Diphenyl Phosphite supplier

Name
Diphenyl Phosphite
EINECS 225-202-8
CAS No. 4712-55-4
Article Data29
CAS DataBase
Density 1.223 g/mL at 25 °C(lit.)
Solubility
Melting Point 12 °C(lit.)
Formula C₁₂H₁₁O₃P
Boiling Point 348.233 °C at 760 mmHg
Molecular Weight 234.191
Flash Point 178.834 °C
Transport Information
Appearance clear liquid
Safety 26-39
Risk Codes 22-37/38-41
Molecular Structure
Hazard Symbols Xn
Synonyms Diphenoxyphosphine oxide;Diphenyl hydrogenphosphite;Doverphos 213;NSC43786;
PSA 59.00000
LogP 3.53410

Synthetic route

: 101-02-0
triphenyl phosphite

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; water at 25℃; Sealed tube;	91%
With phosphonic acid
With water

: 108-95-2
phenol

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With trichlorophosphate In toluene at 70℃; for 1.8h; Temperature;	71.3%
With tetraethylammonium iodide; water In acetonitrile at 50℃; electrosynthesis;	20%
With tetraethyldiamidophosphite
With phosphorus trichloride
With trichlorophosphate In toluene at 50℃; for 1.7h;

: 108-95-2
phenol

A: 2310-89-6
phenyl hydrogen phosphonate

B: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With hypophosphorous acid In toluene for 72h; Reflux; Dean-Stark; Inert atmosphere;	A n/a B 63%
With P4O6 In benzene for 1h; Title compound not separated from byproducts;
With P4O6 In benzene for 1h;

: 5382-00-3
Diphenyl phosphorochloridite

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With pyridine; diethyl ether; water
Multi-step reaction with 2 steps 1: pyridine 2: hydrogen chloride / 0 °C View Scheme

: 14862-35-2
phosphoric acid diphenyl ester-propyl ester

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With hydrogenchloride at 0℃;

: 101-02-0
triphenyl phosphite

: 598-02-7
Diethyl phosphate

A: 2510-86-3
O,O-diethyl O-phenyl phosphate

B: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
In nitromethane at 30℃;

...Expand

: 101-02-0
triphenyl phosphite

: 598-02-7
Diethyl phosphate

A: 4712-55-4
diphenyl hydrogen phosphite

B: (Phosphorigsaeure-diphenylester)-(Phosphorsaeure-diethylester)anhydrid

Conditions

Conditions	Yield
In nitromethane at 30℃; for 8h; Mechanism; Heating; other reactants, other products, other solvents, other temperatures;

...Expand

: 101-02-0
triphenyl phosphite

A: 4712-55-4
diphenyl hydrogen phosphite

B: 108-95-2
phenol

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 25℃; Rate constant; effect of micelles (sodium lauryl sulfate, dodecylhydrogensulfuric acid, n-tetradecansulfonic acid, p-decyloxybenzenesulfonic acid, cetyltrimethylammonium chloride) and electrolytes;

: 108-95-2
phenol

A: 4712-55-4
diphenyl hydrogen phosphite

B: 54921-72-1
phenyl H-phosphonate ammonium salt

Conditions

Conditions	Yield
With P4O6; ammonia 1.) benzene, 1 h; 2.) benzene; Multistep reaction;

: 180906-75-6
C11H15O4P

: 108-95-2
phenol

: 4712-55-4
diphenyl hydrogen phosphite

: 101-02-0
triphenyl phosphite

A: 2310-89-6
phenyl hydrogen phosphonate

B: 115-86-6
phosphoric acid triphenyl ester

C: 4712-55-4
diphenyl hydrogen phosphite

D phosphorous acid: phosphorous acid

Conditions

Conditions	Yield
With oxygen for 2880h; other time;

...Expand

: 7647-01-0
hydrogenchloride

: 14862-35-2
phosphoric acid diphenyl ester-propyl ester

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
at 0℃;

: 54921-72-1
phenyl H-phosphonate ammonium salt

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / pyridine / acetonitrile View Scheme

N-diisopropylcarbodiimide: N-diisopropylcarbodiimide

: 17176-77-1
Dibenzyl phosphite

: 108-95-2
phenol

A: 4712-55-4
diphenyl hydrogen phosphite

B: 3724-14-9
2-hydroxybenzenesulfonamide

Conditions

Conditions	Yield
In pyridine

...Expand

: 2310-89-6
phenyl hydrogen phosphonate

: 108-95-2
phenol

: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
Stage #1: phenyl hydrogen phosphonate With phosphorus pentoxide In 1,4-dioxane at 50℃; for 3h; Inert atmosphere; Stage #2: phenol In 1,4-dioxane at 50℃; for 0.333333h; Solvent; Temperature; Inert atmosphere;	61.4 %Spectr.

