Bromofluoromethane supplier

Name
Bromofluoromethane
EINECS 206-770-6
CAS No. 373-52-4
Article Data8
CAS DataBase
Density 1.773 g/cm³
Solubility
Melting Point
Formula CH₂BrF
Boiling Point 19 °C at 760 mmHg
Molecular Weight 112.929
Flash Point None
Transport Information
Appearance Clear colourless to light yellow liquid
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols T
Synonyms Fluorobromomethane;
PSA 0.00000
LogP 1.30830

Synthetic route

: 1868-53-7
dibromofluoromethane

: 373-52-4
bromofluoromethane

Conditions

Conditions	Yield
	53.1%
With sodium amalgam In water; isopropyl alcohol	50%

: 1868-53-7
dibromofluoromethane

A: 593-53-3
Methyl fluoride

B: 373-52-4
bromofluoromethane

Conditions

Conditions	Yield
With ethanol; zinc

: 353-59-3
halon-1211

A: 1511-62-2
bromodifluoromethane

B: 75-10-5
Difluoromethane

C: 373-52-4
bromofluoromethane

D: 75-09-2
dichloromethane

E: 75-45-6
Chlorodifluoromethane

F: 74-95-3
1,1-dibromomethane

Conditions

Conditions	Yield
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea;

...Expand

: 34557-54-5
methane

: 75-63-8
Bromotrifluoromethane

A: 74-83-9
methyl bromide

B: 593-60-2
Vinyl bromide

C: 373-52-4
bromofluoromethane

D: 75-46-7
trifluoromethan

E: 75-38-7
Vinylidene fluoride

F: 74-95-3
1,1-dibromomethane

Conditions

Conditions	Yield
Mn exchaged zeolite ZSM-5 at 599.85℃; Product distribution; other catalysts, temp.;

...Expand

: 13126-91-5
silver(I) monofluoroacetate

: 373-52-4
bromofluoromethane

Conditions

Conditions	Yield
With bromine at 20 - 80℃; for 1h; Bromination;
With bromine at 50 - 120℃; for 6h; Sealed tube;	1.4 g

silver-fluoroacetate: silver-fluoroacetate

: 373-52-4
bromofluoromethane

Conditions

Conditions	Yield
With bromine

: 1868-53-7
dibromofluoromethane

: 64-17-5
ethanol

zinc: zinc

A: 593-53-3
Methyl fluoride

B: 373-52-4
bromofluoromethane

...Expand

: 397864-40-3
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid

: 373-52-4
bromofluoromethane

: 397864-44-7
fluticasone furoate

Conditions

Conditions	Yield
In butanone at 0 - 22℃;	99.3%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at -20℃;	88%
Stage #1: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid With sodium carbonate In N,N-dimethyl-formamide at -15 - -5℃; for 0.25h; Stage #2: bromofluoromethane In N,N-dimethyl-formamide at -15 - -5℃; for 3.3h;	79.08%

: 373-52-4
bromofluoromethane

: 4-bromobutyl thiophene-2-carboxylate

: C10H13FO2S

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	97%

: 373-52-4
bromofluoromethane

: 1356857-65-2
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-3-methyl-4-(hydroxyimino) pyrrolidine-1-carboxylate

: 1356857-68-5
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-3-methyl-4-(fluoromethoxyimino)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene at 20℃; Cooling;	96.1%

: 373-52-4
bromofluoromethane

: C11H11BrO4

: C12H13FO4

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	96%

: 373-52-4
bromofluoromethane

: 20017-68-9
1-bromo-3,3-diphenylpropane

: 4,4-diphenyl-1-fluorobutane

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	96%

: 373-52-4
bromofluoromethane

: 175463-36-2
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-4-(hydroxyimino)pyrrolidine-1-carboxylate

: 1356857-66-3
tert-butyl 3-((tert-butoxycarbonylamino)methyl)-4-(fluoromethoxyimino)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene at 0 - 20℃;	95%

: 373-52-4
bromofluoromethane

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 64747-74-6
(4-(fluoromethyl)phenyl)(phenyl)methanone

Conditions

Conditions	Yield
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere;	95%

: 373-52-4
bromofluoromethane

: 573-17-1
9-bromophenanthrene

: 9-(fluoromethyl)phenanthrene

Conditions

Conditions	Yield
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere;	95%

: 373-52-4
bromofluoromethane

: 3-bromopropyl 2-(4-isobutylphenyl)propanoate

: C17H25FO2

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	95%

: 1-(4-bromobutoxy)-4-(trifluoromethyl)benzene

: 373-52-4
bromofluoromethane

: C12H14F4O

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	95%

: 373-52-4
bromofluoromethane

: 142253-54-1
tert-butyl 3-cyanoazetidine-1-carboxylate

: 1228581-11-0
tert-butyl 3-cyano-3-(fluoromethyl)azetidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tert-butyl 3-cyanoazetidine-1-carboxylate With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: bromofluoromethane In tetrahydrofuran at -78 - 25℃; for 16.5h; Stage #3: With ammonium chloride In tetrahydrofuran; water at 0℃;	94%

: 439948-95-5
(S)-tert-butyl 1-(7-hydroxy-2,3-dihydro-1H-pyrrolo-[1,2-a]indol-9-yl)propan-2-ylcarbamate

: 373-52-4
bromofluoromethane

: (S)-tert-butyl 1-[7-(fluoromethoxy)-2,3-dihydro-1H-pyrrolo-[1,2-a]indol-9-yl]propan-2-ylcarbamate

Conditions

Conditions	Yield
Stage #1: (S)-tert-butyl 1-(7-hydroxy-2,3-dihydro-1H-pyrrolo-[1,2-a]indol-9-yl)propan-2-ylcarbamate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: bromofluoromethane In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Inert atmosphere;	94%

