Bis(hexamethylene)triamine supplier

Name
BIS(HEXAMETHYLENE)TRIAMINE
EINECS 143-23-7
CAS No. 143-23-7
Article Data7
CAS DataBase
Density 0.887 g/cm³
Solubility 437g/L at 20℃
Melting Point 33-36 °C(lit.)
Formula C₁₂H₂₉N₃
Boiling Point 332.8 °C at 760 mmHg
Molecular Weight 215.382
Flash Point 175.2 °C
Transport Information
Appearance white solid.
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols C
Synonyms 1,6-Hexanediamine,N-(6-aminohexyl)- (9CI);Dihexylamine, 6,6'-diamino- (6CI,7CI,8CI);1,13-Diamino-7-azatridecane;7-Aza-1,13-tridecanediamine;BHMT-HP;Bis(6-aminohexamethyl)amine;Bis(6-aminohexyl)amine;Bis(aminohexyl)amine;Bis(hexamethylene)triamine;Dihexylenetriamine;Dytek BHMT-HP;N-(6-Aminohexyl)-1,6-hexanediamine;NSC 92231;
PSA 64.07000
LogP 3.40570

Synthetic route

: 652130-77-3
8-(2-(trimethylsilyl)ethanesulfonyl)-1,8,15-triazapentadecane

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 100℃;	46%

: 500309-42-2
N1,N13-diacetyl-1,13-diamino-7-azatridecane

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With hydrogenchloride for 2h; Heating; Yield given;

: 124-09-4
1,6-Hexanediamine

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 78 percent / 24 h / 100 °C 2: Raney Ni / benzene / 7 h / Heating 3: 2N HCl / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 49631-88-1
mono-N-acetylhexamethylenediamine

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney Ni / benzene / 7 h / Heating 2: 2N HCl / 2 h / Heating View Scheme

: 4048-33-3
6-amino-1-hexanol

A: 111-49-9
hexamethylene imine

B: 124-09-4
1,6-Hexanediamine

C: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

D: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With ammonia; hydrogen In tert-butyl alcohol at 220℃; under 120012 Torr; for 6h;	A 33 %Chromat. B 20.7 %Chromat. C n/a D n/a

...Expand

: 4048-33-3
6-amino-1-hexanol

A: 124-09-4
1,6-Hexanediamine

B: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 4048-33-3
6-amino-1-hexanol

A: 111-49-9
hexamethylene imine

B: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

C: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

...Expand

: 4048-33-3
6-amino-1-hexanol

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 4048-33-3
6-amino-1-hexanol

A: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

B: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 124-09-4
1,6-Hexanediamine

A: 111-49-9
hexamethylene imine

B: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

C: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With ammonia; hydrogen In tert-butyl alcohol at 220℃; under 120012 Torr; for 6h;

...Expand

: 111-49-9
hexamethylene imine

A: 124-09-4
1,6-Hexanediamine

B: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

C: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With ammonia; hydrogen In tert-butyl alcohol at 220℃; under 120012 Torr; for 6h;

...Expand

: 629-11-8
1,6-hexanediol

A: 111-49-9
hexamethylene imine

B: 124-09-4
1,6-Hexanediamine

C: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

D: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With ammonia; hydrogen In tert-butyl alcohol at 220℃; under 120012 Torr; for 4.5h; Kinetics; Temperature; Pressure; Time;	A 31.9 %Chromat. B 38.4 %Chromat. C n/a D n/a

...Expand

: 629-11-8
1,6-hexanediol

A: 124-09-4
1,6-Hexanediamine

B: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 629-11-8
1,6-hexanediol

A: 111-49-9
hexamethylene imine

B: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

C: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

...Expand

: 629-11-8
1,6-hexanediol

: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 4 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 4: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 629-11-8
1,6-hexanediol

A: 21920-79-6
6-(azepan-1-yl)hexan-1-amine

B: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 4.5 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 3 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme
Multi-step reaction with 4 steps 1: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 2: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 3: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr 4: hydrogen; ammonia; / tert-butyl alcohol / 6 h / 220 °C / 120012 Torr View Scheme

: 111-69-3
hexanedinitrile

A: 111-49-9
hexamethylene imine

B: 124-09-4
1,6-Hexanediamine

C: di(5-cyanopentyl)-amine

D: 2432-74-8
1-amino-5-cyanopentane

E: 143-23-7
1,8,15-triazapentadecane

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium hydroxide; hydrogen In ethanol at 349.84℃; under 15001.5 Torr; for 6h; Reagent/catalyst; Temperature; Pressure; Time; Flow reactor; Sealed tube; Inert atmosphere; Ionic liquid;

