Conditions | Yield |
---|---|
sulfuric acid at 89℃; under 127 Torr; Continuous process; | 99.8% |
In neat (no solvent) at 80℃; for 3h; | 90% |
With sulfuric acid |
Conditions | Yield |
---|---|
Stage #1: acrylic acid With hydroquinone; sodium hydroxide In water at 0 - 20℃; for 0.5h; Large scale; Stage #2: 1-bromo-butane With Aliquat 336; potassium iodide at 70 - 80℃; for 3h; Reagent/catalyst; Temperature; Large scale; | 89.6% |
zirconocene dichloride
hex-3-yne
butyl 2-bromoacrylate
A
acrylic acid n-butyl ester
B
butyl 2,3,4,5-tetraethylbenzoate
Conditions | Yield |
---|---|
Stage #1: zirconocene dichloride With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: hex-3-yne In tetrahydrofuran at 20℃; Inert atmosphere; Stage #3: butyl 2-bromoacrylate Further stages; | A n/a B 67% |
carbon monoxide
acetylene
butan-1-ol
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With bis(acetylacetonate)nickel(II); sodium acetylacetonate In tetrahydrofuran at 230℃; under 1500.15 - 35253.5 Torr; for 0.75h; Reagent/catalyst; Temperature; Pressure; Solvent; Autoclave; | 65.4% |
With copper(ll) bromide; nickel dibromide In acetylacetone at 200℃; under 60006 Torr; | |
With 2-Picolinic acid In tetrahydrofuran at 200℃; under 1500.15 - 37503.8 Torr; for 1h; Autoclave; Inert atmosphere; | |
With nickel(II) sulfamate; 7-propyl-8-hydroxyquinoline; diethylaluminium chloride; triphenylphosphine In n-heptane at 80℃; under 29252.9 - 30753.1 Torr; for 0.666667h; Reagent/catalyst; Solvent; Temperature; Pressure; Autoclave; Inert atmosphere; |
Conditions | Yield |
---|---|
Continuous process; | A n/a B 60% |
Conditions | Yield |
---|---|
With triethylamine In diethyl ether for 16h; Heating; | 53% |
With triethylamine In chloroform at 10℃; for 12h; |
butan-1-ol
A
acrylic acid n-butyl ester
B
2-carboxyethyl acrylate
C
acrylic acid
Conditions | Yield |
---|---|
at 280℃; under 48754.9 Torr; for 0.0933333h; Product distribution / selectivity; | A 31% B 30% C 52% |
Conditions | Yield |
---|---|
With <(2,2'-bipyridine)(2,2':6',2''-terpyridine)RuO>2+; phosphate buffer pH 8.1 for 24h; Ambient temperature; electrocatalytic oxidation with Ru(IV)-complex; | 42% |
Conditions | Yield |
---|---|
With boron fluoride ether at 250℃; Behandeln des Reaktionsprodukts mit Butan-1-ol und Erhitzen des mit Schwefelsaeure versetzten Reaktionsgemisches; |
Conditions | Yield |
---|---|
With lead acetate; silica gel at 400℃; |
Conditions | Yield |
---|---|
With quartz at 510 - 530℃; |
Conditions | Yield |
---|---|
With catalyst from lithium dihydrogenphosphate and graphite at 510℃; |
Conditions | Yield |
---|---|
With sulfuric acid zuletzt bei 160grad; |
Conditions | Yield |
---|---|
With phosphoric acid; pumice stone; hydroquinone; butan-1-ol at 180℃; |
Conditions | Yield |
---|---|
With sulfuric acid Erhitzen des Reaktionsprodukts mit Butan-1-ol oder wenig Wasser auf 170grad; |
acrylic acid methyl ester
butan-1-ol
A
methanol
B
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
at 58 - 85℃; Equilibrium constant; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; hydroquinone Abdestillieren des entstandenen Methanols als azeotropes Gemisch mit Methylacrylat; |
3-chloro-propionic acid butyl ester
N,N-diethylaniline
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
at 200℃; |
butyl 3-bromopropanate
N,N-diethylaniline
A
1-bromo-butane
B
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
at 200℃; |
5-Oxo-5-pyridin-4-yl-pentanoic acid butyl ester; hydrochloride
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
In acetonitrile Quantum yield; Irradiation; |
p-(γ-carbobutoxybutyryl)pyridine
