Butyl isocyanate supplier | CasNO.111-36-4

Name
Butyl isocyanate
EINECS 203-862-8
CAS No. 111-36-4
Article Data81
CAS DataBase
Density 0.87 g/cm³
Solubility
Melting Point 85.5 °C
Formula C₅H₉NO
Boiling Point 115 °C at 760 mmHg
Molecular Weight 99.1326
Flash Point 17.8 °C
Transport Information UN 2485 6.1/PG 1
Appearance Colorless to faintly yellow liquid
Safety 23-26-28-36/37/39-45
Risk Codes 11-21/22-26-34-37-42/43
Molecular Structure
Hazard Symbols F,T+
Synonyms n-Butylisocyanate;Isocyanicacid, butyl ester (6CI,8CI);1-Isocyanatobutane;
PSA 29.43000
LogP 1.12230

Synthetic route

: 41891-17-2
N-butylcarbamoyl chloride

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With triethylamine In toluene for 10h; Solvent; Reagent/catalyst; Reflux;	95%
With N,N-dimethyl-aniline; 1,2-dichloro-benzene
In 1,2-dichloro-ethane
With triethylamine In Dimethyldisulphide at 0 - 5℃; pH=8 - 8.5;

: 591-62-8
N-(ethoxycarbonyl)butylamine

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With Phenyltrichlorosilane at 120 - 165℃; for 0.5h;	88.9%
With boron trichloride; triethylamine In benzene for 0.5h; Heating;	86 % Chromat.

: 29262-59-7
2-(n-butylamino)-2-oxoacetic acid

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate; copper(II) sulfate In hexane; water at 40℃; for 3h;	83%
With ammonium peroxydisulfate; copper diacetate; silver nitrate In hexane; water at 40℃; for 3h;	83%

: 124-38-9
carbon dioxide

: 109-73-9
N-butylamine

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at -78 - 20℃; under 760 Torr;	63%
With di-isopropyl azodicarboxylate; triphenylphosphine 1.) dichloromethane, -5 deg C to -10 deg C, 2.) dichloromethane, -78 deg C, ambient temp.; Yield given; Multistep reaction;

: 29262-59-7
2-(n-butylamino)-2-oxoacetic acid

A: 14040-75-6
N,N'-bis(n-butyl)oxamide

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate In dichloromethane; water at 40℃; for 3h;	A 22% B 49%

: diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate

A: diethyl 2-amino-6-{[(N-n-butylamino)-carbonyloxy-carbamoyl]-methyl}-azulene-1,3-dicarboxylate

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
	A 47% B n/a

: 106-48-9
4-chloro-phenol

A: 17576-37-3
(p-chlorophenyl)methylcarbamate

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With sodium iodide; N-butylamine	A n/a B 14%

: 75-44-5
phosgene

: 3858-78-4
n-butylamine hydrochloride

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With 1,2-dichloro-benzene at 120 - 140℃;
With 1,2-dichloro-benzene at 120 - 140℃;

: 590-28-3
potassium cyanate

: 126-73-8
phosphoric acid tributyl ester

: 111-36-4
n-butyl isocyanide

: 591-62-8
N-(ethoxycarbonyl)butylamine

A: 846-74-2
1,3,5-tributyl-[1,3,5]triazinane-2,4,6-trione

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With calcium oxide at 150 - 200℃;

: 638-29-9
n-valeryl chloride

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With sodium azide; toluene
With sodium azide; tetrabutylammomium bromide In toluene at 60℃; for 0.25h; Reagent/catalyst;

: 29138-75-8
N,N',N'-tributylurea

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 150℃; Equilibrium constant; Thermodynamic data;

: 2769-64-4
n-butyl isonitrile

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With oxygen; bis(dimethylglyoximato)(PPh3)cobalt(II) under 760 Torr; Rate constant; Ambient temperature; further cobaloxime(II) derivatives as active catalysts of oxygen insertion were investigated at substrat to catalyst ratio: 5-20;
With dimethyl sulfoxide; trifluoroacetic anhydride In dichloromethane at -60 - 20℃; for 0.166667h; Inert atmosphere;

