Cyclohexylamine supplier | CasNO.108-91-8

Name
Cyclohexanamine
EINECS 203-629-0
CAS No. 108-91-8
Article Data607
CAS DataBase
Density 0.869 g/cm³
Solubility miscible with water
Melting Point -17 °C
Formula C₆H₁₃ N
Boiling Point 134.5 °C at 760 mmHg
Molecular Weight 99.1759
Flash Point 32.2 °C
Transport Information UN 2357 8/PG 2
Appearance clear liquid
Safety 36/37/39-45-1/2
Risk Codes 10-21/22-34
Molecular Structure
Hazard Symbols C
Synonyms Cyclohexylamine(6CI,8CI);1-Aminocyclohexane;1-Cyclohexylamine;Aminocyclohexane;Aminohexahydrobenzene;Benzenamine, hexahydro-;Hexahydroaniline;Monocyclohexylamine;Cyclohexylamine Acid;
PSA 26.02000
LogP 1.97810

Synthetic route

: 62-53-3
aniline

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With hydrogen In water at 100℃; under 15001.5 Torr; for 1.5h;	100%
Stage #1: aniline With ammonia; hydrogen at 120℃; under 45004.5 Torr; Stage #2: at 150℃;	97.3%
With hydrogen; [(norbornadiene)rhodium(I)chloride]2; phosphinated polydiacetylene In n-heptane at 30℃; under 60800 Torr; for 17h;	80%

: 1122-60-7
1-nitrocyclohexane

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With potassium hydroxide; hydrogen In methanol; water Devarda copper electrode;	100%
With carbon monoxide; Au/TiO2-VS; water In ethanol at 25℃; under 3800.26 Torr; for 4h; Autoclave; chemoselective reaction;	100%
With indium; ammonium chloride In ethanol Heating;	100%

: 19028-72-9
N-(2-hydroxybenzylidene)cyclohexylamine

: 109-73-9
N-butylamine

A: 2565-54-0
(E)-2-((butylimino)methyl)phenol

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
In [D3]acetonitrile at 25℃; Equilibrium constant; Molecular sieve;	A 100% B n/a

...Expand

: C15H20N2O

: 109-73-9
N-butylamine

A: C13H18N2O

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
In [D3]acetonitrile at 25℃; Equilibrium constant; Molecular sieve;	A 100% B n/a

...Expand

: C14H20N2O2S

: 109-73-9
N-butylamine

A: C12H18N2O2S

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
In [D3]acetonitrile at 25℃; Equilibrium constant; Molecular sieve;	A 100% B n/a

...Expand

: 2387-23-7
1,3-Dicyclohexylurea

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With sodium hydroxide at 450℃; for 8h; Temperature; Autoclave; Large scale;	99.49%

: 25070-80-8
prop-2'-en-1'-yl cyclohexylcarbamate

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With tris(2,2'-bipyridine)nickel(II) tetrafluoroborate In N,N-dimethyl-formamide at 20℃; allyl carbamate cleavage; Electrochemical reaction; Zn/stainless steel couple electrodes; current intensity 60 mA; supporting electrolite: tetrabutylammonium tetrafluoroborate;	99%
With aniline; (ϖ-allyl)palladium triflate based catalyst at 30℃;	99%
With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 3h;	100 % Chromat.
With trifluorormethanesulfonic acid; [RuCp(η3-C3H5)(QA)]PF6, QA=quinaldic acid In methanol at 30℃; for 2h;	99 % Spectr.

: 1122-60-7
1-nitrocyclohexane

12percent nickel/Al-SBA-15 fiber: 12percent nickel/Al-SBA-15 fiber

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With hydrogen In ethanol at 109.84℃; under 18751.9 Torr; for 7.5h; Autoclave; Green chemistry; chemoselective reaction;	99%

: 62-53-3
aniline

A: 110-82-7
cyclohexane

B: 108-91-8
cyclohexylamine

C: 101-83-7
N-cyclohexyl-cyclohexanamine

D: 110-83-8
cyclohexene

Conditions

Conditions	Yield
With ammonia; hydrogen at 180 - 200℃;	A n/a B 98.4% C 0.08% D n/a
With hydrogen at 160 - 200℃; under 150015 Torr;	A n/a B 95.9% C 0.45% D n/a

