Dimethoxymethane supplier | CasNO.109-87-5

Name
Dimethoxymethane
EINECS 203-714-2
CAS No. 109-87-5
Article Data229
CAS DataBase
Density 0.86 g/cm³
Solubility 32.3 g/100 mL (16 °C) in water
Melting Point -105 °C
Formula C₃H₈O₂
Boiling Point 45.238 °C at 760 mmHg
Molecular Weight 76.0953
Flash Point -18 °C
Transport Information UN 1234 3/PG 2
Appearance colorless transparent liquid
Safety 16-26-33-7/9-37/39
Risk Codes 11-19-36-36/37/38
Molecular Structure
Hazard Symbols F,Xi
Synonyms 2,4-Dioxapentane;Anesthenyl;Bis(methoxy)methane;Dimethoxymethane;Dimethyl formal;Formal;Formaldehyde dimethyl acetal;Formaldehyde methyl ketal;Methoxymethyl methylether;Methylal;Methylene dimethyl ether;
PSA 18.46000
LogP 0.23670

Synthetic route

: 67-56-1
methanol

: 50-00-0
formaldehyd

A: 109-87-5
Dimethoxymethane

B: 107-31-3
Methyl formate

Conditions

Conditions	Yield
In water at 46 - 100℃; Acidic ion exchange resin;	A 98.2% B 0.6%
Katapak-catalyst In water at 46 - 100℃; Product distribution / selectivity;

...Expand

: 67-56-1
methanol

: 50-00-0
formaldehyd

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With sulfuric acid for 5h; Reagent/catalyst; Reflux;	96%
ion exchange resin with sulphonic acid groups In water at 70℃; for 0.2h; Industry scale;	95.9%
ion-exchange resines In water Product distribution; continuous apparatus (rectification of the formed methylal);

: 22106-70-3
1-(methoxymethyl)-2-pyrrolidinone

: 107-30-2
chloromethyl methyl ether

A: 31282-95-8
1-(chloromethyl)pyrrolidin-2-one

B: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
Heating;	A 96% B n/a

...Expand

: 1112-39-6
dimethyldimethoxysilan

: 14879-83-5
2,2-dimethyl-[1,3,2]dioxasilinane

A: 109-87-5
Dimethoxymethane

B: 77181-39-6
2,2,4,4,6-Pentamethyl-1,3-dioxa-2-silacyclohexane

Conditions

Conditions	Yield
With tin(IV) chloride at 65℃; Product distribution; other reaction conditions; also with 1,3-dioxane and 4,4-dimethyl-1,3-dioxane;	A n/a B 94%

...Expand

: 67-56-1
methanol

: 536-74-3
phenylacetylene

A: 93-58-3
benzoic acid methyl ester

B: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene at 60℃; for 15h; Time; Reagent/catalyst; Concentration; Temperature; Sealed tube;	A 82% B n/a

...Expand

: 115-10-6
Dimethyl ether

A: 67-56-1
methanol

B: 50-00-0
formaldehyd

C: 109-87-5
Dimethoxymethane

D: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With nitrogen; oxygen at 239.84℃; Conversion of starting material;	A 19.4% B 79% C 0.1% D 1.6%
With nitrogen; oxygen at 199.84 - 259.84℃; Rate constant;	A 17.3% B 69.2% C 0% D 1.6%
With nitrogen; oxygen at 239.84℃; Conversion of starting material;	A 22.4% B 60.1% C 0% D 5%

...Expand

: 67-56-1
methanol

: 75-09-2
dichloromethane

: 201230-82-2
carbon monoxide

A: 109-87-5
Dimethoxymethane

B: 79-20-9
acetic acid methyl ester

C: 6290-49-9
methyl methoxyacetate

D: 108-59-8
malonic acid dimethyl ester

Conditions

Conditions	Yield
With Methyl formate; sodium methylate; Co2(CO)6{P(C4H9-n)3}2 at 80℃; under 11250.9 Torr; for 15h; electrolysis;	A 8% B n/a C 3% D 74.5%
With Methyl formate; sodium methylate; Co2(CO)6{P(C4H9-n)3}2 at 80℃; under 11250.9 Torr; for 15h; Product distribution; Mechanism; electrolysis, var. of catalyst, its reduction method, ratio;	A 8% B n/a C 3% D 74.5%
With sodium hydroxide; carbon-doped cobalt at 80℃; under 23560 Torr; for 1h;	A 1.2 % Chromat. B 7.5 % Chromat. C 1.9 % Chromat. D 28.8 % Chromat.

