Chloramine-T supplier | CasNO.127-65-1

Name
Chloramine-T
EINECS 204-854-7
CAS No. 127-65-1
Article Data9
CAS DataBase
Density 1.36g/cm3
Solubility >100 mg/mL in water
Melting Point 167-170 °C(lit.)
Formula C₇H₇ClNNaO₂S
Boiling Point 314.3 °C at 760 mmHg
Molecular Weight 229.663
Flash Point 143.9 °C
Transport Information UN 3263 8/PG 3
Appearance white or yellow powder with a chlorine-like odour
Safety 22-26-36/37/39-45-7-1/2
Risk Codes 22-31-34-42
Molecular Structure
Hazard Symbols Xn,C
Synonyms Benzenesulfonamide,N-chloro-4-methyl-, sodium salt (9CI);p-Toluenesulfonamide, N-chloro-, sodiumsalt (8CI);Acti-chlore;Aktiven;Aktivin;Aseptoclean;Berkendyl;Chloralone;Chlorasan;Chloraseptine;Chlorazan;Chlorazene hydrosol;Chlorazone;Chlorozone;Cloramine T;Clorina;Desinfect;Euclorina;Gyneclorina;Halamid;Kloramin;Kloramine-T;Mannolite;Mianine;Multichlor;N-Chloro-4-methylbenzenesulfonamide sodium salt;N-Chloro-p-toluenesulfonamide sodium salt;N-Chlorotoluenesulfonamidesodium salt;SodiumN-chloro-p-toluenesulfonamide;Sodiump-toluenesulfochloramide;Sodium p-toluenesulfonchloramide;Sodium tosylchloramide;Tampules;Tochlorine;Tolamine;Tosylchloramide sodium;Chloramine T;Chloramine-T;
PSA 42.52000
LogP 3.29200

Synthetic route

: 70-55-3
toluene-4-sulfonamide

: 127-65-1
chloroamine-T

Conditions

Conditions	Yield
With trichloroisocyanuric acid; sodium hydroxide at 20℃; for 1h;	93%
Stage #1: toluene-4-sulfonamide With trichloroisocyanuric acid In methanol at 20℃; for 1h; Stage #2: With sodium hydroxide In methanol at 0 - 20℃; for 0.5h;	92%
With sodium hydroxide; chlorine at 70℃; for 1h;
With sodium hydroxide; chlorine In water at 70℃; for 1h;

: 473-34-7
N,N-dichloro-p-toluenesulfonamide

: 70-55-3
toluene-4-sulfonamide

: 127-65-1
chloroamine-T

Conditions

Conditions	Yield
With indigo carmine; NaOAc-HOAc buffer; sodium perchlorate In water at 39.9℃; Equilibrium constant; var. pH (buffer);

: 70-55-3
toluene-4-sulfonamide

N.N-dichloro-toluenesulfonamide-(4): N.N-dichloro-toluenesulfonamide-(4)

: 127-65-1
chloroamine-T

Conditions

Conditions	Yield
With sodium hydroxide; water

: anti-2'-adamantylidene-9-benzonorbornenylidene sulfide

: 127-65-1
chloroamine-T

: C28H31NO2S2

Conditions

Conditions	Yield
In dichloromethane; acetonitrile at -18℃; for 6h;	100%

: 1112-67-0
tetrabutyl-ammonium chloride

: 127-65-1
chloroamine-T

: tetrabutylammonium N-chloro-p-toluenesulfonamide

Conditions

Conditions	Yield
In water at 5℃; for 5h;	99%

: 701-57-5
1-methylthio-4-nitro-benzene

: 127-65-1
chloroamine-T

: 15436-27-8
S-methyl-S-(4-nitrophenyl)-N-p-tosylsulfilimine

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 16h;	99%
In acetonitrile at 20℃; for 4h;	22%

: 352-93-2
diethyl sulphide

: 127-65-1
chloroamine-T

: 13553-69-0
S,S-Diethyl-N-p-tolylsulfonylsulfilimin

Conditions

Conditions	Yield
In acetonitrile at 20℃;	99%

: 127-65-1
chloroamine-T

: 66-77-3
1-naphthaldehyde

: 81589-31-3
N-(p-toluenesulfonyl)-1-naphthanamide

Conditions

Conditions	Yield
With pyridine; copper(l) chloride In acetonitrile at 20℃; for 18h; Inert atmosphere; Molecular sieve;	99%

: 127-65-1
chloroamine-T

: 123-11-5
4-methoxy-benzaldehyde

: 58734-14-8
4-methoxy-N-tosylbenzamide

Conditions

Conditions	Yield
With pyridine; copper(l) chloride In acetonitrile at 20℃; for 18h; Inert atmosphere; Molecular sieve;	99%

: 5153-67-3
nitrostyrene

: 127-65-1
chloroamine-T

: 4-methyl-N-(2-nitro-1-phenylethyl)benzenesulfonamide

Conditions

Conditions	Yield
With water; iodine In diethyl ether at 20℃; for 1h; regioselective reaction;	99%

