Diethyl phosphite supplier

Name
Diethyl phosphite
EINECS 212-091-6
CAS No. 762-04-9
Article Data258
CAS DataBase
Density 1.072g/mLat 25°C(lit.)
Solubility miscible (hydrolysis) in water
Melting Point -70 °C
Formula C₄H₁₁O₃P
Boiling Point 204.072 °C at 760 mmHg
Molecular Weight 138.103
Flash Point 82.222 °C
Transport Information
Appearance colourless liquid
Safety 26-36/37/39-28-27
Risk Codes 36/37/38-43
Molecular Structure
Hazard Symbols Xi
Synonyms Ethylphosphite, (EtO)2(HO)P (6CI);Diethoxyphosphine oxide;Diethyl acid phosphite;Diethyl hydrogen phosphite;Phosphonic acid,diethyl ester;Diethyl phosphonate;Hydrogendiethyl phosphite;NSC 2665;Diethyl phosphonate;Ethyl phosphonate;phosphonic acid, diethyl ester;
PSA 59.00000
LogP 1.44910

Synthetic route

: 104-15-4
toluene-4-sulfonic acid

: 122-52-1
triethyl phosphite

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 24h; Ambient temperature; molar ratio 1:1;	98%

: 64-17-5
ethanol

: 868-85-9
Dimethyl phosphite

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With sodium carbonate at 120℃; under 760.051 Torr; Reflux; Inert atmosphere;	94.5%
With titanium(IV) isopropylate at 40℃; for 18h;	62%

: 107-10-8
propylamine

: 3277-27-8
diethyl benzoylphosphonate

A: 18104-91-1
diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

B: 10546-70-0
N-(n-propyl)benzamide

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In diethyl ether for 20h; Product distribution; Ambient temperature; variation of time, different solvents, reaction with several amines;	A 55% B 94% C 33%
In diethyl ether for 20h; Ambient temperature;	A 55% B 94% C 33%

...Expand

: 814-49-3
diethyl chlorophosphate

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With potassium naphthalenide In tetrahydrofuran at -78℃; for 1h;	94%
With samarium diiodide In tetrahydrofuran for 3h; Heating;	10%

: 64-17-5
ethanol

: 7719-12-2, 52843-90-0
phosphorus trichloride

A: 75-00-3
chloroethane

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 85℃; under 30.003 Torr; Addition of ca.3% diethyl phosphite (triethyl phosphite or ethyl chloride are also possible);	A n/a B 94%

...Expand

: 122-52-1
triethyl phosphite

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; water at 25℃; Sealed tube;	93%
With water In tetrahydrofuran at 20℃; Inert atmosphere;	87%
With lithium chloride at 200℃; das Lithium-Verbindung (Lithium-diaethyl-phophit) ensteht;

: 64-17-5
ethanol

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With phosphorus trichloride at 5℃;	90%
With phosphorus trichloride	90%
With phosphorus trichloride In chloroform at 5 - 20℃; for 3.16667h;	84.5%

: 6632-88-8
diethyl 1-hydroxy-1-methylethylphosphonate

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With N,N-diethyl-1,1,1-trimethylsilanamine at 110℃; for 0.5h; Inert atmosphere;	86%

: 64-17-5
ethanol

: 65611-14-5
1,2,3-trihydrotetrafluoropropyl dichlorophosphite

A: 65611-25-8
phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

B: 762-04-9
phosphonic acid diethyl ester

C: ethyl 1,1,3-trihydroperfluoropropyl phosphite

Conditions

Conditions	Yield
Ambient temperature;	A n/a B n/a C 85%

...Expand

: 123-38-6
propionaldehyde

: 122-52-1
triethyl phosphite

A: 41760-72-9
diethyl (1-hydroxypropyl)phosphonate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 84% B n/a

...Expand

: 78-84-2
isobutyraldehyde

: 122-52-1
triethyl phosphite

A: 74038-47-4
diethyl (1-hydroxy-2-methylpropyl)phosphonate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 83% B n/a

