5-Ethyl-2-pyridineethanol supplier

Name
5-Ethyl-2-pyridineethanol
EINECS 226-024-3
CAS No. 5223-06-3
Article Data10
CAS DataBase
Density 1.037 g/cm³
Solubility
Melting Point 39-44℃
Formula C₉H₁₃N O
Boiling Point 259.4 °C at 760 mmHg
Molecular Weight 151.208
Flash Point 110.7 °C
Transport Information
Appearance White to Straw Yellow Crystals
Safety 26-36/37/39-36
Risk Codes 21-36-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-(5-Ethyl-2-pyridinyl)ethanol;2-(5-Ethyl-2-pyridyl)ethanol;2-(5-Ethylpyridin-2-yl)ethanol;5-Ethyl-2-(2-hydroxyethyl)pyridine;5-Ethyl-2-(b-hydroxyethyl)pyridine;
PSA 33.12000
LogP 1.17880

Synthetic route

: 104-90-5
5-ethyl-2-methyl-pyridine

: 50-00-0
formaldehyd

A: 5408-74-2
5-ethyl-2-vinyl-pyridine

B: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; ethanol at 220℃;
In water at 155℃; under 4500.45 Torr; for 4h; Pressure; Autoclave;	A n/a B 70 g

...Expand

: 104-90-5
5-ethyl-2-methyl-pyridine

: 50-00-0
formaldehyd

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

Conditions

Conditions	Yield
With sodium hydroxide at 160 - 170℃;
With formic acid; water at 240℃; under 139011 Torr;
With formic acid; 3-tert-butylbenzene-1,2-diol In ethanol for 120h; Heating;
In water at 150 - 160℃; under 3750.38 - 4500.45 Torr; for 3h; Concentration; Time; Pressure; Temperature; Autoclave;

: 104-90-5
5-ethyl-2-methyl-pyridine

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

Conditions

Conditions	Yield
With formaldehyd

: 784149-51-5
3-(6-bromo-pyridin-3-yl)-2-methoxy-2-methyl-propionic acid methyl ester

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 3-{6-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-pyridin-3-yl}-2-methoxy-2-methyl-propionic acid methyl ester

Conditions

Conditions	Yield
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate; palladium diacetate In toluene for 16h; Heating;	100%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 124-63-0
methanesulfonyl chloride

: 144809-26-7
2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5 - 20℃; for 1.5h;	99%
With triethylamine In toluene at 5 - 20℃; for 0.833333h;	98%
With triethylamine In dichloromethane at 20℃; for 24h;	89%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1122-91-4
4-bromo-benzaldehyde

: 114393-97-4
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde

Conditions

Conditions	Yield
With 4,4-bis(2-naphthyl)-1,3,5,7,8-pentamethyl-2,4-diethyl-4-bora-3a,4a-diaza-s-indacene; N,N-dicyclohexylmethylamine; nickel dibromide In N,N-dimethyl-formamide at 40℃; for 48h; Reagent/catalyst; Inert atmosphere;	95%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 350-46-9
4-Fluoronitrobenzene

: 85583-54-6
4-(2-(5-ethyl-2-pyridyl)ethoxy)nitrobenzene

Conditions

Conditions	Yield
With Aliquat 336; sodium hydroxide In 1,2-dichloro-ethane at 0 - 5℃; for 4h; Solvent; Reagent/catalyst; Temperature;	94.4%
With sodium hydroxide In water at 20 - 35℃; for 16h; Product distribution / selectivity;	88.4%
With sodium hydroxide In water; dimethyl sulfoxide at 20 - 35℃; for 12h; Product distribution / selectivity;	88.11%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: (Z)-3,4-dibromo-5-(4-hydroxy-3-methoxybenzylidene)furan-2(5H)-one

: (Z)-3,4-dibromo-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)-3-methoxybenzylidene) furan-2(5H)-one

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement;	81.3%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 90643-32-6
2-(5-ethyl-1-oxypyridin-2-yl)ethanol

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid In water at 100℃; for 14h; Product distribution / selectivity;	81%
With dihydrogen peroxide In acetic acid at 100℃; for 14h;	81%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 3,4-dibromo-5-((4-hydrophenyl)methylene)furan-2(5H)-one

: (Z)-3,4-dibromo-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)furan-2(5H)-one

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement;	78.1%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: (Z)-3,4-dibromo-5-(3-ethoxy-4-hydroxybenzylidene)furan-2(5H)-one

: (Z)-3,4-dibromo-5-(3-ethoxy-4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene) furan-2(5H)-one

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement;	76.3%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1239911-39-7
4'-{[4-butyl-1-(5-hydroxypyrimidin-2-yl)-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

: 1251746-43-6
4'-{[4-butyl-1-{5-[2-(5-ethylpyridin-2-yl)ethoxy]pyrimidin-2-yl}-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; ethanol at 20℃; for 2h; Mitsunobu reaction; Inert atmosphere;	76%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 169772-25-2
tert-butyloxamic acid