: 3898-47-3
phenyl-N-butylcarbamate

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 150℃; Equilibrium constant; Thermodynamic data; variation of temperature;

: 75-44-5
phosgene

: 109-73-9
N-butylamine

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
In ethyl acetate at 60 - 100℃;

: 542-69-8
1-iodo-butane

: 108481-27-2
sodium nitrocyanoamide

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With 1.) MCBPA 1.) 50- deg C, 1 h, acetonitrile, 2.) benzene, 80 deg C, 16 h; Yield given. Multistep reaction;

: C31H27NP2*C5H10ClNNiO

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With copper dichloride In tetrahydrofuran for 0.5h;

: 2594-21-0
methyl N-butylcarbamate

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With boron trichloride; triethylamine In benzene for 0.5h; Heating;	71 % Chromat.

: 109-73-9
N-butylamine

: 503-38-8
trichloromethyl chloroformate

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With pyrographite In ethyl acetate for 5h; Heating;

: 7647-01-0
hydrogenchloride

: 846-74-2
1,3,5-tributyl-[1,3,5]triazinane-2,4,6-trione

: 108-88-3
toluene

: 111-36-4
n-butyl isocyanide

...Expand

N-butyl-N'.N'-diphenyl-urea: N-butyl-N'.N'-diphenyl-urea

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
at 240 - 290℃;

: 591-62-8
N-(ethoxycarbonyl)butylamine

calcium hydroxide: calcium hydroxide

A: 846-74-2
1,3,5-tributyl-[1,3,5]triazinane-2,4,6-trione

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
at 200℃;

...Expand

: 71250-87-8
1-bromo-4-isocyanatobutane

A: 675-20-7
piperidin-2-one

B: 3760-54-1
1-pyrrolidinecarboxaldehyde

C: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride In benzene at 30℃; for 3h; Product distribution; Further Variations:; Reagents; Temperatures; Photolysis;

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: 109-73-9
N-butylamine

: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -80℃;
In toluene at 100℃; Cooling with ice;
In chloroform Cooling with ice; Reflux;

: methyl butyloxamate

A: 111-36-4
n-butyl isocyanide

B sodium-salt of 4-chloro-benzenesulfonic acid amide: sodium-salt of 4-chloro-benzenesulfonic acid amide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KOH / methanol / 15 °C 2: 83 percent / (NH4)2S2O8 / AgNO3, Cu(OAc)2 / hexane; H2O / 3 h / 40 °C View Scheme
Multi-step reaction with 2 steps 1: KOH / methanol / 15 °C 2: 49 percent / (NH4)2S2O8 / AgNO3 / CH2Cl2; H2O / 3 h / 40 °C View Scheme

: 1792-17-2
N,N'-di-n-butylurea

: 111-36-4
n-butyl isocyanide

: PdCl(CONHC4H9)(1,10-phenanthroline)

: 7553-56-2
iodine

: Pd(phen)ClI

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
In hexane react. PdCl(CONC4H9)(phen) and I2 in hexane under N2 atm.; elem. anal.;

...Expand

: PdCl(CONHC4H9)(2,2'-dipyridine)

: 7553-56-2
iodine

: PdClI(bipy)

B: 111-36-4
n-butyl isocyanide

Conditions

Conditions	Yield
In hexane react. PdCl(CONC4H9)(dipy) and I2 in hexane under N2 atm.;

...Expand

: 106-49-0
p-toluidine

: 111-36-4
n-butyl isocyanide

: 22671-74-5
N-butyl-N’-(4-methylphenyl)urea

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 24h; Ambient temperature;	100%
With toluene

: 111-36-4
n-butyl isocyanide

: 4114-31-2
ethylhydrazine carboxylate

: 25544-79-0
ethyl2-(n-butylcarbamoyl)hydrazine-1-carboxylate

Conditions

Conditions	Yield
In toluene at 0 - 90℃; for 0.075h; Inert atmosphere;	100%
In toluene at 20 - 80℃; Inert atmosphere;	96%
In toluene at 90℃; for 4h; Inert atmosphere; Cooling with ice;	96%

: 529-37-3
4(1H)-quinolinone

: 111-36-4
n-butyl isocyanide

: 87722-74-5
1,3-Dibutyl-10,10a-dihydro-1H-1,3,4a-triaza-phenanthrene-2,4,9-trione

