Cyclobutanecarboxylic acid supplier

Name
Cyclobutanecarboxylic acid
EINECS 223-072-7
CAS No. 3721-95-7
Article Data40
CAS DataBase
Density 1.202 g/cm³
Solubility Slightly soluble in water.
Melting Point -7.5 ºC(lit.)
Formula C₅H₈O₂
Boiling Point 195.3 ºC at 760 mmHg
Molecular Weight 100.117
Flash Point 85.4 ºC
Transport Information UN 3265
Appearance Clear colourless to slightly amber liquid
Safety 23-24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Cyclobutane-1-carboxylicacid;NSC 4535;Cyclobutance carboxylic acid;
PSA 37.30000
LogP 0.87110

Synthetic route

: 74-85-1
ethene

: 79-10-7
acrylic acid

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
In dichloromethane at -30 - -20℃; for 3h; Temperature; UV-irradiation;	97%
In cyclohexane at 10 - 16℃; Solvent; Diels-Alder Cycloaddition;	95%

: 1427519-99-0
(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-6-methyl-1,3-diphenylhept-1-yn-3-yl cyclobutanecarboxylate

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 1427520-27-1
((3R,6S)-6-isobutyl-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

Conditions

Conditions	Yield
With Echavarren's catalyst; water In 1,2-dichloro-ethane at 80℃; for 24h; Inert atmosphere; stereoselective reaction;	A n/a B 96%

: 4415-82-1
cyclobutanemethanol

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With C15H27Br2CoN3; potassium hydroxide In toluene at 140℃; for 16h; Cannizzaro Reaction; Inert atmosphere; Sealed tube;	73%
With lead(IV) acetate; calcium carbonate In benzene

: 124-38-9
carbon dioxide

: 4399-47-7
Bromocyclobutane

: 584-08-7
potassium carbonate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; 2.9-dimethyl-1,10-phenanthroline; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C60H36N2 In N,N-dimethyl-formamide at 20℃; for 24h; Molecular sieve; Irradiation;	41%

...Expand

: 120-92-3
cyclopentanone

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With poly(bisanthracenyl) diselenide; dihydrogen peroxide In tert-butyl alcohol for 5h; Heating;	15%
With selenium(IV) oxide; dihydrogen peroxide; tert-butyl alcohol
With dihydrogen peroxide In tert-butyl alcohol

: 2987-17-9
cyclobutylaldehyde

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With silver(l) oxide
With sodium hydroxide at 80℃; for 42h;

: 4426-11-3
cyclobutanecarbonitrile

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide
durch Verseifung;
beim Verseifen;

: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
at 210 - 220℃;

: 98431-45-9
ethyl 3-iodocyclobutane-1-carboxylate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With sodium amalgam; ethanol

: 124-38-9
carbon dioxide

: 53213-06-2, 99503-19-2
cyclobutyltriphenylphosphonium ylide

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
(i) , (ii) (alkaline hydrolysis); Multistep reaction;

: 17684-73-0
2-phenylbicyclo<1.1.1>pentan-2-ol

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 5407-98-7
1-cyclobutyl-1-phenyl-methanone

C: 93061-30-4
bicyclo<1.1.1>pentanone

D: 93039-41-9
3-oxocyclobutyl phenyl ketone

E: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With ruthenium tetroxide In tetrachloromethane; acetonitrile for 72h; CCl4/CH3CN/H2O;

...Expand

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide 1.) EtOH, H2O; 2.) reflux; Multistep reaction;
Multi-step reaction with 2 steps 1: H3O+ 2: Heating View Scheme

: 79341-47-2
-1,1-Cyclobutandicarbonsaeure-diethyleater

A: 3721-95-7
Cyclobutanecarboxylic acid

B: <2-13C>-1-Cyclobutancarbonsaeure

C: 42593-04-4
Cyclobutancarbonsaeure

D: 79341-46-1
-1-Cyclobutancarbonsaeure

Conditions

Conditions	Yield
With potassium hydroxide 1) EtOH, reflux, 2) 160 - 170 deg C; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 109-64-8
1,3-dibromo-propane