...Expand

: 2550-26-7
4-Phenyl-2-butanone

: 108-94-1
cyclohexanone

A: 937-52-0
(R)-1-methyl-3-phenylpropylamine

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; Aspergillus terreus ω-trans aminase; Lysinibacillus fusiformis leucine dehydrogenase; ammonium formate; nicotinamide adenine dinucleotide In aq. buffer at 30℃; for 24h; pH=8.8; Catalytic behavior; Green chemistry; Enzymatic reaction;	A 4.5% B 98.2%

...Expand

: 19573-22-9
cyclohexyl azide

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With magnesium In methanol for 0.25h;	98%
With n-butyllithium; dimethylamine borane In tetrahydrofuran 1.) 0 deg C, 30 min; 2.) 25 deg C, 1 h;	98%
With sodium sulfide; water for 0.5h; Reflux;	95%

: 107969-85-7
(tert-Butyl-diphenyl-silanyl)-cyclohexyl-amine

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With pyridine hydrogenfluoride In tetrahydrofuran; water at 25℃; for 2h; Product distribution;	98%
With methanol; bromine for 24h; Heating;	95%

: 62-53-3
aniline

A: 108-91-8
cyclohexylamine

B: 101-83-7
N-cyclohexyl-cyclohexanamine

Conditions

Conditions	Yield
With lithium hydroxide; hydrogen; 5% ruthenium/lithium aluminate In water at 150℃; under 44718.8 Torr; for 2.08333h; Product distribution / selectivity; Neat (no solvent);	A 97.1% B 1%
With lithium hydroxide; hydrogen; 5% activated charcoal-supported ruthenium catalyst In water at 150℃; under 44718.8 Torr; for 1.21667h; Product distribution / selectivity; Neat (no solvent);	A 91.8% B 5.73%
With hydrogen; 5% ruthenium/lithium aluminate at 150℃; under 44718.8 Torr; for 1.28333 - 3h; Product distribution / selectivity; Neat (no solvent);	A 89.2% B 0.08%

: 108-94-1
cyclohexanone

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With ammonia; hydrogen In methanol at 30℃; for 6h; Autoclave;	97%
With ammonium hydroxide; nickel-aluminum alloy; water at 25℃; for 2h; Temperature; Time; Sonication; Green chemistry;	91%
With ammonia; hydrogen In methanol at 90℃; under 15001.5 Torr; for 4h;	90%

: N-cyclohexyl-2-phenylimidazo[1,2-a]pyridin-3-amine

A: 4589-12-2
N-(pyrid-2-yl)benzamide

B: 108-91-8
cyclohexylamine

C: 2387-23-7
1,3-Dicyclohexylurea

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Reagent/catalyst; Solvent; Schlenk technique; Heating; chemoselective reaction;	A 96% B n/a C n/a

...Expand

: 100-64-1
Cyclohexanone oxime

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With triethylamine alane In tetrahydrofuran for 0.5h; Ambient temperature;	94%
With sodium tetrahydroborate; nickel; sodium hydroxide In methanol; water at 20 - 30℃;	92%
With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride In N,N-dimethyl-formamide for 1.3h; Reflux;	90%

: 98-95-3
nitrobenzene

A: 108-91-8
cyclohexylamine

B: 62-53-3
aniline

Conditions

Conditions	Yield
With hydrogen In water at 80℃; under 15001.5 Torr; for 4h; Catalytic behavior; Autoclave;	A 6.4% B 93.6%
With hydrogen; Ph(III) complex In ethanol at 80℃; for 4h; Product distribution; other catalysts;
With 5 wt% ruthenium/carbon; hydrogen; sodium nitrite In N,N-dimethyl-formamide at 170℃; under 62256.2 Torr; for 4h; Temperature; Pressure; Solvent; Concentration; Autoclave;

: 108-94-1
cyclohexanone

A: 108-91-8
cyclohexylamine

B: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen; magnesium oxide; ruthenium In water at 99.9℃; under 15001.2 Torr; Product distribution;	A 6.5% B 93.5%
With ammonia; hydrogen In methanol; ethanol at 100℃; under 37503.8 Torr; for 3h; Catalytic behavior; Reagent/catalyst; Autoclave;	A 93.4% B 6.6%
With ammonia; hydrogen In methanol at 80℃; for 6h; Autoclave;	A 91% B 9%

: 2211-66-7
N-phenyl(methylidene)cyclohexanamine

: 30540-36-4
1-phenyl-3,4-dimethylphosphole

: C38H34P2

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With iron(II) chloride In toluene at 170℃; for 16h; Inert atmosphere;	A 93% B n/a

