS) / 1) THF, a) -78 deg C, b) -10 deg C, 2) THF, a) -78 deg C, b) room temp.
2: H2SO4 / acetic acid / 95 - 100 °C
View Scheme
4-oxo-2-phenyl-4H-chromen-7-yl acetate
72994-98-0

4-oxo-2-phenyl-4H-chromen-7-yl acetate

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminium chloride / 60 °C
2: aq. NaOH solution; aqueous hydrogen peroxide
View Scheme
C29H24O4
93827-33-9

C29H24O4

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iodine; dimethyl sulfoxide / 12 h / 110 °C
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
1-(2,3,4-tris(benzyloxy)phenyl)ethanone
50439-63-9

1-(2,3,4-tris(benzyloxy)phenyl)ethanone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / toluene / 2 h / 20 °C
2.1: potassium hydroxide / ethanol; water / 36 h / 20 °C
2.2: pH Ca. 5 / Cooling with ice
3.1: iodine; dimethyl sulfoxide / 12 h / 110 °C
4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride; acetic acid / water / 3 h / 20 °C
2: potassium hydroxide / water; ethanol / 20 - 30 °C
3: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere
4: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr
View Scheme
1-(3,4-bis(benzyloxy)-2-hydroxyphenyl)ethanone
2652-27-9

1-(3,4-bis(benzyloxy)-2-hydroxyphenyl)ethanone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydroxide / ethanol; water / 36 h / 20 °C
1.2: pH Ca. 5 / Cooling with ice
2.1: iodine; dimethyl sulfoxide / 12 h / 110 °C
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium hydroxide / water; ethanol / 20 - 30 °C
2: iodine / dimethyl sulfoxide / 7 h / 110 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol; tetrahydrofuran / 40 °C / 4560.31 - 6080.41 Torr
View Scheme
2',3',4'-trihydroxyacetophenone
528-21-2

2',3',4'-trihydroxyacetophenone

benzoyl chloride
98-88-4

benzoyl chloride

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Stage #1: 2',3',4'-trihydroxyacetophenone; benzoyl chloride With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene for 8h; Reflux;
Stage #2: With sodium hydroxide In 1,4-dioxane; methanol
Stage #1: 2',3',4'-trihydroxyacetophenone; benzoyl chloride With potassium carbonate In acetone for 12.1667h; Baker-Venkataraman Rearrangement; Inert atmosphere; Reflux;
Stage #2: In methanol; water for 3h; Inert atmosphere; Reflux;
2'-hydroxy-3',4'-dimethoxyacetophenone
5396-18-9

2'-hydroxy-3',4'-dimethoxyacetophenone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / 1 h / 75 °C
2.1: pyridine; potassium hydroxide / 2 h / 50 - 75 °C
3.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C
3.2: 0.5 h / 0 - 20 °C
4.1: boron tribromide / dichloromethane / Heating
View Scheme
7,8-dimethoxyflavone
65548-54-1

7,8-dimethoxyflavone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With boron tribromide In dichloromethane Heating;
1-(2-benzoyloxy-3,4-dimethoxy-phenyl)-ethanone

1-(2-benzoyloxy-3,4-dimethoxy-phenyl)-ethanone

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine; potassium hydroxide / 2 h / 50 - 75 °C
2.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C
2.2: 0.5 h / 0 - 20 °C
3.1: boron tribromide / dichloromethane / Heating
View Scheme
1-(2-hydroxy-3,4-dimethoxy-phenyl)-3-phenyl-propane-1,3-dione
169788-03-8

1-(2-hydroxy-3,4-dimethoxy-phenyl)-3-phenyl-propane-1,3-dione

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid; sulfuric acid / 1 h / 90 - 110 °C
1.2: 0.5 h / 0 - 20 °C
2.1: boron tribromide / dichloromethane / Heating
View Scheme
7-hydroxyflavone
6665-86-7

7-hydroxyflavone

A

7,4'-Dihydroxyflavon
2196-14-7

7,4'-Dihydroxyflavon

B

6,7-dihydroxyflavone
38183-04-9

6,7-dihydroxyflavone

C

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
With cytochromes P450 in human liver microsomes Kinetics; Enzymatic reaction;
FLAVONE
525-82-6

FLAVONE

A

7,4'-Dihydroxyflavon
2196-14-7

7,4'-Dihydroxyflavon

B

6,7-dihydroxyflavone
38183-04-9

6,7-dihydroxyflavone

C

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: cytochromes P450 in human liver microsomes / Enzymatic reaction
2: cytochromes P450 in human liver microsomes / Enzymatic reaction
View Scheme
FLAVONE
525-82-6

FLAVONE

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: cytochromes P450 in human liver microsomes / Enzymatic reaction
2: cytochromes P450 in human liver microsomes / Enzymatic reaction
View Scheme
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

methyl iodide
74-88-4

methyl iodide

7,8-dimethoxyflavone
65548-54-1

7,8-dimethoxyflavone

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h;94%
With potassium carbonate In acetone at 60℃;
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

allyl bromide
106-95-6

allyl bromide

2-phenyl-7,8-bis(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one

2-phenyl-7,8-bis(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Inert atmosphere; Reflux;78%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

7,8-dihydroxy 4-thioflavone

7,8-dihydroxy 4-thioflavone

Conditions
ConditionsYield
With Lawessons reagent In toluene at 40℃; for 0.5h; Substitution;77%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

4-oxo-2-phenyl-4H-chromene-7,8-diyl Bis(trifluoromethanesulfonate)
1257063-84-5

4-oxo-2-phenyl-4H-chromene-7,8-diyl Bis(trifluoromethanesulfonate)