...Expand

: 2949-92-0
methanethiosulfonic acid S-methyl ester

A: 64-18-6
formic acid

B: 75-75-2
methanesulfonic acid

C: 109-87-5
Dimethoxymethane

D: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With oxygen In methanol Irradiation;	A n/a B 72% C n/a D n/a

...Expand

: 23433-02-5
4-octyl-1,3-dioxane

A: 109-87-5
Dimethoxymethane

B: 6071-32-5
undecane-1,3-diol

Conditions

Conditions	Yield
With methanol; sulfuric acid Heating;	A n/a B 70%

: 67-56-1
methanol

: 74-95-3
1,2-dibromomethane

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With 4-vinylpyridine at 125℃; under 6000.6 Torr; for 2h;	58%

: 67-56-1
methanol

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With oxygen at 139.84℃; under 760.051 Torr; Reagent/catalyst; Temperature; Time; Inert atmosphere;	50%
With V(V) complex at 140℃; under 760.051 Torr; for 4h; Catalytic behavior; Temperature; Sealed tube; chemoselective reaction;	9%
With oxygen; Mo12V3W1.2Cu1.2Sb0.5Ox at 200 - 350℃; Product distribution / selectivity; Gas phase;	1.6%

: 67-56-1
methanol

: 107-31-3
Methyl formate

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With cobalt(II) tetrafluoroborate hexahydrate; hydrogen; bis(trifluoromethanesulfonyl)amide; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 80℃; under 60006 Torr; for 22h; Catalytic behavior; Reagent/catalyst; Schlenk technique; Autoclave;	41%

: 67-56-1
methanol

: 126-99-8
chloroprene

A: 109-87-5
Dimethoxymethane

B: 16906-18-6
2-chloro-3,3-dimethoxyprop-1-ene

C: 4461-52-3
methoxymethanol

D: 292638-85-8
acrylic acid methyl ester

Conditions

Conditions	Yield
With ozone at -78℃; Further byproducts given;	A 24 % Spectr. B 40% C 75 % Spectr. D n/a

...Expand

: 21862-63-5
trans-4-tert-butylcyclohexanol

: 107-30-2
chloromethyl methyl ether

A: 109-87-5
Dimethoxymethane

B: bis(4-tert-butylcyclohexyloxy)methane

C: 89726-87-4
trans-4-tert-butyl-O-(methoxymethyl)cyclohexanol

Conditions

Conditions	Yield
Stage #1: chloromethyl methyl ether With 1H-imidazole In d7-N,N-dimethylformamide for 0.166667h; Stage #2: trans-4-tert-butylcyclohexanol for 24h;	A n/a B n/a C 40%

...Expand

: 67-56-1
methanol

: 1809-02-5
2-chloro-3-methylbutadiene

A: 109-87-5
Dimethoxymethane

B: 79-20-9
acetic acid methyl ester

C: 80-62-6
methacrylic acid methyl ester

D: 108365-85-1
2-Chlor-3,3-dimethoxy-1-buten

Conditions

Conditions	Yield
With ozone at -78℃; Further byproducts given. Yields of byproduct given;	A n/a B n/a C n/a D 39%

...Expand

: 67-56-1
methanol

A: 109-87-5
Dimethoxymethane

B: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With PHTHALIMAX S4 vanadia-titania catalyst; oxygen at 139.84℃; under 760.051 Torr; Inert atmosphere;	A 38% B n/a
at 150℃; for 18h; Product distribution;	A 0.72 mmol B 2.24 mmol
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 20℃; Product distribution; Further Variations:; Catalysts; Electrolysis;

: 67-56-1
methanol

A: 50-00-0
formaldehyd

B: 109-87-5
Dimethoxymethane

C: 115-10-6
Dimethyl ether

Conditions

Conditions	Yield
With oxygen at 169.84℃; under 760.051 Torr; Inert atmosphere;	A n/a B 30% C n/a
With titanium(IV) oxide at 275℃;	A 49 %Chromat. B 7 %Chromat. C 44 %Chromat.
With oxygen at 249.84℃; for 1.16667h; chemoselective reaction;