...Expand

: 6628-00-8
N-Allylcyclohexylamin

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With water; [{Ru(η3:η3-[-CH2C(CH3)=CHCH2]2)(μ-Cl)Cl}2] at 90℃; for 3h;	92%
With tert.-butylhydroperoxide; chromia-pillared montmorillonite catalyst (Cr-PILC) In 2,2,4-trimethylpentane; dichloromethane for 20h; Ambient temperature;	90%
With polymethylhydrosiloxane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃;	89%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 24h; chemoselective reaction;	20%

: 108-98-5
thiophenol

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
thiophenol	92%

: 1124-53-4
N-cyclohexylacetamide

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
Stage #1: N-cyclohexylacetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.0333333h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere;	91%

: 56644-00-9
N-(4-methoxybenzylidene)cyclohexylamine

: 30540-36-4
1-phenyl-3,4-dimethylphosphole

: C40H38O2P2

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With iron(II) chloride In toluene at 170℃; for 16h; Inert atmosphere;	A 91% B n/a

...Expand

: 4383-25-9
N-benzylcyclohexylamine

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide; palladium on activated charcoal In tetrahydrofuran; water; isopropyl alcohol for 6h;	90%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In aq. buffer at 30℃; for 16h; pH=5; Enzymatic reaction;

: 2133-65-5
N-cyclohexylphthalimide

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With hydrazine hydrate In 1,4-dioxane at 110℃; Gabriel Amine Synthesis; Inert atmosphere;	90%

: 2562-37-0
1-nitrocyclohexene

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; borane-THF In tetrahydrofuran at 25℃; for 144h;	89%
With sodium tetrahydroborate; nickel boride In methanol	66%
With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; borane-THF 1.) 25 deg C, 6 days, 2.) 60 -65 deg C, 2 h, 3.) NaOH; Yield given. Multistep reaction;
With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate 1.) THF, reflux, 5.5 h, 2.) heating, 2 h; Yield given. Multistep reaction;

: 51305-92-1
cyclohexyl-thiophen-2-ylmethylene-amine

: 30540-36-4
1-phenyl-3,4-dimethylphosphole

: C34H30P2S2

B: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With iron(II) chloride In toluene at 170℃; for 16h; Inert atmosphere;	A 88% B n/a

...Expand

: 946-80-5
(benzyloxy)benzene

A: 108-91-8
cyclohexylamine

B: 108-88-3
toluene

Conditions

Conditions	Yield
With methanol; 5% Rh/C; ammonia; hydrogen; isopropyl alcohol In Hexadecane at 110℃; under 12001.2 Torr; for 16h; Autoclave;	A 88% B n/a

: 84452-37-9
N-cyclohexyl-1-phenyl-2,2,2-trifluoroethylideneamine

: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With boric acid In ethanol Heating;	87%

: 108-30-5
succinic acid anhydride

: 108-91-8
cyclohexylamine

: 21451-32-1
4-(cyclohexylamine)-4-oxobutanoic acid

Conditions

Conditions	Yield
Stage #1: succinic acid anhydride; cyclohexylamine In N,N-dimethyl acetamide at 20℃; for 24h; Stage #2: In N,N-dimethyl acetamide; xylene at 140℃; for 48h;	100%
In 1,4-dioxane at 80℃; for 0.5h;	90%
In dichloromethane at 20℃; for 0.333333h;	89%

: 75-15-0
carbon disulfide

: 108-91-8
cyclohexylamine

: 1212-29-9
1,3-dicyclohexylthiourea

Conditions

Conditions	Yield
at 100℃; for 12h; Ionic liquid; Green chemistry;	100%
In water at 20℃; for 1h; Green chemistry;	95%
In water at 20℃; for 0.833333h; Green chemistry;	95%

: 108-05-4
vinyl acetate

: 108-91-8
cyclohexylamine

: 1124-53-4
N-cyclohexylacetamide

Conditions

Conditions	Yield
at 90℃; for 1h; microwave irradiation;	100%
With immobilization of Candida cylindracea lipase In hexane at 55℃; for 15h;	99%
With 1-(3-sulfopropyl)pyridinium phosphotungstate In neat (no solvent) at 100℃; for 0.5h; Microwave irradiation;	91%

