Product Name

  • Name

    Dichloromonofluoromethane

  • EINECS 200-869-8
  • CAS No. 75-43-4
  • Article Data57
  • CAS DataBase
  • Density 1.397 g/cm3
  • Solubility Slightly soluble in water
  • Melting Point -135 °C
  • Formula CHCl2F
  • Boiling Point 8.9 °C at 760 mmHg
  • Molecular Weight 102.923
  • Flash Point 130-132°C/3mm
  • Transport Information
  • Appearance COLOURLESS GAS OR COMPRESSED LIQUEFIED GAS, WITH CHARACTERISTIC ODOUR.
  • Safety 59
  • Risk Codes 59
  • Molecular Structure Molecular Structure of 75-43-4 (Dichloromonofluoromethane)
  • Hazard Symbols DangerousN
  • Synonyms AF 22;AF22 (fluorocarbon);Algofrene Type 5;Arcton 7;CFC 21;Dichlorofluoromethane;Dichloromonofluoromethane;F 21;F 21 (fluorocarbon);FC 21;Fluorocarbon-21;Fluorodichloromethane;Freon 21;Genetron 21;HCFC 21;Monofluorodichloromethane;R 21;R 21 (refrigerant);
  • PSA 0.00000
  • LogP 1.71710

Synthetic route

1,1-dichloroperfluoro-2-butanone
87375-48-2

1,1-dichloroperfluoro-2-butanone

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

sodium formate
141-53-7

sodium formate

C

sodium pentafluoropropionate
378-77-8

sodium pentafluoropropionate

Conditions
ConditionsYield
With sodium hydroxide In water Product distribution;A 33.5%
B n/a
C 84.5%
trichlorofluoromethane
75-69-4

trichlorofluoromethane

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide In N,N-dimethyl-formamide at 20℃; for 0.5h;20%
With ruthenium(II) bis(triphenylphosphine) dichloride; hydrogen In ethanol; toluene at 25℃; for 12h; Product distribution; also carbon tetrachloride; also in the presence of RuCl2(dppe)2 or RuHCl(PPh3)2; other solvents; var. time and temp.;
titanium pH=7; Kinetics;
With formate; titanium(IV) oxide In various solvent(s) at 23℃; for 1h; pH=5.9; Kinetics; Further Variations:; pH-values; Irradiation;
dichloromethane
75-09-2

dichloromethane

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With uranium hexafluoride
With hydrogen fluoride; lithium fluoride at 0℃;
chloroform
67-66-3

chloroform

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimonypentachloride; antimony(III) fluoride unter Druck;
With hydrogen fluoride; antimonypentachloride; antimony(III) chloride
With hydrogen fluoride; titanium(IV) fluoride at 127℃;
dichloromethane
75-09-2

dichloromethane

A

Difluoromethane
75-10-5

Difluoromethane

B

R32
593-70-4

R32

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

E

Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

F

trichlorofluoromethane
75-69-4

trichlorofluoromethane

Conditions
ConditionsYield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

A

trifluoromethan
75-46-7

trifluoromethan

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

C

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
zinc aluminate at 300℃; Product distribution; other temperature;
chloroform
67-66-3

chloroform

A

trifluoromethan
75-46-7

trifluoromethan

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times;
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm);
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux;
(dichloro-fluoro-methyl)-tris-dimethylamino-phosphonium; chloride
70393-08-7

(dichloro-fluoro-methyl)-tris-dimethylamino-phosphonium; chloride

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

trichlorofluoromethane
75-69-4

trichlorofluoromethane

C

bromodichlorofluoromethane
353-58-2

bromodichlorofluoromethane

D

dibromochlorofluoromethane
353-55-9

dibromochlorofluoromethane

Conditions
ConditionsYield
With potassium fluoride; bromine In various solvent(s)A 25 % Spectr.
B 15 % Spectr.
C 42 % Spectr.
D 5 % Spectr.
dichloromethane
75-09-2

dichloromethane

A

Difluoromethane
75-10-5

Difluoromethane

B

R32
593-70-4

R32

C

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

D

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

E

Dichlorodifluoromethane
75-71-8

Dichlorodifluoromethane

Conditions
ConditionsYield
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides;
1,1,3,3-tetrachloro-1,3-difluoro-2-propanone
79-51-6

