Cytosine supplier | CasNO.71-30-7

Name
Cytosine
EINECS 200-749-5
CAS No. 71-30-7
Article Data117
CAS DataBase
Density 1.55 g/cm³
Solubility soluble in water
Melting Point >300 °C(lit.)
Formula C₄H₅N₃O
Boiling Point 445.8 °C at 760 mmHg
Molecular Weight 111.103
Flash Point 223.4 °C
Transport Information
Appearance white solid
Safety 26-36-37/39
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms Cyt;2 (1H)-Pyrimidinone, 4-amino-;Cyto sine;4-aminopyrimidin-2(1H)-one;4-amino-2-hydroxypyrimidine;Zytosin;4-amino-2(1H)-pyrimidinone;Cytosine 99.0% min;Cytosine;4-Amino-2(1H)-pyrimidinone;2-Oxy-4-amino pyrimidine;4-amino-2-pyrimidinol;Cytosin;Cytosine (8CI);2(1H)-Pyrimidinone, 4-amino-;4-Aminouracil;2(1H)-pyrimidinone, 6-amino-;4-amino-2-oxo-1,2-dihydropyrimidine;4-amino-3H-pyrimidin-2-one;2(1H)-Pyrimidinone, 4-amino- (9CI);
PSA 71.77000
LogP -0.06670

Synthetic route

: C-(6-Methoxy-2-p-tolyl-quinolin-4-yl)-N-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-methanesulfonamide

A: 117839-37-9
6-methoxy-2-(p-tolyl)quinoline

B: 71-30-7
Cytosine

C: 117839-39-1
6-methoxy-4-methyl-2-(p-tolyl)quinoline

Conditions

Conditions	Yield
In isopropyl alcohol Irradiation; 350 nm;	A n/a B 94% C n/a

...Expand

: 333-49-3
2-thiocytosine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With dihydrogen peroxide at 80℃; for 20h; Temperature;	93%

: 25078-62-0
3-hydroxylacrylic nitrile

: 57-13-6
urea

: 71-30-7
Cytosine

Conditions

Conditions	Yield
Stage #1: 3-hydroxylacrylic nitrile With sodium t-butanolate In tert-butyl alcohol Stage #2: urea In tert-butyl alcohol at 50℃; for 8h; Solvent; Reagent/catalyst; Temperature;	91.5%

: 29878-39-5
urea, monosodium salt

: 25078-62-0
3-hydroxylacrylic nitrile

: 71-30-7
Cytosine

Conditions

Conditions	Yield
Stage #1: 3-hydroxylacrylic nitrile With sodium methylate In methanol Stage #2: urea, monosodium salt In methanol at 40℃; for 6h;	91.5%

: 89186-10-7
urea, monopotassium salt

: 25078-62-0
3-hydroxylacrylic nitrile

: 71-30-7
Cytosine

Conditions

Conditions	Yield
Stage #1: 3-hydroxylacrylic nitrile With sodium methylate In methanol Stage #2: urea, monopotassium salt In methanol at 40℃; for 6h;	91.5%

: 3289-47-2
4-amino-2-methoxypyrimidine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 1h; Temperature;	91.2%
With hydrogenchloride; water

: 2183-66-6
4-amino-2-(methylthio)pyrimidine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water at 90℃; for 1h;	90.9%

: 60722-70-5
2-benzylsulfanyl-pyrimidin-4-ylamine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water at 90℃; for 1h;	90.6%

: 54308-63-3
2-ethylsulfanyl-pyrimidin-4-ylamine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water at 90℃; for 1h;	89.7%
With ethanol; water; dihydrogen peroxide

: 35146-02-2
3,3-diethoxypropenenitrile

: 57-13-6
urea

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With sodium hydroxide In toluene for 12h; Reflux;	89%

: 3650-93-9
5-carboxylcytosine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ammonium chloride In 1-methyl-pyrrolidin-2-one at 180℃; for 8h; Reagent/catalyst; Temperature; Solvent;	87%

