Diclofenac supplier | CasNO.15307-86-5

Name
1-(2,6-Dichlorophenyl)-2-indolinone
EINECS 239-348-5
CAS No. 15307-86-5
Article Data50
CAS DataBase
Density 1.431 g/cm³
Solubility 1.278mg/L(30 oC)
Melting Point 156-158oC
Formula C₁₄H₁₁Cl₂NO₂
Boiling Point 412 ºC at 760 mmHg
Molecular Weight 296.153
Flash Point 203 ºC
Transport Information
Appearance White to yellowish crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aceticacid, [o-(2,6-dichloroanilino)phenyl]- (8CI);Diclac;Diclofenac acid;Diclofenamic acid;Diclomelan;Dicloreuma;N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid;Pennsaid;Voltaflan;[o-(2,6-Dichloroanilino)phenyl]acetic acid;
PSA 49.33000
LogP 4.43710

Synthetic route

: 934548-15-9
[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

A: 34105-57-2
2-amino-N,N-diethylacetamide

B: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A n/a B 100%

: 934548-16-0
[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

A: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

B: 40847-09-4
N-(phenylalanyl)-N,N-diethylamine

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A 100% B n/a

: 15307-79-6
diclofenac sodium

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water; acetone at 20 - 45℃; for 3h; pH=1.4 - 1.6; Solvent;	99%
With hydrogenchloride In water Cooling with ice;	90%
With hydrogenchloride In water at 0 - 20℃;	70%

: 87-65-0
2,6-Dichlorophenol

: methyl 2-(2-(2-bromopropionamido)phenyl)acetate

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 60 - 100℃; for 8h; Temperature; Reagent/catalyst;	95%

: 21789-06-0
N,N-dimethyl-o-(2,6-dichloroanilino)phenylacetamide

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water	92.9%

: 70690-44-7
2-[(2,6-dichlorophenyl)-N-benzylamino]-phenylacetic acid

: 7732-18-5
water

: 95-50-1
1,2-dichloro-benzene

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
In tetrahydrofuran; hexane; toluene	91.2%

...Expand

: 83281-95-2
2-<(2,6-dichlorophenyl)amino>-α-(methylthio)phenylacetic acid

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With nickel In ethanol Heating;	85%

: 15362-40-0
1-(2,6-dichlorophenyl)indolin-2-one

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
In hydrogenchloride; toluene liquid HCl;	84.4%

: 26159-34-2
Naprelan

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃;	82.2%

: 18698-97-0
ortho-bromophenylacetic acid

: 608-31-1
2,6-Dichloroaniline

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With D-myo-inositol; copper; caesium carbonate In water at 100℃; for 30h;	82%

: 2444-36-2
2'-chloro-benzeneacetic acid

: 608-31-1
2,6-Dichloroaniline

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; potassium iodide In 1,4-dioxane at 130 - 150℃; for 7h; Concentration; Solvent; Inert atmosphere;	80%
With copper(l) iodide; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 165℃; for 12h; Ullmann Condensation; Sealed tube;	34%
With copper(I) chloride; potassium carbonate; potassium iodide In N,N-dimethyl-formamide; xylene at 150 - 152℃; for 5h;

: rhodium(III) chloride

: 75294-57-4
o-(N-allyl-2,6-dichloroanilino)phenylacetic acid

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; water; benzene	72%

: 18698-97-0
ortho-bromophenylacetic acid

: 608-31-1
2,6-Dichloroaniline

: 111-46-6
diethylene glycol

A: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

B: C12H16O5

Conditions

Conditions	Yield
With L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate; potassium carbonate at 110℃; for 12h; Inert atmosphere;	A 72% B 17%

...Expand

: 40400-15-5
2-(2-iodophenyl)acetonitrile

: 608-31-1
2,6-Dichloroaniline

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Stage #1: 2-(2-iodophenyl)acetonitrile With potassium hydroxide In ethanol at 80℃; for 12h; Inert atmosphere; Sealed tube; Stage #2: 2,6-Dichloroaniline With copper(l) iodide; potassium carbonate In toluene at 100℃; for 12h; Inert atmosphere; Sealed tube;	70%