: 766-90-5
cis-1-phenyl-1-propylene

: 127-65-1
chloroamine-T

: (1RS,2RS)-2-iodo-1-phenyl-1-(p-toluenesulfonamido)propane

Conditions

Conditions	Yield
With water; iodine at 20℃; for 1h; stereoselective reaction;	99%

: 127-65-1
chloroamine-T

: 86442-41-3
1-tert-Butylsulfanyl-hexane

: S-t-butyl-S-hexyl-N-tosylsulfilimine

Conditions

Conditions	Yield
In methanol at 20℃; for 4h;	98%

: 127-65-1
chloroamine-T

: 21849-40-1
dibromamine-T

Conditions

Conditions	Yield
With bromine In water	98%
With bromine In water for 2h;	90%
With bromine In water for 1h;

: 623-13-2
4-methylphenyl methylsulfide

: 127-65-1
chloroamine-T

: 24702-26-9, 37831-86-0, 4235-12-5
S-p-Tolyl-S-methyl-N-p-tosylsulfimid

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 16h;	98%

: 127-65-1
chloroamine-T

: C36H28N4O17S

: C43H35N5O19S2

Conditions

Conditions	Yield
With Aliquat 336 In dichloromethane for 24h; Ambient temperature;	98%

: 6163-64-0
tert-butyl methyl sulphide

: 127-65-1
chloroamine-T

: 41469-78-7
S-(tert-butyl)-S-methyl-N-(p-tolylsulfonyl)sulfilimine

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 16h;	98%
With Aliquat 336 In dichloromethane Schlenk technique; Inert atmosphere;

: 127-65-1
chloroamine-T

: (1S,2S,5S,6S)-9-Thia-bicyclo[3.3.1]nonane-2,6-diol

: 2,6-dihydroxy-9-thiabicyclo[3.3.1]nonane-N-(4-methylphenyl)sulfonylsulfilimine

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 16h;	98%

: 79-41-4
poly(methacrylic acid)

: 127-65-1
chloroamine-T

: 2-hydroxy-2-methyl-3-(toluene-4-sulfonylamino)-propionic acid

Conditions

Conditions	Yield
With potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate In water for 6h;	98%

: 97-65-4
2-methylenesuccinic acid

: 127-65-1
chloroamine-T

: 2-hydroxy-2-[(toluene-4-sulfonylamino)-methyl]-succinic acid

Conditions

Conditions	Yield
With potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate In water for 6h;	98%
	96%

: 127-65-1
chloroamine-T

: 110-17-8
(2E)-but-2-enedioic acid

: D,L-threo-N-(p-toluenesulfonamido)-β-hydroxyaspartic acid

Conditions

Conditions	Yield
With potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate In water for 6h;	98%

: 1202-36-4
diphenyl telluride

: 127-65-1
chloroamine-T

: 78727-83-0
N-(p-tolylsulfonyl)diphenyltellurimide

Conditions

Conditions	Yield
With 18-crown-6 ether In chloroform for 0.166667h; Heating;	97%

: 292638-84-7
styrene

: 127-65-1
chloroamine-T

: 24395-14-0
N-(p-tolylsulfonyl)-2-phenylaziridine

Conditions

Conditions	Yield
With iodine; benzyltriethylammonium bromide at 20℃; for 1h;	97%
With iodine In acetonitrile at 20℃; for 48h; Inert atmosphere;	93%
With iodine In acetonitrile for 10h; Ambient temperature; neutral buffer, pH 6.86;	91%

: 127-65-1
chloroamine-T

: 110-83-8
cyclohexene

: 68820-12-2
cyclohexyl-N-tosyl aziridine

Conditions

Conditions	Yield
With phenyltrimethylammonium tribromide In acetonitrile at 25℃; for 12h;	97%
With C44H36N8(2+)5I(1-)Mn(3+) In aq. phosphate buffer at 20℃; for 24h; pH=7; Catalytic behavior; pH-value;	93%
With phenyltrimethylammonium tribromide In acetonitrile at 20℃; for 40h;	89%

: 928-95-0
(E)-2-Hexen-1-ol

: 127-65-1
chloroamine-T

: ((2S*,3R*)-3-propyl-1-tosylaziridin-2-yl)methanol

Conditions

Conditions	Yield
With phenyltrimethylammonium tribromide In acetonitrile at 25℃; for 12h;	97%
With iodine; Aliquat 336 at 20℃; for 3h;	79%
With iodine; silica gel; potassium carbonate In water at 20℃; for 3h;	58%
With phenyltrimethylammonium tribromide In acetonitrile at 20℃; for 12h; Sharpless aziridination;

: 127-65-1
chloroamine-T

: 6522-21-0, 10502-30-4, 14965-28-7
endo,endo-2,6-Dichlor-9-thiabicyclo<3.3.1>nonan

: N-((1R,2R,5R,6R)-2,6-Dichloro-9λ4-thia-bicyclo[3.3.1]non-9-ylidene)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 16h;	97%

