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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% methyl cholate 1448-36-8 Producer

Cas:1448-36-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Methyl cholate

Cas:1448-36-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cholic acid methyl ester

Cas:1448-36-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

CHOLIC ACID METHYL ESTER

Cas:1448-36-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1448-36-8 with competitive price

Cas:1448-36-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cholan-24-oic acid,3,7,12-trihydroxy-, methyl ester, (3a,5b,7a,12a)- 1448-36-8

Cas:1448-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

CHOLIC ACID METHYL ESTER CAS:1448-36-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

CHOLIC ACID METHYL ESTER CAS:1448-36-8

Cas:1448-36-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cholan-24-oic acid,3,7,12-trihydroxy-, methyl ester, (3a,5b,7a,12a)-

Cas:1448-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cholan-24-oic acid,3,7,12-trihydroxy-, methyl ester, (3a,5b,7a,12a)-

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cholan-24-oic acid,3,7,12-trihydroxy-, methyl ester, (3a,5b,7a,12a)-

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3Alpha,7Alpha,12Alpha-Trihydroxy-5Beta-Cholan-24-Oic Acid Methyl Ester

Cas:1448-36-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CHOLIC ACID METHYL ESTER,1448-36-8

Cas:1448-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

CHOLICACIDMETHYL

Cas:1448-36-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ Methyl Cholate /Manufacturer in China

Cas:1448-36-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

methyl cholateAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

methyl cholate

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Methyl Cholate

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

methyl cholate

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

CHOLIC ACID METHYL ESTER(P)

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3Alpha,7Alpha,12Alpha-Trihydroxy-5Beta-Cholan-24-Oic Acid Methyl Ester

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

CHOLIC ACID METHYL ESTER

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Cholan-24-oic acid,3,7,12-trihydroxy-, methyl ester, (3a,5b,7a,12a)-

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

Cholic Acid methyl ester

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

CHOLIC ACID METHYL CAS No.1448-36-8

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Methyl cholate cas 1448-36-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Methyl cholate cas 1448-36-8

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

CHOLIC ACID METHYL ESTER

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

CHOLIC ACID METHYL ESTER

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Asure Biochem CO.,LTD.

*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:1kg/tin 5kg/tin 25kg/carton Application:Pharmaceutical raw materials, making injection powder oral agent Tr

CHOLIC ACID METHYL

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5g Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Cholic Acid Methyl Ester

Cas:1448-36-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methanol
67-56-1

methanol

cholic acid
81-25-4

cholic acid

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With diazomethyl-trimethyl-silane In methanol; toluene at 20℃; for 2h;100%
With acetyl chloride at 20℃; for 72h;100%
With acetyl chloride at 20℃; for 0.75h;100%
cholic acid
81-25-4

cholic acid

A

methyl chelate

methyl chelate

B

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
In tetrahydrofuranA 100%
B n/a
cholic acid
81-25-4

cholic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
In methanol; hexane; toluene at 20℃;100%
cholic acid
81-25-4

cholic acid

acetyl chloride
75-36-5

acetyl chloride

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
In methanol for 12.5h; Cooling with ice;99%
In methanol
cholic acid
81-25-4

cholic acid

methyl iodide
74-88-4

methyl iodide

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;97%
With cesium fluoride In N,N-dimethyl-formamide
7-α,12-α-dihydroxycholin-4-ene-3-one carboxylic acid methyl ester
55319-79-4

7-α,12-α-dihydroxycholin-4-ene-3-one carboxylic acid methyl ester

A

methyl 3β,7α,12α-trihydroxy-5α-cholan-24-oate
14772-93-1

methyl 3β,7α,12α-trihydroxy-5α-cholan-24-oate

B

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With sodium tetrahydroborate In pyridine for 20h; Ambient temperature;A 77%
B 23%
With sodium tetrahydroborate In pyridine for 20h; Ambient temperature;A 77%
B 23%
methyl 3α,7α-diacetoxy-12α-hydroxy cholanate
3749-87-9

methyl 3α,7α-diacetoxy-12α-hydroxy cholanate

B

Methyl 12α-hydroxy-5β-cholanate
1249-70-3

Methyl 12α-hydroxy-5β-cholanate

C

methyl 7α,12a-dihydroxy-5β-cholan-24-oate
3701-54-0

methyl 7α,12a-dihydroxy-5β-cholan-24-oate

D

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With potassium Sodium; iso-butanol; Tris(3,6-dioxaheptyl)amine In tetrahydrofuran Ambient temperature; var. cat.: 18-crown-6; Yield given. Yields of byproduct given;A n/a
B 58%
C n/a
D n/a
methyl 3α,7α-diacetoxy-12α-hydroxy cholanate
3749-87-9

