Cortodoxone supplier | CasNO.152-58-9

Name
CORTEXOLONE
EINECS 205-805-2
CAS No. 152-58-9
Article Data45
CAS DataBase
Density 1.222 g/cm³
Solubility 44.08mg/L(37 oC)
Melting Point 205-208 °C
Formula C₂₁H₃₀O₄
Boiling Point 524.518 °C at 760 mmHg
Molecular Weight 346.467
Flash Point 285.097 °C
Transport Information
Appearance Crystalline solid
Safety 24/25-22
Risk Codes 11-23/24/25-39/23/24/25
Molecular Structure
Hazard Symbols F,T
Synonyms Compound S(6CI);11-Deoxy-17-hydrocorticosterone;11-Deoxy-17-hydroxycorticosterone;11-Deoxycortisol;11-Deoxycortisone;11-Deoxyhydrocortisone;11-Desoxy-17a-hydroxycorticosterone;Cortexolone;Cortifen;Cortisol, 11-deoxy-;Cortodoxone;NSC 18317;ReichsteinS;Reichstein's compound S;Reichstein's substance S;SKF 3050;Substance S;
PSA 74.60000
LogP 2.81080

Synthetic route

: 110801-53-1
(8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[1-tripropylsilanyloxy-eth-(Z)-ylidene]-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid	88%

: 640-87-9
cortexolone 21-acetate

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With water; potassium carbonate In methanol at 20℃; for 3h; Inert atmosphere;	85%
With methanol; potassium hydrogencarbonate

: 1807-15-4
17,21-diacetoxy-4-pregnene-3,20-dione

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With potassium hydroxide In methanol Ambient temperature;	80%
With potassium hydroxide

: C25H37BrNO2(1+)*Cl(1-)

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With water; potassium carbonate In acetone at 20℃; for 72h; Inert atmosphere;	70%

: 20380-17-0
21-bromo-17α-hydroxy-4-pregnene-3,20-dione

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With potassium carbonate for 0.166667h; Heating;	68%
With water; potassium carbonate In acetone at 20℃; for 0.5h; Inert atmosphere;	57%

: 640-87-9
cortexolone 21-acetate

A: 152-58-9
Cortexolone

B: 566-12-1
9α-hydroxycortexolone

Conditions

Conditions	Yield
With disodium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; menadione; corn-steep liquor In water; N,N-dimethyl-formamide at 28℃; for 40h; Rhodococcus sp.;	A 30% B 50%

: 110-86-1
pyridine

: 59005-57-1
17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)

: 152-58-9
Cortexolone

: 64-85-7
21-Hydroxyprogesterone

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
mit Hilfe von Trichothecium roseum;

: 64-85-7
21-Hydroxyprogesterone

A: 152-58-9
Cortexolone

B: 298-65-7
6β,21-dihydroxypregna-4-en-3,20-dione

Conditions

Conditions	Yield
mit Hilfe von Trichothecium roseum;

: 59005-57-1
17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With pyridine

: 57-83-0
Progesterone

A: 50-23-7
HYDROCORTISONE

B: 68-96-2
17-hydroxyprogesterone

C: 64-85-7
21-Hydroxyprogesterone

D: 50-22-6
Corticosterone

E: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human adrenal tissue; NADP; magnesium chloride at 37℃; for 2h; Product distribution; <3H>labeled;	A 36.3 % Chromat. B n/a C n/a D 4.7 % Chromat. E n/a

...Expand

: 57-83-0
Progesterone

A: 68-96-2
17-hydroxyprogesterone

B: 64-85-7
21-Hydroxyprogesterone

C: 50-22-6
Corticosterone

D: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human kidney tissue; NADP; magnesium chloride at 37℃; for 2h; Product distribution; <3H>labeled;	A 2.3 % Chromat. B 21.1 % Chromat. C n/a D 32.5 % Chromat.

...Expand

: 68-96-2
17-hydroxyprogesterone

A: 50-23-7
HYDROCORTISONE

B: 58-22-0
testosterone

C: 63-05-8
Androstenedione

D: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With D-glucose 6-phosphate; sporadic adrenal pheochromocytomas; oxygen; NADP; glucose 6-phosphate dehydrogenase at 37℃; for 1h; Product distribution; <4-14C>-labeled;	A 20.6 % Turnov. B 1.1 % Turnov. C 2.3 % Turnov. D 14.8 % Turnov.

