Creatinine supplier | CasNO.60-27-5

Name
Creatinine
EINECS 200-466-7
CAS No. 60-27-5
Article Data55
CAS DataBase
Density 1.474 g/cm³
Solubility soluble in water
Melting Point 295 °C (dec.)(lit.)
Formula C₄H₇N₃O
Boiling Point 201.1oC
Molecular Weight 113.119
Flash Point 290 °C
Transport Information UN 1789 8/PG 3
Appearance white powder
Safety 26-36/37/39-45-24/25-36
Risk Codes 34-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms Creatinine(8CI);1-Methylglycocyamidine;1-Methylhydantoin-2-imide;2-Amino-1-methyl-1,5-dihydroimidazol-4-one;2-Amino-1-methylimidazolin-4-one;NSC 13123;TEGO Cosmo C 250;
PSA 58.69000
LogP -1.15310

Synthetic route

: 1414382-33-4
C5H8N2O2

: 60-27-5
creatinine

Conditions

Conditions	Yield
With ammonium hydroxide In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	90%

: 13200-60-7
Sarcosine ethyl ester

: 420-04-2
CYANAMID

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 25℃;

: N-carbamimidoyl-N-methyl-glycine methyl ester

: 623-11-0
1-methyl-4-nitrosobenzene

: 60-27-5
creatinine

Conditions

Conditions	Yield
Reaktion des Hydrochlorids;

: 67-07-2
Phosphocreatine

: 60-27-5
creatinine

Conditions

Conditions	Yield
beim Erhitzen von Calcium-kreatinphosphat;

: 132478-02-5
N-carbamimidoyl-N-methyl-glycine methyl ester; hydrochloride

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 60-27-5
creatinine

: 132478-02-5
N-carbamimidoyl-N-methyl-glycine methyl ester; hydrochloride

: 60-27-5
creatinine

Conditions

Conditions	Yield
beim trocknen Erhitzen;

: N-carbamimidoyl-N-methyl-glycine butyl ester; hydrochloride

: 60-27-5
creatinine

Conditions

Conditions	Yield
beim trocknen Erhitzen;

: 123-41-1
cholin hydroxide

A: 60-27-5
creatinine

B: 57-00-1
Creatinine

Conditions

Conditions	Yield
Bei der Einw.von Gemischen aus Gehirn- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;
Bei der Einw.von Gemischen aus Muskel- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;

: 64-19-7
acetic acid

: 57-00-1
Creatinine

: 60-27-5
creatinine

: 13200-60-7
Sarcosine ethyl ester

: 420-04-2
CYANAMID

: 113-00-8
guanidine nitrate

: 60-27-5
creatinine

...Expand

: 13200-60-7
Sarcosine ethyl ester

: 113-00-8
guanidine nitrate

: 60-27-5
creatinine

Conditions

Conditions	Yield
at -15℃; Reagiert analog mit dl-Leucin-aethylester, d-Glutaminsaeure-diaethylester und dl-Tyrosin-aethylester;
at -15℃;

: 64-17-5
ethanol

: 132478-02-5
N-carbamimidoyl-N-methyl-glycine methyl ester; hydrochloride

: 109-89-7
diethylamine

: 60-27-5
creatinine

...Expand

: 64-17-5
ethanol

: N-carbamimidoyl-N-methyl-glycine butyl ester; hydrochloride

: 109-89-7
diethylamine

: 60-27-5
creatinine

...Expand

: 15366-32-2
ethyl 2-(3-methylguanidino)acetate hydrochloride

: 109-89-7
diethylamine

: 71-43-2
benzene

: 60-27-5
creatinine

...Expand

: 64-18-6
formic acid

: 57-00-1
Creatinine

: 60-27-5
creatinine

: 623-11-0
1-methyl-4-nitrosobenzene

: 57-00-1
Creatinine

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 37.5℃; Geschwindigkeit bei verschiedener Konzentration;
at 50.2℃; Geschwindigkeit bei verschiedener Konzentration;

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 57-00-1
Creatinine

: 60-27-5
creatinine

: 57-00-1
Creatinine

: 76-03-9
trichloroacetic acid

: 60-27-5
creatinine

Conditions

Conditions	Yield
Geschwindigkeit;

: 57-00-1
Creatinine

: 60-27-5
creatinine

Conditions

Conditions	Yield
im menschlichen und tierischen Organismus;
at 37 - 38℃; Geschwindigkeit bei Inkubation von Extrakten aus Hirn- und Muskelgeweben;
bei Einw. von Muskelextrakt;
under 3420 Torr; bei 3-stdg. Erhitzen;

: creatine

: 60-27-5
creatinine

Conditions

Conditions	Yield
With hydrogenchloride at 30℃; Rate constant;

: phosphorocreatine

A: 60-27-5
creatinine

B: creatine

Conditions

Conditions	Yield
With hydrogenchloride at 30℃; Rate constant; Mechanism; reaction in 18O-enriched water;