...Expand

: 143-23-7
1,8,15-triazapentadecane

: 98-59-9
p-toluenesulfonyl chloride

: 187839-67-4
N,N',N"-tritosyl-7-aza-tridecanetriamine

Conditions

Conditions	Yield
With potassium carbonate In water at 70℃; for 24h;	98%

: 143-23-7
1,8,15-triazapentadecane

: 19494-73-6
1-[(2-oxazepan-1-yl)carbonyl]azepan-2-one

: C26H47N5O4

Conditions

Conditions	Yield
	95%
In toluene at 80℃; for 20h; Inert atmosphere;	80%
In toluene at 60℃;
In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; for 8h; Inert atmosphere;

: cobalt pivalate

: chromium(III) fluoride tetrahydrate

: 143-23-7
1,8,15-triazapentadecane

: 75-98-9
Trimethylacetic acid

: [H2N((CH2)6NHCOtBu)2][Cr(III)7Co(II)F8(pivalate)16]

Conditions

Conditions	Yield
With ((CH3)3CCO)2O In further solvent(s) heating mixt. of 1 equiv. of triamine deriv., 5 equiv. of chromium compd., 1 equiv. of cobalt compd. and 6 equiv. of pivalic anhydride in pivalic acid at 160°C for 30 h;	92%

...Expand

: chromium(III) fluoride tetrahydrate

: [Ni2(μ-OH2)(μ-trimethylacetate)2(trimethylacetate)2(trimethylacetic acid)4]

: 143-23-7
1,8,15-triazapentadecane

: 75-98-9
Trimethylacetic acid

: [H2N((CH2)6NHCOtBu)2][Cr(III)7Ni(II)F8(pivalate)16]

Conditions

Conditions	Yield
With ((CH3)3CCO)2O In further solvent(s) heating mixt. of 1 equiv. of triamine deriv., 5 equiv. of chromium compd., 1 equiv. of nickel compd. and 6 equiv. of pivalic anhydride in pivalic acid at 160°C for 30 h;	92%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 143-23-7
1,8,15-triazapentadecane

: 187839-71-0
di-tert-butyl (((tert-butoxycarbonyl)azanediyl)bis(hexane-6,1-diyl))dicarbamate

Conditions

Conditions	Yield
In methanol for 12h;	91%
In dichloromethane for 12h;	82%

: 98519-65-4
7-chloro-4-bromo-quinoline

: 143-23-7
1,8,15-triazapentadecane

: N1-(7-chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-hexane-1,6-diamine

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane; water at 120℃; for 14h; Sealed tube; Inert atmosphere;	90%

: 143-23-7
1,8,15-triazapentadecane

: 57-06-7
N-allyl isothiocyanate

: C24H44N6S3

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h; Cooling with ice;	86%

: 143-23-7
1,8,15-triazapentadecane

: 74-88-4
methyl iodide

: 2,2,9,9,16,16-hexamethyl-2,9,16-triazoniaheptadecane triiodide

Conditions

Conditions	Yield
With 1,2,2,6,6-pentamethylpiperidine In N,N-dimethyl-formamide at 20℃;	85%

: 72652-31-4
2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one

: 143-23-7
1,8,15-triazapentadecane

: N,N'-(azanediylbis(hexane-6',1'-diyl))bis(4-chloro-1H-pyrrole- 2-carboxamide)

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;	84%

: manganese carbonate * 2 H2O

: chromium(III) fluoride tetrahydrate

: 143-23-7
1,8,15-triazapentadecane

: 75-98-9
Trimethylacetic acid

: [H2N((CH2)6NHCOtBu)2][Cr(III)7Mn(II)F8(pivalate)16]

Conditions

Conditions	Yield
With ((CH3)3CCO)2O In further solvent(s) heating mixt. of 1 equiv. of triamine deriv., 5 equiv. of chromium compd., 1 equiv. of manganese compd. and 6 equiv. of pivalic anhydride in pivalic acid at 160°C for 30 h;	81%

...Expand

: 143-23-7
1,8,15-triazapentadecane

: 298-12-4
Glyoxilic acid

: 454466-23-0
[6-(6-amino-hexylamino)-hexylamino]-acetic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃;	80%

: tert-butyl {[(tert-butoxycarbonyl)imino](1H-pyrazol-1-yl)methyl}(ethyl)carbamate