methyl 3α,7α-diacetoxy-12α-hydroxy cholanate

A

Methyl 12α-hydroxy-5β-cholanate
1249-70-3

Methyl 12α-hydroxy-5β-cholanate

B

methyl deoxycholate
3245-38-3

methyl deoxycholate

C

methyl 7α,12a-dihydroxy-5β-cholan-24-oate
3701-54-0

methyl 7α,12a-dihydroxy-5β-cholan-24-oate

D

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With potassium Sodium; iso-butanol; Tris(3,6-dioxaheptyl)amine In tetrahydrofuran Ambient temperature; var. cat.: 18-crown-6; Yields of byproduct given;A 58%
B n/a
C n/a
D n/a
cholic acid
81-25-4

cholic acid

methyl cholate
1448-36-8

methyl cholate

methyl 3,7,12-trioxo-5β-cholan-24-oate
7727-82-4

methyl 3,7,12-trioxo-5β-cholan-24-oate

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate
methyl 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate
10538-64-4

methyl 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate

A

methyl cholate
1448-36-8

methyl cholate

B

(R)-4-((3R,5S,7R,8R,9S,10S,12R,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

(R)-4-((3R,5S,7R,8R,9S,10S,12R,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

Conditions
ConditionsYield
With borane tert-butylamine In methanol for 3h; Ambient temperature; Yield given. Yields of byproduct given;
3α-ethoxycarbonyloxy-7α,12α-dihydroxy-5β-cholan-24-oic acid methyl ester
21059-36-9

3α-ethoxycarbonyloxy-7α,12α-dihydroxy-5β-cholan-24-oic acid methyl ester

A

methyl cholate
1448-36-8

methyl cholate

B

methyl 3α,12α-dihydroxy-7-oxo-5β-cholanate
10538-65-5, 15073-97-9, 15180-34-4, 81644-39-5, 81644-40-8

methyl 3α,12α-dihydroxy-7-oxo-5β-cholanate

Conditions
ConditionsYield
With N-Bromosuccinimide Multistep reaction;
methyl cholate acetonitrile

methyl cholate acetonitrile

A

methyl cholate
1448-36-8

methyl cholate

B

acetonitrile
75-05-8

acetonitrile

Conditions
ConditionsYield
at 85℃; Rate constant; Kinetics; Thermodynamic data; Heating; Ea; var. temp.;
3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid methyl ester

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid methyl ester

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate
3,7,12,-trioxo-5β-cholan-24-oic acid methyl ester

3,7,12,-trioxo-5β-cholan-24-oic acid methyl ester

A

methyl cholate
1448-36-8

methyl cholate

B

3β,7α,12α-trihydroxy-5β-cholan-24-oic acid methyl ester
28050-54-6

3β,7α,12α-trihydroxy-5β-cholan-24-oic acid methyl ester

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate
3-oxo cholic acid methyl ester
14772-99-7

3-oxo cholic acid methyl ester

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 25 percent / DDQ / dioxane / 10 h / Heating
2: H2 / tris(triphenylphosphine)-rhodium chloride / benzene
3: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 25 percent / DDQ / dioxane / 10 h / Heating
2: NaBH4 / methanol / 2 h / Ambient temperature
3: MnO2 / CHCl3 / 60 h
4: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature
View Scheme
methyl 3-oxo-7α,12α-dihydroxy-1,4-choladienate
111102-58-0

methyl 3-oxo-7α,12α-dihydroxy-1,4-choladienate

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / tris(triphenylphosphine)-rhodium chloride / benzene
2: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: NaBH4 / methanol / 2 h / Ambient temperature
2: MnO2 / CHCl3 / 60 h
3: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature
View Scheme
(R)-4-((7R,8R,9S,10R,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester
125626-89-3

