1,1-dichloroperfluoro-2-butanone
A
Dichlorofluoromethane
B
sodium formate
C
sodium pentafluoropropionate
Conditions | Yield |
---|---|
With sodium hydroxide In water Product distribution; | A 33.5% B n/a C 84.5% |
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide In N,N-dimethyl-formamide at 20℃; for 0.5h; | 20% |
With ruthenium(II) bis(triphenylphosphine) dichloride; hydrogen In ethanol; toluene at 25℃; for 12h; Product distribution; also carbon tetrachloride; also in the presence of RuCl2(dppe)2 or RuHCl(PPh3)2; other solvents; var. time and temp.; | |
titanium pH=7; Kinetics; | |
With formate; titanium(IV) oxide In various solvent(s) at 23℃; for 1h; pH=5.9; Kinetics; Further Variations:; pH-values; Irradiation; |
Conditions | Yield |
---|---|
With uranium hexafluoride | |
With hydrogen fluoride; lithium fluoride at 0℃; |
Conditions | Yield |
---|---|
With antimonypentachloride; antimony(III) fluoride unter Druck; | |
With hydrogen fluoride; antimonypentachloride; antimony(III) chloride | |
With hydrogen fluoride; titanium(IV) fluoride at 127℃; |
dichloromethane
A
Difluoromethane
B
R32
C
Chlorodifluoromethane
D
Dichlorofluoromethane
E
Dichlorodifluoromethane
F
trichlorofluoromethane
Conditions | Yield |
---|---|
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time; |
Chlorodifluoromethane
A
trifluoromethan
B
Dichlorofluoromethane
C
chloroform
Conditions | Yield |
---|---|
zinc aluminate at 300℃; Product distribution; other temperature; |
chloroform
A
trifluoromethan
B
Chlorodifluoromethane
C
Dichlorofluoromethane
Conditions | Yield |
---|---|
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times; | |
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm); | |
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux; |
(dichloro-fluoro-methyl)-tris-dimethylamino-phosphonium; chloride
A
Dichlorofluoromethane
B
trichlorofluoromethane
C
bromodichlorofluoromethane
D
dibromochlorofluoromethane
Conditions | Yield |
---|---|
With potassium fluoride; bromine In various solvent(s) | A 25 % Spectr. B 15 % Spectr. C 42 % Spectr. D 5 % Spectr. |
dichloromethane
A
Difluoromethane
B
R32
C
Chlorodifluoromethane
D
Dichlorofluoromethane
E
Dichlorodifluoromethane
Conditions | Yield |
---|---|
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides; |
1,1,3,3-tetrachloro-1,3-difluoro-2-propanone
acetone
A
Dichlorofluoromethane
B
HCFC-141b
C
trichlorofluoromethane
D
1-chloro-1-fluoroethane
E
1,1-Dichloroethylene
F
CFC-112a
Conditions | Yield |
---|---|
With propene; sulphur hexafluoride for 0.5h; Rate constant; Ambient temperature; Irradiation; also with acetone-d6; |
Conditions | Yield |
---|---|
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 24h; | A 1 % Spectr. B n/a |
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 24h; Yield given; |
Conditions | Yield |
---|---|
at 100℃; |
Conditions | Yield |
---|---|
Electrolysis; |
Dichlorofluoromethane
Conditions | Yield |
---|---|
With chlorine |
chloroform
antimonypentachloride
antimony(III) fluoride
A
Chlorodifluoromethane
B
Dichlorofluoromethane
chloroform
hydrogen fluoride
A
Chlorodifluoromethane
B
Dichlorofluoromethane
chloroform
hydrogen fluoride
A
Chlorodifluoromethane
B
Dichlorofluoromethane
1,2-dimethoxyethane
fluorodichloroiodomethane
A
Dichlorofluoromethane
B
CFC-112a
1,1,3-trichloro-1,3,3-trifluoroacetone
benzene
A
Dichlorofluoromethane
B
2-chloro-2,2-difluoroacetic acid
dichlorofluoroacetic acid
water
A
formic acid
B
Dichlorofluoromethane
C
methylammonium carbonate
Conditions | Yield |
---|---|
at 71 - 95℃; Rate constant; |
dichloromethane
A
R32
B
Chlorodifluoromethane
C
Dichlorofluoromethane
Conditions | Yield |
---|---|
With rhenium(VII) fluoride for 4h; Product distribution; other transition metal fluorides; |
trichlorofluoromethane
A
R32
B
dichloromethane
C
Dichlorofluoromethane
D
chloroform
Conditions | Yield |
---|---|
In neat (no solvent) Kinetics; mechanism discussed;; |
trifluoromethan
chloroform
A
Chlorodifluoromethane
B
Dichlorofluoromethane
Conditions | Yield |
---|---|
aluminum(III) fluoride at 240℃; for 0.00858333h; | |