: 101-02-0
triphenyl phosphite

A: 2310-89-6
phenyl hydrogen phosphonate

B: 4712-55-4
diphenyl hydrogen phosphite

Conditions

Conditions	Yield
With [Pt(H2O)2(1,1'-bis(diphenylphosphanyl)octamethylferrocene)](trifluoromethylsulfonate)2; water In tetrahydrofuran at 20℃; for 8h; Catalytic behavior; Mechanism; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Sealed tube;

: 4712-55-4
diphenyl hydrogen phosphite

: 100-52-7
benzaldehyde

: 62-53-3
aniline

: 3360-68-7
diphenyl α-(phenylamino)benzylphosphonate

Conditions

Conditions	Yield
With mesoporous silica-sulfonic acid produced from sugarcane bagasse ash In dichloromethane at 20℃; for 0.333333h; Solvent; Concentration; Reagent/catalyst; Kabachnik-Fields Reaction; Green chemistry;	100%
With ytterbium(III) chloride In acetonitrile at 20℃; for 24h;	98%
With zinc(II) L-prolinate complex In dichloromethane at 20℃; for 0.333333h; Catalytic behavior; Solvent; Kabachnik-Fields Reaction;	98%

...Expand

: 111-87-5
octanol

: 4712-55-4
diphenyl hydrogen phosphite

: 121-44-8
triethylamine

: triethylammonium octyl hydrogen phosphonate

Conditions

Conditions	Yield
In pyridine at 20℃; for 0.5h;	100%

...Expand

: (2,3-dihydroxy-4-methoxy-phenyl)-(1,2,3-trimethoxy-8,9-dihydro-7H-benzocyclohepten-5-yl)-methanone

: 4712-55-4
diphenyl hydrogen phosphite

: C50H50O13P2

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In tetrachloromethane; acetonitrile at -20℃;	100%

: 4712-55-4
diphenyl hydrogen phosphite

: 555-16-8
4-nitrobenzaldehdye

: 62-53-3
aniline

: 3360-69-8
diphenyl 1-phenylamino-1-(4-nitrophenyl)methanephosphonate

Conditions

Conditions	Yield
With C2O4(2-)2Ce(3+)2C5H9NO2*(x)H2O In toluene at 20℃; for 0.166667h; Kabachnik-Fields Reaction;	99%
With zinc(II) L-prolinate complex In dichloromethane at 20℃; for 0.75h; Kabachnik-Fields Reaction;	95%
at 20℃; for 0.0833333h; Kabachnik-Fields Reaction; Ionic liquid;	69%
(i) EtOH, (ii) /BRN= 2051909/; Multistep reaction;

...Expand

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 4712-55-4
diphenyl hydrogen phosphite

: diphenyl 1-benzyl-2,5-dioxopyrrolidin-3-ylphosphonate

Conditions

Conditions	Yield
With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In toluene at 20℃; for 0.0833333h;	99%

: 12146-37-1, 124717-04-0
(bicyclo[2.2.1]hepta-2,5-diene)tetracarbonylmolybdenum(0)

: 500561-67-1
dichloro(2,4,6-tribromophenoxy)(1,2-diphenoxy)phosphorane

: 4712-55-4
diphenyl hydrogen phosphite

: 500561-81-9
cis-tetracarbonylbis(diphenylchlorophosphite)molybdenum(0)

Conditions

Conditions	Yield
In benzene under N2; phosphite (1 equiv.) added to benzene soln. of phosphorane; reacted for 24 h; solid Mo complex (0.5 equiv.) added; 1 h; monitored by (31)P NMR spectra;	99%

...Expand

: 1155765-86-8
N-[(4-methylphenyl)methylidene]-(6-methyl-2-pyridinesulfonamide)

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-39-1
(S)-diphenyl [(6-methyl-2-pyridinesulfonyl)amino-(4-methylphenyl)methyl]phosphonate

Conditions

Conditions	Yield
With dihydroquinine In toluene at -78℃; for 1h; optical yield given as %ee;	99%

: 1155765-88-0
N-[(4-methoxyphenyl)methylidene]-(6-methyl-2-pyridinesulfonamide)

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-39-1
(S)-diphenyl [(6-methyl-2-pyridinesulfonyl)amino-(4-methylphenyl)methyl]phosphonate

Conditions

Conditions	Yield
With dihydroquinine In toluene at -78℃; for 1h; optical yield given as %ee;	99%