...Expand

: 67-56-1
methanol

A: 50-00-0
formaldehyd

B: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With oxygen at 159.84℃; under 760.051 Torr; Temperature; Inert atmosphere;	A n/a B 28%
With oxygen; iron(II) molybdate at 200 - 250℃; Product distribution / selectivity; Gas phase;	A n/a B 1.4%
molecular sieve at 230℃; Product distribution; Mechanism; other alcohols; other catalysts;

: 67-56-1
methanol

A: 109-87-5
Dimethoxymethane

B: 115-10-6
Dimethyl ether

Conditions

Conditions	Yield
With oxygen at 169.84℃; under 760.051 Torr; Reagent/catalyst; Temperature; Inert atmosphere;	A 28% B n/a
With oxygen; molybdenum(VI) oxide at 215℃; Product distribution; Investigation of methanol conversion in contact with MoO3 in a flow reactor in helium as a carrier gas. Investigation of the effect of the oxygen partial pressure in the reactive gas and reaction time in the absence of oxygen.;
With 2,6-di-tert-butyl-pyridine; H5PV2Mo10O40; oxygen; silica gel at 179.85℃; Product distribution; Further Variations:; Reagents;

: 67-56-1
methanol

A: 109-87-5
Dimethoxymethane

B: 115-10-6
Dimethyl ether

C: 107-31-3
Methyl formate

Conditions

Conditions	Yield
With oxygen at 159.84℃; under 760.051 Torr; Reagent/catalyst; Temperature; Inert atmosphere;	A 28% B n/a C n/a
With PHTHALIMAX S4 vanadia-titania catalyst; oxygen at 159.84℃; under 760.051 Torr; Inert atmosphere;	A 17% B n/a C n/a
With silicomolybdic acid at 170℃; for 1h; Product distribution; other reagents, other organic oxygen-containing compounds;

...Expand

: 67-56-1
methanol

A: 109-87-5
Dimethoxymethane

B: 107-31-3
Methyl formate

C: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With phosphotungstic acid; platinum In water at 20℃; Product distribution; electrocatalytic oxidation of methanol investigated;	A n/a B 26% C n/a
With phosphotungstic acid; platinum In water at 20℃; electrocatalytic oxidation;	A n/a B 26% C n/a
With helium; water; oxygen at 24.9℃; under 757.6 Torr; Product distribution; gas phase fuel cell; variation of pressures;

...Expand

: 81618-17-9
1-hexadecene ozonide

A: 109-87-5
Dimethoxymethane

B: 2765-11-9
n-pentadecanal

C: 107-31-3
Methyl formate

D: 1002-84-2
palmitic acid

E: 7132-64-1
pentadecanoic acid methyl ester

F: 52517-73-4
1,1-dimethoxy-pentadecane

Conditions

Conditions	Yield
In methanol at 90℃; for 6h; Mechanism; Product distribution; Kinetics; other solvents; other objects of study: energy data, velocity constant;	A 19.6% B 8.8% C 21.3% D 20.3% E 2.2% F 14.1%

...Expand

: 767-09-9
butyl-[1,2,4]trioxolane

: 67-56-1
methanol

A: 110-62-3
pentanal

B: 109-87-5
Dimethoxymethane

C: 107-31-3
Methyl formate

D: 624-24-8
methyl valerate

E: 26450-58-8
1,1-dimethoxy-pentane

F: 109-52-4
valeric acid

Conditions

Conditions	Yield
at 90℃; for 6h; Product distribution; Thermodynamic data; Rate constant; other temperature, ΔS (excit.), ΔG (excit.), ΔH (excit.);	A 2.8% B 18.3% C 20.4% D 3.7% E 18.4% F 15.9%

...Expand

: 767-09-9
butyl-[1,2,4]trioxolane

A: 50-00-0
formaldehyd

B: 110-62-3
pentanal

C: 109-87-5
Dimethoxymethane

D: 107-31-3
Methyl formate

E: 26450-58-8
1,1-dimethoxy-pentane

F: 109-52-4
valeric acid

Conditions

Conditions	Yield
In methanol at 90℃; for 6h; Mechanism; Product distribution;	A 2.1% B 2.8% C 18.3% D 20.4% E 18.4% F 15.9%