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
In acetonitrile Quantum yield; Irradiation; |
Conditions | Yield |
---|---|
With porcine pancreatic lipase In tetrahydrofuran for 48h; Ambient temperature; Yield given; | |
With zirconium(IV) acetylacetonate; 4-methoxy-phenol at 70℃; for 2.91667h; Kinetics; Reagent/catalyst; Inert atmosphere; | |
With 10H-phenothiazine; 2,6-di-tert-butyl-4-methyl-phenol; 4-methoxy-phenol; di(n-butyl)tin oxide at 110℃; under 60.006 - 97.5098 Torr; for 4.5h; |
carbon monoxide
acetylene
butan-1-ol
A
propionic acid butyl ester
B
acrylic acid n-butyl ester
C
dibutyl succinate
Conditions | Yield |
---|---|
With hydrogenchloride; dicarbonyl(η5-cyclopentadienyl)nitrosylchromium at 70℃; under 750.06 Torr; Rate constant; other catalysts; |
carbon monoxide
acetylene
butan-1-ol
A
Dibutyl maleate
B
acrylic acid n-butyl ester
C
dibutyl succinate
D
dibutyl fumarate
Conditions | Yield |
---|---|
(PdPPh3Cl2)CO at 25℃; Product distribution; effect of the catalyst to the production and the selectivity; |
Conditions | Yield |
---|---|
In 2,2,4-trimethylpentane at 37℃; immobilized lipase from Candida cylindracea; |
2,3-butanedione mono-oxime acrylate
butan-1-ol
A
acrylic acid n-butyl ester
B
butane-2,3-dione mono-oxime
Conditions | Yield |
---|---|
With porcine pancreatic lipase In tetrahydrofuran for 48h; Ambient temperature; Yield given; |
cyclohexanone oxime acrylate
butan-1-ol
A
Cyclohexanone oxime
B
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With porcine pancreatic lipase In tetrahydrofuran for 48h; Ambient temperature; Yield given; |
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With N,N-diethylaniline at 200℃; |
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
at 240℃; |
Conditions | Yield |
---|---|
With hydrogen; Pd(II) complex containing tridentate hydrazonic ligands In methanol at 40℃; for 5h; Hydrogenation; | 100% |
With C44H40IrNP2; hydrogen In benzene-d6 at 25℃; under 760.051 Torr; Catalytic behavior; Reagent/catalyst; Schlenk technique; | 100% |
With hydrogen; Pd-polymethylhydrosiloxane nanocomposite In benzene at 20℃; for 4h; | 94% |
acrylic acid n-butyl ester
Butyl 2,3-dibromopropanoate
Conditions | Yield |
---|---|
With bromine In dichloromethane at 0 - 20℃; for 15h; Inert atmosphere; | 100% |
With bromine In tetrachloromethane | 96% |
With bromine at 20℃; | 96% |
With bromine In tetrachloromethane; dichloromethane | 77% |
With bromine In acetic acid at 30℃; Mechanism; Rate constant; |
bromobenzene
acrylic acid n-butyl ester
(E)-3-(phenyl)acrylic acid butyl ester
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; sodium carbonate; [PdClMe(MeSC6H4CH2PPh2)] at 130℃; for 72h; Heck arylation; | 100% |
With tetrabutylammonium acetate; resin-PPh2-Pd(OAc)2 In carbon dioxide at 120℃; under 155149 Torr; for 16h; Heck reaction; | 100% |
With tetrabutylammonium acetate; polyurea-encapsulated Pd(OAc)2 In various solvent(s) at 100℃; Heck reaction; | 99% |
1-bromo-4-methoxy-benzene
acrylic acid n-butyl ester
(E)-3-(4-methoxyphenyl)acrylic acid butyl ester
Conditions | Yield |
---|---|
With 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 130℃; for 20h; Heck cross-coupling; | 100% |
With phenyl carbamate; tetrabutylammomium bromide; potassium carbonate; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 2h; Heck-type reaction; | 99% |
With potassium carbonate; di-μ-acetato-bis[2-[bis(1,1-dimethylethyl)phosphino]-2-methylpropyl-C,P]dipalladium In ISOPROPYLAMIDE | 99.2% |
acrylic acid n-butyl ester
4-bromo-benzaldehyde
butyl (E)-4-formylcinnamate
Conditions | Yield |
---|---|
