Difluorochloromethane supplier

Name
Chlorodifluoromethane
EINECS 200-871-9
CAS No. 75-45-6
Article Data92
CAS DataBase
Density 1.277 g/cm³
Solubility slightly soluble in water
Melting Point -146 °C
Formula CHClF₂
Boiling Point -40.8 °C
Molecular Weight 86.4687
Flash Point
Transport Information UN 1018
Appearance Colourless gas
Safety 23-59
Risk Codes 40-59
Molecular Structure
Hazard Symbols F
Synonyms Algeon 22;Algofrene 22;Algofrene 6;Arcton 22;Arcton 4;CFC 22;Chlorodifluoromethane;Daiflon 22;Difluoromonochloromethane;Dymel 22;F 22 (halocarbon);FC 22;FC 22 (halocarbon);FKW 22;Flugene22;Forane 22;Freon 22;Frigen 22;Fron 22;HFA 22;Haltron 22;Isceon 22;Isotron 22;Khladon 22;Korfron 22;Propellant 22;Refrigerant R 22;Solkane 22;Ucon 22;
PSA 0.00000
LogP 1.44780

Synthetic route

: chlorodifluoromethyllithium

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol In N,N,N,N,N,N-hexamethylphosphoric triamide decompn. in the presence of CF3CH2OH at reflux temp., 12 h;	100%
In N,N,N,N,N,N-hexamethylphosphoric triamide

: 75-09-2
dichloromethane

: 7664-41-7
ammonia

A: 74-90-8
hydrogen cyanide

B: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 723 K;	A 98.3% B 0.6%
nickel In neat (no solvent) steady-state flow reaction over Ni catalyst at 673 K;	A 75.4% B 1.7%

...Expand

: 79-53-8
chloropentafluoroacetone

A: 75-45-6
Chlorodifluoromethane

B: 354-34-7
trifluoroacetyl fluoride

C: 2925-22-6
2,2-difluoroacetyl fluoride

D: 152239-89-9
C3HClF6O

Conditions

Conditions	Yield
With chlorine monofluoride; cesium fluoride 1.) -140 degC to -75 degC over 6 h, 2.) -75 degC, 2 h; Further byproducts given;	A n/a B n/a C n/a D 90%

...Expand

: 75-09-2
dichloromethane

: 7664-41-7
ammonia

A: 74-90-8
hydrogen cyanide

B: 75-10-5
Difluoromethane

C: 75-45-6
Chlorodifluoromethane

D: 124-38-9
carbon dioxide

E: 201230-82-2
carbon monoxide

Conditions

Conditions	Yield
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %);	A 81.8% B 0.1% C 0.6% D 10.4% E 6.8%
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %);	A 66.2% B 0.2% C 1.4% D 12.9% E 18.8%
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %);	A 64.6% B 0.3% C 0.2% D 0.6% E 0.8%

...Expand

: 1895-39-2
sodium chlorodifluoroacetate

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃;	68%

: 75-09-2
dichloromethane

: 7664-41-7
ammonia

A: 74-90-8
hydrogen cyanide

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 75-45-6
Chlorodifluoromethane

E: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K;	A 53.4% B 0.3% C 0.5% D 7.6% E 0.5%

...Expand

: 1717-59-5
2,2-difluoro-2-(fluorosulfonyl)acetic acid

: 1005-30-7
sodium 4-iodo-benzoate

A: 75-45-6
Chlorodifluoromethane

B: 120608-87-9
4-Iodo-benzoic acid difluoromethyl ester

Conditions

Conditions	Yield
With potassium chloride In acetonitrile at 50℃; for 2.5h;	A n/a B 45%

...Expand

: 79-38-9
Chlorotrifluoroethylene

: 152239-89-9
C3HClF6O

A: 75-45-6
Chlorodifluoromethane

B: 354-34-7
trifluoroacetyl fluoride

C: 2925-22-6
2,2-difluoroacetyl fluoride

D: 2-(2,2-Dichloro-1,1,2-trifluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions

Conditions	Yield
In trichlorofluoromethane for 18h; -135 degC to 25 degC; Further byproducts given;	A n/a B n/a C n/a D 40%

...Expand

: 420-49-5
chlorodifluoroiodomethane

: potassium hydroxide

A: 75-45-6
Chlorodifluoromethane

B: 584-08-7
potassium carbonate

Conditions

Conditions	Yield
In ethanol decompn. with alc. KOH at 35°C in 48h;;	A 24% B n/a
In ethanol

...Expand

: 75-43-4
Dichlorofluoromethane

: 1188-14-3
Triethylgerman

A: 75-10-5
Difluoromethane

B: 75-09-2
dichloromethane

C: 75-46-7
trifluoromethan

D: 75-45-6
Chlorodifluoromethane

E: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;	A n/a B n/a C 22% D 16% E n/a

...Expand

: 34557-54-5
methane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With chromium fluoride; hydrogen fluoride; chlorine at 275 - 300℃;

: 75-10-5
Difluoromethane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With chlorine

: 75-09-2
dichloromethane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With hydrogen fluoride; lithium fluoride Electrolysis;

: 75-43-4
Dichlorofluoromethane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With aluminium trichloride Siedetemperatur;

: 67-66-3
chloroform

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With hydrogen fluoride; antimonypentachloride at 80℃;
With calcium fluoride; silver fluoride at 250℃;
With antimony(III) fluoride

: 75-71-8
Dichlorodifluoromethane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With hydrogen; platinum at 685℃;
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With hydrogen Heating;

: 116-15-4
perfluoropropylene

A: 116-14-3
polytetrafluoroethylene

B: 75-45-6
Chlorodifluoromethane

C: 76-16-4
Hexafluoroethane

Conditions

Conditions	Yield
Ambient temperature; Irradiation; also CF2HCl;

...Expand

: 75-09-2
dichloromethane

A: 75-10-5
Difluoromethane

B: 593-70-4
R32

C: 75-45-6
Chlorodifluoromethane

D: 75-43-4
Dichlorofluoromethane

E: 75-71-8
Dichlorodifluoromethane

F: 75-69-4
trichlorofluoromethane

Conditions

Conditions	Yield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;

...Expand

: 75-43-4
Dichlorofluoromethane

A: 75-09-2
dichloromethane

B: 75-45-6
Chlorodifluoromethane

C: 67-66-3
chloroform

Conditions

Conditions	Yield
With silica gel at 149.9℃; for 6h; Product distribution;

...Expand

: 75-43-4
Dichlorofluoromethane

A: 75-46-7
trifluoromethan

B: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With antimony tetrachloride fluoride at 100℃; Kinetics; kinetic batch run;

: 75-43-4
Dichlorofluoromethane

A: 75-46-7
trifluoromethan

B: 75-45-6
Chlorodifluoromethane

C: 67-66-3
chloroform

Conditions

Conditions	Yield
zinc aluminate at 250℃; Product distribution; other temperature;

...Expand

: 67-66-3
chloroform

A: 75-46-7
trifluoromethan

B: 75-45-6
Chlorodifluoromethane

C: 75-43-4
Dichlorofluoromethane

Conditions

Conditions	Yield
With antimony tetrachloride fluoride at 100℃; Kinetics; Product distribution; kinetic behaviour of different fluorinated antimony compound in fluorination (SbCl4F, SbCl5 + SbF3Cl2, SbCl5 + SbF5, SbCl5 + SbF3) at different reaction times;
With antimony tetrachloride fluoride at 100℃; under 7600 Torr; Kinetics; Product distribution; Equilibrium constant; kinetic at three different temperatures (85, 100, 115 deg C) and at different pressures ( 7.3, 8.0, 10.0, 10.5, 13.0, 13.8 atm);
With hydrogen fluoride; antimonypentachloride at 70 - 90℃; under 10746.4 - 10953.3 Torr; Product distribution / selectivity; Heating / reflux;

