cholic acid
Conditions | Yield |
---|---|
With phosphate buffer; 3α-HSDH from Pseudomonas paucimobilis; NAD; iso-butanol In water at 22℃; for 48h; | 100% |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.0666667h; microwave irradiation; | 99% |
10-undecenyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.1h; microwave irradiation; | 98% |
octanyl cholate
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.0833333h; microwave irradiation; | 98% |
ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.0666667h; microwave irradiation; | 97% |
With sodium hydroxide In ethanol at 30℃; for 1h; | 15 mg |
benzyl 3α,7α,12α-trihydroxyl-5β-cholestane-24-carboxylic ester
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.0666667h; microwave irradiation; | 96% |
(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.0666667h; microwave irradiation; | 95% |
sodium N-nitrosotaurocholate
A
2-hydroxyethanesulfonic acid
B
cholic acid
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; Mechanism; pH 7.0 - 9.0; | A 61% B 94% |
octacos-10-enyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate
cholic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water for 0.133333h; microwave irradiation; | 94% |
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; Mechanism; pH 7.0 - 9.0; | A 85% B 50% |
Conditions | Yield |
---|---|
With sodium In propan-1-ol for 3h; Reflux; | A 10% B 80% |
dehydrocholic acid
A
cholic acid
B
7α,12α-dihydroxy-3-oxocholanoic acid
C
7α,12β-dihydroxy-3-keto-5β-cholan-24-oic acid
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol at 20℃; for 10h; Product distribution; Further Variations:; Reagents; Solvents; | A 42% B 23% C 15% |
Conditions | Yield |
---|---|
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran at 20 - 40℃; for 17h; | 29.6% |
cholic acid
Conditions | Yield |
---|---|
Umwandlung im Organismus des Meerschweinchens; | |
Multi-step reaction with 2 steps 1: pyridine / Erwaermen auf dem Dampfbad 2: CrO3; acetic acid / und Erwaermen des Reaktionsprodukts mit aethanol.KOH View Scheme |
cholic acid
Conditions | Yield |
---|---|
at 130℃; |
Conditions | Yield |
---|---|
With cultures of aspergillus cinnamomeus | |
With cultures of gliocladium spec |
Conditions | Yield |
---|---|
With Tris-HCl buffer; coenzyme-A; rat liver homogenate; ATP; magnesium chloride; nicotinamide adenine dinucleotide In methanol at 37℃; for 1h; incubation aerobically; pH= 8.5; |
(24S,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid
cholic acid
Conditions | Yield |
---|---|
With Tris-HCl buffer; coenzyme-A; rat liver homogenate; ATP; magnesium chloride; nicotinamide adenine dinucleotide In methanol at 37℃; for 1h; incubation aerobically; pH= 8.5; |
(24S,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid
cholic acid
Conditions | Yield |
---|---|
With Tris-HCl buffer; coenzyme-A; rat liver homogenate; ATP; magnesium chloride; nicotinamide adenine dinucleotide In methanol at 37℃; for 1h; incubation aerobically; pH= 8.5; |
(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid
cholic acid
Conditions | Yield |
---|---|
With Tris-HCl buffer; coenzyme-A; rat liver homogenate; ATP; magnesium chloride; nicotinamide adenine dinucleotide In methanol at 37℃; for 1h; incubation aerobically; pH= 8.5; |
(24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid
cholic acid
Conditions | Yield |
---|---|
With Tris-HCl buffer; coenzyme-A; rat liver homogenate; ATP; magnesium chloride; nicotinamide adenine dinucleotide In methanol at 37℃; for 1h; incubation aerobically; pH= 8.5; |
cholic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; acetone at 37℃; Kinetics; var. temp., solvent; |
Conditions | Yield |
---|---|
at 85℃; Rate constant; Kinetics; Mechanism; Heating; energy data; Ea; var. temp.; |
A
cholic acid
Conditions | Yield |
---|---|
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation; |
A
cholic acid
Conditions | Yield |
---|---|
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation; |
A
cholic acid
Conditions | Yield |
---|---|
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation; |
Conditions | Yield |
---|---|
Hydrogenation; |
A
cholic acid
Conditions | Yield |
---|---|