: 105-53-3
diethyl malonate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutyl-ammonium chloride 1) rt, 1 h, 2) distillation; Yield given. Multistep reaction;

: 109-64-8
1,3-dibromo-propane

: 105-53-3
diethyl malonate

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 1h; Ambient temperature; other subst. 1,3-dibromo compounds, other phase transfer catalysts;
With sodium hydroxide; tetrabutyl-ammonium chloride for 1h; Ambient temperature; Yield given. Yields of byproduct given;

...Expand

: 14924-53-9
ethyl cyclobutylcarboxylate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 2-oxo-2-cyclobutyldiazoethane

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 6540-33-6
cyclobutylacetic acid

Conditions

Conditions	Yield
With dirhodium tetraacetate In dichloromethane for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 7446-08-4
selenium(IV) oxide

: 7722-84-1
dihydrogen peroxide

: 120-92-3
cyclopentanone

: 75-65-0
tert-butyl alcohol

: 3721-95-7
Cyclobutanecarboxylic acid

...Expand

: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
at 210 - 220℃;

: 30466-31-0
cyclobutanecarboxylic acid phenyl ester

A: 3721-95-7
Cyclobutanecarboxylic acid

B: 108-95-2
phenol

C salicyloylcyclobutane: salicyloylcyclobutane

Conditions

Conditions	Yield
at 300℃;

...Expand

: 7664-93-9
sulfuric acid

: 403595-50-6
2-cyano-3-cyclobutyl-3-oxo-propionic acid ethyl ester

A: 141-82-2
malonic acid

B: 3721-95-7
Cyclobutanecarboxylic acid

...Expand

: 120-92-3
cyclopentanone

A: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

B: 13392-69-3
valeric acid

C: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With dibutyl ether; bis[3,5-bis(trifluoromethyl)diphenyl] diselenide In 2,2,2-trifluoroethanol at 20℃; for 8h; Product distribution; Further Variations:; Catalysts; Solvents; Baeyer-Villiger oxidation;

...Expand

: 59078-45-4
cyclobutylidenemethanone

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
With sodium perchlorate; water at 25℃; Kinetics;

: 120-92-3
cyclopentanone

furan(?): furan(?)

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 13 percent / Pb(OAc)4, 70percent HClO4 / 28 h / Ambient temperature 2: 2N NaOH View Scheme

: 28246-87-9
ethyl 1-cyano-1-cyclobutanecarboxylate

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Hydrolysis View Scheme

: 1503-98-6
cyclobutyl amide

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: P2O5 / durch Destillation 2: beim Verseifen View Scheme

: 1120-56-5
methylidenecyclobutane

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hypochlorous acid 3: silver oxide View Scheme

: 98070-78-1
1-chloromethyl-cyclobutanol

: 3721-95-7
Cyclobutanecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: silver oxide View Scheme

: 3721-95-7
Cyclobutanecarboxylic acid

: 5006-22-4
Cyclobutanecarbonyl chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene Heating;	100%
With phosphorus trichloride
With thionyl chloride

: 3721-95-7
Cyclobutanecarboxylic acid

: 41248-13-9
1-hydroxycyclobutane-1-carboxylic acid

Conditions

Conditions	Yield
Stage #1: Cyclobutanecarboxylic acid With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at 0 - 20℃; for 18.5h; Metallation; Stage #2: With oxygen In tetrahydrofuran; hexane at 20℃; for 18h; Oxidation;	100%
Stage #1: Cyclobutanecarboxylic acid With n-butyllithium; diisopropylamine In tetrahydrofuran; n-heptane at -20 - 20℃; Stage #2: With oxygen In tetrahydrofuran; n-heptane for 19h; Stage #3: With hydrogenchloride In water