...Expand

: 75-71-8
Dichlorodifluoromethane

A: 74-90-8
hydrogen cyanide

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 75-45-6
Chlorodifluoromethane

E: 124-38-9
carbon dioxide

F: 201230-82-2
carbon monoxide

Conditions

Conditions	Yield
With O3Ti(2-)*Ni(2+); ammonia at 499.9℃; Product distribution; other catalysts;

...Expand

: 353-59-3
halon-1211

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;
With bromine at 349.9℃; Equilibrium constant; different reagent and reactant concentrations and reaction temperatures;

: 353-59-3
halon-1211

A: 1511-62-2
bromodifluoromethane

B: 75-10-5
Difluoromethane

C: 373-52-4
bromofluoromethane

D: 75-09-2
dichloromethane

E: 75-45-6
Chlorodifluoromethane

F: 74-95-3
1,2-dibromomethane

Conditions

Conditions	Yield
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea;

...Expand

: 75-38-7
Vinylidene fluoride

: 152239-89-9
C3HClF6O

A: 75-45-6
Chlorodifluoromethane

B: 354-34-7
trifluoroacetyl fluoride

C: 2-(2-Chloro-1,1-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

D: 2-(2-Chloro-2,2-difluoro-ethoxy)-1,1,1,2,3,3-hexafluoro-propane

Conditions

Conditions	Yield
In trichlorofluoromethane for 24h; -141 degC to 25 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 116-14-3
polytetrafluoroethylene

A: 75-45-6
Chlorodifluoromethane

B: 354-25-6
2-chloro-1,1,2,2-tetrafluoroethane

C: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

D: 115-25-3
Octafluorocyclobutane

Conditions

Conditions	Yield
With hydrogenchloride at 660℃; under 760 Torr; Mechanism; Ar-diluted mixtures, flow conditions; other temperatures;

...Expand

: 79-38-9
Chlorotrifluoroethylene

: 152239-93-5
C3HCl2F5O

A: 75-45-6
Chlorodifluoromethane

B: 354-27-8
chlorodifluoroacetyl fluoride

C: 1-Chloro-2-(1,2-dichloro-1,2,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

D: 1-Chloro-2-(2,2-dichloro-1,1,2-trifluoro-ethoxy)-1,1,2,3,3-pentafluoro-propane

Conditions

Conditions	Yield
In trichlorofluoromethane for 18h; -136 degC to 20 degC; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 75-09-2
dichloromethane

A: 75-10-5
Difluoromethane

B: 593-70-4
R32

C: 75-45-6
Chlorodifluoromethane

D: 75-43-4
Dichlorofluoromethane

E: 75-71-8
Dichlorodifluoromethane

Conditions

Conditions	Yield
With osmium pentafluoride oxide Product distribution; other transition-metal oxide fluorides;

...Expand

: 75-71-8
Dichlorodifluoromethane

: 812-15-7
1,1,1,2,2-pentamethyldisilane

A: 75-77-4
chloro-trimethyl-silane

B: 993-07-7
trimethylsilan

C: 75-45-6
Chlorodifluoromethane

D: 1560-28-7
pentamethylchlorodisilane

E: 75-78-5
dimethylsilicon dichloride

Conditions

Conditions	Yield
at 436.9 - 492.9℃; under 1.5 - 3 Torr; Product distribution; Thermodynamic data; other temp.;

...Expand

: 2-[2-(5-bromo-2-hydroxyphenyl)-ethyl]-3-chlorobenzonitrile

: 75-45-6
Chlorodifluoromethane

: 2-[2-(5-bromo-2-difluoromethoxyphenyl)-ethyl]-3-chlorobenzonitrile

Conditions

Conditions	Yield
With potassium hydroxide In isopropyl alcohol at 20 - 65℃; for 1.1h;	100%

: 75-45-6
Chlorodifluoromethane

: 944334-01-4
4-bromo-2-vinyloxy-1-methoxybenzene

: 944333-99-7
4-bromo-2-cyclopropoxy-1-methoxybenzene

Conditions

Conditions	Yield
With dimethyl zinc(II) In toluene at -40 - 20℃; for 28.25h;	100%