: 1073-67-2
4-vinylbenzyl chloride

: 127-65-1
chloroamine-T

: N-(2-chloro-2-(4-chlorophenyl)ethyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With Trimethylacetic acid In 1,2-dichloro-ethane at 50℃;	97%
Stage #1: 4-vinylbenzyl chloride; chloroamine-T With carbon dioxide In benzene at 20℃; under 7600 Torr; for 6h; Stage #2: With sodium sulfite In water; benzene	74%

: 127-65-1
chloroamine-T

: 73057-68-8
rac-1-allylcyclopent-2-enol

: C8H11BrO

: cis-N-(5-allyl-6-oxabicyclo[3.1.0]hex-2-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With phenyltrimethylammonium tribromide In acetonitrile at 20℃; for 36h; Inert atmosphere;	A n/a B 97%

...Expand

: 37780-82-8
4-methoxyphenyl allyl sulfide

: 127-65-1
chloroamine-T

: 1403961-71-6
N-allyl-N-(4-methoxyphenylthio)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
In ethanol at 20℃; Green chemistry;	97%

: dirhodium tetra(α,α,α′,α′-tetramethyl-1,3-benzenedipropanamidate) tetrafluoroborate

: 127-65-1
chloroamine-T

: C39H51ClN5O6Rh2S*C2H3N*0.4CH2Cl2

Conditions

Conditions	Yield
In acetonitrile at -35℃; for 72h; Inert atmosphere;	97%

: 4456-34-2
bis(4-methoxyphenyl)telluride

: 127-65-1
chloroamine-T

: 62486-35-5
Te,Te-di(p-methoxyphenyl)-N-(p-tolylsulfonyl)tellurimide

Conditions

Conditions	Yield
With 18-crown-6 ether In chloroform for 0.166667h;	96%

: 127-65-1
chloroamine-T

: 79-10-7
acrylic acid

: 2-hydroxy-3-(toluene-4-sulfonylamino)-propionic acid

Conditions

Conditions	Yield
	96%
With potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate In water for 8h;	94%

: 26326-05-6
1-butene-2,3,4-tricarboxylic acid ester

: 127-65-1
chloroamine-T

: C14H17NO9S

Conditions

Conditions	Yield
	96%

: syn-2'-adamantylidene-9-benzonorbornenylidene sulfide

: 127-65-1
chloroamine-T

A: 2'-adamantylidene-9-benzonorbornenylidene

B: anti-2'-adamantylidene-9-benzonorbornenylidene sulfide

C: C28H31NO2S2

Conditions

Conditions	Yield
In dichloromethane; acetonitrile at -18℃; for 6h;	A 3% B 1% C 96%

...Expand

Chloramine-T Specification

The IUPAC name of this chemical is sodium chloro-(4-methylphenyl)sulfonylazanide. With the CAS registry number 127-65-1, it is also named as Chloramine-T. The classification codes are anti-infective agents; anti-infective agents, local; disinfectants; indicators and reagents; mutation data; noxae; oxidants. It is white or yellow powder with a chlorine-like odour. And it is soluble in water, insoluble in benzene, chloroform and ether. Additionally, Sodium N-chloro-4-toluene sulfonamide is stable and incompatible with strong oxidizing agents. It may decompose violently if heated above 130 °C. Besides, people should keep this product in the cool and dry aera.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.27; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 3; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 1; (6)Flash Point: 143.9 °C; (7)Enthalpy of Vaporization: 55.54 kJ/mol; (8)Boiling Point: 314.3 °C at 760 mmHg; (9)Vapour Pressure: 0.000472 mmHg at 25°C; (10)Rotatable Bond Count: 1; (11)Exact Mass: 226.978372; (12)MonoIsotopic Mass: 226.978372; (13)Topological Polar Surface Area: 43.5; (14)Heavy Atom Count: 13; (15)Complexity: 231.

Preparation of Sodium N-chloro-4-toluene sulfonamide: It is a by-product in the production of saccharin. It can be obtained by amination, salifing and chlorination of paratoluensulfonylchloride.

Uses of Sodium N-chloro-4-toluene sulfonamide: It is used for washing wounds, mucous membrane disinfection, drinking water disinfection and sterilization of medical devices, etc. It is also used in the preparation for sterilization agent, and the determination and indicator of sulfonamides.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and may cause sensitization by inhalation, so people should not breathe dust. When contact with acids, it liberates toxic gas. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Keep locked up and out of the reach of children.

People can use the following data to convert to the molecule structure.
1. SMILES:[Na+].O=S(=O)([N-]Cl)c1ccc(cc1)C
2. InChI:InChI=1/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1
3. InChIKey:VDQQXEISLMTGAB-UHFFFAOYAP

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	parenteral	200mg/kg (200mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.
guinea pig	LDLo	subcutaneous	900mg/kg (900mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.
mouse	LDLo	parenteral	300mg/kg (300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.
rabbit	LDLo	intravenous	25mg/kg (25mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

Product Name

Chloramine-T

Synthetic route

Chloramine-T Specification

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