: 542-69-8
1-iodo-butane

: 3721-95-7
Cyclobutanecarboxylic acid

: 58148-13-3
1-butylcyclobutane carboxylic acid

Conditions

Conditions	Yield
Stage #1: Cyclobutanecarboxylic acid With lithium diethylamide In tetrahydrofuran; n-heptane; ethylbenzene at 0 - 20℃; for 2h; Stage #2: 1-iodo-butane In tetrahydrofuran; n-heptane; ethylbenzene at 20℃;	100%
With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 12h;
Stage #1: Cyclobutanecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: 1-iodo-butane In tetrahydrofuran at 0 - 20℃; for 12h;

: 3721-95-7
Cyclobutanecarboxylic acid

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 666853-33-4
C16H28N2O3

Conditions

Conditions	Yield
With hydrogenchloride; dmap; diethylamine In dichloromethane	100%

: 3721-95-7
Cyclobutanecarboxylic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: (S)-N-(1-phenylethyl)cyclobutanecarboxamide

Conditions

Conditions	Yield
With tetramethylorthosilicate In toluene at 110℃; for 2h; Inert atmosphere;	100%

: 3721-95-7
Cyclobutanecarboxylic acid

: methyl 3-amino-4-(((2,2-difluorobenzo[d][1,3]dioxol-4-yl)methyl)amino)benzoate

: methyl 3-(cyclobutanecarboxamido)-4-(((2,2-difluorobenzo[d][1,3]dioxol-4-yl)methyl)amino)benzoate

Conditions

Conditions	Yield
With triethylamine; HATU In dichloromethane at 22℃; for 2h; Inert atmosphere;	99%

: 3721-95-7
Cyclobutanecarboxylic acid

: 53-43-0
dehydroepiandrosterone

: 1345406-89-4
3β-cyclobutylcarbonyloxy-5-androsten-17-one

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In chloroform at 20℃; for 2h;	98%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;	90.4%
With dmap; dicyclohexyl-carbodiimide In chloroform at 20℃; for 2h;	84%
With dmap; dicyclohexyl-carbodiimide In chloroform Steglich Esterification;
With dmap; dicyclohexyl-carbodiimide

: 524-38-9
N-hydroxyphthalimide

: 3721-95-7
Cyclobutanecarboxylic acid

: 1,3-dioxoisoindolin-2-yl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere;	98%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 25℃;	90%
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 5h;	89%

: 3721-95-7
Cyclobutanecarboxylic acid

: 616-38-6
carbonic acid dimethyl ester

: 765-85-5
methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube;	98%

: 3721-95-7
Cyclobutanecarboxylic acid

: 743478-65-1
cyclobutylmalonyl Dichloride

Conditions

Conditions	Yield
With oxalyl dichloride In triethylamine at 55℃; for 120h; Heating / reflux; Nitrogen atmosphere;	97%

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1S*,2R*)-1-methyl-2-((S*)-5-methylhex-4-en-2-yl)cyclopropyl]methanol

: [(1S*,2R*)-1-methyl-2-((S*)-5-methylhex-4-en-2-yl)cyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	97%

: 3721-95-7
Cyclobutanecarboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1.5h; Ambient temperature;	96%
With lithium aluminium tetrahydride In diethyl ether	72%
With lithium aluminium tetrahydride; diethyl ether

: 3721-95-7
Cyclobutanecarboxylic acid

: (2S,3R,4S,5S)-ethyl 5-(2-(azetidin-1-yl)pyridin-3-yl)-3-(tert-butyl)-4-nitropyrrolidine-2-carboxylate

: (2S,3R,4S,5S)-ethyl 5-(2-(azetidin-1-yl)pyridin-3-yl)-3-(tert-butyl)-1-(cyclobutanecarbonyl)-4-nitropyrrolidine-2-carboxylate

Conditions

Conditions	Yield
Stage #1: Cyclobutanecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; Stage #2: (2S,3R,4S,5S)-ethyl 5-(2-(azetidin-1-yl)pyridin-3-yl)-3-(tert-butyl)-4-nitropyrrolidine-2-carboxylate With triethylamine In dichloromethane for 0.5h; Cooling with ice;	96%