: 76064-23-8
3-hydroxyacrylonitrile sodium salt

: 57-13-6
urea

: 71-30-7
Cytosine

Conditions

Conditions	Yield
In toluene for 5h;	84%

: 19981-17-0, 20611-81-8, 123092-13-7, 17292-62-5
sodium cyanamide

: 76299-81-5
N4-<(Dimethylamino)methylene>cytosine

A: 71-30-7
Cytosine

B: 39687-97-3
<(Dimethylamino)methylene>cyanamide

Conditions

Conditions	Yield
In isopropyl alcohol for 2h; Heating;	A n/a B 81%

...Expand

: 76299-81-5
N4-<(Dimethylamino)methylene>cytosine

A: 71-30-7
Cytosine

B: 39687-97-3
<(Dimethylamino)methylene>cyanamide

Conditions

Conditions	Yield
With sodium cyanamide In isopropyl alcohol for 2h; Heating;	A n/a B 81%

: 35551-31-6
4-methylsulfanylpyrimidin-2(1H)-one

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ferrous(II) sulfate heptahydrate; ammonium hydroxide at 80℃; for 72h;	77%

: 1257309-82-2
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

A: 2655-79-0
N-(1,3-propanediol-2-yl)acetamide

B: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ammonium hydroxide; water In methanol at 70℃; for 24h; Sealed tube;	A 71% B 75%

: C5H6N2O2

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene at 120℃; under 11251.1 Torr; for 20h; Autoclave;	74%

: 76299-81-5
N4-<(Dimethylamino)methylene>cytosine

A: 71-30-7
Cytosine

B: 76299-79-1
N-[6-Oxo-6,7-dihydro-pyrimido[1,6-a][1,3,5]triazin-(4E)-ylidene]-guanidine; hydrochloride

Conditions

Conditions	Yield
With guanidine hydrochloride In isopropyl alcohol for 17h; Heating;	A 67% B 8%

: 951-77-9
2'-Deoxycytidine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With purine nucleoside phosphorylase at 14 - 15℃; pH=7; aq. phosphate buffer; Enzymatic reaction;	60%
	4 % Chromat.

: 1257309-82-2
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

A: 2655-79-0
N-(1,3-propanediol-2-yl)acetamide

B: 4-amino-1-{N-[1-hydroxy-3-(pivaloyloxymethyl)prop-2-yl]acetylaminomethyl}-1H-pyrimidin-2-one

C: 4-(amino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

D: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ammonium hydroxide; water In methanol at 20℃; for 24h;	A 58% B 4% C 12% D 60%

...Expand

: 65-46-3
CYTIDINE

A: 71-30-7
Cytosine

B: 66-22-8
uracil

Conditions

Conditions	Yield
With sodium persulfate In water at 75℃; for 4h; sodium phosphate buffer pH 7.0, other substrates;	A 53% B 6%

: 67-56-1
methanol

: 2022-85-7
Flucytosine

A: 31458-47-6
5-methoxycytosine

B: 71-30-7
Cytosine

C: 6-methoxycytosine

Conditions

Conditions	Yield
for 3h; Mechanism; Product distribution; Irradiation; other alcohol;	A 36% B 9% C 31%
for 3h; Irradiation;	A 36% B 9% C 31%

...Expand

: 134665-72-8
1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride

A: 71-30-7
Cytosine

B: 1,4-anhydro-2-C-cyano-2-deoxy-D-erythropent-1-enitol

C: 2'-C-cyano-2'-deoxy-1-β-D-ribo-pentofuranosylcytosine

Conditions

Conditions	Yield
With Tris-HCl buffer at 37℃; for 6h; Rate constant; Mechanism; var. salt concentration and pH of buffer;	A n/a B 28% C 33%

...Expand

: α-cytidine-5′-phosphate

A: 71-30-7
Cytosine

B: C9H12N3O7P(2-)

C: C9H11N2O8P(2-)

D: C6H8NO7P(2-)

E: C9H12N3O7P(2-)

F: C9H11N2O8P(2-)

G: 66-22-8
uracil

H: C9H11N2O8P(2-)

Conditions

Conditions	Yield
In water at 90℃; for 16h; pH=6.5; Irradiation; Inert atmosphere;	A 12% B 5% C 11% D 22% E 5% F 9% G 14% H 5%

...Expand

: 7461-50-9
2-chloropyrimidin-4-amine

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water

: 6220-43-5
4-ethoxypyrimidin-2-one

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With ethanol; ammonia at 120℃;

: 61445-73-6
(4-amino-pyrimidin-2-ylsulfanyl)-acetic acid

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With hydrogenchloride; water

: 32747-18-5
cytidinium sulphate

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With sulfuric acid at 125℃; im Rohr;