Conditions

Conditions	Yield
N,N,N',N'-tetramethylguanidine In N,N-dimethyl-formamide for 1h; Ambient temperature;	100%
With N,N,N',N'-tetramethylguanidine In N,N-dimethyl-formamide Ambient temperature;
With N,N,N',N'-tetramethylguanidine

: 104446-67-5
methyl 4-<(6-aminoindol-1-yl)methyl>-3-methoxybenzoate

: 111-36-4
n-butyl isocyanide

: 104446-81-3
methyl 4-<<6-(N-butylureido)indol-1-yl>methyl>-3-methoxybenzoate

Conditions

Conditions	Yield
In dichloromethane for 72h;	100%

: 111-36-4
n-butyl isocyanide

: 357-70-0
Galantamine

: 138963-44-7
(4aS,6R,8aS)-5,6,9,10,11,12-hexahydro-3-methoxy-11-methyl-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol n-butylcarbamate

Conditions

Conditions	Yield
In tetrahydrofuran for 48h; Heating;	100%

: 150-76-5
4-methoxy-phenol

: 111-36-4
n-butyl isocyanide

: n-butylcarbamic acid 4-methoxyphenyl ester

Conditions

Conditions	Yield
With triethylamine In toluene for 2.5h; Inert atmosphere; Reflux;	100%
With pyridine In dichloromethane at 25℃; Yield given;
With pyridine In dichloromethane at 25℃; for 48h; Condensation;
With pyridine In dichloromethane at 25℃; for 48h; Addition;

: 288156-90-1
4-[3-aminobenzoyl]-1-methylpiperidine

: 111-36-4
n-butyl isocyanide

: 288157-80-2
4-[3-(butylureido)benzoyl]-1-methylpiperidine

Conditions

Conditions	Yield
With poly(4-vinyl pyridine) In tetrahydrofuran for 240h;	100%

: 442682-77-1
6-(2-Furyl)-1H-purine-2-amine

: 111-36-4
n-butyl isocyanide

: 442683-00-3
2-Amino-N-n-butyl-6-(2-furyl)-9H-purine-9-carboxamide

Conditions

Conditions	Yield
With dmap In P2O5; N,N-dimethyl-formamide	100%

: 13368-42-8
4-(trimethylsilyl)morpholine

: 111-36-4
n-butyl isocyanide

: trimethyl-N-butylmorpholin-4-carboxamidosilane

Conditions

Conditions	Yield
In pentane at 0 - 20℃; Inert atmosphere; Schlenk technique;	100%

: 4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzohydrazide

: 111-36-4
n-butyl isocyanide

: N-butyl-2-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoyl)hydrazine-1-carboxamide

Conditions

Conditions	Yield
In ethanol at 70℃; for 4h;	99.63%

: 3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzohydrazide

: 111-36-4
n-butyl isocyanide

: N-butyl-2-(3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoyl)hydrazine-1-carboxamide

Conditions

Conditions	Yield
In ethanol at 70℃; for 4h;	99.36%

: 141816-27-5
2-{3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy}-6-methyl aniline

: 111-36-4
n-butyl isocyanide

: 141799-76-0
E-5324

Conditions

Conditions	Yield
In chloroform for 12h; Heating;	99%

: 109-73-9
N-butylamine

: 111-36-4
n-butyl isocyanide

: 1792-17-2
N,N'-di-n-butylurea

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 1h;	99%
In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	99%
In tetrahydrofuran
In dichloromethane at 0 - 25℃; for 1h;
In dichloromethane at 0 - 25℃; for 1h;