: 3721-95-7
Cyclobutanecarboxylic acid

: 797-63-7
levonorgestrel

: 86679-36-9
D-(-)-norgestrel 17β-cyclobutanecarboxylate

Conditions

Conditions	Yield
With sodium carbonate; trifluoroacetic anhydride In benzene for 1.5h; Ambient temperature;	95.4%

: 3721-95-7
Cyclobutanecarboxylic acid

: 74-88-4
methyl iodide

: 32936-76-8
1-methylcyclobutane carboxylic acid

Conditions

Conditions	Yield
Stage #1: Cyclobutanecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran; hexane at 5℃; for 0.25h; Stage #2: methyl iodide In tetrahydrofuran; hexane at 20℃;	95%
Stage #1: Cyclobutanecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 1h; Stage #2: methyl iodide In tetrahydrofuran at 20℃;	92.1%
Stage #1: Cyclobutanecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran at 20℃;	92.1%

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1S*,2R*)-1-methyl-2-((R*)-5-methylhex-4-en-2-yl)cyclopropyl]methanol

: [(1S*,2R*)-1-methyl-2-((R*)-5-methylhex-4-en-2-yl)cyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	95%

: 3721-95-7
Cyclobutanecarboxylic acid

: 5-(4-bromothiophen-2-yl)pyridin-3-amine

: N-(5-(4-bromothiophen-2-yl)pyridin-3-yl)cyclobutanecarboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	94.6%

: 186581-53-3, 908094-01-9
diazomethane

: 3721-95-7
Cyclobutanecarboxylic acid

: 765-85-5
methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
In diethyl ether for 0.5h; Ambient temperature;	94%

: 3721-95-7
Cyclobutanecarboxylic acid

: (4-amino-azepan-1-yl)-[7-methoxy-8-(2-methyl-propenyl)-1-thiophen-3-yl-1,4-dihydro-chromeno[4,3-c]pyrazole-3-yl]methanone

: cyclobutanecarboxylic acid {1-[7-methoxy-8-(2-methyl-propenyl)-1-thiophen-3-yl-1,4-dihydro-chromeno[4,3-c]pyrazole-3-carbonyl]-azepan-4-yl}-amide

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;	94%

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1R*,2S*)2-((S*)-1-cyclohexylethyl)-1-methylcyclopropyl]methanol

: [(1R*,2S*)-2-((S*)-1-cyclohexylethyl)-1-methylcyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	94%

: 933043-85-7
2-[2-(3-chloro-phenyl)-2H-tetrazol-5-yl]-piperidine hydrochloride

: 3721-95-7
Cyclobutanecarboxylic acid

: cyclobutyl-{2-[2-(3-chloro-phenyl)-2H-tetrazol-5-yl]-piperidin-1-yl}-methanone

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane at 25℃; for 20h;	93%

: 870-46-2
t-butoxycarbonylhydrazine

: 3721-95-7
Cyclobutanecarboxylic acid

: tert-butyl 2-(cyclobutanecarbonyl)hydrazine-1-carboxylate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 25℃; for 1h;	93%

: 3721-95-7
Cyclobutanecarboxylic acid

: 1416881-52-1
(4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile

: 2,3,4,6-tetra(9H-carbazol-9-yl)-5-cyclobutylbenzonitrile

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide Inert atmosphere; Irradiation;	93%

: 141-30-0
3,6-dichlorpyridazine

: 3721-95-7
Cyclobutanecarboxylic acid

: 107228-57-9
3,6-dichloro-4-cyclobutylpyridazine

Conditions

Conditions	Yield
Stage #1: 3,6-dichlorpyridazine; Cyclobutanecarboxylic acid With sulfuric acid; silver nitrate In water at 70℃; for 0.0166667h; Stage #2: With ammonium peroxydisulfate In water at 20℃; for 0.416667 - 0.583333h; Stage #3: With ammonia In water at 5℃;	92%
With ammonium persulfate; sulfuric acid; silver nitrate In water
With ammonium persulfate; sulfuric acid; silver nitrate In water
With ammonium peroxydisulfate; sulfuric acid; silver nitrate In water at 72℃;