Conditions
ConditionsYield
With pyridine In dichloromethane at -78 - 0℃; Inert atmosphere;76%
Stage #1: 7,8-dihydroxyflavone With pyridine In dichloromethane at -78℃; for 0.166667h; Inert atmosphere;
Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at -78 - 0℃; Inert atmosphere;
76%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

triethylamine
121-44-8

triethylamine

[Et3NH]2[{(O2)C15H8O2}3Si]

[Et3NH]2[{(O2)C15H8O2}3Si]

Conditions
ConditionsYield
With tetraethoxy orthosilicate In acetonitrile at 20℃; for 24h; Inert atmosphere;70%
3-chloro-3-methylbut-1-yne
1111-97-3

3-chloro-3-methylbut-1-yne

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

1,8-diazabicyclo[5.4.0]undec-7-ene
6674-22-2

1,8-diazabicyclo[5.4.0]undec-7-ene

7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one
786706-00-1

7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With CuCl2 In acetonitrile69%
3-chloro-3-methylbut-1-yne
1111-97-3

3-chloro-3-methylbut-1-yne

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one
786706-00-1

7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride In acetonitrile at 0 - 20℃;69%
With copper(l) iodide; potassium carbonate; potassium iodide In acetone at 50℃; for 4h;62%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

ethylenediamine
107-15-3

ethylenediamine

4-(7-phenyl-2,3-dihydro-1H-1,4-diazepin-5-yl)benzene-1,2,3-triol

4-(7-phenyl-2,3-dihydro-1H-1,4-diazepin-5-yl)benzene-1,2,3-triol

Conditions
ConditionsYield
In ethanol at 100℃;56%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

acetic anhydride
108-24-7

acetic anhydride

4-oxo-2-phenyl-4H-chromene-7,8-diyl diacetate
109688-08-6

4-oxo-2-phenyl-4H-chromene-7,8-diyl diacetate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;53.3%
With potassium carbonate In dichloromethane at 20℃;53.3%
With sodium acetate
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

2,3-dibromopropionic acid ethyl ester
3674-13-3

2,3-dibromopropionic acid ethyl ester

A

7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one
121869-37-2

7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

B

7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one
121869-36-1

7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 20h; Heating;A 8%
B 44%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

2,3-dibromopropionic acid ethyl ester
3674-13-3

2,3-dibromopropionic acid ethyl ester

1360

1360

A

7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one
121869-37-2

7,8-<3-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

B

7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one
121869-36-1

7,8-<2-(Ethoxycarbonyl)-ethylenedioxy>-2-phenyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 20h; Heating;A 8%
B 44%
BOC-glycine
4530-20-5

BOC-glycine

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

C29H32N2O10
1609067-52-8

C29H32N2O10

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In pyridine for 24h; Cooling with ice;25%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

isopentanoyl chloride
108-12-3

isopentanoyl chloride

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(3-methylbutanoate)
1609067-34-6

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(3-methylbutanoate)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;23.1%
With potassium carbonate In dichloromethane at 20℃;23.1%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

ethyl isocyanate
109-90-0

ethyl isocyanate

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(ethylcarbamate)
1609067-38-0

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(ethylcarbamate)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;22.5%
With potassium carbonate In dichloromethane at 20℃;22.5%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

5-deoxyscutellaprostin-A

5-deoxyscutellaprostin-A

Conditions
ConditionsYield
With silver carbonate In acetone; benzene at 60℃; for 24h;21%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

pivaloyl chloride
3282-30-2

pivaloyl chloride

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(2,2-dimethylpropanoate)
1609067-33-5

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(2,2-dimethylpropanoate)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;20.9%
With potassium carbonate In dichloromethane at 20℃;20.9%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(4-methylpiperazine-1-carboxylate).
1609067-46-0

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(4-methylpiperazine-1-carboxylate).

Conditions
ConditionsYield
Stage #1: 1-methyl-piperazine; bis(trichloromethyl) carbonate In tetrahydrofuran at -78℃; for 1h;
Stage #2: 7,8-dihydroxyflavone In pyridine; water; acetone at 0 - 20℃;
20.2%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

propionyl chloride
79-03-8

propionyl chloride

4-oxo-2-phenyl-4H-chromene-7,8-diyl dipropionate
1609067-36-8

4-oxo-2-phenyl-4H-chromene-7,8-diyl dipropionate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;17.4%
With potassium carbonate In dichloromethane at 20℃;17.4%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(dimethylcarbamate)
1609067-35-7

4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(dimethylcarbamate)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;15.9%
With potassium carbonate In dichloromethane at 20℃;15.9%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

diethyl (4-oxo-2-phenyl-4H-chromene-7,8-diyl) bis(carbonate)
1609067-37-9

diethyl (4-oxo-2-phenyl-4H-chromene-7,8-diyl) bis(carbonate)

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃;15.9%
With potassium carbonate In dichloromethane at 20℃;15.9%
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

7,8-dimethoxyflavone
65548-54-1

7,8-dimethoxyflavone

Conditions
ConditionsYield
With diethyl ether
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide
20757-83-9

[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

8-phenyl-[1,3]dioxolo[4,5-h]chromen-6-one
4476-32-8

8-phenyl-[1,3]dioxolo[4,5-h]chromen-6-one

Conditions
ConditionsYield
With potassium carbonate; acetone
7,8-dihydroxyflavone
38183-03-8

7,8-dihydroxyflavone

dimethyl sulfate
77-78-1

dimethyl sulfate

7,8-dimethoxyflavone
65548-54-1

7,8-dimethoxyflavone

Conditions
ConditionsYield
With potassium carbonate; acetone
With alkaline solution
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