With chromium(VI) oxide; acetic acid und Erwaermen des Reaktionsprodukts mit aethanol.KOH; |
Conditions | Yield |
---|---|
With diazomethyl-trimethyl-silane In methanol; toluene at 20℃; for 2h; | 100% |
With acetyl chloride at 20℃; for 72h; | 100% |
With acetyl chloride at 20℃; for 0.75h; | 100% |
Conditions | Yield |
---|---|
With sodium hydroxide; sodium perchlorate; sodium chloride In water at 25℃; for 40h; pH=12; Electrochemical reaction; 50 mA; | 100% |
With sodium bromate; ammonium cerium (IV) nitrate In water; acetonitrile at 80℃; for 3h; Temperature; Green chemistry; | 95% |
With sodium bromate; ammonium cerium (IV) nitrate In water; acetonitrile at 80℃; for 3.3h; | 95% |
cholic acid
dimethyl amine
(R)-N,N-dimethyl-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-17-yl)valeramide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 100% |
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 30 min then rt., 2 h; | 78% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 10h; | 74.2% |
With water at 250℃; | |
With tributyl-amine; chloroformic acid ethyl ester Multistep reaction; |
cholic acid
ethylenediamine
N-(2-aminoethyl)(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-amide
Conditions | Yield |
---|---|
Stage #1: cholic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 20h; Stage #2: ethylenediamine In dimethyl sulfoxide at 20℃; for 24h; | 100% |
With tributyl-amine; isobutyl chloroformate 1) dioxane, 10 deg C, 2) H2O, 10 deg C, 1 h; Yield given. Multistep reaction; |
1-hydroxy-pyrrolidine-2,5-dione
cholic acid
cholic acid N-succinimidyl ester
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran; acetonitrile at 20℃; for 24h; Inert atmosphere; | 100% |
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 100% |
With dicyclohexyl-carbodiimide In tetrahydrofuran; acetonitrile at 25℃; for 18h; | 97% |
Conditions | Yield |
---|---|
In tetrahydrofuran | A 100% B n/a |
Conditions | Yield |
---|---|
In methanol; hexane; toluene at 20℃; | 100% |
N-Methyltaurine
cholic acid
3α,7α,12α-trihydroxy-5β-cholan-24-oyl-N-methyltaurine
Conditions | Yield |
---|---|
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In N,N-dimethyl-formamide at 20℃; for 1h; | 100% |
ethanol
cholic acid
ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate
Conditions | Yield |
---|---|
With sulfuric acid for 10h; | 99% |
With toluene-4-sulfonic acid; sodium sulfate for 0.05h; microwave irradiation; | 95% |
With lipase from the fungus rhizomucor miehei In di-isopropyl ether at 40℃; for 48h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Enzymatic reaction; | 85% |
Conditions | Yield |
---|---|
In methanol; chloroform at 45℃; for 18h; | 99% |
Conditions | Yield |
---|---|
at 20℃; for 17h; | 99% |
for 12h; Heating; | 79% |
at 20℃; for 17h; |
Conditions | Yield |
---|---|
In pyridine at 20 - 25℃; for 7h; | 99% |
With pyridine at 80℃; for 14h; | 99% |
With triethylamine for 24h; Reflux; | 80% |
With pyridine at 80℃; for 43h; |
cholic acid
methyl iodide
(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trimethoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]-phenanthren-17-yl]pentanoic acid
Conditions | Yield |
---|---|
Stage #1: cholic acid With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 0 - 41℃; for 60h; | 99% |
Stage #1: cholic acid With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 72h; Inert atmosphere; | 82% |
Stage #1: cholic acid With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 0 - 20℃; for 36h; | 64% |
Stage #1: cholic acid With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 18h; Inert atmosphere; | 62% |
Conditions | Yield |
---|---|
In methanol for 12.5h; Cooling with ice; | 99% |
In methanol |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran Reflux; | 92% |
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 88% |
Conditions | Yield |
---|---|
With pyridine; dmap at 50℃; for 2h; | 98% |
With pyridine; dmap at 20℃; for 3.5h; | 95.5% |
With dmap In pyridine for 3.5h; 0 deg C then rt., 3.5 h; | 94.7% |
Conditions | Yield |
---|---|
at 60℃; for 4h; | 98% |
Conditions | Yield |
---|---|