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1R*,2S*)-1-methyl-(2-((S*)-1-phenylethyl)cyclopropyl)]methanol

: [(1R*,2S*)-1-methyl-2-((S*)-1-phenylethyl)cyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	92%

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1R*,2S*)-1-methyl-(2-((R*)-1-phenylethyl)cyclopropyl)]methanol

: [(1R*,2S*)-1-methyl-2-((R*)-1-phenylethyl)cyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	92%

: 3721-95-7
Cyclobutanecarboxylic acid

: [(1R*,2S*)2-((R*)-1-cyclohexylethyl)-1-methylcyclopropyl]methanol

: [(1R*,2S*)-2-((R*)-1-cyclohexylethyl)-1-methylcyclopropyl]methyl cyclobutanecarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In toluene for 1h; Inert atmosphere;	92%

: 3721-95-7
Cyclobutanecarboxylic acid

: 13633-25-5
1-Bromo-4-phenylbutane

: C15H20O

Conditions

Conditions	Yield
With 6,6'-dimethyl-2,2'-bipyridine; nickel(II) bromide trihydrate; di-tert-butyl dicarbonate; sodium iodide; magnesium chloride; zinc In N,N-dimethyl acetamide at 30℃; for 24h; regioselective reaction;	91%

Cyclobutanecarboxylic acid Specification

The Cyclobutanecarboxylic acid, with the CAS registry number 3721-95-7, is also known as Cyclo-butyl formic acid. It belongs to the product categories of Acids and Derivatives; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Cyclobutanes & Cyclobutenes; Simple 4-Membered Ring Compounds; Cycloalkanes; C1 to C5; Carbonyl Compounds; Carboxylic Acids. Its EINECS registry number is 223-072-7. This chemical's molecular formula is C₅H₈O₂ and molecular weight is 100.12. What's more, its IUPAC name is the same with its product name. This chemical can be prepared by Cyclobutane-1, 1-dicarboxylic acid. This reaction needs the temperature of 160 °C. The yield is 86-91 %.

Physical properties about Cyclobutanecarboxylic acid are: (1)ACD/LogP: 0.65; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.14; (4)ACD/LogD (pH 7.4): -1.93; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 8.84; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 26.3 Å²; (13)Index of Refraction: 1.501; (14)Molar Refractivity: 24.55 cm³; (15)Molar Volume: 83.2 cm³; (16)Surface Tension: 49.5 dyne/cm; (17)Density: 1.202 g/cm³; (18)Flash Point: 85.4 °C; (19)Enthalpy of Vaporization: 47.56 kJ/mol; (20)Boiling Point: 195.3 °C at 760 mmHg; (21)Vapour Pressure: 0.182 mmHg at 25 °C.

Uses of Cyclobutanecarboxylic acid: (1) it is used in organic synthesis; (2) it is used to produce other chemicals. For example, it can react with Methanol to get Cyclobutanecarboxylic acid methyl ester. The reaction occurs with reagent H₂SO₄ and other condition of heating for 8 hours. The yield is 75 %.

Cyclobutanecarboxylic acid can react with Methanol to get Cyclobutanecarboxylic acid methyl ester.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should avoid contacting with skin, eyes and wear suitable protective clothing. You can not breathe the gas/fumes/vapour/spray. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(O)C1CCC1
(2) InChI: InChI=1S/C5H8O2/c6-5(7)4-2-1-3-4/h4H,1-3H2,(H,6,7)
(3) InChIKey: TXWOGHSRPAYOML-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1270mg/kg (1270mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. Link to PubMed
mouse	LD50	subcutaneous	1270mg/kg (1270mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969. Link to PubMed

Product Name

Cyclobutanecarboxylic acid

Synthetic route

Cyclobutanecarboxylic acid Specification

Related Products

Hot Products