1,1,3,3-tetrachloro-1,3-difluoro-2-propanone

acetone
67-64-1

acetone

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

HCFC-141b
1717-00-6

HCFC-141b

C

trichlorofluoromethane
75-69-4

trichlorofluoromethane

D

1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

E

1,1-Dichloroethylene
75-35-4

1,1-Dichloroethylene

F

CFC-112a
76-12-0

CFC-112a

Conditions
ConditionsYield
With propene; sulphur hexafluoride for 0.5h; Rate constant; Ambient temperature; Irradiation; also with acetone-d6;
chloroform
67-66-3

chloroform

A

trifluoromethan
75-46-7

trifluoromethan

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 24h;A 1 % Spectr.
B n/a
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 24h; Yield given;
chloroform
67-66-3

chloroform

AgF

AgF

CaF2

CaF2

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
at 100℃;
dichloromethane
75-09-2

dichloromethane

hydrogen fluoride
7664-39-3

hydrogen fluoride

lithium fluoride

lithium fluoride

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
Electrolysis;
silver-

silver-

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
With chlorine
chloroform
67-66-3

chloroform

antimonypentachloride
7647-18-9

antimonypentachloride

antimony(III) fluoride
7783-56-4

antimony(III) fluoride

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

chloroform
67-66-3

chloroform

hydrogen fluoride
7664-39-3

hydrogen fluoride

antimony (V)-halide

antimony (V)-halide

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

chloroform
67-66-3

chloroform

hydrogen fluoride
7664-39-3

hydrogen fluoride

coal

coal

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1,2-dimethoxyethane
110-71-4

1,2-dimethoxyethane

fluorodichloroiodomethane
420-48-4

fluorodichloroiodomethane

zinc

zinc

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

CFC-112a
76-12-0

CFC-112a

1,1,3-trichloro-1,3,3-trifluoroacetone
79-52-7

1,1,3-trichloro-1,3,3-trifluoroacetone

benzene
71-43-2

benzene

potassium hydroxide

potassium hydroxide

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

dichlorofluoroacetic acid
354-19-8

dichlorofluoroacetic acid

water
7732-18-5

water

A

formic acid
64-18-6

formic acid

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

C

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

D

carbon monoxide

carbon monoxide

Conditions
ConditionsYield
at 71 - 95℃; Rate constant;
dichloromethane
75-09-2

dichloromethane

A

R32
593-70-4

R32

B

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

C

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

D

HF, ReF6

HF, ReF6

Conditions
ConditionsYield
With rhenium(VII) fluoride for 4h; Product distribution; other transition metal fluorides;
trichlorofluoromethane
75-69-4

trichlorofluoromethane

hydrogen

hydrogen

A

R32
593-70-4

R32

B

dichloromethane
75-09-2

dichloromethane

C

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

D

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
In neat (no solvent) Kinetics; mechanism discussed;;
trifluoromethan
75-46-7

trifluoromethan

chloroform
67-66-3

chloroform

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

Conditions
ConditionsYield
aluminum(III) fluoride at 240℃; for 0.00858333h;
aluminum(III) fluoride at 160℃; for 0.00111111h;
trifluoromethan
75-46-7

trifluoromethan

A

Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

B

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

C

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
With dichloromethane; chlorine at 250℃; for 0.00138889h; Concentration; Temperature; Reagent/catalyst;A 6.9 %Chromat.
B 7.2 %Chromat.
C 23.7 %Chromat.
-butyl vinyl ether
111-34-2

-butyl vinyl ether

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

2-n-Butoxy-1-chloro-1-fluorocyclopropane
95241-05-7

2-n-Butoxy-1-chloro-1-fluorocyclopropane

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 40℃; for 12h; Inert atmosphere;96%
With sodium hydroxide; tetraethylammonium bromide In dichloromethane at 5℃; for 6h;79%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

diphenylvinylidene-methyl-amine
13911-54-1

diphenylvinylidene-methyl-amine

C16H14FNO
134920-47-1

C16H14FNO

Conditions
ConditionsYield
With potassium tert-butylate In hexane at -10℃;92%
1,4-dioxene
543-75-9

1,4-dioxene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

7-chloro-7-fluoro-2,5-dioxabicyclo<4.1.0>heptane
40623-35-6, 40623-36-7, 120201-74-3