...Expand

: 68-96-2
17-hydroxyprogesterone

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
With α-D-glucose 6-phosphate; 21-hydroxylase from human fetal adrenals; glucose-6-phosphate-dehydrogenase; potassium chloride; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride Equilibrium constant; interaction with cytochrome P-450 obtained from microsomes and mitochondria from human fetal adrenals in dependence on conc.; apparent spectral dissociation const.; inhibition by danazol;
With CYP21 Enzymatic reaction;
With recombinant human cytochrome P450 21A2; water In aq. phosphate buffer at 37℃; Enzymatic reaction;
With wild-type human cytochrome P450 21A2 Kinetics; Reagent/catalyst; Enzymatic reaction;

: 67-56-1
methanol

: 1097-51-4, 16356-47-1
16α,17α-epoxyprogesterone

A: 152-58-9
Cortexolone

B: 119005-10-6
20,20-dimethoxy-16α,17α-epoxypregn-4-en-21-ol-3-one

Conditions

Conditions	Yield
With potassium hydroxide; [bis(acetoxy)iodo]benzene at 20℃; for 7h;	A 0.08 g B 0.15 g

...Expand

: 1097-51-4, 16356-47-1
16α,17α-epoxyprogesterone

A: 68-96-2
17-hydroxyprogesterone

B: 152-58-9
Cortexolone

C: 100167-82-6
16α,17α-epoxypregn-4-en-21-ol-3,20-dione

Conditions

Conditions	Yield
With potassium hydroxide; [bis(acetoxy)iodo]benzene In methanol at 20℃; for 8h;	A 0.02 g B 0.02 g C 0.19 g

...Expand

: 145-13-1
Pregnenolone

A: 50-23-7
HYDROCORTISONE

B: 58-22-0
testosterone

C: 63-05-8
Androstenedione

D: 64-85-7
21-Hydroxyprogesterone

E: 50-22-6
Corticosterone

F: 152-58-9
Cortexolone

G DHEA: DHEA

Conditions

Conditions	Yield
With D-glucose 6-phosphate; sporadic adrenal pheochromocytomas; oxygen; NADP; glucose 6-phosphate dehydrogenase at 37℃; for 1h; Product distribution; <4-14C>-labeled;	A 12.6 % Turnov. B 0.9 % Turnov. C 1.9 % Turnov. D 2.4 % Turnov. E 6.8 % Turnov. F 2.3 % Turnov. G n/a

...Expand

: C26H37NO5

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent 2: hydrolysis 3: 80 percent / KOH / methanol / Ambient temperature View Scheme

: 84542-27-8
C28H39NO7

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrolysis 2: 80 percent / KOH / methanol / Ambient temperature View Scheme

: 387-79-1
17-Hydroxypregnenolone

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 10 percent / CuBr2 / tetrahydrofuran / 2 h / Heating 2: 65 percent / 8 N CrO3 / acetone / 0.08 h 3: 68 percent / aq. K2CO3 / 0.17 h / Heating View Scheme

: 2827-40-9
21-bromo-3β,17α-dihydroxy-5-pregnen-20-one

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / 8 N CrO3 / acetone / 0.08 h 2: 68 percent / aq. K2CO3 / 0.17 h / Heating View Scheme

: 1096-38-4
16-dehydroprogesterone

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 79 percent / RhCl(PPh3)3 2: 88 percent / mCPBA, KHCO3 View Scheme

: 17-hydroxy-20βF-acetoxy-3-oxo-pregnen-(4)-al-(21)

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous methanol.KHCO3 2: pyridine View Scheme

: 57-83-0
Progesterone

A: 64-85-7
21-Hydroxyprogesterone

B: 1334177-12-6
2β,16β-hydroxyprogesterone

C: 152-58-9
Cortexolone

D: 17779-71-4, 438-07-3, 2781-78-4, 14264-44-9
16β-hydroxyprogesterone

E: 604-29-5, 604-28-4, 123287-83-2
2beta-Hydroxyprogesterone

Conditions

Conditions	Yield
With Bacillus megaterium cytochrome P450 BM3 monooxygenase (V78L/A82F/F87A)-expressing cells at 25℃; for 24h; diastereoselective reaction;

...Expand

: 57-83-0
Progesterone

A: 64-85-7
21-Hydroxyprogesterone

B: 152-58-9
Cortexolone

C: 17779-71-4, 438-07-3, 2781-78-4, 14264-44-9
16β-hydroxyprogesterone

D: 604-29-5, 604-28-4, 123287-83-2
2beta-Hydroxyprogesterone

Conditions

Conditions	Yield
With Bacillus megaterium cytochrome P450 BM3 monooxygenase (R47Y/T49F/V78T/A82F/F78A)-expressing cells at 25℃; for 24h; diastereoselective reaction;

...Expand

: 57-83-0
Progesterone

: 152-58-9
Cortexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CYP17A1 / Enzymatic reaction 2: CYP21 / Enzymatic reaction View Scheme

: 3-O-ethoxypregnenolone

A: 63-05-8
Androstenedione

B: 152-58-9
Cortexolone

C: 595-77-7
R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

D: C21H30O5

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C 2: acetic acid / methanol / 3 h / 20 °C 3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction 4: zebrafish P450 17A1 enzyme; 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction View Scheme