: phosphorocreatinine

: 60-27-5
creatinine

Conditions

Conditions	Yield
With hydrogenchloride at 30℃; Rate constant;

: 7647-01-0
hydrogenchloride

: 57-00-1
Creatinine

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 37.5℃; Geschwindigkeit bei verschiedener Konzentration;
at 50.2℃; Geschwindigkeit bei verschiedener Konzentration;
at 120℃; Geschwindigkeit bei verschiedener Konzentration;

: 7732-18-5
water

: 57-00-1
Creatinine

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 100℃;
at 38℃; Geschwindigkeit bei pH 6.0 bis pH 7.5;

: 57-00-1
Creatinine

aqueous picric acid: aqueous picric acid

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 100℃; Geschwindigkeit;

: 57-00-1
Creatinine

mineral acid: mineral acid

: 60-27-5
creatinine

: 67-07-2
Phosphocreatine

: 7732-18-5
water

: 60-27-5
creatinine

Conditions

Conditions	Yield
at 38℃; Geschwindigkeit der Hydrolyse und der Umwandlung beim pH 6.0 bis 7.5;
at 37℃; Geschwindigkeit der Hydrolyse und der Umwandlung beim pH 1 bis 8;

: 67-07-2
Phosphocreatine

acid: acid

: 60-27-5
creatinine

Conditions

Conditions	Yield
neben der Hydrolyse;

: 67-07-2
Phosphocreatine

HCl(gas): HCl(gas)

A: 60-27-5
creatinine

B 5-phosphono-3-methyl-hydantoic acid: 5-phosphono-3-methyl-hydantoic acid

Conditions

Conditions	Yield
at 103℃;

...Expand

: 60-27-5
creatinine

: 42059-80-3
6-nitro-4-oxo-4H-chromene-3-carbaldehyde

: 2-Imino-1-methyl-5-[1-(6-nitro-4-oxo-4H-chromen-3-yl)-meth-(Z)-ylidene]-imidazolidin-4-one

Conditions

Conditions	Yield
With boric acid In dimethyl sulfoxide for 0.05h; microwave irradiation;	98%

: 60-27-5
creatinine

: 1217-89-6
1-benzylisatin

: 1-benzyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	98%

: 60-27-5
creatinine

: 4290-94-2
N-ethylisatin

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-1-ethylindolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	97%

: 60-27-5
creatinine

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-1-methylindolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	96%

: 60-27-5
creatinine

: 91-56-5
indole-2,3-dione

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	95%

: 60-27-5
creatinine

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 5-bromo-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	95%

: 60-27-5
creatinine

: 56932-61-7
1-hexyl-2,3-dihydro-1H-indole-2,3-dione

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-1-hexylindolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	95%

: 60-27-5
creatinine

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: C12H11FN4O3

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.00833333h; Microwave irradiation; Cooling;	94%

: 60-27-5
creatinine

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 5-fluoro-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	94%

: 60-27-5
creatinine

: 17630-76-1
5-chloroindole 2,3-dione

: 5-chloro-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	94%

: 60-27-5
creatinine

: 28284-05-1
N-benzoylisatin

: 1-benzoyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	94%

: 98-03-3
thiophene-2-carbaldehyde

: 60-27-5
creatinine

: 5- 2-imino-1-methyl imidazolid-4-one

Conditions

Conditions	Yield
for 0.0541667h; Irradiation;	93%

: 60-27-5
creatinine

: 88-89-1
2,4,6-Trinitrophenol

: C10H8N6O8(2-)*2Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In methanol Heating;	92%

: 60-27-5
creatinine

: 99053-86-8
2-(5,7-Bis-benzyloxy-4,6-dimethyl-1H-indol-3-yl)-ethylamine

: 99053-92-6
5,7-dihydroxy-4,6-dimethyltryptamine creatinine sulfate

Conditions

Conditions	Yield
With sulfuric acid; hydrogen; palladium on activated charcoal In ethanol under 2068.6 Torr; for 6h; Ambient temperature;	92%

: 60-27-5
creatinine

: 42248-31-7
6-Chloro-4-oxo-4H-chromene-3-carbaldehyde

: 5-[1-(6-Chloro-4-oxo-4H-chromen-3-yl)-meth-(Z)-ylidene]-2-imino-1-methyl-imidazolidin-4-one

Conditions

Conditions	Yield
With boric acid In dimethyl sulfoxide for 0.05h; microwave irradiation;	92%

: 60-27-5
creatinine

: 21591-87-7
1-[(4-chlorophenyl)carbonyl]-1H-indole-2,3-dione

: C19H15ClN4O4

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Microwave irradiation; Cooling;	92%

: 60-27-5
creatinine

: 611-09-6
5-nitroisatin

: C12H11N5O5

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Microwave irradiation; Cooling;	92%