: 100754-92-5
potassium 2-iodophenylacetate

: 608-31-1
2,6-Dichloroaniline

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate at 100℃; Ullmann coupling;	61%

: 137138-22-8
2-<(2,6-Dichlorphenacyl)amino>phenylessigsaeure-2-oxopropylester

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With buffer pH 8.0 In 1,4-dioxane; acetonitrile at 57℃; half-life time of hydrolysis at different pH;

: 2-(4-morpholino)ethyl<(o-2,6 dichlorophenylanilino)phenyl acetate> hydrochloride

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
at 37℃; Rate constant; t1/2, simulated gastric fluid, rate plasma, further reagents, temperatures;

: [2-(2,6-Dichloro-phenylamino)-phenyl]-acetic acid 3-morpholin-4-yl-propyl ester; hydrochloride

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
at 37℃; Rate constant; t1/2, simulated gastric fluid, rate plasma, further reagents;

: [2-(2,6-Dichloro-phenylamino)-phenyl]-acetic acid 4-morpholin-4-yl-butyl ester; hydrochloride

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
at 37℃; Rate constant; t1/2, simulated gastric fluid, rate plasma, further reagents;

: [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid (benzoyl-ethoxycarbonylmethyl-amino)-methyl ester

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With NADPH-generating system; rat liver homogenate at 37℃; Enzyme kinetics; Hydrolysis; Enzymatic reaction;

: 15307-79-6
diclofenac sodium

A: 59-48-3
2-oxoindole

B: 87-65-0
2,6-Dichlorophenol

C: 15362-40-0
1-(2,6-dichlorophenyl)indolin-2-one

D: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
In phosphate buffer at 45℃; Kinetics; Thermodynamic data; Further Variations:; pH-values; Temperatures;

...Expand

: 89796-99-6
aceclofenac

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With sodium hydroxide for 3h; Heating;

: 15307-93-4
N-phenyl-2,6-dichloroaniline

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: benzene / 6 h / Heating 2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 4: 91 percent / 2N NaOH / ethanol / 48 h / Heating 5: 85 percent / Raney nickel / ethanol / Heating View Scheme
Multi-step reaction with 5 steps 1: benzene / 6 h / Heating 2: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature 3: SnCl4 / CCl4 / 0.83 h / Ambient temperature 4: 91 percent / 2N NaOH / ethanol / 48 h / Heating 5: 85 percent / Raney nickel / ethanol / Heating View Scheme

: 83281-93-0
N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 2: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 3: 91 percent / 2N NaOH / ethanol / 48 h / Heating 4: 85 percent / Raney nickel / ethanol / Heating View Scheme
Multi-step reaction with 4 steps 1: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature 2: SnCl4 / CCl4 / 0.83 h / Ambient temperature 3: 91 percent / 2N NaOH / ethanol / 48 h / Heating 4: 85 percent / Raney nickel / ethanol / Heating View Scheme

: 83281-94-1
1-(2,6-dichlorophenyl)-3-(methylthio)oxindole

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / 2N NaOH / ethanol / 48 h / Heating 2: 85 percent / Raney nickel / ethanol / Heating View Scheme

: 83281-96-3
N-(2,6-dichlorophenyl)-α-(methylsulfinyl)acetanilide

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 2: 91 percent / 2N NaOH / ethanol / 48 h / Heating 3: 85 percent / Raney nickel / ethanol / Heating View Scheme

: α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: SnCl4 / CCl4 / 0.83 h / Ambient temperature 2: 91 percent / 2N NaOH / ethanol / 48 h / Heating 3: 85 percent / Raney nickel / ethanol / Heating View Scheme

: 1224508-84-2
4-((3,3-dimethylbutoxy)carbonyloxy)benzyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With water at 37℃; pH=7.4; Kinetics;

: 5292-43-3
bromoacetic acid tert-butyl ester

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 139272-68-7
2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 144830-14-8
(+)-O-Demethyltramadol

: (+)-O-desmethyl-tramadol diclofenac salt

Conditions

Conditions	Yield
With water In acetonitrile at 20℃; under 760.051 Torr; Product distribution / selectivity;	100%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 73986-53-5, 80456-81-1, 144830-14-8, 144830-15-9
(±)-cis-2-[(dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol

: (rac)-O-desmethyl-tramadol diclofenac salt

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; Product distribution / selectivity;	100%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 73986-53-5
O-desmethyltramadol

: O-desmethyl-tramadol-diclofenac

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; Product distribution / selectivity;	100%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 768-94-5
1-Adamantanamine

: C10H17N*C14H11Cl2NO2

Conditions

Conditions	Yield
In methanol at 20℃;	100%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 2,2'-dimethyl-[1,1'-biphenyl]iodonium trifluoromethanesulfonate salt

: C28H22Cl2INO2

Conditions

Conditions	Yield
With copper diacetate; sodium carbonate; (3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole) In dichloromethane; water at 30℃; for 12h; enantioselective reaction;	99%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: C10H20N2O2S

: C24H29Cl2N3O3S

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h; Acylation;	98%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: cinnamyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide at 20℃; for 4h;	98%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 15307-78-5
2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

Conditions

Conditions	Yield
In methanol; hexane; benzene at 25℃; for 1h;	96%
With methanol In Dimethyl ether

: 67-56-1
methanol

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 15307-78-5
2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

Conditions

Conditions	Yield
With sulfuric acid for 0.25h; Reflux;	96%
Stage #1: methanol; [2-(2,6-dichloroanilino)phenyl]acetic acid With hydrogenchloride In water for 6h; Reflux; Stage #2: With sodium carbonate In water	91%
Stage #1: methanol; [2-(2,6-dichloroanilino)phenyl]acetic acid With hydrogenchloride In water for 6h; Reflux; Stage #2: With sodium hydrogencarbonate In water Cooling with ice; Saturated solution;	91%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 104425-36-7
acetic acid N-oxysuccinimide ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In 1,4-dioxane for 8h; Ambient temperature;	95%
With dicyclohexyl-carbodiimide In dichloromethane for 1h;	90%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 5℃;
Stage #1: 1-hydroxy-pyrrolidine-2,5-dione; [2-(2,6-dichloroanilino)phenyl]acetic acid In tetrahydrofuran at 0 - 5℃; for 0.166667h; Inert atmosphere; Stage #2: With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; Inert atmosphere;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

: 49715-04-0
chlorosulfuric acid chloromethyl ester

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: chloromethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 20℃; for 1h;	95%
With Bu4HSO4 In dichloromethane; water at 20℃; for 1h;

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 1528768-73-1
(5-methyl-2-phenyl-1,3-dioxan-5-yl)methyl 4-hydroxybenzoate

: 1528768-90-2
(5-methyl-2-phenyl-1,3-dioxan-5-yl)methyl 4-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)benzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran; dichloromethane at 0 - 20℃; for 18h;	95%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 255735-88-7
[(2R)-2-aminopropyl]carbamic acid,1,1-dimethylethyl ester

: Boc-propylamide-diclofenac

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1.5h; Cooling with ice;	95%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 15362-40-0
1-(2,6-dichlorophenyl)indolin-2-one

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;	94%
With thionyl chloride In dichloromethane; ethyl acetate at 50℃; for 2h; Concentration; Temperature;	92%
With hydrogenchloride In acetonitrile at 78.85℃; for 5h; Rate constant; Kinetics; Mechanism; energy data: ΔH(activ.), ΔS(activ.); ΔE(activ.)var. amount of acetonitrile, var. temp.;

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 306776-45-4
3-{Methyl{[(nitrosothio)cyclohexyl]methyl}amino)propan-1-ol

: 3-{Methyl{[(nitrosothio)cyclohexyl]methyl}amino)propyl 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h; Acylation;	94%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 109-89-7
diethylamine

: diclofenac diethylamine

Conditions

Conditions	Yield
In acetone at 50 - 55℃; for 2h; pH=8.5 - 10.0;	93.7%

: 2916-31-6
2,2-dimethyl-1,3-dioxolane

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

A: 15362-40-0
1-(2,6-dichlorophenyl)indolin-2-one

B: 5-(2,6-dichloro-phenyl)-6,6-dimethyl-5,9-dihydro-6H-7-oxa-5-aza-benzocyclohepten-8-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol Cyclization;	A n/a B 93%