7-chloro-7-fluoro-2,5-dioxabicyclo<4.1.0>heptane

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 20℃; for 14h;91%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

isobutene
115-11-7

isobutene

1-chloro-1-fluoro-2,2-dimethylcyclopropane
1891-96-9

1-chloro-1-fluoro-2,2-dimethylcyclopropane

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at 0 - 20℃;88%
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In water at 0℃; for 4h; Cooling with ice;87%
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h;87%
Beta-pinene
177698-19-0

Beta-pinene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

2'-chloro-2'-fluoro-6,6-dimethylbicyclo<3.1.1>heptane-2-spiro-1'-cyclopropane
135654-99-8, 135684-70-7

2'-chloro-2'-fluoro-6,6-dimethylbicyclo<3.1.1>heptane-2-spiro-1'-cyclopropane

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 10h; ultrasonicator;85%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

isoprene
78-79-5

isoprene

1-chloro-1-fluoro-2-methyl-2-vinylcyclopropane
17725-43-8

1-chloro-1-fluoro-2-methyl-2-vinylcyclopropane

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 10℃;85%
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at -10 - -5℃; for 8h;78%
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at -5 - 0℃; for 9h;
triphenylketeneimine
14181-84-1

triphenylketeneimine

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

C21H16FNO
134920-49-3

C21H16FNO

Conditions
ConditionsYield
With potassium tert-butylate In hexane at -10℃;83%
N-(2-methyl-1-propenylidene)aniline
14016-34-3

N-(2-methyl-1-propenylidene)aniline

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

C11H12FNO
134920-46-0

C11H12FNO

Conditions
ConditionsYield
With potassium tert-butylate In hexane at -10℃;83%
2,3-Dimethyl-2-butene
563-79-1

2,3-Dimethyl-2-butene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1-chloro-1-fluoro-2,2,3,3-tetramethylcyclopropane
1727-63-5

1-chloro-1-fluoro-2,2,3,3-tetramethylcyclopropane

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h;81%
With n-butyllithium In hexane
With n-butyllithium
1-methylcyclohex-1-ene
591-49-1

1-methylcyclohex-1-ene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

7-chlor-7-fluor-1-methylbicyclo<4.1.0>heptan

7-chlor-7-fluor-1-methylbicyclo<4.1.0>heptan

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether for 1h;80%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

2-(Chloro-fluoro-methyl)-2-isopropenyl-malonic acid tert-butyl ester ethyl ester
95311-30-1, 95311-49-2

2-(Chloro-fluoro-methyl)-2-isopropenyl-malonic acid tert-butyl ester ethyl ester

2-Fluoromethyl-2-isopropenyl-malonic acid tert-butyl ester ethyl ester
95311-35-6

2-Fluoromethyl-2-isopropenyl-malonic acid tert-butyl ester ethyl ester

Conditions
ConditionsYield
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In benzene for 2h; Heating;80%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

ethyl 2-(diphenylmethyleneamino)propanoate
69555-16-4

ethyl 2-(diphenylmethyleneamino)propanoate

Ethyl 2-(2-chloro-2-fluoro-3,3-diphenylaziridin-1-yl)propanoate

Ethyl 2-(2-chloro-2-fluoro-3,3-diphenylaziridin-1-yl)propanoate

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water In dichloromethane at 7 - 8℃; for 4.33333h; Cycloaddition;79%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1,1'-dichloro-2,2'-difluoroethene
79-35-6

1,1'-dichloro-2,2'-difluoroethene

A

1,1,3,3-tetrachloro-1,2,2-trifluoropropane
422-52-6

1,1,3,3-tetrachloro-1,2,2-trifluoropropane

B

1,1,2,2-tetrachloro-3,3,3-trifluoropropane
422-35-5

1,1,2,2-tetrachloro-3,3,3-trifluoropropane

C

1,1,1,3-tetrachloro-2,2,3-trifluoropropane
422-50-4

1,1,1,3-tetrachloro-2,2,3-trifluoropropane

D

1,2,2,3-tetrachloro-1,1,3-trifluoropropane
144909-54-6

1,2,2,3-tetrachloro-1,1,3-trifluoropropane

Conditions
ConditionsYield
With aluminium trichloride at 0℃; for 10h;A 78.5%
B 5.3%
C n/a
D 16.1%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1-ethoxy-1-phenoxy ethylene
102069-99-8

1-ethoxy-1-phenoxy ethylene

ethyl phenyl 2,2-chlorofluorocyclopropane acetal

ethyl phenyl 2,2-chlorofluorocyclopropane acetal

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 0℃; for 2h;76%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