...Expand

: 67-56-1
methanol

: 75-09-2
dichloromethane

A: 109-87-5
Dimethoxymethane

B: 93298-60-3
1-((2R,4S,5R)-4-Ethoxymethoxy-5-ethoxymethoxymethyl-tetrahydro-furan-2-yl)-5-trifluoromethyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydroxide at 140℃;	A n/a B 19%

...Expand

: 67-56-1
methanol

: 2568-90-3
di-n-butyloxymethane

A: 109-87-5
Dimethoxymethane

B: 76050-97-0
1-butoxy-1-methoxymethane

C: 71-36-3
butan-1-ol

Conditions

Conditions	Yield
at 160 - 180℃; reagiert analog mit Decylalkohol;

...Expand

: 67-56-1
methanol

: 412013-41-3
formaldehyde-[bis-(2-methyl-butyl)-acetal]

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With hydrogenchloride

: 67-56-1
methanol

: 75-09-2
dichloromethane

: 109-87-5
Dimethoxymethane

Conditions

Conditions	Yield
With sodium hydroxide at 100 - 125℃; unter Druck;
With sodium hydroxide at 100 - 125℃; unter Druck;

: 67-56-1
methanol

: 4497-29-4
bis(bromomethyl) ether

: 109-87-5
Dimethoxymethane

: 67-56-1
methanol

: 625-56-9
Chloromethyl acetate

A: 109-87-5
Dimethoxymethane

B: 79-20-9
acetic acid methyl ester

Conditions

Conditions	Yield
at 50℃;

...Expand

: 109-87-5
Dimethoxymethane

: 53555-42-3
2,2-Dimethyl-1,3-propanedithiol

: 60311-39-9
5,5-Dimethyl-1,3-dithiane

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate	100%
With boron trifluoride diethyl etherate; acetic acid In chloroform for 0.5h; Heating;	100%
	88.7%
With trifluoroborane diethyl ether; acetic acid In chloroform

: 109-87-5
Dimethoxymethane

: 3068-00-6
D,L-1,2,4-butanetriol

: 4728-06-7
(1,3-dioxan-4-yl)methanol

Conditions

Conditions	Yield
	100%

: 109-87-5
Dimethoxymethane

: 56472-17-4
2,2-diethyl-1,3-propanedithiol

: 134434-07-4
5,5-Diethyl-1,3-dithiane

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate	100%
With boron trifluoride diethyl etherate; acetic acid In chloroform for 0.5h; Heating;	100%

: 109-87-5
Dimethoxymethane

: 6482-32-2
2-(hydroxymethyl)butane-1,4-diol

: 115430-92-7
5-(2-hydroxyethyl)-1,3-dioxane

Conditions

Conditions	Yield
	100%

: 109-87-5
Dimethoxymethane

: 104-54-1
3-Phenylpropenol

: 88738-40-3, 91970-13-7
γ-Phenyl-allylalkohol-methoxy-methylether

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; lithium bromide for 0.75h; Ambient temperature;	100%
With 12-tungstophosphoric acid immobilized on [bmim][FeCl4] at 75 - 82℃; for 0.00555556h; Microwave irradiation;	98%
With 1-butyl-3-methylimidazolium tetrachloroindate for 0.025h; Microwave irradiation; chemoselective reaction;	97%
With tin(IV)octabromotetraphenylporphyrinato trifluoromethanesulfonate at 20℃; for 0.0833333h;	95%

: 109-87-5
Dimethoxymethane

: 87-91-2
diethyl (2R,3R)-tartrate

: 100449-52-3
(+)-(2R,3R)-diethyl 2,3-bismethoxymethoxybutanedioate

Conditions

Conditions	Yield
With phosphorus pentaoxide In chloroform for 2.5h; Ambient temperature;	100%
With phosphorus pentoxide In dichloromethane for 5h; Ambient temperature;	100%
With phosphorus pentoxide In chloroform for 2h; Alkylation;	97%
With phosphorus pentoxide In dichloromethane	96%
With phosphorus pentoxide In dichloromethane