(R)-4-((7R,8R,9S,10R,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: MnO2 / CHCl3 / 60 h
2: 23 percent / NaBH4 / pyridine / 20 h / Ambient temperature
View Scheme
cholic acid
81-25-4

cholic acid

bromine
10097-32-2

bromine

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
In methanol
cholic acid
81-25-4

cholic acid

methyl cholate
1448-36-8

methyl cholate

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 12h;
methyl cholate
1448-36-8

methyl cholate

methyl 3,7,12-trioxo-5β-cholan-24-oate
7727-82-4

methyl 3,7,12-trioxo-5β-cholan-24-oate

Conditions
ConditionsYield
With pyridinium dichromate100%
With pyridinium dichromate100%
With pyridinium dichromate100%
methyl cholate
1448-36-8

methyl cholate

acetic anhydride
108-24-7

acetic anhydride

methyl 3,7,12-triacetoxycholan-24-oate
6818-44-6

methyl 3,7,12-triacetoxycholan-24-oate

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 1h;100%
With pyridine; dmap at 20℃; for 1h;100%
With pyridine; dmap at 20℃; for 3h;98%
methyl n-dodecanoate
111-82-0

methyl n-dodecanoate

methyl cholate
1448-36-8

methyl cholate

Dodecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
151112-03-7

Dodecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
at 60℃; under 8 Torr; for 20h; Candida antarctica lipase immobilized on Florisil with Triton X-100;100%
methyl myristoate
124-10-7

methyl myristoate

methyl cholate
1448-36-8

methyl cholate

Tetradecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Tetradecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
at 60℃; under 8 Torr; for 20h; Candida antarctica lipase immobilized on Florisil with Triton X-100;100%
hexadecanoic acid methyl ester
112-39-0

hexadecanoic acid methyl ester

methyl cholate
1448-36-8

methyl cholate

Hexadecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Hexadecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
at 60℃; under 8 Torr; for 20h; Candida antarctica lipase immobilized on Florisil with Triton X-100;99%
methyl cholate
1448-36-8

methyl cholate

cholic acid
81-25-4

cholic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol; water for 0.0666667h; microwave irradiation;99%
methyl cholate
1448-36-8

methyl cholate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

methyl 3α-O-(tert-butyl-dimethylsilanyloxy)-7α,12α-dihydroxy-5β-cholan-24-oate
73677-12-0

methyl 3α-O-(tert-butyl-dimethylsilanyloxy)-7α,12α-dihydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 2h;99%
With pyridine; 1H-imidazole In dichloromethane at 50℃; for 18h;99%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h;92%
methyl cholate
1448-36-8

methyl cholate

3-oxo cholic acid methyl ester
14772-99-7

3-oxo cholic acid methyl ester

Conditions
ConditionsYield
With Ag2CO3 on Celite In toluene Reflux; Inert atmosphere;98%
With silver carbonate In toluene for 12h; Reflux; Dean-Stark;94%
With 4-methyl-morpholine; 6C6H15P*4CF3O3S(1-)*2Ru(2+); acetone at 35℃; for 4h; Inert atmosphere; Sealed tube;94%
methyl cholate
1448-36-8

methyl cholate

3α,7α,12α-trihydroxycholan-24-ol
3758-71-2

3α,7α,12α-trihydroxycholan-24-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran98%
With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Heating / reflux;98%
With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Heating / reflux;98%
methyl cholate
1448-36-8

methyl cholate

ethylenediamine
107-15-3

ethylenediamine

N-(2-aminoethyl)(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-amide
78793-09-6

N-(2-aminoethyl)(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-amide

Conditions
ConditionsYield
In methanol at 20℃; for 48h;98%
In methanol at 69 - 71℃;93%
at 73℃; for 16h;93%
methyl cholate
1448-36-8

methyl cholate

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

methyl 3α,7α,12α-tri(methoxymethoxy)-5β-cholan-24-oate
637350-96-0

methyl 3α,7α,12α-tri(methoxymethoxy)-5β-cholan-24-oate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In benzene at 20℃; for 240h;98%
formic acid
64-18-6

formic acid

methyl cholate
1448-36-8

methyl cholate

methyl 3α,7α,12α-triformyloxy-5β-cholanoate
33744-75-1

methyl 3α,7α,12α-triformyloxy-5β-cholanoate

Conditions
ConditionsYield
at 20℃; for 72h;96%
With perchloric acid at 50℃; for 1.5h;86%
methyl cholate
1448-36-8

methyl cholate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

methyl (3α,5β,7α,12α)-7,12-dihydroxy-3-(p-toluenesulfonyloxy)cholan-24-oate

methyl (3α,5β,7α,12α)-7,12-dihydroxy-3-(p-toluenesulfonyloxy)cholan-24-oate

Conditions
ConditionsYield
With pyridine at -10 - -6℃; for 15h;95.3%
methyl cholate
1448-36-8

methyl cholate

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

3α,7α,12α-trihydroxy-24-methylsulfinylmethyl-5β-cholan-24-one
168131-38-2

3α,7α,12α-trihydroxy-24-methylsulfinylmethyl-5β-cholan-24-one

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0℃; for 0.666667h;95%
methyl cholate
1448-36-8

methyl cholate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Methyl 3α-methanesulphonyloxy-7α,12α-dihydroxy-5β-cholan-24-oate
160836-52-2