Yield

Multi-step reaction with 4 steps
1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C
2: acetic acid / methanol / 3 h / 20 °C
3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction
4: zebrafish P450 17A1 enzyme; 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme

...Expand

: 3-O-ethoxypregnenolone

A: 152-58-9
Cortexolone

B: 595-77-7
R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

C: C21H30O5

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C 2: acetic acid / methanol / 3 h / 20 °C 3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction 4: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish b5 enzyme; NADPH-P450 reductase; zebrafish P450 17A2 enzyme / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction View Scheme

Yield

Multi-step reaction with 4 steps
1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C
2: acetic acid / methanol / 3 h / 20 °C
3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction
4: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish b5 enzyme; NADPH-P450 reductase; zebrafish P450 17A2 enzyme / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme

...Expand

: C23H36O4

A: 63-05-8
Androstenedione

B: 152-58-9
Cortexolone

C: 595-77-7
R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

D: C21H30O5

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid / methanol / 3 h / 20 °C 2: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction 3: zebrafish P450 17A1 enzyme; 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction View Scheme

...Expand

: 152-58-9
Cortexolone

: 108-24-7
acetic anhydride

: 640-87-9
cortexolone 21-acetate

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.5h;	100%
With pyridine

: 152-58-9
Cortexolone

: 21-dehydrohydrocortexolone dimer

Conditions

Conditions	Yield
With air; copper diacetate In methanol for 5h;	100%

: 152-58-9
Cortexolone

: 3282-30-2
pivaloyl chloride

: 6920-52-1
17-Hydroxy-21-trimethylacetoxy-4-pregnen-3,20-dion

Conditions

Conditions	Yield
With dmap In pyridine at 0℃; for 2h;	99%
With pyridine; dichloromethane

: 152-58-9
Cortexolone

: 124-63-0
methanesulfonyl chloride

: 82427-84-7
17α-hydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	97%

: 617-86-7
triethylsilane

: 152-58-9
Cortexolone

: 17-hydroxy-21-(triethylsiloxy)pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
AuCl(xanthphos) In chloroform; N,N-dimethyl-formamide at 50℃; for 6h;	96%

: 152-58-9
Cortexolone

: 84869-31-8
17,21,21-trihydroxy-4-pregnene-3,20-dione

Conditions

Conditions	Yield
With copper diacetate; air In methanol for 7h; Ambient temperature;	95%

: 152-58-9
Cortexolone

: 105562-13-8
11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions

Conditions	Yield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;	92%

: 152-58-9
Cortexolone

: 118916-30-6
20-hydroxy-3,11-dioxo-4,cis-17(20)-pregnadien-21-al

Conditions

Conditions	Yield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;	92%

: 108-22-5
Isopropenyl acetate

: 152-58-9
Cortexolone

: 640-87-9
cortexolone 21-acetate

Conditions

Conditions	Yield
With Rhizopus oryzae lipase immobilized on Lewatit 1600 resin In di-isopropyl ether at 55℃; for 48h; regioselective reaction;	91%

: 152-58-9
Cortexolone

: 118864-85-0
20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions

Conditions	Yield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;	89%

: 152-58-9
Cortexolone

: 149-30-4
2-Mercaptobenzothiazole

: (8R,10R,13S,14S,17R)-17-(2-(benzo[d]thiazol-2-ylthio)acetyl)-17-hydroxy-10,13-dimethyl1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 0.166667h;	88%

hexanes-ethyl acetate: hexanes-ethyl acetate

: 152-58-9
Cortexolone

: 10486-86-9
methyl 17α-hydroxy-3-oxoandrost-4-ene-17-carboxylate

Conditions

Conditions	Yield
With sulfuric acid; sodium hydrogencarbonate In methanol	87%

: 152-58-9
Cortexolone

: 63-05-8
Androstenedione

Conditions

Conditions	Yield
In water; acetonitrile at 20℃; Electrochemical reaction;	86%
With ammonium hydroxide; iodine In water; acetonitrile at 50℃; for 24h;	78%
With manganese(IV) oxide In chloroform for 4h; Heating;	67.6%

: 152-58-9
Cortexolone

: 73818-55-0, 15596-07-3
Bestmann ylide

: 18104-63-7
4-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

Conditions

Conditions	Yield
In benzene for 3h; Heating;	86%

: 152-58-9
Cortexolone

: 124-63-0
methanesulfonyl chloride

: 20380-16-9
17α-hydroxy-21-chloro-4-pregnene-3,20-dione

Conditions

Conditions	Yield
With dmap In dichloromethane for 4h; Reflux;	85%

: 152-58-9
Cortexolone

: 633-29-4
17α-hydroxyandrost-4-en-3-one-17β-carboxylic acid

Conditions

Conditions	Yield
With sodium periodate In tetrahydrofuran; methanol at 20℃; for 2h;	82%
With methanol; periodic acid
With periodic acid In methanol
Multi-step reaction with 2 steps 1: TsOH / dioxane; butan-2-one 2: aq. HIO4 / methanol View Scheme
With sodium hydroxide; sulfuric acid In methanol; water; acetone