: 53087-13-1
3-(benzyloxy)phenyl bromide

: 373-52-4
bromofluoromethane

: 1-(benzyloxy)-3-(fluoromethyl)benzene

Conditions

Conditions	Yield
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere;	94%

: 373-52-4
bromofluoromethane

: 637-59-2
1-Bromo-3-phenylpropane

: 909912-96-5
4-fluoro-1-phenylbutane

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Sealed tube; Glovebox;	94%

: 373-52-4
bromofluoromethane

: C11H13BrO3

: C12H15FO3

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	94%

: 185112-61-2
9-(3-bromophenyl)carbazole

: 373-52-4
bromofluoromethane

: 9-(3-(fluoromethyl)phenyl)-9H-carbazole

Conditions

Conditions	Yield
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere;	93%

: 26608-06-0
3-bromodibenzofuran

: 373-52-4
bromofluoromethane

: 3-(fluoromethyl)dibenzo[b,d]furan

Conditions

Conditions	Yield
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere;	93%

: 373-52-4
bromofluoromethane

: 3439-71-2
4-<(4-bromobutyl)oxy>-3-methoxybenzaldehyde

: C13H17FO3

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	93%

: 373-52-4
bromofluoromethane

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 1-benzyloxy-4-fluorobutane

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	93%

: 373-52-4
bromofluoromethane

: 3-bromopropyl 1-naphthoate

: C15H15FO2

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	93%

: 373-52-4
bromofluoromethane

: C8H9BrO3

: C9H11FO3

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	93%

: 373-52-4
bromofluoromethane

: C18H27BrO3

: C19H29FO3

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	92%

: 373-52-4
bromofluoromethane

: C18H23BrO3

: C19H25FO3

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	92%

: 373-52-4
bromofluoromethane

: 588-63-6
3-phenoxypropyl bromide

: 70659-95-9
(4-fluorobutoxy)benzene

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	92%

: 373-52-4
bromofluoromethane

: C10H6BrF5O2

: C11H8F6O2

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	92%

: 373-52-4
bromofluoromethane

: C13H14BrNO2

: C14H16FNO2

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;	92%

: 373-52-4
bromofluoromethane

: 80474-45-9
17-propionate carbothioic acid

: 80474-14-2
flixotide

Conditions

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h;	91.7%
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity;	84.51%
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: bromofluoromethane In acetone at 0 - 5℃;	80%

: 373-52-4
bromofluoromethane

: C26H28F2O6S

: fluticasone furoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at -10 - 0℃; for 16h; Inert atmosphere;	91.12%

: 373-52-4
bromofluoromethane

: 5122-94-1
4-biphenylboronic acid

: 4-(fluoromethyl)-1,1‘-biphenyl

Conditions

Conditions	Yield
With dmap; 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); potassium carbonate In 1,4-dioxane at 70℃; for 12h; Reagent/catalyst; Solvent; Concentration; Suzuki Coupling;	91%
With dmap; 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); potassium carbonate In 1,4-dioxane; 1,2-dimethoxyethane at 70℃; for 24h; Catalytic behavior; Kinetics; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Inert atmosphere;	90%

: 373-52-4
bromofluoromethane

: 1591-31-7
4-iodo-biphenyl

: 4-(fluoromethyl)-1,1‘-biphenyl

Conditions

Conditions	Yield
With pyridine-4-carbonitrile; nickel(II) iodide; manganese; 4,4'-dimethyl-2,2'-bipyridines In N,N-dimethyl acetamide at 40℃; for 24h; Inert atmosphere; Sealed tube;	91%

Bromofluoromethane Specification

The Methane, bromofluoro-(6CI,7CI,8CI,9CI) is an organic compound with the formula CH₂BrF. The IUPAC name of this chemical is bromo(fluoro)methane. With the CAS registry number 373-52-4, it is also named as Bromofluoromethane. The product's category is Fluoro-containing Compounds. Besides, it is clear colourless to light yellow liquid, which is an important reagent in the manufacture of intermediates, pharmaceuticals and other chemicals.

Physical properties about Methane, bromofluoro-(6CI,7CI,8CI,9CI) are: (1)ACD/LogP: 0.94; (2)ACD/LogD (pH 5.5): 0.94; (3)ACD/LogD (pH 7.4): 0.94; (4)ACD/BCF (pH 5.5): 3.03; (5)ACD/BCF (pH 7.4): 3.03; (6)ACD/KOC (pH 5.5): 76.99; (7)ACD/KOC (pH 7.4): 76.99; (8)Index of Refraction: 1.375; (9)Molar Refractivity: 14.57 cm³; (10)Molar Volume: 63.6 cm³; (11)Polarizability: 5.77×10^-24cm³; (12)Surface Tension: 19.3 dyne/cm; (13)Density: 1.773 g/cm³; (14)Enthalpy of Vaporization: 25.49 kJ/mol; (15)Boiling Point: 19 °C at 760 mmHg; (16)Vapour Pressure: 940 mmHg at 25°C.

Uses of Methane, bromofluoro-(6CI,7CI,8CI,9CI): it can be used to produce 2-acetylamino-2-fluoromethyl-malonic acid diethyl ester at temperature of -35 °C. This reaction is a kind of Alkylation. It will need reagent (Et₂N)₃P=NMe and solvent CH₂Cl₂. The yield is about 49.9%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: BrCF
(2)InChI: InChI=1/CH2BrF/c2-1-3/h1H2
(3)InChIKey: LHMHCLYDBQOYTO-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/CH2BrF/c2-1-3/h1H2
(5)Std. InChIKey: LHMHCLYDBQOYTO-UHFFFAOYSA-N

Product Name

Bromofluoromethane

Synthetic route

Bromofluoromethane Specification

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