Stage #1: cholic acid With O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In chloroform; N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1,8-diaminooctan In chloroform; N,N-dimethyl-formamide at 20℃; for 4h; | 98% |
Conditions | Yield |
---|---|
at 60℃; for 4h; | 97% |
With perchloric acid; acetic anhydride Esterification; | 92% |
at 55℃; for 24h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 97% |
With cesium fluoride In N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 15h; | 97% |
1-Tetradecanol
cholic acid
tetradecyl 3α,7α,12α-trihydroxy-5β-cholanate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid at 40 - 50℃; for 15h; | 97% |
With lipase from the fungus rhizomucor miehei In di-isopropyl ether at 40℃; for 48h; Enzymatic reaction; | 54% |
Conditions | Yield |
---|---|
Stage #1: cholic acid With O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 9H-fluoren-9-ylmethyl N-(4-aminobutyl)carbamate hydrochloride In N,N-dimethyl-formamide for 4h; | 97% |
Conditions | Yield |
---|---|
In ethanol at 25℃; for 0.5h; | 97% |
cholic acid
tert-butyl alcohol
(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester
Conditions | Yield |
---|---|
Stage #1: cholic acid With trifluoroacetic anhydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Stage #2: tert-butyl alcohol In tetrahydrofuran at 0 - 20℃; for 7h; Stage #3: With ammonium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 16h; | 96.7% |
With toluene-4-sulfonic acid; sodium sulfate In 1,4-dioxane for 0.166667h; microwave irradiation; | 93% |
Stage #1: cholic acid With trifluoroacetic anhydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Stage #2: tert-butyl alcohol In tetrahydrofuran at 20℃; for 7h; | 92% |
With ammonium hydroxide; trifluoroacetic anhydride Yield given. Multistep reaction; |
The Cholic acid, with the CAS registry number 81-25-4, is also known as Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-. Its EINECS registry number is 201-337-8. This chemical's molecular formula is C24H40O5 and molecular weight is 408.5714. Its IUPAC name is called (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. This chemical's classification code is Mutation data. Meanwhile, this product can be used as emulsifier.
Physical properties of Cholic acid: (1)ACD/LogP: 2.88; (2)ACD/LogD (pH 5.5): 2.064; (3)ACD/LogD (pH 7.4): 0.268; (4)ACD/BCF (pH 5.5): 13.885; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 133.915; (7)ACD/KOC (pH 7.4): 2.137; (8)#H bond acceptors: 5; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 7; (11)Index of Refraction: 1.558; (12)Molar Refractivity: 111.241 cm3; (13)Molar Volume: 344.844 cm3; (14)Surface Tension: 50.874 dyne/cm; (15)Density: 1.185 g/cm3; (16)Flash Point: 320.956 °C; (17)Enthalpy of Vaporization: 100.176 kJ/mol; (18)Boiling Point: 583.876 °C at 760 mmHg; (19)Vapour Pressure: 0 mmHg at 25°C.
Preparation of Cholic acid: the process of ethanol crystallization method are: (1)Hydrolysis of cattle, sheep bile acid; (2)Acidification of sodium hydroxide; (3)Dissolution, crystallization heavy crystallization of sulfuric acid crude bile acid; (4)Ethanol refined bile acid.
Cholic acid, along with chenodeoxycholic acid, is one of two major bile acids produced by the liver where it is synthesized from cholesterol. These derivatives are made from cholyl-CoA, which forms a conjugate with either glycine, or taurine, yielding glycocholic and taurocholic acid respectively. Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more). Cholic acid and chenodeoxycholic acid are the most important human bile acids. Some other mammals synthesize predominantly deoxycholic acid.
When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(CCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
(2)Isomeric SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4C@@]3(CC[C@H](C4)O)C)O)O)C
(3)InChI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
(4)InChIKey: BHQCQFFYRZLCQQ-OELDTZBJSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 330mg/kg (330mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 323, 1970. | |
mouse | LD50 | oral | 4950mg/kg (4950mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. Vol. (103), Pg. 29, 1985. |
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