: 75-45-6
Chlorodifluoromethane

: 140675-43-0
2-Fluoro-6-hydroxybenzonitrile

: 221202-14-8
2-(difluoromethoxy)-6-fluorobenzonitrile

Conditions

Conditions	Yield
With sodium hydroxide In diethylene glycol dimethyl ether; water at 20 - 65℃;	99%
Stage #1: 2-Fluoro-6-hydroxybenzonitrile With sodium hydroxide In 1,2-dimethoxyethane; water at 65℃; Stage #2: Chlorodifluoromethane In 1,2-dimethoxyethane; water at 20 - 65℃;
With sodium hydroxide In 1,4-dioxane; water at 65℃;

: 75-45-6
Chlorodifluoromethane

: (1-Benzyloxymethyl-prop-2-ynyloxy)-tert-butyl-dimethyl-silane

: (1-Benzyloxymethyl-4,4-difluoro-but-2-ynyloxy)-tert-butyl-dimethyl-silane

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;	98%

: 645-00-1
m-iodonitrobenzene

: 75-45-6
Chlorodifluoromethane

: 98-46-4
3-trifluoromethylnitrobenzene

Conditions

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;	98%

: 75-45-6
Chlorodifluoromethane

: 66225-40-9
N-ethyl-N-methylbutan-1-amine

: N-butyl-N-(difluoromethyl)-N-methylammonium nitrate

Conditions

Conditions	Yield
With sodium hydroxide; sodium nitrate In tetrahydrofuran; water at 20℃;	97%

: 75-45-6
Chlorodifluoromethane

: 144432-79-1
4-biphenylboronic acid 1,2-ethanediol ester

: 4-phenyl-α,α-difluorotoluene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;	97%
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;	95%

: 5-methyl-2-phenyl-1,2,4-triazolidin-3-one

: 75-45-6
Chlorodifluoromethane

: 4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichlorophenyl)-1,2,4-triazol-5(1H)-one

Conditions

Conditions	Yield
Stage #1: 5-methyl-2-phenyl-1,2,4-triazolidin-3-one With chlorine In water; 1,2-dichloro-ethane at 20 - 80℃; for 5.36h; Molecular sieve; Stage #2: With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 140℃; for 4h; Stage #3: Chlorodifluoromethane In 5,5-dimethyl-1,3-cyclohexadiene; Triethylene glycol dimethyl ether at 185℃; for 0.5h;	96.1%

: 75-45-6
Chlorodifluoromethane

: 651-84-3
4-trifluoromethyl-2,3,5,6-tetrafluorothiophenol

: 1-Difluoromethylsulfanyl-2,3,5,6-tetrafluoro-4-trifluoromethyl-benzene

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 45℃; for 3h;	96%

: 67249-20-1
1-decylpiperidine

: 75-45-6
Chlorodifluoromethane

: N-decyl-N-(difluoromethyl)piperidinium chloride

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3.5h;	96%

: 102-82-9
tributyl-amine

: 75-45-6
Chlorodifluoromethane

: N,N,N-tributyl-N-(difluoromethyl)ammonium chloride

Conditions

Conditions	Yield
Stage #1: tributyl-amine With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.0333333h; Stage #2: Chlorodifluoromethane In tetrahydrofuran; water	96%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 3h;	92%

: 75-45-6
Chlorodifluoromethane

: K(1+)*C14H14BO3(1-)

: 4-phenyl-α,α-difluorotoluene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;	96%

: 75-45-6
Chlorodifluoromethane

: 116-14-3
polytetrafluoroethylene

Conditions

Conditions	Yield
With high nickel alloy at 420 - 955℃; for 6.94444E-05h; Temperature;	95.2%
In gas Product distribution; Irradiation; dependence on pressure and light intensity;
Pyrolysis;