: 67-63-0
isopropyl alcohol

: 111-36-4
n-butyl isocyanide

: 36452-62-7
Butyl-carbamic acid isopropyl ester

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -78℃;	99%

: 3977-29-5
2-amino-6-methyl-3H-pyrimidin-4-one

: 111-36-4
n-butyl isocyanide

: N-[(butylamino)carbonyl]-6-methylisocytosine

Conditions

Conditions	Yield
With pyridine for 2h; Heating;	99%

: 111-36-4
n-butyl isocyanide

: C-(7-Methoxy-naphthalen-1-yl)-methylamine; hydrochloride

: 1-Butyl-3-(7-methoxy-naphthalen-1-ylmethyl)-urea

Conditions

Conditions	Yield
In diethyl ether for 0.5h; Ambient temperature;	99%

: 918441-54-0
(S)-2-(4-bromophenyl)-1-methylethanol

: 111-36-4
n-butyl isocyanide

: 918441-57-3
2-(4-bromophenyl)-1-(S)-methylethyl N-butylcarbamate

Conditions

Conditions	Yield
With dibutyltin dilaurate In chloroform for 16h; Heating;	99%

: 946837-62-3
benzo[d]oxazol-2-yl-(3-hydroxyphenyl)methanone

: 111-36-4
n-butyl isocyanide

: 3-(benzo[d]oxazole-2-carbonyl)phenyl butylcarbamate ester

Conditions

Conditions	Yield
With triethylamine In toluene at 20℃; for 12h;	99%

: 77888-52-9
2-(N,N-Diethylaminosulfonyl)benzenesulfonamide

: 88372-21-8
2-(N,N-dimethylaminosulfonyl)benzene-sulfonamide

: 111-36-4
n-butyl isocyanide

: 147542-69-6
N-(n-Butylamino)carbonyl-2-(N,N-dimethylaminosulfonyl)benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; potassium carbonate In water; acetonitrile	99%

...Expand

: 1352800-33-9
C16H20O2

: 111-36-4
n-butyl isocyanide

: 1352800-51-1
C21H29NO3

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In 1,2-Dichloropropane at 20℃; for 0.3h; Inert atmosphere;	99%

: 60835-68-9
4-(hydroxymethyl)-2-methoxyphenyl acetate

: 111-36-4
n-butyl isocyanide

: 1362456-67-4
4-(((butylcarbamoyl)oxy)methyl)-2-methoxyphenyl acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 72h;	99%

: 13324-66-8
N-benzylcyclopropanamine

: 111-36-4
n-butyl isocyanide

: 1-benzyl-3-butyl-1-cyclopropylurea

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	99%

: 1356856-79-5
(5R,7R)-[3,3,0']-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-hydroxybicyclooctane

: 111-36-4
n-butyl isocyanide

: 1379466-15-5
(5R,7R)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4'-t-butylphenyl)-7-(butylcarbamoyloxy)bicyclooctane

Conditions

Conditions	Yield
With copper(l) chloride In N,N-dimethyl-formamide at 20℃; for 4h;	98.2%

: 115-19-5
2-methyl-but-3-yn-2-ol

: 111-36-4
n-butyl isocyanide

: 59255-60-6
butylcarbamic acid 1,1-dimethyl-prop-2-ynyl ester

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -78℃;	98%

: 111-36-4
n-butyl isocyanide

: 75-65-0
tert-butyl alcohol

: 59255-58-2
tert-butyl butylcarbamate

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at -78℃;	98%
copper(II) 2-ethylhexanoate In benzene Heating;

: 5418-95-1
2-guanidinobenzimidazole

: 111-36-4
n-butyl isocyanide

: 78650-23-4
2-Guanidino-benzoimidazole-1-carboxylic acid butylamide

Conditions

Conditions	Yield
In acetone for 1h; cooling (T< 5 deg C);	98%

: 111-36-4
n-butyl isocyanide

: 72885-90-6
3H-benzimidazo<2,1-c><1,2,4>dithiazol-3-thione

: 85997-29-1
2-butylbenzimidazo<1,2-d><1,2,4>thiadiazol-3(2H)-one

Conditions

Conditions	Yield
Heating;	98%

: 153338-65-9
17β-(N-butylamino)-4-methyl-4-aza-5α-androstan-3-one

: 111-36-4
n-butyl isocyanide

: 17β-(ureylene-N,N'-dibutyl)-4-methyl-4-aza-5α-androstan-3-one

Conditions

Conditions	Yield
With morpholine In tetrahydrofuran for 16h; Ambient temperature;	98%

: 111-36-4
n-butyl isocyanide

: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-Cyclopropylamino-1,4a,6a-trimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one