...Expand

: 3277-27-8
diethyl benzoylphosphonate

: 100-46-9
benzylamine

A: 18104-91-1
diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

B: 1485-70-7
N-benzylbenzamide

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In diethyl ether for 3h; Ambient temperature;	A 12% B 82% C 45%

...Expand

: 122-52-1
triethyl phosphite

: 21749-63-3
2-(methylamino)benzenethiol

A: 65605-24-5
2-methylaminophenyl ethyl sulphide

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 150℃; for 10h;	A 70% B 82%

...Expand

: 64-17-5
ethanol

: 118467-50-8
S,S-diethyl O-(trimethylsilyl) phosphorodithioite

: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
	81.8%

: 126-68-1
O,O,O-triethyl phosphorothioate

A: 598-02-7
Diethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With magnesium monoperoxyphthalate hexahydrate In water at 25℃; for 24h;	A 10% B 81% C 9%

...Expand

: N-(diethoxyphosphinyl)-p-benzoquinone imine

A: 637-61-6
benzoquinone N-chloroimine

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether 0 deg C, 0.5 h then 20 deg C, 2 h;	A 63% B 81%

: 99-61-6
3-nitro-benzaldehyde

: 122-52-1
triethyl phosphite

A: 50652-91-0
diethyl 1-hydroxy-1-(3-nitrophenyl)methylphosphonate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 80% B n/a

...Expand

: 123-11-5
4-methoxy-benzaldehyde

: 122-52-1
triethyl phosphite

A: 49640-96-2
diethyl (hydroxy(4-methoxyphenyl)methyl)phosphonate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 80% B n/a

...Expand

: 108-94-1
cyclohexanone

: 122-52-1
triethyl phosphite

A: 42763-00-8
diethyl (1-hydroxycyclohexyl)phosphonate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 80% B n/a

...Expand

: 64-17-5
ethanol

A: 78-40-0
triethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With phosphorous; CuCl2bpy3 In N,N-dimethyl-formamide at 50℃; Electrolysis;	A 79.3% B 5.4% C 15.3%
With phosphorous; CuCl2bpy3 In acetonitrile at 50℃; Electrolysis;	A 55% B 15.5% C 29.5%
With phosphorous; CuCl2bpy3 at 50℃; Electrolysis;	A 28.5% B 17.5% C 16%

...Expand

: 3277-27-8
diethyl benzoylphosphonate

: 64-04-0
phenethylamine

A: 18104-91-1
diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

B: 3278-14-6
N-phenethylbenzamide

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In diethyl ether for 1h; Ambient temperature;	A 20% B 79% C 43%

...Expand

: 3277-27-8
diethyl benzoylphosphonate

: 109-73-9
N-butylamine

A: 18104-91-1
diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

B: 2782-40-3
N-butylbenzamide

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In diethyl ether for 0.333333h; Ambient temperature;	A 18% B 79% C 42%

...Expand

: 2258-42-6
Acetic formic anhydride

: 122-52-1
triethyl phosphite

A: 90723-21-0
(diethoxyphosphinyl)methyl diethyl phosphate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 20℃; for 20h;	A 79% B 12%

...Expand

: 104-55-2
3-phenyl-propenal

: 122-52-1
triethyl phosphite

A: 79158-10-4
(1-hydroxy-3-phenyl-allyl)-phosphonic acid diethyl ester

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; dichloromethane at -10℃; for 1h;	A 79% B n/a

...Expand

: 22950-57-8
diisopropyl benzoylphosphonate

: 141-43-5
ethanolamine

A: 18838-10-3
N-(2-hydroxyethyl)-benzamide

B: 16180-99-7
2-benzamidoethyl benzoate

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran for 72h; Ambient temperature;	A 78% B 9% C 3%

...Expand

: 3277-27-8
diethyl benzoylphosphonate

: 78-81-9
isobutylamine

A: 18104-91-1
diethyl 1-(diethylphosphoryloxy)-1-phenylmethylphosphonate

B: 5705-57-7
N-isobutyl-benzamide

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
In diethyl ether for 1h; Ambient temperature;	A 22% B 77% C 40%

...Expand

: 2-(bromo(phenyl)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 122-52-1
triethyl phosphite