: 108-91-8
cyclohexylamine

: 98-88-4
benzoyl chloride

: 1759-68-8
N-benzoylcyclohexylamine

Conditions

Conditions	Yield
With sodium hydroxide In water at 25℃; for 1h;	100%
Stage #1: cyclohexylamine; benzoyl chloride With pyridine In dichloromethane at 20℃; for 0.333333h; Stage #2: With poly{trans-bicyclo[2.2.1]hept-5-ene-2,3-di(chlorocarbonyl)} In dichloromethane at 20℃; for 0.5h;	99%
With pyridine In dichloromethane at 0 - 20℃;	97%

: 108-91-8
cyclohexylamine

: 79-04-9
chloroacetyl chloride

: 23605-23-4
2-Chloro-N-cyclohexylacetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With triethylamine In dichloromethane at 20 - 27℃; for 1h;	100%
In acetonitrile at 5 - 20℃; for 2h;	93%

: 108-91-8
cyclohexylamine

: 532-55-8
Benzoyl isothiocyanate

: 4921-92-0
TM-2-97

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h;	100%
In dichloromethane at 5℃; Inert atmosphere;	99%
In dichloromethane at 5 - 20℃; Inert atmosphere;	99%

: 108-91-8
cyclohexylamine

: 1493-27-2
ortho-nitrofluorobenzene

: 6373-71-3
N-cyclohexyl-2-nitroaniline

Conditions

Conditions	Yield
In toluene at 25℃; Rate constant; also in DMSO;	100%
In toluene at 25℃;	100%
	97%

: 108-91-8
cyclohexylamine

: 98-59-9
p-toluenesulfonyl chloride

: 80-30-8
N-cyclohexyl-p-toluenesulfonamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.5h; Inert atmosphere;	100%
With pyridine at 0 - 25℃; Inert atmosphere; Schlenk technique;	99%
With triethylamine In tetrahydrofuran at 0 - 20℃;	95%

: 108-91-8
cyclohexylamine

: 3378-45-8, 17606-86-9, 26049-06-9
N,N'-dicyclohexyldiazene N,N'-dioxide

Conditions

Conditions	Yield
With sodium percarbonate; N,N,N',N'-tetraacetylethylenediamine; sodium hydrogencarbonate In dichloromethane; water for 3h; Ambient temperature;	100%
With sodium perborate; N,N,N',N'-tetraacetylethylenediamine; sodium hydrogencarbonate In water; ethyl acetate for 2.5h; Ambient temperature;	75%
With peracetic acid

: 108-91-8
cyclohexylamine

: 762-04-9
phosphonic acid diethyl ester

: 32405-88-2
diethyl cyclohexylphosphoramidate

Conditions

Conditions	Yield
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15 - 20℃; for 2h;	100%
With copper(ll) bromide In ethyl acetate at 25℃; for 3h;	89%
With tetrachloromethane at 20℃; for 1h; Atherton-Todd Synthesis;	85%

: 108-91-8
cyclohexylamine

: 98-09-9
benzenesulfonyl chloride

: 3237-31-8
N-cyclohexylbenzenesulfonamide

Conditions

Conditions	Yield
With picoline In dichloromethane at 20℃; for 1h;	100%
With pyridine In dichloromethane at 0 - 20℃;	85%
With pyridine

: 27550-59-0
4-hydroxyphthalic anhydride

: 108-91-8
cyclohexylamine

: 3975-51-7
2-cyclohexyl-5-hydroxyisoindoline-1,3-dione

Conditions

Conditions	Yield
In toluene at 110℃; for 12h; Molecular sieve; Inert atmosphere;	100%
In toluene Heating;	82%

: 1177-35-1
2,4,6-Tris(4-methylphenoxy)-1,3,5-triazine

: 108-91-8
cyclohexylamine

: 79922-90-0
(4,6-Bis-p-tolyloxy-[1,3,5]triazin-2-yl)-cyclohexyl-amine

Conditions

Conditions	Yield
	100%

: 67-56-1
methanol

: 108-91-8
cyclohexylamine

: 98-94-2
N,N-dimethyl-cyclohexanamine

Conditions

Conditions	Yield
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 100℃;	100%
With Cu1-Mo1/TiO2 In neat liquid at 20℃; for 21h; Catalytic behavior; Inert atmosphere; UV-irradiation;	94%
With [Cp*Ir(2-(1H-benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole)Cl][Cl]; caesium carbonate at 120℃; for 12h; Schlenk technique;	94%