: 136918-14-4
phthalimide

: 152-58-9
Cortexolone

: 2-(2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 0.166667h;	82%

: 152-58-9
Cortexolone

A: 57-83-0
Progesterone

B: 64-85-7
21-Hydroxyprogesterone

Conditions

Conditions	Yield
With trimethylsilyl iodide In acetonitrile for 3h; Ambient temperature;	A 5% B 72%
With trimethylsilyl iodide In acetonitrile for 3h; Ambient temperature;	A 5% B 72%
With trimethylsilyl iodide In chloroform for 3h; Ambient temperature;	A 53% B 10%
With trimethylsilyl iodide In chloroform for 3h; Ambient temperature;	A 38% B 48%

: 50-00-0
formaldehyd

: 152-58-9
Cortexolone

: 6173-64-4
17,20:20,21-bismethylenedioxy-4-pregnen-3-one

Conditions

Conditions	Yield
With hydrogenchloride In chloroform; water at 20℃; for 5h;	71%
With hydrogenchloride; chloroform

: 152-58-9
Cortexolone

A: 118864-86-1
20-hydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al

B: 118864-85-0
20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane Heating;	A 10% B 71%
With zinc diacetate; acetic acid Heating;	A 6% B 16.6%
With zinc diacetate; acetic acid Heating;	A 6% B 16.6%

: 152-58-9
Cortexolone

: 57099-41-9
17α,21-Dihydroxypregn-4-en-3,20-dione 21-phosphate

Conditions

Conditions	Yield
With pyridine; 2-cyanoethyl phosphate; dicyclohexyl-carbodiimide	70%

: 152-58-9
Cortexolone

: 77-76-9
2,2-dimethoxy-propane

: 55388-55-1
17,21-dihydroxy-3-methoxypregna-3,5-dien-20-one 17,21-acetonide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 6h; Heating;	61%

: 152-58-9
Cortexolone

: 21085-72-3
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

: 105403-76-7
pregn-4-en-17α,21-diol-3,20-dione-21-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucuronate)

Conditions

Conditions	Yield
With silver carbonate In toluene for 6h; Koenigs-Knorr synthesis; Reflux;	48%

: 152-58-9
Cortexolone

A: 128-19-8
(8R,9S,10R,13S,14S,17R)-17-((R)-1,2-Dihydroxy-ethyl)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

B: 3946-10-9
4-pregnen-17α,20β,21-triol-3-one

Conditions

Conditions	Yield
With sodium tetrahydroborate; calcium chloride In water; ethyl acetate at -27℃;	A n/a B 40%

Cortodoxone Specification

The Pregn-4-ene-3,20-dione,17,21-dihydroxy- is an organic compound with the formula C₂₁H₃₀O₄. The IUPAC name of this chemical is (8R,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one. With the CAS registry number 152-58-9, it is also named as 11-Desoxycortisol. The product's categories are Pharmaceutical Raw Materials; Steroids; Biochemistry; Hydroxyketosteroids; Intermediates and Fine Chemicals; Pharmaceuticals. Besides, it is crystalline solid, which should be stored in a sealed place. And it can be used for glucocorticoid receptor binding. This chemical can be prepared by separating extraction of Adrenal.

Physical properties about Pregn-4-ene-3,20-dione,17,21-dihydroxy- are: (1)ACD/LogP: 2.74; (2)#H bond acceptors: 4; (3)#H bond donors: 2; (4)#Freely Rotating Bonds: 4; (5)Polar Surface Area: 52.6 Å²; (6)Index of Refraction: 1.577; (7)Molar Refractivity: 94.05 cm³; (8)Molar Volume: 283.4 cm³; (9)Polarizability: 37.28×10^-24 cm³; (10)Surface Tension: 52.8 dyne/cm; (11)Density: 1.22 g/cm³; (12)Flash Point: 285.1 °C; (13)Enthalpy of Vaporization: 91.87 kJ/mol; (14)Boiling Point: 524.5 °C at 760 mmHg; (15)Vapour Pressure: 3.41E-13 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following:
It is toxic in contact with skin and if swallowed. Besides, this chemical is harmful if swallowed.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
(2)InChIKey: WHBHBVVOGNECLV-OBQKJFGGBG
(3)Std. InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
(4)Std. InChIKey: WHBHBVVOGNECLV-OBQKJFGGSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	100mg/kg (100mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,

Product Name

CORTEXOLONE

Synthetic route

Cortodoxone Specification

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