: 143-23-7
1,8,15-triazapentadecane

: tert‐butyl N‐({[6‐({6‐[({[(tert‐butoxy)carbonyl](ethyl)amino}({[(tert‐butoxy)carbonyl]imino})methyl)amino]hexyl}amino)hexyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)‐N‐ethylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at 20℃; for 16h;	80%

: 143-23-7
1,8,15-triazapentadecane

: N,N′-di-boc-N-crotyl-1H-pyrazole-1-carboxamidine

: C27H53N5O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol; acetonitrile at 50℃; for 5h;	79%

: 143-23-7
1,8,15-triazapentadecane

: 83-44-3
Deoxycholic acid

: (4R,4'R)-N,N'-(azanediylbis(hexane-6,1-diyl))bis(4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide)

Conditions

Conditions	Yield
Stage #1: 1,8,15-triazapentadecane; Deoxycholic acid With benzotriazol-1-ol; triethylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 24h; Inert atmosphere;	79%

: 50371-52-3
4,5-dibromopyrrol-2-yl trichloromethyl ketone

: 143-23-7
1,8,15-triazapentadecane

: N,N'-(azanediylbis(hexane-6',1'-diyl))bis(4,5-dibromo-1H-pyrrole-2-carboxamide)

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;	78%
In tetrahydrofuran at 19℃; for 36h;	68%

: 143-23-7
1,8,15-triazapentadecane

: 76-83-5
trityl chloride

: N-trityl-N'-[6-(trityl-amino)-hexyl]-hexane-1,6-diamine

Conditions

Conditions	Yield
With triethylamine In chloroform	75%

: zinc(II) hydroxide carbonate

: chromium(III) fluoride tetrahydrate

: 143-23-7
1,8,15-triazapentadecane

: 75-98-9
Trimethylacetic acid

: [H2N((CH2)6NHCOtBu)2][Cr(III)7Zn(II)F8(pivalate)16]

Conditions

Conditions	Yield
With ((CH3)3CCO)2O In further solvent(s) heating mixt. of 1 equiv. of triamine deriv., 5 equiv. of chromium compd., 1 equiv. of zinc compd. and 6 equiv. of pivalic anhydride in pivalic acid at 160°C for 30 h;	75%

...Expand

: 143-23-7
1,8,15-triazapentadecane

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: tert‐butyl N‐[({6‐[(6‐aminohexyl)amino]hexyl}amino)({[(tert‐butoxy)carbonyl]amino})methylidene]carbamate

Conditions

Conditions	Yield
In tetrahydrofuran; methanol at 50℃; for 16h;	74%

: 143-23-7
1,8,15-triazapentadecane

: 81-25-4
cholic acid

: (4R,4'R)-N,N'-(azanediylbis(hexane-6,1-diyl))bis(4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide)

Conditions

Conditions	Yield
Stage #1: 1,8,15-triazapentadecane; cholic acid With benzotriazol-1-ol; triethylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 24h; Inert atmosphere;	72%

: S-methylisothiourea hemisulphate

: 143-23-7
1,8,15-triazapentadecane

: 13516-25-1
1,1‘-(azanediylbis(hexane-6,1-diyl))diguanidine

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 16h;	71%
With hydrogen bromide; acetic acid In ethanol; water at 20℃; for 16h;	71%

: 124-09-4
1,6-Hexanediamine

: 111-26-2
hexan-1-amine

: 143-23-7
1,8,15-triazapentadecane

: 111-49-9
hexamethylene imine

Conditions

Conditions	Yield
	70%

...Expand

: 143-23-7
1,8,15-triazapentadecane

: tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)(cyclopropylmethyl)carbamate

: tert‐butyl N‐({[6‐({6‐[({[(tert‐butoxy)carbonyl](cyclopropylmethyl)amino}({[(tert‐butoxy)carbonyl]imino})methyl)amino]hexyl}amino)hexyl]amino}({[(tert‐butoxy)carbonyl]imino})methyl)‐N‐(cyclopropylmethyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at 20℃; for 16h;	69%

: 24424-99-5
di-tert-butyl dicarbonate

: 143-23-7
1,8,15-triazapentadecane

: 86536-93-8
N1-Boc-N6-(6-(Boc-amino)hexyl)hexane-1,6-diamine

Conditions

Conditions	Yield
In methanol at -80℃; for 1h;	68%

: malachite

: chromium(III) fluoride tetrahydrate

: 143-23-7
1,8,15-triazapentadecane

: 75-98-9
Trimethylacetic acid

: [H2N((CH2)6NHCOtBu)2][Cr(III)7Cu(II)F8(pivalate)16]