With 2-n-butyl-1,1,1,3,3-tetramethylguanidine acetate; palladium dichloride at 140℃; for 0.25h; | 100% |
With sodium acetate In ISOPROPYLAMIDE | 100% |
With sodium acetate In ISOPROPYLAMIDE | 100% |
acrylic acid n-butyl ester
para-bromoacetophenone
(E)-3-(4-acetylphenyl)acrylic acid butyl ester
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate In N,N-dimethyl acetamide at 100℃; for 3h; Product distribution; Further Variations:; Reagents; Heck reaction; | 100% |
With tributyl-amine In N,N-dimethyl-formamide at 150℃; for 1h; Heck reaction; | 100% |
With C29H33Cl2N5Pd; tetrabutylammomium bromide; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 4h; Heck reaction; Inert atmosphere; | 100% |
iodobenzene
acrylic acid n-butyl ester
(E)-3-(phenyl)acrylic acid butyl ester
Conditions | Yield |
---|---|
With triethylamine; polymer(fiber)-supported palladium In 1,4-dioxane at 100℃; for 2h; Heck reaction; | 100% |
With caesium carbonate; 1,3-bis(mesityl)imidazolium chloride; bis(acetylacetonate)nickel(II) In N,N-dimethyl-formamide at 150℃; for 3h; Heck reaction; | 100% |
With tetramethylquanidine; sodium acetate; palladium dichloride In N,N-dimethyl acetamide at 140℃; for 2h; Heck reaction; | 100% |
acrylic acid n-butyl ester
para-nitrophenyl bromide
(E)-n-butyl 4-nitrocinnamate
Conditions | Yield |
---|---|
With tetramethylquanidine; sodium acetate; palladium dichloride In N,N-dimethyl acetamide at 140℃; for 20h; Heck reaction; | 100% |
With 2-n-butyl-1,1,1,3,3-tetramethylguanidine acetate; palladium dichloride at 140℃; for 0.25h; | 100% |
With tri-n-propylamine In 1-methyl-pyrrolidin-2-one at 125℃; for 1h; Mizoroki-Heck reaction; Inert atmosphere; | 100% |
iodobenzene
acrylic acid n-butyl ester
n-butyl cinnamate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 140℃; for 24h; Heck reaction; | 100% |
With tributyl-amine In N,N-dimethyl acetamide at 100℃; for 4h; Reagent/catalyst; Inert atmosphere; | 100% |
With tributyl-amine In N,N-dimethyl acetamide at 100℃; for 4h; Reagent/catalyst; | 100% |
Conditions | Yield |
---|---|
With diethylene glycol dibutyl ether; [PdBr2]([Ph2PCH2C(Ph)=N(2,6-iPr2C6H3)]) In N,N-dimethyl acetamide at 130℃; for 20h; Product distribution; Further Variations:; Catalysts; Heck coupling; | 100% |
With water; potassium carbonate In 1-methyl-pyrrolidin-2-one at 135℃; for 24h; Catalytic behavior; Heck Reaction; | 99% |
With tributyl-amine; Palladium bipyridyl complex anchored on nanosized MCM-41 In various solvent(s) at 170℃; for 16h; Heck reaction; | 98% |
acrylic acid n-butyl ester
9-benzyl-6-hypoxanthine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 80℃; for 20h; Addition; | 100% |
3-methoxyphenyl bromide
acrylic acid n-butyl ester
(E)-n-butyl 3-(3-methoxyphenyl)acrylate
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 140℃; for 12h; Heck reaction; | 100% |
With di-tert-butylneopentylphosphonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 24℃; for 24h; Heck Reaction; Glovebox; | 98% |
With bis(1,1'-ethylene-3,3'-divinylimidazole-2,2'-diylidene)nickel(II) dibromide dihydrate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 4h; Heck Reaction; Inert atmosphere; Schlenk technique; | 96% |
acrylic acid n-butyl ester
4-tolyl iodide
(E)-n-butyl 3-(p-tolyl)acrylate
Conditions | Yield |
---|---|
With 1-tert-butyl-3-(2-(diphenylarsinyl)benzyl)-1H-imidazol-3-ium chloride; caesium carbonate; bis(dibenzylideneacetone)-palladium(0) In ISOPROPYLAMIDE at 60℃; for 20h; Heck reaction; Inert atmosphere; | 100% |
With triethylamine; bis(N-methylimidazol-2-yl)Pd(Cl)Me In various solvent(s) at 120℃; for 0.5h; Heck coupling; | 99% |