: 109-87-5
Dimethoxymethane

: 107536-00-5
1-Methylsulfanyl-4-phenyl-1-(toluene-4-sulfonyl)-butan-2-ol

: 107536-02-7
1-(2-Methoxymethoxy-1-methylsulfanyl-4-phenyl-butane-1-sulfonyl)-4-methyl-benzene

Conditions

Conditions	Yield
With phosphorus pentoxide In chloroform for 1h; Ambient temperature;	100%

: 109-87-5
Dimethoxymethane

: 107536-13-0
2-Methylsulfanyl-1-phenyl-2-(toluene-4-sulfonyl)-ethanol

: 107536-05-0
1-(2-Methoxymethoxy-1-methylsulfanyl-2-phenyl-ethanesulfonyl)-4-methyl-benzene

Conditions

Conditions	Yield
With phosphorus pentoxide In chloroform for 1h; Ambient temperature;	100%

: 109-87-5
Dimethoxymethane

: 74676-69-0
2β-bromo-1α,3β-dihydroxycycloheptane

: 74676-70-3
2β-bromo-1α,3β-bis(methoxymethoxy)-cycloheptane

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane	100%

: 109-87-5
Dimethoxymethane

: 87-91-2, 13811-71-7, 21066-72-8, 57968-71-5, 122406-96-6, 128851-23-0
L-(+)-diethyl tartrate

: 100449-52-3
2,3-Bis-methoxymethoxy-succinic acid diethyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide	100%

: 109-87-5
Dimethoxymethane

: 100-51-6
benzyl alcohol

: 31600-55-2
benzyl methoxymethyl ether

Conditions

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 1h;	100%
zirconium(IV) chloride at 20℃; for 1h;	97%
With tin(IV)octabromotetraphenylporphyrinato trifluoromethanesulfonate at 20℃; for 0.0833333h;	97%

: 109-87-5
Dimethoxymethane

: 87-91-2
diethyl (2R,3R)-tartrate

: 21154-13-2, 60077-28-3, 70561-17-0
trans-(4R,5R)-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester

Conditions

Conditions	Yield
With 3 A molecular sieve; Amberlyst 15 ion-exchange resin In ethyl acetate for 24h; Heating;	100%
With boron trifluoride diethyl etherate In Isopropyl acetate	100%

: 109-87-5
Dimethoxymethane

: 939-05-9
3-hydroxy-5-phenylisoxazole

: 2-Methoxymethyl-5-phenyl-isoxazol-3-one

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane at 20℃; for 2h;	100%

: 109-87-5
Dimethoxymethane

: 190841-64-6
3,3'-Dimethyl-biphenyl-2,2'-dithiol

: 4,8-Dimethyl-5,7-dithia-dibenzo[a,c]cycloheptene

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane for 12h; Ambient temperature;	100%

: 109-87-5
Dimethoxymethane

: (1RS,2RS,3SR,4RS,5RS)-1-[(benzyloxy)methyl]-2-endo,4-endo-dibromo-8-oxabicyclo[3.2.1]oct-6-en-3-endo-ol

: (1RS,2SR,3SR,4SR,5RS)-1-[(benzyloxy)methyl]-2-endo,4-endo-dibromo-3-(methoxymethoxy)-8-oxabicyclo[3.2.1]oct-6-ene

Conditions

Conditions	Yield
With phosphorus pentoxide at 20℃; for 0.166667h;	100%
With phosphorus pentoxide In dichloromethane at 20℃;	89%

: 109-87-5
Dimethoxymethane

: 13811-71-7
diethyl (2S,3S)-tartrate

: 159593-22-3
diethyl (2S,3S)-2,3-di-O-methoxymethyl-tartrate

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane	100%
With phosphorus pentoxide In dichloromethane for 3h;	100%
With phosphorus pentoxide In chloroform for 2h; Alkylation;	84%
With phosphorus pentoxide In dichloromethane
With phosphorus pentoxide In dichloromethane at 0℃; for 10h; Inert atmosphere;

: 109-87-5
Dimethoxymethane

: (1R,4S,5S,6S)-6-Hydroxy-4,5-bis-methoxymethoxy-6-triisopropylsilanyloxymethyl-cyclohex-2-ene-1,2-dicarboxylic acid dimethyl ester

: (3aS,4R,7S,7aS)-7-Methoxymethoxy-3a-triisopropylsilanyloxymethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxole-4,5-dicarboxylic acid dimethyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide at 0℃; Condensation; Cyclization;	100%