: N-(tert-butyl)-3-ethyl-6-(2-hydroxyethyl)picolinamide

Conditions

Conditions	Yield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; tetraethylammonium tosylate In acetonitrile Schlenk technique; Inert atmosphere; Electrochemical reaction; Irradiation; Sealed tube;	73%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1194-02-1
4-fluorobenzonitrile

: 136402-00-1
4-[2-(5-ethylpyridin-2-yl)ethoxy] benzonitrile

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran	67%
With sodium hydride

: 33252-28-7
6-chloronicotinonitrile

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 695171-53-0
2-[2-(5-ethyl-2-pyridyl)ethoxy]-5-pyridonitrile

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 2h;	64.5%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 81684-30-2
5-ethyl-2-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In acetic acid under 3677.5 Torr;	63%
With acetic acid; platinum Hydrogenation;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 3,4-dichloro-5-(4-hydroxybenzylidene)furan-2(5H)-one

: (Z)-3,4-dichloro-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)furan-2(5H)-one

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -2 - 20℃; for 24.5h; Mitsunobu Displacement;	54.3%

: (-)-chalepin

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 32315-10-9
bis(trichloromethyl) carbonate

: C29H33NO6

Conditions

Conditions	Yield
Stage #1: (-)-chalepin; bis(trichloromethyl) carbonate With dmap In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 5-ethyl-2-(2-hydroxyethyl)pyridine In dichloromethane at 20℃; Inert atmosphere;	50%

...Expand

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 321371-23-7
3-(4-hydroxy-phenyl)-2-[(4-isopropyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester

: 3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-2-[(4-isopropyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Condensation;	46%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 4-formylphenyl(mesityl)iodonium bromide

: 114393-97-4
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde

Conditions

Conditions	Yield
Stage #1: 5-ethyl-2-(2-hydroxyethyl)pyridine With sodium hydride In tert-butyl methyl ether; mineral oil at 20℃; for 0.25h; Inert atmosphere; Sealed tube; Stage #2: 4-formylphenyl(mesityl)iodonium bromide In tert-butyl methyl ether; mineral oil at 50℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction;	45%

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
With aluminum oxide at 420℃;
With potassium hydroxide at 175℃; Erhitzen unter vermindertem Druck;
With potassium hydroxide Heating; Yield given;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 123-08-0
4-hydroxy-benzaldehyde

: 114393-97-4
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide; p-toluenesulfonyl chloride; benzyltri(n-butyl)ammonium chloride 1.) H2O, CH2Cl2, r.t., 2 h; 2.) H2O, 40-50 deg C, 12 h; Yield given. Multistep reaction;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 196810-09-0
(S)-2-<(2-benzoylphenyl)amino>-3-(4-hydroxyphenyl)propionic acid methyl ester

: 219653-68-6
(S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propionic acid methyl ester

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature;

: 7647-01-0
hydrogenchloride

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
at 160 - 170℃; nachfolgenden Erwaermen mit Natronlauge;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

potassium hydroxide: potassium hydroxide

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Destillation;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 64-17-5
ethanol

sodium: sodium

A: 116836-21-6
2,5-diethyl-piperidine

B 5-ethyl-2-<β-oxy-ethyl>-piperidine: 5-ethyl-2-<β-oxy-ethyl>-piperidine

...Expand

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-(4-hydroxy-benzyl)-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione

: (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Condensation;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 312689-81-9
(S)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-(4-hydroxy-benzyl)-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione

: 312689-59-1
(S)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Condensation;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 86788-49-0
7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester

: 616200-86-3
7-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-2-oxo-2H-chromene-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 74124-79-1
di(succinimido) carbonate

: N-succinimidyl 2-(5-ethylpyridin-2-yl)ethyl carbonate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 18h;

5-Ethyl-2-pyridineethanol Chemical Properties

5-Ethyl-2-pyridineethanol(5223-06-3) exists as white to straw yellow crystals.
Molecular Structure:
Molecular Formula: C9H13NO.
Molecular Weight: 151.21.
Density: 1.037 g/cm³.
Boiling Point: 127 ℃(5 mmHg).
Flash Point: 110.7 ℃.

5-Ethyl-2-pyridineethanol Uses

5-Ethyl-2-pyridineethanol(5223-06-3) is used as building block in chemical synthesis. 5-Ethyl-2-pyridineethanol(5223-06-3) is used as raw material of Pioglitazone that can cure sugar diabetes type two.

5-Ethyl-2-pyridineethanol Safety Profile

Harmful in contact with skin. Risk of serious damage to eyes. Toxic in contact with skin.

Product Name

5-Ethyl-2-pyridineethanol

Synthetic route

5-Ethyl-2-pyridineethanol Chemical Properties

5-Ethyl-2-pyridineethanol Uses

5-Ethyl-2-pyridineethanol Safety Profile

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