: 61310-53-0
3-ethoxyacrylonitrile

: 57-13-6
urea

: 71-30-7
Cytosine

Conditions

Conditions	Yield
With sodium butanolate

: 24424-99-5
di-tert-butyl dicarbonate

: 71-30-7
Cytosine

: 1108637-27-9
C19H29N3O7

Conditions

Conditions	Yield
With dmap In tetrahydrofuran at 70℃; for 0.116667h; Microwave irradiation; Green chemistry;	100%
With dmap In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;	91%
With dmap In tetrahydrofuran

: 71-30-7
Cytosine

: C26H33FO6Si

: C28H34FN3O5Si

Conditions

Conditions	Yield
Stage #1: Cytosine With N,O-bis-(trimethylsilyl)-acetamide In 1,2-dichloro-ethane at 20℃; for 2h; Reflux; Stage #2: C26H33FO6Si With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; for 2h; Reflux;	100%

: 71-30-7
Cytosine

: 1122-44-7
5-iodocytosine

Conditions

Conditions	Yield
With N-iodo-succinimide In N,N-dimethyl-formamide for 12.5h; Sonographic reaction; Inert atmosphere;	99%
With iodine; iodic acid In acetic acid at 40℃;	96%
With iodine; iodic acid; acetic acid In tetrachloromethane; water at 50℃;	86%

: 6006-65-1
N,N-dimethylformamide dipropyl acetal

: 71-30-7
Cytosine

: 79044-11-4
N4-<(Dimethylamino)methylene>-1-propylcytosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Heating;	99%

: 71-30-7
Cytosine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 77738-01-3
N4-<(Dimethylamino)methylene>-1-methylcytosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Heating; other N,N-dimethylformamide dialkyl(diaralkyl) acetales;	99%
In N,N-dimethyl-formamide for 24h; Heating;	99%
trifluoroacetic acid for 15h; Heating;	98%
With trifluoroacetic acid

: 71-30-7
Cytosine

: 1188-33-6
N,N-dimethylformamide diethyl diacetal

: 79044-10-3
N4-<(Dimethylamino)methylene>-1-ethylcytosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Heating;	99%

: 24424-99-5
di-tert-butyl dicarbonate

: 71-30-7
Cytosine

: tert-butyl 4-[bis(tert-butoxycarbonyl)amino]-2-oxopyrimidine-1(2H)-carboxylate

Conditions

Conditions	Yield
With dmap In tetrahydrofuran at 20℃; Inert atmosphere;	99%

: 71-30-7
Cytosine

: (propa-1,2-dien-1-yloxy)cyclohexane

: (S)-4-amino-1-(1-(cyclohexyloxy)allyl)pyrimidin-2(1H)-one

Conditions

Conditions	Yield
With pyridine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane at 20℃; for 24h; Inert atmosphere; enantioselective reaction;	98.5%

: 71-30-7
Cytosine

: 108-24-7
acetic anhydride

: 14631-20-0
4-N-Acetylcytosine

Conditions

Conditions	Yield
With phosphoric acid at 100℃; for 8h;	98%
With pyridine for 2.5h; Heating;	97.2%
With pyridine at 20℃; for 24h;	85%

: 6006-65-1
N,N-dimethylformamide dipropyl acetal

: 71-30-7
Cytosine

: 76299-81-5
N4-<(Dimethylamino)methylene>cytosine

Conditions

Conditions	Yield
With trifluoroacetic acid at 85 - 90℃; for 12h;	98%

: 18503-90-7
N,N-dimethylformamide di-n-butyl acetal

: 71-30-7
Cytosine

: 79044-12-5
1-Butyl-N4-<(dimethylamino)methylene>cytosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Heating;	98%

: 71-30-7
Cytosine

: 97-72-3
2-Methylpropionic anhydride

: 97626-98-7
N6-isobutyrylaminocytosine

Conditions

Conditions	Yield
With pyridine for 2h; Heating;	98%
In N,N-dimethyl-formamide Heating;	80%

: 71-30-7
Cytosine

: dibutylformamide dineopentyl acetal

: N,N-Dibutyl-N'-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-formamidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 2h; Ambient temperature;	98%

: 71-30-7
Cytosine

: 406215-03-0
2-Chloro-N-[2-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide

: 406215-10-9
2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide

Conditions

Conditions	Yield
Stage #1: Cytosine With sodium hydride; triethylamine In N,N-dimethyl-formamide for 0.0833333h; Stage #2: 2-Chloro-N-[2-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide In N,N-dimethyl-formamide at 20℃; Further stages.;	98%