...Expand

: 2955-88-6
1-pyrrolidineethanol

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: diclofenac epolamine

Conditions

Conditions	Yield
In acetone	92%

: 528-43-8
Magnolol

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 5,5'-diallyl-2'-hydroxy-[1,1'-biphenyl]-2-yl-2-(2-((2,6-dichlorophenyl)amino)phenyl) acetate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;	92%
With dmap In dichloromethane at 25 - 30℃;	92%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 2-fluoro-1-phenyl-2-(pyrimidin-2-ylsulfonyl)ethan-1-one

: 2-((2,6-dichlorophenyl)amino)phenethyl (Z)-4-((1-fluoro-2-phenyl-2-(pyrimidin-2-yloxy)vinyl)sulfonyl)butanoate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 100℃; for 12h; Inert atmosphere; Molecular sieve;	92%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 159982-36-2
2-ethyl-2-(nitrosothio)butan-1-ol

: C20H22Cl2N2O3S

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h; Acylation;	91%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 141-43-5
ethanolamine

: diclofenac/monoethanolamine

Conditions

Conditions	Yield
In acetone	90%

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

: 139115-91-6
2-(2-tert-butyloxycarbonylaminoethoxy)ethanol

: 1133407-62-1
[2-(2,6-dichlorophenylamino)phenyl]acetic acid 2-(2-tert-butoxycarbonylaminoethoxy)ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;	90%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 4h; Cooling with ice;	1.166 g
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 35℃; for 2h;	2.44 g

Diclofenac Specification

The IUPAC name of Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]- is 2-[2-(2,6-dichloroanilino)phenyl]acetic acid. With the CAS registry number 15307-86-5, it is also named as Diclofenac. The product's categories are Indoles and Derivatives; Pharmacetical. It is a non-steroidal anti-inflammatory drug which originated from Ciba-Geigy (now Novartis) in 1973. And it was first introduced in the UK in 1979. Additioanlly, this drug may be supplied as either the sodium or potassium salt in the United Kingdom, India, Brazil and the United States. And most often as the sodium salt in China.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 4.55; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.206; (4)ACD/LogD (pH 7.4): 1.437; (5)ACD/BCF (pH 5.5): 76.63; (6)ACD/BCF (pH 7.4): 1.305; (7)ACD/KOC (pH 5.5): 322.878; (8)ACD/KOC (pH 7.4): 5.501; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.662; (13)Molar Refractivity: 76.531 cm³; (14)Molar Volume: 206.819 cm³; (15)Polarizability: 30.339×10^-24 cm³; (16)Surface Tension: 57.998 dyne/cm; (17)Enthalpy of Vaporization: 70.067 kJ/mol; (18)Vapour Pressure: 0 mmHg at 25°C; (19)Rotatable Bond Count: 4; (20)Exact Mass: 295.016684; (21)MonoIsotopic Mass: 295.016684; (22)Topological Polar Surface Area: 49.3; (23)Heavy Atom Count: 19; (24)Complexity: 304.

Uses of Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]-: It is used to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea. What's more, this drug is often used to treat chronic pain associated with cancer, particularly if inflammation is also present. It is used for musculoskeletal complaints. The Benzeneacetic acid,2-[(2,6-dichlorophenyl)amino]- is better tolerated NSAIDs. Though 20% of patients on long-term treatment experience side effects, only 2% have to discontinue the drug.

People can use the following data to convert to the molecule structure.
1. SMILES:c1ccc(c(c1)CC(=O)O)Nc2c(cccc2Cl)Cl
2. InChI:InChI=1/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intramuscular	1070ug/kg (1.07mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 117, Pg. 1058, 1992.
man	TDLo	oral	29mg/kg (29mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 173, 1995.
mouse	LD50	intraperitoneal	345mg/kg (345mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 44, 1993.
mouse	LD50	oral	170mg/kg (170mg/kg)		Pharmazie. Vol. 37, Pg. 148, 1982.
rat	LD50	oral	62500ug/kg (62.5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.

Product Name

1-(2,6-Dichlorophenyl)-2-indolinone

Synthetic route

Diclofenac Specification

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