: 506-68-3
bromocyane

: 108-91-8
cyclohexylamine

: 4421-48-1
N-cyanocyclohexylamine

Conditions

Conditions	Yield
	100%
In diethyl ether; tetrahydrofyran at 0℃; for 1h;	96%
With triethylamine In diethyl ether at 0℃;	88%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 108-91-8
cyclohexylamine

: 66937-55-1
N-cyclohexylglycine t-butyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol at 20℃; for 12h;	100%
With triethylamine In ethanol Ambient temperature;
With sodium hydrogencarbonate In ethanol	31.9 g (97%)

: 7468-67-9
o-formylbenzonitrile

: 108-91-8
cyclohexylamine

: 93680-04-7
3-(cyclohexylamino)isoindolin-1-one

Conditions

Conditions	Yield
at 20℃; for 9h;	100%
With N,N,N,N-tetraethylammonium tetrafluoroborate In acetonitrile at 20℃; Electrolysis;	60%

: 108-91-8
cyclohexylamine

: 13068-20-7
N-bis-(methylsulfanylmethylene)benzenesulfonamide

: 5667-51-6
N1-phenylsulfonyl-N2,N3-dicyclohexylguanidine

Conditions

Conditions	Yield
for 7h; Heating;	100%

: 110905-37-8
(E)-(4-Oxo-2-butenyl)phosphonsaeure-diethylester

: 108-91-8
cyclohexylamine

: 129422-73-7
(5-aza-5-cyclohexylpenta-2,4-dienyl)diethoxyphosphin-1-one

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	100%
With molecular sieve In tetrahydrofuran Ambient temperature; Yield given;

: 74119-49-6
(1-Cyan-2-dimethylaminovinyl)phosphonsaeure-diethylester

: 108-91-8
cyclohexylamine

: 98934-45-3
((Z)-1-Cyano-2-cyclohexylamino-vinyl)-phosphonic acid diethyl ester

Conditions

Conditions	Yield
In ethanol Heating;	100%

: 74119-48-5
2-Diethoxyphosphoryl-3-dimethylaminoacrylsaeure-ethylester

: 108-91-8
cyclohexylamine

: 24654-86-2
(Z)-3-Cyclohexylamino-2-(diethoxy-phosphoryl)-acrylic acid ethyl ester

Conditions

Conditions	Yield
In ethanol Heating;	100%

: 104272-95-9
t-butyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate

: 108-91-8
cyclohexylamine

: 3712-40-1
tert-butyl cyclohexylcarbamate

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 0.166667h; Ambient temperature;	100%

: 81917-67-1
N-(1-Benzotriazolylcarbonyl)-DL-alanin

: 108-91-8
cyclohexylamine

: 86211-51-0
D,L-alanine cyclohexylamide

Conditions

Conditions	Yield
In water; acetone for 3h; Ambient temperature;	100%

: 108-91-8
cyclohexylamine

: 100-52-7
benzaldehyde

: 4383-25-9
N-benzylcyclohexylamine

Conditions

Conditions	Yield
With lithium In tetrahydrofuran at 25℃; for 2h; Inert atmosphere;	100%
Stage #1: cyclohexylamine; benzaldehyde In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%
With 1.1 wt% Pd/NiO; hydrogen In ethanol at 25℃; under 760.051 Torr; for 10h;	98%

: 108-91-8
cyclohexylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 3459-75-4
N,N-dimethyl-N'-cyclohexylformamidine

Conditions

Conditions	Yield
at 60℃;	100%
In methanol at 25℃; for 12h;	98%
1.) 50 deg C, 5 h, 2.) room temperature, 12 h;	92%
In benzene for 1h; Heating;	64%

: 108-91-8
cyclohexylamine

: 125103-12-0
2-Chloro-3-<α-cyano-α-(benzimidazol-2-yl)methylene>3,4-dihydroquinoxaline

: 120340-88-7
1-Cyclohexyl-2-Amino-3-(benzimidazol-2-yl)pyrrolo<2,3-b>quinoxaline

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.666667h; Heating;	100%

: 108-91-8
cyclohexylamine

: 125103-13-1
[3-Chloro-1H-quinoxalin-(2Z)-ylidene]-(1-methyl-1H-benzoimidazol-2-yl)-acetonitrile