: 71-30-7
Cytosine

: 4‐amino‐[5,6‐D2]pyrimidin‐2(1H)‐one deuterium chloride

Conditions

Conditions	Yield
Stage #1: Cytosine With platinum(IV) oxide; sodium tetrahydroborate; palladium on activated charcoal; water-d2 at 160℃; for 1.33333h; Microwave irradiation; Stage #2: With hydrogen chloride at 0℃;	98%

: silver hexafluoroantimonate

: chloromethyl(1,5-cyclooctadiene)platinum(II)

: 71-30-7
Cytosine

: 921800-07-9, 921800-01-3, 1160938-96-4
[(1,5-cyclooctadiene)PtMe(cytosine)](SbF6)

Conditions

Conditions	Yield
In acetone (Ar); Ag salt was added to stirred soln. of Pt in acetone; stirred for 30 min; filtered; suspn. of cytosine in acetone was added; stirred for 30min; solvent removed; washed (H2O); dried (vac.); elem. anal.;	97.5%

...Expand

: 71-30-7
Cytosine

: C4(2)H5N3O

Conditions

Conditions	Yield
Stage #1: Cytosine With molybdenum(IV) oxide; sodium tetrahydroborate; palladium 10% on activated carbon; water-d2 at 20 - 160℃; for 1.83333h; Microwave irradiation; Stage #2: With hydrogen chloride In water for 0.333333h;	97.5%

: 71-30-7
Cytosine

: N4-sulfamoylcytosine

Conditions

Conditions	Yield
With pyridine; sulfamate de pentachlorophenyle at 100℃; for 2h; regioselective transfer of the sulfamoyl group to the extracyclic NH2 group of amniopyrimidines and amonopurines;	97%
With pyridine; sulfamate de pentachlorophenyle at 100℃; for 2h;	97%

: 61296-25-1
N,N-Dimethylformamide diallyl acetal

: 71-30-7
Cytosine

: 79044-13-6
1-Allyl-N4-<(dimethylamino)methylene>cytosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Heating;	96%

: 71-30-7
Cytosine

: 7732-18-5
water

: barium(II) perchlorate

: {[Ba(cytosine)2(H2O)](ClO4)2}n

Conditions

Conditions	Yield
Stage #1: Cytosine; water at 45℃; for 0.5h; Stage #2: barium(II) perchlorate at 20℃;	96%

...Expand

: 71-30-7
Cytosine

: 2022-85-7
Flucytosine

Conditions

Conditions	Yield
Stage #1: Cytosine With hydrogen fluoride at -15 - 0℃; Inert atmosphere; Stage #2: at -20℃; for 4h; Inert atmosphere; Further stages;	95.7%
With 1,1,1,3',3',3'-hexafluoro-propanol; fluorine at 20℃; under 1125.11 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere;	87.4%
With formic acid for 1.5h; Time; Flow reactor; Autoclave;	63%
With formic acid; fluorine at 9℃; for 0.0833333h; Temperature; Concentration; Inert atmosphere;

: 71-30-7
Cytosine

: 2240-25-7
5-bromocytosine

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 15℃; for 1h; Reagent/catalyst; Solvent; Sonication;	95.6%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 25℃; for 10h; Large scale;	93.6%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 25℃; for 10h;	93.6%

: 71-30-7
Cytosine

: 100-07-2
4-methoxy-benzoyl chloride

: 51820-70-3
N4-(4-methoxybenzoyl)-cytosine

Conditions

Conditions	Yield
With pyridine at 20℃;	95%
With pyridine at 80℃; for 2h; Acylation;	93%
With pyridine at 80℃; for 2h;	81%
With pyridine; dmap In dichloromethane at 20℃; Inert atmosphere;

: 71-30-7
Cytosine

: 496848-33-0
tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate

: 496848-38-5
tert-butyl (2RS,3S,5R)-2-[4-amino-2-oxopyrimidin-1(2H)-yl]-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: Cytosine; tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 0.5h; Heating; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; for 16h;	95%

: bis(η3-allyl-μ-chloropalladium(II))

: 71-30-7
Cytosine

: 96226-53-8
η3-allylchloro(cytosine)palladium(II)

Conditions

Conditions	Yield
In methanol soln. stirred for 3h, pptn (molar ratio complex : ligand = 1:2); filtered, washed (MeOH, ether), dried (vac.), elem. anal.;	95%