A: 78-40-0
triethyl phosphate

B: 1080-32-6
O,O-diethyl benzylphosphonate

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 130℃; for 0.5h; Inert atmosphere;	A n/a B 76% C n/a

...Expand

: 104-15-4
toluene-4-sulfonic acid

: 122-52-1
triethyl phosphite

A: 762-04-9
phosphonic acid diethyl ester

B: 80-40-0
ethyl ester of p-toluenesulfonic acid

Conditions

Conditions	Yield
In toluene for 24h; Product distribution; Heating; investigate effect of molar ratio, solvent and temperature;	A n/a B 75%

...Expand

: 98-01-1
furfural

: 762-04-9
phosphonic acid diethyl ester

: 20627-09-2
diethyl (hydroxy(furan-2-yl)methyl)phosphonate

Conditions

Conditions	Yield
With triethylamine In neat (no solvent) at 20℃; Pudovik Reaction; Inert atmosphere;	100%
With triethylamine at 50℃; Pudovik Reaction; Inert atmosphere; Sealed tube;	100%
With 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine supported on polystyrene In neat (no solvent) at 30℃; for 3h; Pudovik Reaction; Green chemistry;	99%

: 555-16-8
4-nitrobenzaldehdye

: 762-04-9
phosphonic acid diethyl ester

: 1776-87-0
diethyl (hydroxy(4-nitrophenyl)methyl)phosphonate

Conditions

Conditions	Yield
With magnesium oxide for 0.17h;	100%
With {(μ-η5:η1):η1-2-[(2,6-Me2C6H3)NCH2](C4H3N)SmN(SiMe3)2}2 In toluene at 20℃; for 0.166667h; Inert atmosphere;	99%
With [(μ-η5:η1):η1:η1-3-(2-C4H3NCH=NCH2CH2)C8H5N]Yb3(μ3-O)-(μ2-Cl)2(THF)2[N(SiMe3)2] In neat (no solvent) at 20℃; for 0.166667h; Inert atmosphere;	99%

: 100-52-7
benzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 1663-55-4
diethyl [hydroxy(phenyl)methyl]phosphonate

Conditions

Conditions	Yield
	100%
With {(μ-η5:η1):η1-2-[(2,6-Me2C6H3)NCH2](C4H3N)SmN(SiMe3)2}2 at 20℃; for 0.0833333h; Inert atmosphere; neat (no solvent);	99%
With C42H74LiN6Si4Yb at 20℃; for 0.333333h; Neat (no solvent); Inert atmosphere;	99%

: 62-53-3
aniline

: 762-04-9
phosphonic acid diethyl ester

: 1445-38-1
diethyl phenylphosphoramidate

Conditions

Conditions	Yield
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane at 15 - 20℃; for 4h;	100%
With iodine In neat (no solvent) at 20℃; for 0.5h; Solvent;	86%
With copper(l) iodide; oxygen In acetonitrile at 55℃; under 760.051 Torr; for 24h;	84%

: 762-04-9
phosphonic acid diethyl ester

: 552-89-6
2-nitro-benzaldehyde

: 79202-15-6
diethyl (hydroxy)(2-nitrophenyl)methylphosphonate

Conditions

Conditions	Yield
With triethylamine In neat (no solvent) at 20℃; for 24h; Pudovik Reaction; Inert atmosphere;	100%
With triethylamine at 50℃; Pudovik Reaction; Inert atmosphere; Sealed tube;	100%
With C42H74LiN6Si4Yb at 20℃; for 0.333333h; Neat (no solvent); Inert atmosphere;	98%

: 762-04-9
phosphonic acid diethyl ester

: 814-49-3
diethyl chlorophosphate

Conditions

Conditions	Yield
With tert-butylhypochlorite In dichloromethane at 20℃; Inert atmosphere;	100%
With trichloroisocyanuric acid In acetonitrile at 20℃;	98%
With 1,3-dichloro-5,5-dimethylhydantoin In tetrachloromethane; acetonitrile at 20℃; for 0.166667h;	97%