: 60-27-5
creatinine

: 91-56-5
indole-2,3-dione

: C12H12N4O3

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.00555556h; Microwave irradiation; Cooling;	92%

: 60-27-5
creatinine

: 723-89-7
1-phenyl-indole-2,3-dione

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-1-phenylindolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	92%

: 60-27-5
creatinine

: 58836-98-9
1-benzenesulphonyl-2,3-dihydroindole-2,3-dione

: 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-1-(phenylsulfonyl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	92%

: 98-01-1
furfural

: 60-27-5
creatinine

: 5--2-imino-1-methyl imidazolid-4-one

Conditions

Conditions	Yield
for 0.0583333h; Irradiation;	91%

: 60-27-5
creatinine

: 121-33-5
vanillin

: 29974-40-1
5-<(4-hydroxy-3-methoxyphenyl)methylene> 2-imino-1-methyl imidazolid-4-one

Conditions

Conditions	Yield
for 0.0125h; Irradiation;	91%
With sodium acetate; acetic acid for 4h; Reflux;	15.2%

: 60-27-5
creatinine

: 171734-73-9
1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde

: 1207733-64-9
C20H17BrN4O

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Aldol condensation; Microwave irradiation;	91%

: 60-27-5
creatinine

: 99448-79-0
C15H8ClNO3

: C19H15ClN4O4

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Microwave irradiation; Cooling;	91%

: 60-27-5
creatinine

: 17630-76-1
5-chloroindole 2,3-dione

: C12H11ClN4O3

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Microwave irradiation; Cooling;	91%

: 60-27-5
creatinine

: 611-09-6
5-nitroisatin

: 109-77-3
malononitrile

: 2-(5-nitro-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-2-oxoindolin-3-yl)malononitrile

Conditions

Conditions	Yield
Stage #1: 5-nitroisatin; malononitrile With chloroauric acid In water at 20℃; for 0.25h; Stage #2: creatinine In water for 0.5h; Reflux; diastereoselective reaction;	91%

...Expand

: 60-27-5
creatinine

: 574-17-4
1-acetyl-1H-indole-2,3-dione

: 1-acetyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	91%

: 60-27-5
creatinine

: 17826-05-0
5,6-Dibromoisatin

: 5,6-dibromo-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one

Conditions

Conditions	Yield
With chloroauric acid In water for 0.5h; Aldol Addition; Reflux; diastereoselective reaction;	91%

: 60-27-5
creatinine

: 10511-51-0
1-Benzylindole-3-carboxaldehyde

: 1207733-60-5
(Z)-2-amino-5-[(1-benzyl-1-H-indol-3-yl)methylene]-1-methyl-1H-imidazol-4(5H)-one

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Aldol condensation; Microwave irradiation;	90%

: 60-27-5
creatinine

: 773-91-1
5-fluoro-1-methylisatin

: C13H13FN4O3

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 0.0111111h; Microwave irradiation; Cooling;	90%

Creatinine Chemical Properties

Molecular Structure:

Molecular Formula: C₄H₇N₃O
Molecular Weight: 113.1179
IUPAC Name: 2-Amino-3-methyl-4H-imidazol-5-one
Synonyms of Creatinine (CAS NO.60-27-5): 1-Methylglycocyamidine ; 1-Methylhydantoin-2-imide ; AI3-15321 ; Creatinine ; Creatinine,heated ; EINECS 200-466-7 ; NSC 13123 ; UNII-AYI8EX34EU ; 2-Imino-1-methylimidazolidin-4-one ; 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl- ; Creatinine (VAN) (8CI)
CAS NO: 60-27-5
Classification Code: Amino ACIDS SERIES ; Heterocycles ; CO - CZBuilding Blocks ; Alphabetic ; C ; Heterocyclic Building Blocks ; Imidazolines/Imidazolidines
Melting point: 295 °C
Index of Refraction: 1.65
Molar Refractivity: 28.01 cm³
Molar Volume: 76.7 cm³
Surface Tension: 59.5 dyne/cm
Density: 1.47 g/cm³
Flash Point: 75.5 °C
Enthalpy of Vaporization: 43.74 kJ/mol
Boiling Point: 201.1 °C at 760 mmHg
Vapour Pressure: 0.313 mmHg at 25°C

Creatinine Uses

Creatinine (CAS NO.60-27-5) is mainly monitored for as a simple test and it is the most commonly used indicator of renal function.

Creatinine Safety Profile

Hazard Codes of Creatinine (CAS NO.60-27-5): Irritant Xi,Xn
Risk Statements: 34-36/37/38-20/21/22
R34: Causes burns.
R36/37/38: Irritating to eyes, respiratory system and skin.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37/39-45-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25: Avoid contact with skin and eyes.
RIDADR: UN 1789 8/PG 3
WGK Germany: 3
F: 9-23
HS Code: 29332990

Product Name

Creatinine

Synthetic route

Creatinine Chemical Properties

Creatinine Uses

Creatinine Safety Profile

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