: 37622-90-5
4-ethoxycarbonylpyrazole

: 75-45-6
Chlorodifluoromethane

: 129819-40-5
ethyl 1-(difluoromethyl)-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;	95%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;	41%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130 - 140℃; for 3h;	41%

: 75-45-6
Chlorodifluoromethane

: 123-08-0
4-hydroxy-benzaldehyde

: 73960-07-3
4-difluoromethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 4-hydroxy-benzaldehyde With sodium hydroxide; 18-crown-6 ether In water; isopropyl alcohol for 0.5h; Stage #2: Chlorodifluoromethane In water; isopropyl alcohol at 65℃; for 5 - 6h;	95%
With sodium hydroxide; sodium dithionite In 1,4-dioxane; water at 65 - 70℃; for 5h;	76%
With sodium hydroxide; Tris(3,6-dioxaheptyl)amine In toluene at 105℃; for 1.17h;	24%

: 75-45-6
Chlorodifluoromethane

: 68-34-8
phenyl toluenesulfonamide

: N-(difluoromethyl)-4-methyl-N-phenylbenzenesulfonamide

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide at 60 - 70℃;	95%

: C10H21N(CH3)C2H5

: 75-45-6
Chlorodifluoromethane

: N-decyl-N-(difluoromethyl)-N-ethyl-N-methylammonium chloride

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 2h;	95%

: 120-03-6
2-(p-tolyl)-1H-benzimidazole

: 75-45-6
Chlorodifluoromethane

: 1309978-33-3
1-(difluoromethyl)-2-(4-methylphenyl)-1H-benzimidazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃;	95%

: 636-98-6
p-nitrobenzene iodide

: 75-45-6
Chlorodifluoromethane

: 402-54-0
p-nitrobenzotrifluoride

Conditions

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;	95%

: 75-45-6
Chlorodifluoromethane

: 13922-41-3
1-Naphthylboronic acid

: 53731-26-3
1-(difluoromethyl)naphthalene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 48h; Inert atmosphere; Sealed tube;	95%

: 75-45-6
Chlorodifluoromethane

: 60134-93-2
3-(tert-butyldimethylsilyloxy)oct-1-yne

: 183996-60-3
tert-Butyl-[1-(3,3-difluoro-prop-1-ynyl)-hexyloxy]-dimethyl-silane

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h;	94%

: 866130-43-0
4-(5-hydroxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 75-45-6
Chlorodifluoromethane

: 866130-44-1
4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at -78 - 100℃; for 12h;	94%

: 75-45-6
Chlorodifluoromethane

: 66-99-9
β-naphthaldehyde

: 131581-40-3
1,1-difluoro-2-(2-naphthyl)ethene

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride; triphenylphosphine; methyloxirane In N,N-dimethyl-formamide at 110℃; for 6h; Wittig Olefination; Sealed tube; Molecular sieve; Inert atmosphere;	94%

: 75-45-6
Chlorodifluoromethane

: 90-14-2
1-Iodonaphthalene

: 26458-04-8
1-trifluoromethylnaphthalene

Conditions

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 120℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;	94%

: 75-45-6
Chlorodifluoromethane

: K(1+)*C18H22BO3(1-)

: 4-phenyl-α,α-difluorotoluene

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; hydroquinone In 1,4-dioxane at 110℃; for 48h; Schlenk technique; Inert atmosphere;	94%

: 75-45-6
Chlorodifluoromethane

: tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate

: 1-[7-(difluoromethoxy)spiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-yl]ethanone

Conditions

Conditions	Yield
Stage #1: Chlorodifluoromethane; tetrabutylammonium 7-acetylspiro[1,3-benzodioxole-2,4'-tetrahydrothiopyran]-4-olate In N,N-dimethyl-formamide at 50 - 55℃; Large scale; Stage #2: With water; sodium hydroxide In N,N-dimethyl-formamide at 45 - 55℃; Large scale;	94%