: 624-31-7
4-tolyl iodide

: 762-04-9
phosphonic acid diethyl ester

: 1754-46-7
diethyl 4-methylphenylphosphonate

Conditions

Conditions	Yield
With Pd(PPh2)(m-C6H4SO3Na)*(H2O)4; triethylamine In water; acetonitrile for 1.5h; Ambient temperature;	100%
With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; triethylamine In toluene for 0.183333h; Irradiation;	91%
With water extract of rice straw ash (WERSA) In water at 90℃; for 4h;	90%

: 802274-28-8
benzyl-(4-isopropyl-benzyliden)-amine

: 762-04-9
phosphonic acid diethyl ester

: 135473-53-9
[Benzylamino-(4-isopropyl-phenyl)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; for 14h;	100%

: Benzyl-[1-(3-isopropyl-phenyl)-meth-(E)-ylidene]-amine

: 762-04-9
phosphonic acid diethyl ester

: 135473-51-7
[Benzylamino-(3-isopropyl-phenyl)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; for 14h;	100%

: Benzyl-[1-(4-isopropyl-phenyl)-eth-(E)-ylidene]-amine

: 762-04-9
phosphonic acid diethyl ester

: 135473-54-0
[1-Benzylamino-1-(4-isopropyl-phenyl)-ethyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; for 14h;	100%

: 93367-11-4
(2S,3S)-3-benzyloxy-1,2-epoxybutane

: 762-04-9
phosphonic acid diethyl ester

: Diethyl (2S,3S)-3-(benzyloxy)-2-hydroxybutanephosphonate

Conditions

Conditions	Yield
With n-butyllithium; boron trifluoride diethyl etherate In tetrahydrofuran; hexane 1.) -78 deg C, 15 min, 2.) -78 deg C, 2 h;	100%

: 75373-45-4
(2S,3R,4R)-2,4-Dimethyl-2-phenyl-3,4-dihydro-2H-pyrrole-3-carboxylic acid ethyl ester; compound with picric acid

: 762-04-9
phosphonic acid diethyl ester

: 75373-35-2, 82264-46-8, 117179-25-6, 117179-26-7
(2R,3R,4S,5R)-5-(Diethoxy-phosphoryl)-2,4-dimethyl-2-phenyl-pyrrolidine-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
at 130℃; for 3h;	100%

: 75373-48-7, 117102-99-5
(3S,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester

: 762-04-9
phosphonic acid diethyl ester

: 75373-37-4, 82264-47-9, 82264-48-0
(1R,3S,4R)-1-(Diethoxy-phosphoryl)-3-phenyl-2-aza-spiro[4.5]decane-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
at 130℃; for 3h;	100%

: 114185-04-5
(2R,3S)-3-(benzyloxy)-1,2-epoxybutane

: 762-04-9
phosphonic acid diethyl ester

: 144911-95-5
Diethyl (2R,3S)-3-(benzyloxy)-2-hydroxybutanephosphonate

Conditions

Conditions	Yield
With n-butyllithium; boron trifluoride diethyl etherate In tetrahydrofuran; hexane 1.) -78 deg C, 15 min, 2.) -78 deg C, 2 h;	100%

: 762-04-9
phosphonic acid diethyl ester

: 117083-21-3, 117083-40-6
(2S,3S)-3-Methyl-2-phenyl-3,4-dihydro-2H-pyrrole-3-carboxylic acid ethyl ester

: 67257-55-0, 82240-40-2, 117083-39-3, 117102-93-9, 117102-94-0
(2S,3R,5R)-5-(Diethoxy-phosphoryl)-3-methyl-2-phenyl-pyrrolidine-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
at 130℃; for 3h;	100%

: 762-04-9
phosphonic acid diethyl ester

: 117102-91-7, 117102-97-3
(2R,3R)-4,4-Dimethyl-2-phenyl-3,4-dihydro-2H-pyrrole-3-carboxylic acid ethyl ester

: 82240-45-7, 82240-46-8, 117119-15-0
(2S,3R,5R)-5-(Diethoxy-phosphoryl)-4,4-dimethyl-2-phenyl-pyrrolidine-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
at 130℃; for 3h;	100%

: 10031-82-0
4-ethoxybenzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 76725-94-5
diethyl ((4-ethoxyphenyl)(hydroxy)methyl)phosphonate