N-(2,2-diphenylvinylidene)-4-methoxyaniline
40012-82-6

N-(2,2-diphenylvinylidene)-4-methoxyaniline

C22H18FNO2
134920-50-6

C22H18FNO2

Conditions
ConditionsYield
With potassium tert-butylate In hexane at -10℃;76%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

tris-iso-propylsilyl acetylene
89343-06-6

tris-iso-propylsilyl acetylene

1-(triisopropylsilyl)-3-chloro-3-fluoropropyne
284471-09-6

1-(triisopropylsilyl)-3-chloro-3-fluoropropyne

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Alkylation;76%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1-(3-Methyl-but-3-en-1-ynyl)-adamantane
124746-03-8

1-(3-Methyl-but-3-en-1-ynyl)-adamantane

A

1-(1-adamantylethinyl)-2-chloro-2-fluoro-1-methyl-cyclopropane
124746-13-0

1-(1-adamantylethinyl)-2-chloro-2-fluoro-1-methyl-cyclopropane

B

1-adamantyl-2-(2-chloro-2-fluoro-1-methylcyclopropyl)-cyclopropenone
124746-17-4

1-adamantyl-2-(2-chloro-2-fluoro-1-methylcyclopropyl)-cyclopropenone

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 24h; Ambient temperature;A 75%
B 3%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

phenylacetylene
536-74-3

phenylacetylene

1-chloro-1-fluoro-3-phenylprop-2-yne
108234-26-0

1-chloro-1-fluoro-3-phenylprop-2-yne

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -100 - -70℃;75%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1,3-di-tert-butylcyclopentadiene
73046-16-9

1,3-di-tert-butylcyclopentadiene

1,3-di-tert-butyl-4-fluorobenzene
65130-67-8

1,3-di-tert-butyl-4-fluorobenzene

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 4h; Ambient temperature;75%
1,1-dimethoxyethylene
922-69-0

1,1-dimethoxyethylene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1-chloro-1-fluoro-2,2-dimethoxycyclopropane

1-chloro-1-fluoro-2,2-dimethoxycyclopropane

Conditions
ConditionsYield
With Aliquat 336; methoxybenzene; potassium hydroxide In water at 20 - 30℃; for 3h; Reagent/catalyst;74.8%
With tetrabutylammomium bromide; potassium hydroxide In hexane; water at 5 - 10℃;27 g
2,5-dimethylhexa-1,5-dien-3-yne
3725-05-1

2,5-dimethylhexa-1,5-dien-3-yne

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

bis-(2-chloro-2-fluoro-1-methylcyclopropyl)acetylene
124746-14-1

bis-(2-chloro-2-fluoro-1-methylcyclopropyl)acetylene

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 24h; Ambient temperature;73%
trans-2-Butene
624-64-6

trans-2-Butene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

1-Chlor-1-fluor-2,3-dimethylcyclopropan
16496-06-3, 16496-07-4, 56586-48-2

1-Chlor-1-fluor-2,3-dimethylcyclopropan

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane at 0 - 20℃;73%
trans-2-Butene
624-64-6

trans-2-Butene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

3-chloro-3-fluoro-trans-1,2-dimethylcyclopropane

3-chloro-3-fluoro-trans-1,2-dimethylcyclopropane

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In water at 0℃; for 4h; Cooling with ice;73%
With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide In dichloromethane; water at 0℃; for 4h;73%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

3-Chloro-2-methylpropene
563-47-3

3-Chloro-2-methylpropene

1-Chlor-2-chlormethyl-1-fluor-2-methylcyclopropan
40841-57-4

1-Chlor-2-chlormethyl-1-fluor-2-methylcyclopropan

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether at 0℃; for 1h;72%
With potassium hydroxide; benzyltrimethylammonium chloride
With perhydrodibenzo-18-crown-6; potassium hydroxide
3-butyn-2-yl tetrahydropyranyl ether
57188-99-5

3-butyn-2-yl tetrahydropyranyl ether

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

2-(4-Chloro-4-fluoro-1-methyl-but-2-ynyloxy)-tetrahydro-pyran

2-(4-Chloro-4-fluoro-1-methyl-but-2-ynyloxy)-tetrahydro-pyran

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -100 - -70℃;70%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

(E)-1-chloro-3-methylpent-2-ene
53309-84-5

(E)-1-chloro-3-methylpent-2-ene

1-Aethyl-2-chlor-3-chlormethyl-2-fluor-1-methylcyclopropan

1-Aethyl-2-chlor-3-chlormethyl-2-fluor-1-methylcyclopropan

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether for 1h;70%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