With potassium phosphate; N,N'-(1,2-ethanediylidene)bishexahydro-1H-azepin-1-amine; tetrabutylammomium bromide; dichloro bis(acetonitrile) palladium(II) In N,N-dimethyl-formamide at 130℃; for 24h; Mizoroki-Heck reaction; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 140℃; for 24h; Heck reaction; | 100% |
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane In N,N-dimethyl-formamide at 130℃; for 20h; Heck reaction; | 92% |
p-nitrobenzene iodide
acrylic acid n-butyl ester
(E)-n-butyl 4-nitrocinnamate
Conditions | Yield |
---|---|
With C29H33Cl2N5Pd; tetrabutylammomium bromide; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 3h; Heck reaction; Inert atmosphere; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h; Heck reaction; Inert atmosphere; regioselective reaction; | 99% |
With 4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine; diamminedichloropalladium(II); tributyl-amine In water at 140℃; for 12h; Mizoroki-Heck cross-coupling; Sealed tube; | 99% |
1-Chloro-4-iodobenzene
acrylic acid n-butyl ester
butyl (E)-4-chlorocinnamate
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium (0); 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride In N,N-dimethyl-formamide at 120℃; for 0.5h; Heck reaction; Inert atmosphere; | 100% |
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; Mizoroki-Heck reaction; Inert atmosphere; | 100% |
With 1,3-bis(5-ferrocenylisoxazoline-3-yl)benzene; tetrabutylammomium bromide; sodium acetate; palladium diacetate In water at 80℃; for 4h; Heck Reaction; diastereoselective reaction; | 95% |
acrylic acid n-butyl ester
4-Iodoacetophenone
(E)-3-(4-acetylphenyl)acrylic acid butyl ester
Conditions | Yield |
---|---|
With C29H33Cl2N5Pd; tetrabutylammomium bromide; sodium carbonate In N,N-dimethyl acetamide at 140℃; for 3h; Heck reaction; Inert atmosphere; | 100% |
With tributyl-amine; chloro-[2-(9-phenyl-1,10-phenanthrolin-2-yl)phenyl]palladium In 1-methyl-pyrrolidin-2-one at 140℃; for 15h; Heck Reaction; Inert atmosphere; | 100% |
With phenyl carbamate; potassium carbonate; palladium diacetate In N,N-dimethyl-formamide at 130℃; for 2h; Heck-type reaction; | 99% |
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With Ethyl 2-bromopropionate; bis(1,3-dicyclohexyl-2,3-dihydro-1H-imidazolyl)Cl2RuCHPh In toluene at 85℃; for 16h; | 100% |
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With Ethyl 2-bromopropionate; bis[1,3-(i-Pr)2-2,3-dihydro-1H-imidazolyl]Cl2PCy3RuCHPh In toluene at 85℃; for 16h; | 100% |
bromobenzene
acrylic acid n-butyl ester
n-butyl cinnamate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 0.75h; Catalytic behavior; Reagent/catalyst; | 100% |
With Br(1-)*C27H29BrN5Pd(1+); potassium carbonate In 1-methylpiperidin-2-one at 140℃; for 8h; Heck reaction; | 99% |
With C8H19Cl2N2O2PPd; tetrabutylammomium bromide; sodium hydrogencarbonate at 140℃; for 4h; Heck reaction; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 140℃; for 45h; Heck reaction; | 100% |
With triethylamine; bis(N-methylimidazol-2-yl)Pd(Cl)Me In various solvent(s) at 120℃; for 4h; Heck coupling; | 80% |
With palladium diacetate; caesium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 24h; Heck Reaction; Schlenk technique; | 77% |
1-bromo-3-chlorobenzene
acrylic acid n-butyl ester
3-chloro-trans-cinnamic acid n-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 120℃; for 5h; Heck reaction; | 100% |
With tetrabutylammonium acetate; palladium diacetate at 100℃; for 0.5h; Heck reaction; Air atmosphere; Ionic liquid; chemoselective reaction; |
acrylic acid n-butyl ester
1-bromo-3,5-di-tert-butylbenzene