aluminum(III) fluoride at 160℃; for 0.00111111h; |
trifluoromethan
A
Chlorodifluoromethane
B
Dichlorofluoromethane
C
chloroform
Conditions | Yield |
---|---|
With dichloromethane; chlorine at 250℃; for 0.00138889h; Concentration; Temperature; Reagent/catalyst; | A 6.9 %Chromat. B 7.2 %Chromat. C 23.7 %Chromat. |
-butyl vinyl ether
Dichlorofluoromethane
2-n-Butoxy-1-chloro-1-fluorocyclopropane
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 40℃; for 12h; Inert atmosphere; | 96% |
With sodium hydroxide; tetraethylammonium bromide In dichloromethane at 5℃; for 6h; | 79% |
Conditions | Yield |
---|---|
With potassium tert-butylate In hexane at -10℃; | 92% |
1,4-dioxene
Dichlorofluoromethane
7-chloro-7-fluoro-2,5-dioxabicyclo<4.1.0>heptane
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 20℃; for 14h; | 91% |
Dichlorofluoromethane
isobutene
1-chloro-1-fluoro-2,2-dimethylcyclopropane
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at 0 - 20℃; | 88% |
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In water at 0℃; for 4h; Cooling with ice; | 87% |
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h; | 87% |
Beta-pinene
Dichlorofluoromethane
2'-chloro-2'-fluoro-6,6-dimethylbicyclo<3.1.1>heptane-2-spiro-1'-cyclopropane
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 10h; ultrasonicator; | 85% |
Dichlorofluoromethane
isoprene
1-chloro-1-fluoro-2-methyl-2-vinylcyclopropane
Conditions | Yield |
---|---|
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 10℃; | 85% |
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at -10 - -5℃; for 8h; | 78% |
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at -5 - 0℃; for 9h; |
Conditions | Yield |
---|---|
With potassium tert-butylate In hexane at -10℃; | 83% |
Conditions | Yield |
---|---|
With potassium tert-butylate In hexane at -10℃; | 83% |
2,3-Dimethyl-2-butene
Dichlorofluoromethane
1-chloro-1-fluoro-2,2,3,3-tetramethylcyclopropane
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h; | 81% |
With n-butyllithium In hexane | |
With n-butyllithium |
Conditions | Yield |
---|---|
With potassium hydroxide; 18-crown-6 ether for 1h; | 80% |
Dichlorofluoromethane
2-(Chloro-fluoro-methyl)-2-isopropenyl-malonic acid tert-butyl ester ethyl ester
2-Fluoromethyl-2-isopropenyl-malonic acid tert-butyl ester ethyl ester
Conditions | Yield |
---|---|
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In benzene for 2h; Heating; | 80% |
Dichlorofluoromethane
ethyl 2-(diphenylmethyleneamino)propanoate
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water In dichloromethane at 7 - 8℃; for 4.33333h; Cycloaddition; | 79% |
Dichlorofluoromethane
1,1'-dichloro-2,2'-difluoroethene
A
1,1,3,3-tetrachloro-1,2,2-trifluoropropane
B
1,1,2,2-tetrachloro-3,3,3-trifluoropropane
C
1,1,1,3-tetrachloro-2,2,3-trifluoropropane
D
1,2,2,3-tetrachloro-1,1,3-trifluoropropane
Conditions | Yield |
---|---|
With aluminium trichloride at 0℃; for 10h; | A 78.5% B 5.3% C n/a D 16.1% |
Dichlorofluoromethane
1-ethoxy-1-phenoxy ethylene
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 0℃; for 2h; | 76% |
Dichlorofluoromethane
N-(2,2-diphenylvinylidene)-4-methoxyaniline
C22H18FNO2
Conditions | Yield |
---|---|
With potassium tert-butylate In hexane at -10℃; | 76% |
Dichlorofluoromethane
tris-iso-propylsilyl acetylene
1-(triisopropylsilyl)-3-chloro-3-fluoropropyne
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Alkylation; | 76% |
Dichlorofluoromethane
1-(3-Methyl-but-3-en-1-ynyl)-adamantane
A
1-(1-adamantylethinyl)-2-chloro-2-fluoro-1-methyl-cyclopropane
B
1-adamantyl-2-(2-chloro-2-fluoro-1-methylcyclopropyl)-cyclopropenone
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 24h; Ambient temperature; | A 75% B 3% |
Dichlorofluoromethane
phenylacetylene
1-chloro-1-fluoro-3-phenylprop-2-yne
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -100 - -70℃; | 75% |
Dichlorofluoromethane
1,3-di-tert-butylcyclopentadiene
1,3-di-tert-butyl-4-fluorobenzene
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 4h; Ambient temperature; | 75% |