: 75-45-6
Chlorodifluoromethane

: C25H23ClN2O3

: C26H24F2N2O3

Conditions

Conditions	Yield
With dmap; 4,4'-diamino-2,2'-bipyridyl; magnesium chloride; nickel dichloride; zinc In N,N-dimethyl acetamide at 60℃; for 12h; Molecular sieve;	94%

: 75-45-6
Chlorodifluoromethane

: C11H6BrF3

: 2-(3-bromophenyl)-3-((difluoromethyl)selanyl)-4-(trifluoromethyl)selenophene

Conditions

Conditions	Yield
With selenium; water; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 10h; Schlenk technique; Inert atmosphere; regioselective reaction;	94%

Difluorochloromethane Chemical Properties

Molecular Formula: CHClF₂
Molecular Weight: 86.47
EINECS: 200-871-9
Index of Refraction: 1.278
Density: 1.277 g/cm³
Melting point: -146 °C
Boiling Point: 155 °C
Water solubility: Slightly soluble
Appearance: Colourless gas
Structure of Difluorochloromethane (CAS NO.75-45-6):

IUPAC Name: Chloro(difluoro)methane
Product Category of Difluorochloromethane (CAS NO.75-45-6): refrigerants;Organics;Refrigerant

Difluorochloromethane Uses

Difluorochloromethane (CAS NO.75-45-6) is mainly used as mainlyPropellant, fumigant, insecticide. It was once commonly used as a propellant and in air conditioning applications.

Difluorochloromethane Production

Difluorochloromethane (CAS NO.75-45-6) can be prepared from Chloroform : HCCl₃ + 2HF → HCF₂Cl + 2HCl .

Difluorochloromethane Toxicity Data With Reference

1.	mmo-sat 33 pph/24H-C	TOLED5 Toxicology Letters. 2 (1978),1.
2.	mma-sat 33 pph/24H-C	TOLED5 Toxicology Letters. 2 (1978),1.
3.	ihl-rat LC50:35 pph/15M	HUTODJ Human Toxicology. 1 (1982),239.
4.	ihl-mus LC50:28 pph/20M	TXAPA9 Toxicology and Applied Pharmacology. 59 (1981),64.
5.	ihl-dog LCLo:70 pph	TXAPA9 Toxicology and Applied Pharmacology. 2 (1960),363.

Difluorochloromethane Consensus Reports

It is reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Difluorochloromethane Safety Profile

Hazard Codes: Flammable F
Risk Statements: 40-59
R40:Limited evidence of a carcinogenic effect.
R59:Dangerous to the ozone layer.
Safety Statements: 23-59
S23:Do not breathe vapour.
S59:Refer to manufacturer / supplier for information on recovery / recycling.
Mildly toxic by inhalation. Experimental reproductive effects. Mutation data reported. An asphyxiant in high concentrations. At elevated pressures, 50% mixtures with air are combustible although ignition is difficult. When heated to decomposition it emits toxic fumes of F⁻ and Cl⁻.

Difluorochloromethane Standards and Recommendations

OSHA PEL: TWA 1000 ppm
ACGIH TLV: TWA 1000 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 500 ppm (1800 mg/m³)
DOT Classification: 2.2; Label: Nonflammable Gas

Difluorochloromethane Specification

Difluorochloromethane , its cas register number is 75-45-6. It also can be called Chlorodifluoromethane ; Fluorocarbon 22 ; Freon R-22 ; and Freon 22 . Difluorochloromethane (CAS NO.75-45-6) is shipped as a liquefied gas under its own vapor pressure, and is noncombustible. Difluorochloromethane can asphyxiate by the displacement of air. Contact with the liquid can cause frostbite.

Product Name

Chlorodifluoromethane

Synthetic route

Difluorochloromethane Chemical Properties

Difluorochloromethane Uses

Difluorochloromethane Production

Difluorochloromethane Toxicity Data With Reference

Difluorochloromethane Consensus Reports

Difluorochloromethane Safety Profile

Difluorochloromethane Standards and Recommendations

Difluorochloromethane Specification

Related Products

Hot Products