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 140℃; for 24h; Heck reaction; | 100% |
Conditions | Yield |
---|---|
With trans-[PdCl2(1-phenyl imidazole)2]; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 24h; Catalytic behavior; Reagent/catalyst; Heck Reaction; Inert atmosphere; | 100% |
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tetrabutylammomium bromide; triethylamine In N,N-dimethyl-formamide at 140℃; for 20h; Reagent/catalyst; Heck Reaction; Sealed tube; Inert atmosphere; Schlenk technique; | 99% |
With C24H21ClN2PdS; potassium carbonate In N,N-dimethyl acetamide for 24h; Reagent/catalyst; Heck Reaction; Inert atmosphere; Heating; | 96% |
acrylic acid n-butyl ester
poly-n-butyl acrylate, obtained by anionic polymerization, initiated with the tBuOK/iBu3Al system, Mn = 46100, Mw/Mn = 2.30; monomer(s): n-butyl acetate
Conditions | Yield |
---|---|
With potassium tert-butylate; triisobutylaluminum In toluene at 0 - 20℃; | 100% |
With potassium tert-butylate; triisobutylaluminum In toluene at 0 - 20℃; | 100% |
Conditions | Yield |
---|---|
With 1,4-benzoquinoline; toluene-4-sulfonic acid; palladium diacetate In acetic acid; toluene at 22℃; for 17h; | 100% |
acrylic acid n-butyl ester
Conditions | Yield |
---|---|
With potassium tert-butylate; triisobutylaluminum In hexane; toluene at 0 - 20℃; for 2h; | 100% |
acrylic acid n-butyl ester
4-bromo-benzaldehyde
butyl (E)-4-formylcinnamate
Conditions | Yield |
---|---|
With sodium acetate In ISOPROPYLAMIDE | 100% |
acrylic acid n-butyl ester
2-Methylaziridine
3-(2-methylaziridin-1-yl)propionic acid butyl ester
Conditions | Yield |
---|---|
at 20℃; for 20h; Michael Condensation; | 100% |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; Mizoroki-Heck reaction; Inert atmosphere; | 100% |
With 4,4’‐bis(trimethylammoniummethyl)‐2,2’‐bipyridine; diamminedichloropalladium(II); tributyl-amine In water at 140℃; for 12h; Mizoroki-Heck cross-coupling; Sealed tube; | 99% |
With palladium diacetate; triethylamine In acetonitrile at 180℃; under 41254.1 Torr; for 0.166667h; Mizoroki-Heck coupling; | 94% |
Butyl acrylate, also known as 2-Propenoic acid, butyl ester, clear colorless, flammable liquid with a sharp characteristic odor. It is soluble in alcohol, ether, acetone and other organic solvents, but almost insoluble in water. What's more, n-butyl acrylate is incompatible with strong oxidizing agents, strong acids, strong bases. It can be polymerized into polymer and copolymer used in industry.
Butyl acrylate reacts exothermically with acids to liberate heat along with alcohols and acids. Reacts with strong oxidizing agents, perhaps sufficiently exothermically to ignite the reaction products. Mixing with basic solutions generates heat. Generates flammable hydrogen with alkali metals and hydrides. Attacks many plastics [Handling Chemicals Safely 1980. p. 233]. Polymerizes readily, generating much heat in a reaction that is favored by heat and light [Handling Chemicals Safely 1980. p. 235].
Other properties of Butyl acrylate are: (1)ACD/LogP: 2.39; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.39; (4)ACD/LogD (pH 7.4): 2.39; (5)ACD/BCF (pH 5.5): 38.41; (6)ACD/BCF (pH 7.4): 38.41; (7)ACD/KOC (pH 5.5): 473.96; (8)ACD/KOC (pH 7.4): 473.96; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 26.3 Å2; (13)Index of Refraction: 1.418; (14)Molar Refractivity: 35.97 cm3; (15)Molar Volume: 142.6 cm3; (16)Polarizability: 14.26×10-24 cm3; (17)Surface Tension: 26.7 dyne/cm; (18)Density: 0.898 g/cm3; (19)Flash Point: 39.4 °C; (20)Enthalpy of Vaporization: 38.29 kJ/mol; (21)Boiling Point: 145.9 °C at 760 mmHg; (22)Vapour Pressure: 4.75 mmHg at 25°C.