Conditions | Yield |
---|---|
With Aliquat 336; methoxybenzene; potassium hydroxide In water at 20 - 30℃; for 3h; Reagent/catalyst; | 74.8% |
With tetrabutylammomium bromide; potassium hydroxide In hexane; water at 5 - 10℃; | 27 g |
2,5-dimethylhexa-1,5-dien-3-yne
Dichlorofluoromethane
bis-(2-chloro-2-fluoro-1-methylcyclopropyl)acetylene
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 24h; Ambient temperature; | 73% |
trans-2-Butene
Dichlorofluoromethane
1-Chlor-1-fluor-2,3-dimethylcyclopropan
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at 0 - 20℃; | 73% |
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In water at 0℃; for 4h; Cooling with ice; | 73% |
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h; | 73% |
Dichlorofluoromethane
3-Chloro-2-methylpropene
1-Chlor-2-chlormethyl-1-fluor-2-methylcyclopropan
Conditions | Yield |
---|---|
With potassium hydroxide; 18-crown-6 ether at 0℃; for 1h; | 72% |
With potassium hydroxide; benzyltrimethylammonium chloride | |
With perhydrodibenzo-18-crown-6; potassium hydroxide |
3-butyn-2-yl tetrahydropyranyl ether
Dichlorofluoromethane
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -100 - -70℃; | 70% |
Dichlorofluoromethane
(E)-1-chloro-3-methylpent-2-ene
Conditions | Yield |
---|---|
With potassium hydroxide; 18-crown-6 ether for 1h; | 70% |
Dichlorofluoromethane
3-(tetrahydropyran-2'-yloxy)propyne
2-(4-chloro-4-fluorobut-2-ynyloxy)-tetrahydro-2H-pyran
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -100 - -70℃; | 70% |
Stage #1: 3-(tetrahydropyran-2'-yloxy)propyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: Dichlorofluoromethane In tetrahydrofuran; hexane at -100 - -50℃; |
Conditions | Yield |
---|---|
With sodium hydroxide; benzyltrimethylammonium chloride In water; benzene at 50℃; under 2206.5 - 3677.5 Torr; for 4h; | 70% |
Dichlorofluoromethane
3,3-dimethyl-allyl chloride
1-Chloro-3-chlormethyl-1-fluor-2,2-dimethylcyclopropan
Conditions | Yield |
---|---|
With potassium hydroxide; 18-crown-6 ether for 1h; | 70% |
The Dichlorofluoromethane is an organic compound with the formula CHCl2F. The IUPAC name of this chemical is dichloro(fluoro)methane. With the CAS registry number 75-43-4, it is also named as methane, dichlorofluoro-. The product's categories are Refrigerants; Organics. Besides, it should be stored in a cool and ventilated place. It is used as a refrigerant.
Physical properties about Dichlorofluoromethane are: (1)ACD/LogP: 1.40; (2)ACD/LogD (pH 5.5): 1.4; (3)ACD/LogD (pH 7.4): 1.4; (4)ACD/BCF (pH 5.5): 6.83; (5)ACD/BCF (pH 7.4): 6.83; (6)ACD/KOC (pH 5.5): 137.75; (7)ACD/KOC (pH 7.4): 137.75; (8)Index of Refraction: 1.366; (9)Molar Refractivity: 16.5 cm3; (10)Molar Volume: 73.6 cm3; (11)Polarizability: 6.54×10-24cm3; (12)Surface Tension: 19.9 dyne/cm; (13)Density: 1.397 g/cm3; (14)Enthalpy of Vaporization: 24.65 kJ/mol; (15)Boiling Point: 8.9 °C at 760 mmHg; (16)Vapour Pressure: 1340 mmHg at 25°C.
Preparation: this chemical can be prepared by trichloro-fluoro-methane. This reaction will need reagent HMPT and solvent dimethylformamide. The reaction time is 30 min with reaction temperature of 20 °C. The yield is about 20%.
Uses of Dichlorofluoromethane: it can be used to produce 7-chlor-7-fluor-1-methylbicyclo[4.1.0]heptan . It will need reagent 55percent KOH, 18-crown-6 with reaction time of 1 hour. The yield is about 80%.
You can still convert the following datas into molecular structure:
(1)SMILES: ClC(Cl)F
(2)InChI: InChI=1/CHCl2F/c2-1(3)4/h1H
(3)InChIKey: UMNKXPULIDJLSU-UHFFFAOYAU
(4)Std. InChI: InChI=1S/CHCl2F/c2-1(3)4/h1H
(5)Std. InChIKey: UMNKXPULIDJLSU-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LCLo | inhalation | 10pph/1H (100000ppm) | Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. | |
mouse | LC50 | inhalation | > 800gm/m3/2H (800000mg/m3) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(11), Pg. 38, 1976. |
rat | LC50 | inhalation | 49900ppm/4H (49900ppm) | "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 187, 1986. |
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