Conditions

Conditions	Yield
With aluminum oxide for 48h; Ambient temperature;	100%
With cholin hydroxide In neat (no solvent) at 20℃; for 0.1h; Green chemistry;	96%

: 762-04-9
phosphonic acid diethyl ester

: 623-47-2
propynoic acid ethyl ester

: 1112-29-4
ethyl β,β-bis(diethoxyphosphoryl)propionate

Conditions

Conditions	Yield
With aluminum oxide; potassium hydroxide In dichloromethane at 20℃; for 0.0833333h;	100%
With sodium hexamethyldisilazane 1) THF, -50 deg C, 15 min; 2) THF, -50 deg C, 10 min; Yield given. Multistep reaction;
With aluminum oxide; potassium hydroxide at 20℃; for 0.0833333h; Yield given;

: 762-04-9
phosphonic acid diethyl ester

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 181178-75-6
[Hydroxy-(2,3,4-trimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With aluminum oxide for 48h; Ambient temperature;	100%

: 66-77-3
1-naphthaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 1090-21-7
diethyl hydroxy(naphth-1-yl)methylphosphonate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 20℃; for 17h;	100%
With N-ethyl-N,N-diisopropylamine at 20℃; for 18h;	100%
With (2,6-iPr2PhNH)5SmLi2(THF)2 In hexane at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere;	99%

: 874-42-0
2,4-dichlorobenzaldeyhde

: 762-04-9
phosphonic acid diethyl ester

: 6625-15-6
diethyl [(2-4-dichlorophenyl)(hydroxy)methyl]phosphonate

Conditions

Conditions	Yield
With magnesium oxide for 0.17h;	100%
With C42H74LiN6Si4Yb at 20℃; for 0.333333h; Neat (no solvent); Inert atmosphere;	99%
With [(μ-η5:η1):η1:η1-3-(2-C4H3NCH=NCH2CH2)C8H5N]Yb3(μ3-O)-(μ2-Cl)2(THF)2[N(SiMe3)2] In neat (no solvent) at 20℃; for 0.166667h; Inert atmosphere;	98%

Diethyl phosphite Consensus Reports

Reported in EPA TSCA Inventory.

Diethyl phosphite Specification

The Diethyl phosphite, with the CAS registry number 762-04-9 and EINECS registry number 212-091-6, is also called phosphonic acid, diethyl ester. And the molecular formula of this chemical is C₄H₁₁O₃P. It is a kind of colorless liquid, and belongs to the following product categories: Pharmaceutical Intermediates; Organic Building Blocks; Organic Phosphates/Phosphites; Catalysis and Inorganic Chemistry; Phosphorus Compounds; Phosphorus Precursors.

The physical properties of Diethyl phosphite are as following: (1)ACD/LogP: -0.26; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 0; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 18; (8)ACD/KOC (pH 7.4): 18; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 59 Å².

Preparation of Diethyl phosphite: It can be prepared by absolute ethyl alcohol and phosphorus trichloride. The reaction will need the solvent carbon tetrachloride. The raction time is 1 hour with the temperature of 70°C. And the solvent can be removed by pressure reduction.
3C₂H₅OH+PCl₃→(C₂H₅O)₂PHO+C₂H₅Cl+2HCl↑

Uses of Diethyl phosphite: It can be used as intermediate of extraction agent and phosphoric acid esters. It is also used as solvent and acid acceptor in the synthesis of polypeptide. What's more, it is also used in the synthetic reaction, such as reduction of phenol.

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and may also cause sensitization by skin contact. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Take off immediately all contaminated clothing; After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: O=P(OCC)OCC
(2)InChI: InChI=1/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3
(3)InChIKey: MJUJXFBTEFXVKU-UHFFFAOYAQ

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	2020uL/kg (2.02mL/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat	LD50	oral	3900mg/kg (3900mg/kg)		Albright & Wilson Inc. Vol. #OPB-3, Pg. 1984,

Product Name

Diethyl phosphite

Synthetic route

Diethyl phosphite Consensus Reports

Diethyl phosphite Specification

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