: 109-87-5
Dimethoxymethane

: 347377-80-4
C28H25NO8

: 347377-82-6
C29H25NO8

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate at 0 - 20℃; for 12h;	100%

: 109-87-5
Dimethoxymethane

: 122743-18-4
methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate

: (4R,5S)-5-Phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane for 1h;	100%

: 109-87-5
Dimethoxymethane

: 117406-91-4
(2R,3S)-2,3-Dihydroxy-butyric acid methyl ester

: (4S,5R)-5-Methyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane for 1h;	100%

: 109-87-5
Dimethoxymethane

: 147501-89-1
(R)-2,3-dihydroxy-2-methyl-propionic acid methyl ester

: (R)-4-Methyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane for 1h;	100%

: 109-87-5
Dimethoxymethane

: 401479-91-2
(2R,3S)-4-Benzyloxy-2,3-dihydroxy-butyric acid methyl ester

: (4R,5S)-5-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With phosphorus pentoxide In dichloromethane for 1h;	100%

: 109-87-5
Dimethoxymethane

: 435286-39-8
(-)-(2S)-5-benzenesulfonyl-1-tosyloxy-pent-3-ene-2-ol

: 527729-31-3
(+)-(2S)-5-benzenesulfonyl-2-methoxymethoxy-1-tosyloxy-pent-3-ene

Conditions

Conditions	Yield
With phosphorus pentoxide In chloroform at 20℃; for 1h;	100%

: 109-87-5
Dimethoxymethane

: 5055-10-7
(2S)-2-hydroxy-1,4-bis<(methansulfonyl)oxy>butane

: 532983-45-2
(S)-1,4-di-O-mesyl-O-(methoxymethyl)-1,2,4-butanetriol

Conditions

Conditions	Yield
With phosphorus pentoxide In chloroform at 20℃; for 0.75h;	100%

: 109-87-5
Dimethoxymethane

: 873-76-7
para-Chlorobenzyl alcohol

: 1200-16-4
1-chloro-4-[(methoxymethoxy)methyl]benzene

Conditions

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 1.2h;	100%
With zirconyl triflate at 20℃; for 0.166667h; neat (no solvent); chemoselective reaction;	100%
With 12-tungstophosphoric acid immobilized on [bmim][FeCl4] at 75 - 82℃; for 0.00555556h; Microwave irradiation;	98%

: 109-87-5
Dimethoxymethane

: 57-87-4
Ergosterol

: 95307-27-0
O-methoxymethyl-ergosterol

Conditions

Conditions	Yield
With phosphorus pentoxide	100%
With phosphorus pentoxide at 20℃; for 1h;	89%

: 109-87-5
Dimethoxymethane

: 200353-88-4
ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate

: 663905-19-9
bis(3-ethoxycarbonyl-4,7-dihydro-4,7-ethano-2H-isoindol-1-yl)methane

Conditions

Conditions	Yield
With sulfuric acid In dichloromethane; acetic acid at 20℃; for 1h;	100%

: 655237-87-9
1-(3-bromo-4-hydroxyphenyl)-acetone

: 109-87-5
Dimethoxymethane

: 873804-36-5
1-[3-bromo-4-(methoxymethoxy)phenyl]acetone

Conditions

Conditions	Yield
With phosphorus pentoxide In toluene at -5 - 5℃; for 17h; Product distribution / selectivity;	100%

: 109-87-5
Dimethoxymethane

: 480-66-0
2,4,6-trihydroxyacetophenone

: 65490-09-7
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

Conditions

Conditions	Yield
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide In dichloromethane at 20 - 30℃; for 3.5h; Stage #2: 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 10℃;	100%
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide at 20℃; for 2h; Inert atmosphere; Stage #2: 2,4,6-trihydroxyacetophenone With diisopropylamine In dichloromethane for 3h; Inert atmosphere; Cooling with ice; regioselective reaction;	50%
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide In dichloromethane at 20℃; for 3.5h; Stage #2: 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃;

: 109-87-5
Dimethoxymethane

: 1258391-68-2
(2,6-dibromo-3,5-dihydroxyphenyl)(3,5-dichloro-2-hydroxy-6-methoxy-4-methylphenyl)methanone