: 120340-89-8
1-Cyclohexyl-3-(1-methyl-1H-benzoimidazol-2-yl)-1H-pyrrolo[2,3-b]quinoxalin-2-ylamine

Conditions

Conditions	Yield
for 0.0833333h; Heating;	100%

: 108-91-8
cyclohexylamine

: 100-10-7
4-dimethylamino-benzaldehyde

: 31235-64-0
N-<<4-(dimethylamino)phenyl>methylene>cyclohexylamine

Conditions

Conditions	Yield
With sodium sulfate In methanol for 4h; Ambient temperature;	100%

Cyclohexylamine Specification

The Cyclohexylamine, with the cas registry number 108-91-8, is a kind of colorless liquid with an odor of ammonia. Being sensitive to air and light, it is soluble in water and may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Besides, its product categories are including Pharmaceutical Intermediates.

The physical properties of this chemical are as follows: (1)ACD/LogP: 1.40; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.7; (4)ACD/LogD (pH 7.4): -1.44; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24; (13)Index of Refraction: 1.459; (14)Molar Refractivity: 31.22 cm³; (15)Molar Volume: 114 cm³; (16)Polarizability: 12.37 ×10^-24cm³; (17)Surface Tension: 31.4 dyne/cm; (18)Density: 0.869 g/cm³; (19)Flash Point: 32.2 °C; (20)Enthalpy of Vaporization: 36.14 kJ/mol; (21)Boiling Point: 134.5 °C at 760 mmHg; (22)Vapour Pressure: 8.07 mmHg at 25°C.

Use of this chemical: Cyclohexylamine could react with N-tert-Butyl-3-oxobutyramid to produce N-tert-Butyl-3-(cyclohexylamino)crotonsaeure-amid, with the following condition: reagent: conc. HCl ; solvent: CH₂Cl₂; reaction temp.: 2 hours; yield: 87%.

As to its usage, it is widely applied in many ways. It could be used as the thiofide, the raw material for synthetic fibre, dye and vapour-phase inhibitor; It could also used in producing reactive dye, softening agent, solaziquone, and as the intermediate of phytocide Hexazinone, rubber accelerator, petroleum additive and rust inhibitor; Then it is usually used in organic synthesis, rubber synthesis, and also could be as the preservative and sour gas absorbent. When store it, keep it in a dry, cool and well-ventilated place, away from the oxidizing agent, acids.

When you are dealing with this kind of chemical, you should be much more careful and then take some measures to protect yourself. For one thing, it is corrosive which may destroy living tissue on contact. If in contact with skin and if swallowed, it will be harmful. For another thing, it is flammable and then causes burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. If in case of accident or if you feel unwell seek medical advice immediately (show the label where possible). When store it, keep locked up and out of the reach of children.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C1CCC(CC1)N
(2)InChI: InChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
(3)InChIKey: PAFZNILMFXTMIY-UHFFFAOYSA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	200mg/kg (200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
guinea pig	LCLo	inhalation	1200ppm/7H (1200ppm)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
mammal (species unspecified)	LD50	intraperitoneal	200mg/kg (200mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES VASCULAR: SHOCK LIVER: OTHER CHANGES	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.
mouse	LC50	inhalation	1070mg/m3 (1070mg/m3)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.
mouse	LD50	intraperitoneal	129mg/kg (129mg/kg)		Pharmaceutical Chemistry Journal Vol. 22, Pg. 469, 1988.
mouse	LD50	intravenous	200mg/kg (200mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
mouse	LD50	oral	224mg/kg (224mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 41, 1982.
mouse	LD50	subcutaneous	1150mg/kg (1150mg/kg)		Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 4, Pg. 659, 1958.
mouse	LD50	unreported	770mg/kg (770mg/kg)		Toxicology and Applied Pharmacology. Vol. 14, Pg. 654, 1969.
rabbit	LCLo	inhalation	150ppm/7H (150ppm)		Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
rabbit	LD50	skin	320uL/kg (0.32mL/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit	LDLo	parenteral	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Industrial and Engineering Chemistry. Vol. 29, Pg. 1247, 1937.
rat	LC50	inhalation	7500mg/m3 (7500mg/m3)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.
rat	LD50	intraperitoneal	300mg/kg (300mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
rat	LD50	oral	11mg/kg (11mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0534836,

Product Name

Cyclohexanamine

Synthetic route

Cyclohexylamine Specification

Related Products

Hot Products