: 128-09-6
N-chloro-succinimide

: 71-30-7
Cytosine

: 2347-43-5
5-chloro-cytosine

Conditions

Conditions	Yield
With acetic acid at 70 - 77℃; for 4.3h;	95%

: 1146197-36-5
(3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-2,3-diyl diacetate

: 71-30-7
Cytosine

: (2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-3-yl acetate

Conditions

Conditions	Yield
Stage #1: Cytosine In acetonitrile at 20℃; for 3h; Vorbrueggen Nucleoside Synthesis; Stage #2: (3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-2,3-diyl diacetate With tin(IV) chloride In acetonitrile at 65℃; for 1h;	95%

: 71-30-7
Cytosine

: 134877-43-3
α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate

: β-1-(2’-deoxy-2’,2’-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Conditions

Conditions	Yield
Stage #1: Cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Reflux; Industrial scale; Stage #2: α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate With hydrogenchloride; phosphomolybdic acid In pentan-1-ol at 128 - 137℃; for 5h; Temperature; Solvent; Industrial scale;	95%
Stage #1: Cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 3h; Reflux; Stage #2: α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate With phosphotungstic acid In i-Amyl alcohol at 64℃; Reagent/catalyst; Temperature; Solvent; Time; Further stages;

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 71-30-7
Cytosine

: [Ru(η6-p-cymene)(cytosine-κN4)Cl2]

Conditions

Conditions	Yield
In methanol for 4h; Inert atmosphere;	95%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 71-30-7
Cytosine

: (2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 100℃; for 2h;	95%

Cytosine Chemical Properties

Molecule structure of Cytosine (CAS NO.71-30-7):

IUPAC Name: 6-Amino-1H-pyrimidin-2-one
Molecular Weight: 111.102 g/mol
Molecular Formula: C₄H₅N₃O
Density: 1.55 g/cm³
Melting Point: >300 °C(lit.)
Boiling Point: 445.8 °C at 760 mmHg
Flash Point: 223.4 °C
Index of Refraction: 1.688
Molar Refractivity: 27.3 cm³
Molar Volume: 71.5 cm³
Surface Tension: 69.2 dyne/cm
Enthalpy of Vaporization: 73.1 kJ/mol
Vapour Pressure: 1.46E-08 mmHg at 25 °C
Storage Temp.: store at RT.
Water Solubility: soluble
XLogP3: -1.7
H-Bond Donor: 2
H-Bond Acceptor: 2
Tautomer Count: 9
Exact Mass: 111.043262
MonoIsotopic Mass: 111.043262
Topological Polar Surface Area: 67.5
Heavy Atom Count: 8
Canonical SMILES: C1=C(NC(=O)N=C1)N
InChI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
InChIKey: OPTASPLRGRRNAP-UHFFFAOYSA-N
EINECS: 200-749-5
Product Categories: Pharmaceutical Intermediates; PYRIMIDINE; FINE Chemical & INTERMEDIATES; Pyridines, Pyrimidines, Purines and Pteredines; Pyrimidine series; Nucleotides and Nucleosides; Cidofovir; Biochemistry; Nucleobases and their analogs; Nucleosides, Nucleotides & Related Reagents; Nucleic acids; Bases & Related Reagents; Nucleotides

Cytosine History

In 1894, Cytosine was discovered by Albrecht Kossel when it was hydrolysed from calf thymus tissues. A structure was proposed in 1903, and was synthesized in the laboratory in the same year. The first time any quantum mechanical properties were harnessed to process information took place on August 1st in 1998 when researchers at Oxford implemented David Deutsch's algorithm on a two qubit NMRQC based on the cytosine molecule.

Cytosine Uses

Cytosine (CAS NO.71-30-7) is used as pharmaceutical intermediates.

Cytosine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2222mg/kg (2222mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 207, Pg. 504, 1978.

Cytosine Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: UW7350150
Hazard Note: Irritant

Cytosine Specification

Cytosine (CAS NO.71-30-7) is also named as 4-Amino-2(1H)-pyrimidinone ; 4-Amino-2-hydroxypyrimidine ; AI3-52281 ; Cyt ; Cytosinimine ; NSC 27787 ; 2(1H)-Pyrimidinone, 4-amino- . Cytosine (CAS NO.71-30-7) is white solid.

Product Name

Cytosine

Synthetic route

Cytosine Chemical Properties

Cytosine History

Cytosine Uses

Cytosine Toxicity Data With Reference

Cytosine Safety Profile

Cytosine Specification

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