: 1258391-78-4
(2,6-dibromo-3,5-bis(methoxymethoxy)phenyl)(3,5-dichloro-2-hydroxy-6-methoxy-4-methylphenyl)methanone

Conditions

Conditions	Yield
With phosphorus pentoxide at 20℃; for 3h;	100%

Dimethoxymethane Standards and Recommendations

OSHA PEL: TWA 1000 ppm
ACGIH TLV: TWA 1000 ppm
DFG MAK: 1000 ppm (3200 mg/m³)
DOT Classification: 3; Label: Flammable Liquid

Dimethoxymethane Analytical Methods

For occupational chemical analysis use NIOSH: Methylal, 1611.

Dimethoxymethane Specification

The Dimethoxymethane , with cas registry number of 109-87-5, is a clear colorless flammable liquid with a chloroform-like odor and a pungent taste. Its IUPAC name and systematic name are called the same which is dimethoxymethane . The superlist names about this chemical include Dimethoxymethane ; Methane, dimethoxy- ; Methylal ; Methylal [UN1234] [Flammable liquid] ; UN1234 . This compound is soluble in three parts water and miscible with most common organic solvents. It is sensitive to moisture. May form explosive peroxides upon exposure to air. It is incompatible with strong oxidizing agents, strong acids. It should be stored at temp. 2-8°C.

Physical properties about Dimethoxymethane are:
(1) # of Rule of 5 Violations: 0 ; (2) ACD/BCF (pH 5.5): 1 ; (3) ACD/BCF (pH 7.4): 1 ; (4) ACD/KOC (pH 5.5): 17.09 ; (5) ACD/KOC (pH 7.4): 17.09 ; (6) #H bond acceptors: 2 ; (7) #H bond donors: 0 ; (8) #Freely Rotating Bonds: 2 ; (9) Polar Surface Area: 18.46 Å² ; (10) Index of Refraction: 1.348 ; (11) Molar Refractivity: 19.43 cm³ ; (12) Molar Volume: 90.7 cm³ ; (13) Surface Tension: 19.5 dyne/cm ; (14) Density: 0.838 g/cm³ ; (15) Enthalpy of Vaporization: 27.72 kJ/mol ; (16) Boiling Point: 45.2 °C at 760 mmHg ; (17) Vapour Pressure: 365 mmHg at 25°C ; (18) Refractive index: n20/D 1.354.

Preparation of Dimethoxymethane:
there are two simple ways. One is it is prepared by oxidation of methanol . The other way is by the reaction of formaldehyde with methanol.

Uses information of Dimethoxymethane:
This chemical mainly used in organic synthesis. Here is an example, it can be used to prepared 1,3-dithia-5-cycloheptene with but-2c-ene-1,4-dithiol .

This reaction just needs a reagent boron trifluoride . The yield is about 37%.

Safety information of Dimethoxymethane:
When you are using this chemical, please be cautious about it as the following:
Moderately toxic by subcutaneous route. Mildly toxic by ingestion and inhalation. Can cause injury to lungs, liver, kidneys, and the heart. A narcotic and anesthetic in high concentrations. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderately explosive when exposed to heat or flame. May ignite or explode when heated with oxygen. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

You can still convert the following datas into molecular structure:
(1) SMILES:COCOC;
(2) InChI:InChI=1/C3H8O2/c1-4-3-5-2/h3H2,1-2H3;
(3) InChIKey:NKDDWNXOKDWJAK-UHFFFAOYAE

The toxicity data of Dimethoxymethane is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	57gm/m³/7H (57000mg/m³)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 259, 1986.
rabbit	LD	skin	> 16mL/kg (16mL/kg)	SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	National Technical Information Service. Vol. OTS0536049,
rabbit	LD50	oral	5708mg/kg (5708mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 29, Pg. 730, 1932.
rat	LC50	inhalation	15000ppm (15000ppm)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 73, 1974.
rat	LDLo	intraperitoneal	5gm/kg (5000mg/kg)		National Technical Information Service. Vol. OTS0524346,

Product Name

Dimethoxymethane

Synthetic route

Dimethoxymethane Standards and Recommendations

Dimethoxymethane Analytical Methods

Dimethoxymethane Specification

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