: 17β-(ureylene-N-cyclopropyl-N'-butyl)-4-methyl-4-aza-5α-androst-1-ene-3-one

Conditions

Conditions	Yield
With morpholine In tetrahydrofuran for 16h; Ambient temperature;	98%

: 118-55-8
phenyl Salicylate

: 111-36-4
n-butyl isocyanide

A: 3898-47-3
phenyl-N-butylcarbamate

B: 162936-60-9
3-butyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione

Conditions

Conditions	Yield
With dmap; triethylamine In dimethyl sulfoxide for 12h; Ambient temperature;	A n/a B 98%

...Expand

Butyl isocyanate Consensus Reports

Reported in EPA TSCA Inventory.

Butyl isocyanate Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid, Poison; DOT Class: 6.1; Label: Poison; DOT Class: 6.1; Label: Poison, Flammable Liquid; DOT Class: 3; Label: Flammable Liquid, Poison

Butyl isocyanate Specification

The N-Butyl isocyanate, with the CAS registry number 111-36-4 and EINECS registry number 203-862-8, has the systematic name of 1-isocyanatobutane. And the molecular formula of this chemical is C₅H₉NO. It is a kind of colorless to faintly yellow liquid, and belongs to the following product categories: Pharmaceutical Intermediates; Isocyanate; Organics; Isocyanates; Nitrogen Compounds; Organic Building Blocks. In addition, it should be stored at 2-8°C.

The physical properties of N-Butyl isocyanate are as following: (1)ACD/LogP: 2.42; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.42; (4)ACD/LogD (pH 7.4): 2.42; (5)ACD/BCF (pH 5.5): 40.95; (6)ACD/BCF (pH 7.4): 40.95; (7)ACD/KOC (pH 5.5): 496.18; (8)ACD/KOC (pH 7.4): 496.18; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 29.43 Å²; (13)Index of Refraction: 1.429; (14)Molar Refractivity: 29.3 cm³; (15)Molar Volume: 113.6 cm³; (16)Polarizability: 11.61×10^-24cm³; (17)Surface Tension: 29.6 dyne/cm; (18)Density: 0.87 g/cm³; (19)Flash Point: 17.8 °C; (20)Enthalpy of Vaporization: 35.34 kJ/mol; (21)Boiling Point: 115 °C at 760 mmHg; (22)Vapour Pressure: 19.4 mmHg at 25°C.

Preparation and uses of N-Butyl isocyanate: It can be prepared by N-butylamine and phosgene. Add N-butylamine and o-dichlorohenzene to the reactor, and pass hydrogen chloride gas till it is saturated. Pass excess phosgene in the temperature of 110-160°C till the solution becomes clear. Distill and collect the distillation cut before 160°C. Distill again, and collect the distillation cut between 106-120°C. Add anhydrous potassium sulfite, and then filter, the product desired is obtained. In addition, it is used as intermediate in organic systhesis, and it is also used in the production of bactericide Benlate.

You should be cautious while dealing with this chemical. It is a kind of highly flammable chemcial whcih is harmful in contact with skin and if swallowed. It is very toxic by inhalation and irritating to the respiratory system. Besides, it may also cause sensitization by inhalation and skin contact. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer); After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer); In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C=N/CCCC
(2)InChI: InChI=1/C5H9NO/c1-2-3-4-6-5-7/h2-4H2,1H3
(3)InChIKey: HNHVTXYLRVGMHD-UHFFFAOYAO

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	250mg/kg (250mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(3), Pg. 53, 1976.
guinea pig	LD50	skin	> 1gm/kg (1000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0528347,
mouse	LC50	inhalation	680mg/m³ (680mg/m³)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(3), Pg. 53, 1976.
mouse	LD50	intravenous	1mg/kg (1mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05701,
mouse	LD50	oral	150mg/kg (150mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(3), Pg. 53, 1976.
rabbit	LDLo	skin	6gm/kg (6000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL)	National Technical Information Service. Vol. OTS0528441,
rat	LC50	inhalation	3gm/m³(3000mg/m³)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(3), Pg. 53, 1976.
rat	LD50	oral	600mg/kg (600mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(3), Pg. 53, 1976.

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