Methyl 3α-methanesulphonyloxy-7α,12α-dihydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With pyridine; dmap at 20℃; Cooling with ice;95%
With triethylamine In dichloromethane at 0℃; for 0.166667h;87%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere;84%
1,6-Hexanediamine
124-09-4

1,6-Hexanediamine

methyl cholate
1448-36-8

methyl cholate

N-hexylamino-3α,7α,12α-trihydroxy-5β-cholan-24-cholanoamide
142970-26-1

N-hexylamino-3α,7α,12α-trihydroxy-5β-cholan-24-cholanoamide

Conditions
ConditionsYield
In methanol at 69 - 71℃;95%
at 73℃; for 16h;95%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

methyl cholate
1448-36-8

methyl cholate

methyl 3α,7α,12α-tris(chlorocarbonyloxy)-5β-cholan-24-oate

methyl 3α,7α,12α-tris(chlorocarbonyloxy)-5β-cholan-24-oate

Conditions
ConditionsYield
With pyridine In benzene at 25℃; for 24h;95%
methyl cholate
1448-36-8

methyl cholate

methyl iodide
74-88-4

methyl iodide

methyl 3α,7α-dimethoxy-12α-hydroxy-5β-cholan-24-oate
1351984-85-4

methyl 3α,7α-dimethoxy-12α-hydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃;94%
With sodium hydride In tetrahydrofuran at 20℃; for 12h;94%
Stage #1: methyl cholate With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;
94%
methyl cholate
1448-36-8

methyl cholate

acetic anhydride
108-24-7

acetic anhydride

methyl 3α,7α-diacetoxy-12α-hydroxy cholanate
3749-87-9

methyl 3α,7α-diacetoxy-12α-hydroxy cholanate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 25℃; for 5h;92%
With dmap; triethylamine In dichloromethane at 28℃;92%
With dmap; triethylamine In dichloromethane at 0 - 28℃;92%
methyl cholate
1448-36-8

methyl cholate

ethanolamine
141-43-5

ethanolamine

N-(2-hydroxyethyl)-3α,7α,12α-trihydroxy-5β-cholan-24-amide
63266-83-1

N-(2-hydroxyethyl)-3α,7α,12α-trihydroxy-5β-cholan-24-amide

Conditions
ConditionsYield
In methanol Heating;92%
methyl cholate
1448-36-8

methyl cholate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

methyl 3α-methanesulfonyl-7α,12α-dihydroxy-5β-cholan-24-oate
1204197-58-9

methyl 3α-methanesulfonyl-7α,12α-dihydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With pyridine at 20℃; Inert atmosphere;92%
methyl cholate
1448-36-8

methyl cholate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

7α,12α-dihydroxy-3α-(toluene-sulfonyl-(4)-oxy)-5β-cholanoic acid-(24)-methyl ester
28192-77-0

7α,12α-dihydroxy-3α-(toluene-sulfonyl-(4)-oxy)-5β-cholanoic acid-(24)-methyl ester

Conditions
ConditionsYield
In pyridine; benzene Ambient temperature;91%
In pyridine at 10℃; for 16h;90%
With pyridine88%
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

methyl cholate
1448-36-8

methyl cholate

3,7,12-triscarbamyl cholic acid methyl ester

3,7,12-triscarbamyl cholic acid methyl ester

Conditions
ConditionsYield
In chloroform for 16h;91%
methanesulfonic acid
75-75-2

methanesulfonic acid

methyl cholate
1448-36-8

methyl cholate

methyl 3β-mesyloxycholate
175340-06-4

methyl 3β-mesyloxycholate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 40℃; for 24h;90%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40 - 50℃; for 24h;
With dmap; triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 48h; Mitsunobu reaction;
With dmap; di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 8h; Mitsunobu Displacement;
With di-isopropyl azodicarboxylate; triphenylphosphine
methyl cholate
1448-36-8

methyl cholate

Trimethylenediamine
109-76-2

Trimethylenediamine

cholic acid 3-aminopropylamide

cholic acid 3-aminopropylamide

Conditions
ConditionsYield
In methanol at 65℃; for 72h;89%
at 20℃; for 168h;

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