Conditions

Conditions	Yield
With ((CH3)3CCO)2O In further solvent(s) heating mixt. of 1 equiv. of triamine deriv., 5 equiv. of chromium compd., 1 equiv. of copper compd. and 6 equiv. of pivalic anhydride in pivalic acid at 160°C for 30 h;	64%

...Expand

: 143-23-7
1,8,15-triazapentadecane

: 81-25-4
cholic acid

: (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N,N-bis(6-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)hexyl)pentanamide

Conditions

Conditions	Yield
Stage #1: 1,8,15-triazapentadecane; cholic acid With benzotriazol-1-ol; triethylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; for 24h; Inert atmosphere;	62%

: 143-23-7
1,8,15-triazapentadecane

: 100-52-7
benzaldehyde

: 1135274-04-2
N1-benzyl-N6-(6-(benzylamino)hexyl)hexane-1,6-diamine

Conditions

Conditions	Yield
Stage #1: 1,8,15-triazapentadecane; benzaldehyde In isopropyl alcohol at 0 - 20℃; for 2h; Stage #2: With hydrogen; palladium 10% on activated carbon In isopropyl alcohol under 1500.15 Torr; for 16h;	61%

: 2483-46-7, 65360-27-2, 119962-72-0
2,6-bis-tert-butoxycarbonylamino-hexanoic acid

: 143-23-7
1,8,15-triazapentadecane

: N1-(Boc-Lys-Boc)-N6-[{6-(Boc-Lys-Boc)amido}hexyl]hexane-1,6-diamine

Conditions

Conditions	Yield
Stage #1: 2,6-bis-tert-butoxycarbonylamino-hexanoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; Stage #2: 1,8,15-triazapentadecane In dichloromethane; N,N-dimethyl-formamide for 48h;	60%

: 143-23-7
1,8,15-triazapentadecane

: tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)(cyclopropylmethyl)carbamate

: C27H53N5O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol; acetonitrile at 50℃; for 5h;	57%

: 1135274-06-4
C27H33NO5S

: 143-23-7
1,8,15-triazapentadecane

: 1135274-08-6
C69H101N3O12S3

Conditions

Conditions	Yield
In isopropyl alcohol for 16h; Heating / reflux;	52%

Bis(hexamethylene)triamine Specification

The Bis(hexamethylene)triamine is an organic compound with the formula C₁₂H₂₉N₃. The systematic name of this chemical is N-(6-aminohexyl)hexane-1,6-diamine. With the CAS registry number 143-23-7, it is also named as 1,6-Hexanediamine, N- (6-aminohexyl)-.

Physical properties about Bis(hexamethylene)triamine are: (1)ACD/LogP: 0.98; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -4.12; (4)ACD/LogD (pH 7.4): -4.11; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 14; (12)Polar Surface Area: 9.72 Å²; (13)Index of Refraction: 1.474; (14)Molar Refractivity: 68.3 cm³; (15)Molar Volume: 242.7 cm³; (16)Polarizability: 27.07×10^-24cm³; (17)Surface Tension: 36.2 dyne/cm; (18)Density: 0.887 g/cm³; (19)Flash Point: 175.2 °C; (20)Enthalpy of Vaporization: 57.56 kJ/mol; (21)Boiling Point: 332.8 °C at 760 mmHg; (22)Vapour Pressure: 0.000143 mmHg at 25°C.

Uses of Bis(hexamethylene)triamine: it can be used to produce N-trityl-N'-[6-(trityl-amino)-hexyl]-hexane-1,6-diamine. It will need reagent Et₃N and solvent CHCl₃. The yield is about 75%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical can cause burns. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: NCCCCCCNCCCCCCN
(2)InChI: InChI=1/C12H29N3/c13-9-5-1-3-7-11-15-12-8-4-2-6-10-14/h15H,1-14H2
(3)InChIKey: MRNZSTMRDWRNNR-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C12H29N3/c13-9-5-1-3-7-11-15-12-8-4-2-6-10-14/h15H,1-14H2
(5)Std. InChIKey: MRNZSTMRDWRNNR-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LDLo	skin	200mg/kg (200mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI LIVER: OTHER CHANGES	National Technical Information Service. Vol. OTS0534833,
rat	LD50	oral	450mg/kg (450mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0534833,

Product Name

BIS(HEXAMETHYLENE)TRIAMINE

Synthetic route

Bis(hexamethylene)triamine Specification

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