3-(tetrahydropyran-2'-yloxy)propyne
6089-04-9

3-(tetrahydropyran-2'-yloxy)propyne

2-(4-chloro-4-fluorobut-2-ynyloxy)-tetrahydro-2H-pyran
108268-38-8

2-(4-chloro-4-fluorobut-2-ynyloxy)-tetrahydro-2H-pyran

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -100 - -70℃;70%
Stage #1: 3-(tetrahydropyran-2'-yloxy)propyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: Dichlorofluoromethane In tetrahydrofuran; hexane at -100 - -50℃;
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

thiophenol
108-98-5

thiophenol

chlorofluoromethyl phenyl sulfide
116109-54-7

chlorofluoromethyl phenyl sulfide

Conditions
ConditionsYield
With sodium hydroxide; benzyltrimethylammonium chloride In water; benzene at 50℃; under 2206.5 - 3677.5 Torr; for 4h;70%
Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

3,3-dimethyl-allyl chloride
503-60-6

3,3-dimethyl-allyl chloride

1-Chloro-3-chlormethyl-1-fluor-2,2-dimethylcyclopropan
344323-87-1

1-Chloro-3-chlormethyl-1-fluor-2,2-dimethylcyclopropan

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether for 1h;70%

Dichloromonofluoromethane Consensus Reports

Reported in EPA TSCA Inventory.

Dichloromonofluoromethane Standards and Recommendations

OSHA PEL: TWA 10 ppm
ACGIH TLV: TWA 10 ppm
DFG MAK: 10 ppm (43 mg/m3)
DOT Classification:  2.2; Label: Nonflammable Gas

Dichloromonofluoromethane Analytical Methods

For occupational chemical analysis use NIOSH: see DICHLOROFLUOROMETHANE, 2516.

Dichloromonofluoromethane Specification

The Dichlorofluoromethane is an organic compound with the formula CHCl2F. The IUPAC name of this chemical is dichloro(fluoro)methane. With the CAS registry number 75-43-4, it is also named as methane, dichlorofluoro-. The product's categories are Refrigerants; Organics. Besides, it should be stored in a cool and ventilated place. It is used as a refrigerant.

Physical properties about Dichlorofluoromethane are: (1)ACD/LogP: 1.40; (2)ACD/LogD (pH 5.5): 1.4; (3)ACD/LogD (pH 7.4): 1.4; (4)ACD/BCF (pH 5.5): 6.83; (5)ACD/BCF (pH 7.4): 6.83; (6)ACD/KOC (pH 5.5): 137.75; (7)ACD/KOC (pH 7.4): 137.75; (8)Index of Refraction: 1.366; (9)Molar Refractivity: 16.5 cm3; (10)Molar Volume: 73.6 cm3; (11)Polarizability: 6.54×10-24cm3; (12)Surface Tension: 19.9 dyne/cm; (13)Density: 1.397 g/cm3; (14)Enthalpy of Vaporization: 24.65 kJ/mol; (15)Boiling Point: 8.9 °C at 760 mmHg; (16)Vapour Pressure: 1340 mmHg at 25°C.

Preparation: this chemical can be prepared by trichloro-fluoro-methane. This reaction will need reagent HMPT and solvent dimethylformamide. The reaction time is 30 min with reaction temperature of 20 °C. The yield is about 20%.



Uses of Dichlorofluoromethane: it can be used to produce 7-chlor-7-fluor-1-methylbicyclo[4.1.0]heptan . It will need reagent 55percent KOH, 18-crown-6 with reaction time of 1 hour. The yield is about 80%.

You can still convert the following datas into molecular structure:
(1)SMILES: ClC(Cl)F
(2)InChI: InChI=1/CHCl2F/c2-1(3)4/h1H
(3)InChIKey: UMNKXPULIDJLSU-UHFFFAOYAU
(4)Std. InChI: InChI=1S/CHCl2F/c2-1(3)4/h1H
(5)Std. InChIKey: UMNKXPULIDJLSU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LCLo inhalation 10pph/1H (100000ppm)   Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.
mouse LC50 inhalation > 800gm/m3/2H (800000mg/m3) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(11), Pg. 38, 1976.
rat LC50 inhalation 49900ppm/4H (49900ppm)   "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 187, 1986.

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