Preparation of Butyl acrylate: The production methods of acrylate are from acrylonitrile hydrolysis, β-propiolactone, Reppe method and improved Reppe method, cyanoethanol and the direct oxidation of propylene.
1. From cyanoethanol: The reaction of chloroethanol and sodium cyanide generates cyanoethanol which can hydrolyze to produce acrylic in the presence of sulfuric acid.
2. From acrylonitrile hydrolysis: As a rich source of acrylonitrile, this method to produce acrylate has been developed. Now, the industrialized methods contains Societe Ugine and Standard Oil Co (O-hio). Heat acrylonitrile and sulfuric acid to 90 °C to make acrylonitrile be hydrolyzed into acrylamide sulfate. The further esterification of this sulfate produces acrylate. Recently, it has been reported that when use acrylonitrile as raw material from one-step production, the yield of ether is 95%.
3. From β-propiolactone: Use acetic acid or acetone as raw materials, phosphate ester as catalyst to generate ethenone by pyrolysis at 625-730 °C. And then react with anhydrous methyl ester in the presence of AICI3 or BF3 catalyst to produce β-propiolactone by gas reaction at 25 °C. If the end product is acrylic, the propiolactone contacts with hot 100% phosphoric acid to obtain acrylic. If the end product is acrylate, the crude propiolactone may not go through purification, but directly reacts with the corresponding alcohol and sulfuric acid.
Uses of Butyl acrylate: Acrylic acid and its esters are widely used in industry. In use, it tends to aggregate acrylate into polymers or copolymers. Butyl acrylate (as well as methyl esterl, ethyl ester, 2-ethylhexoate) belongs to the soft monomer, which can copolymerize, crosslink and stem graft with a variety of hard monomers such as methyl methacrylate, styrene, acrylonitrile, vinyl acetate, and functional monomers such as HEMA, HpAA, glycidyl ester to produce a variety of 200-700 acrylic resin products. These products are widely used as coatings, adhesives, modified acrylic fibers, plastics modification, fiber and fabric processing, paper processing agents, leather processing, acrylic rubber, etc.
Safty of Butyl acrylate: Butyl acrylate is harmful by inhalation, in contact with skin and if swallowed. It is also irritating to eyes, respiratory system and skin. If you want to contact this product, you must wear suitable gloves and avoid contact with eyes. Moreover, it is harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. You should avoid release to the environment. Refer to special instructions / safety data sheets.
You can still convert the following datas into molecular structure:
(1)SMILES:O=C(OCCCC)\C=C;
(2)Std. InChI:InChI=1S/C7H12O2/c1-3-5-6-9-7(8)4-2/h4H,2-3,5-6H2,1H3;
(3)Std. InChIKey:CQEYYJKEWSMYFG-UHFFFAOYSA-N;
The toxicity data of Butyl acrylate as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LC50 | inhalation | 7800mg/m3 (7800mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986. | |
mouse | LC50 | inhalation | 7800mg/m3/2H (7800mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 28, 1982. | |
mouse | LD50 | intraperitoneal | 200mL/kg (200mL/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | National Technical Information Service. Vol. OTS05220809, |
mouse | LD50 | oral | 5880mg/kg (5880mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. |
rabbit | LD50 | skin | 2mL/kg (2mL/kg) | Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
rabbit | LDLo | oral | 2mL/kg (2mL/kg) | National Technical Information Service. Vol. OTS0520808, | |
rat | LC50 | inhalation | 2730ppm/4H (2730ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Toxicology and Environmental Health. Vol. 16, Pg. 811, 1985. |
rat | LD50 | intraperitoneal | 550mg/kg (550mg/kg) | Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 36, Pg. 58, 1975. | |
rat | LD50 | oral | 900mg/kg (900mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 28, 1982. | |
rat | LDLo | skin | 1700mg/kg (1700mg/kg) | Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 223, 1980. |
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