: 1155765-95-9
N-(1-naphthylmethylidene)-(6-methyl-2-pyridinesulfonamide)

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-67-5
(R)-diphenyl [(6-methyl-2-pyridinesulfonyl)amino-(1-naphthyl)methyl]phosphonate

Conditions

Conditions	Yield
With hydroquinidine In toluene at -78℃; for 1h; optical yield given as %ee;	99%

: 1155765-96-0
N-(2-naphthylmethylidene)-(6-methyl-2-pyridinesulfonamide)

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-69-7
(R)-diphenyl [(6-methyl-2-pyridinesulfonyl)amino-(2-naphthyl)methyl]phosphonate

Conditions

Conditions	Yield
With hydroquinidine In toluene at -78℃; for 1h; optical yield given as %ee;	99%

: 1155765-35-7
N-benzylidene-(6-methyl-2-pyridine)sulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-37-9
(S)-diphenyl (6-methyl-2-pyridylsulfonylamino)phenylmethylphosphonate

Conditions

Conditions	Yield
With dihydroquinine In toluene at -78℃; for 1h; optical yield given as %ee;	99%

: 1155765-35-7
N-benzylidene-(6-methyl-2-pyridine)sulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1155765-82-4
(R)-diphenyl (6-methyl-2-pyridylsulfonylamino)phenylmethylphosphonate

Conditions

Conditions	Yield
With hydroquinidine In toluene at -40℃; for 1h; optical yield given as %ee;	99%

: 5153-67-3
nitrostyrene

: 4712-55-4
diphenyl hydrogen phosphite

: (2-nitro-1-phenyl-ethyl)-phosphonic acid diphenyl ester

Conditions

Conditions	Yield
With 3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione In dichloromethane at 0℃; Michael condensation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 3156-51-2, 51870-94-1
3-[(E)-2-nitroeth-1-enyl]-1H-indole

: 4712-55-4
diphenyl hydrogen phosphite

: 1211565-18-2
(R)-diphenyl 1-(1H-indol-3-yl)-2-nitroethylphosphonate

Conditions

Conditions	Yield
With 3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione In dichloromethane at 0℃; for 0.25h; Michael condensation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1485-00-3, 22568-48-5
5-((E)-2-nitroethenyl)-1,3-benzodioxole

: 4712-55-4
diphenyl hydrogen phosphite

: (1-benzo[1,3]dioxol-5-yl-2-nitro-ethyl)-phosphonic acid diphenyl ester

Conditions

Conditions	Yield
With 3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione In dichloromethane at 0℃; Michael condensation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 4712-55-4
diphenyl hydrogen phosphite

: 21461-46-1, 37629-37-1
(E)-2-(2-nitrovinyl)naphthalene

: 1211565-17-1
(R)-diphenyl 1-(2-naphthyl)-2-nitroethylphosphonate

Conditions

Conditions	Yield
With 3-((1R,2R)-2-(piperidin-1-yl)cyclohexylamino)-4-(4-(trifluoromethyl)phenylamino)cyclobut-3-ene-1,2-dione In dichloromethane at 0℃; Michael condensation; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-82-6
N-{1-(4-methoxyphenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-78-3
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(p-methoxyphenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 140h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-80-4
N-{1-(4-chlorophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-79-4
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(p-chlorophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 51h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-80-4
N-{1-(4-chlorophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-95-4
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(p-chlorophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; hydroquinidine In toluene at -20℃; for 51h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1202246-66-9
N-{1-(4-bromophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-96-5
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(p-bromophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; hydroquinidine In toluene at -20℃; for 86h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1202246-67-0
N-{1-(4-fluorophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-81-8
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(p-fluorophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 72h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1202246-69-2
N-{1-(3-chlorophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-82-9
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(m-chlorophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 67h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1202246-69-2
N-{1-(3-chlorophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-98-7
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(m-chlorophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; hydroquinidine In toluene at -20℃; for 67h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 1202246-70-5
N-{1-(3-bromophenyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-83-0
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(m-bromophenyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 85h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-83-7
N-{1-(2-naphthyl)ethylidene}-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-85-2
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-(2-naphthyl)ethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 84h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-79-1
N-(1-phenylethylidene)-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-58-9
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-phenylethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; dihydroquinine In toluene at -20℃; for 60h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 327175-79-1
N-(1-phenylethylidene)-2,4,6-trimethylphenylsulfonamide

: 4712-55-4
diphenyl hydrogen phosphite

: 1202246-63-6
diphenyl 1-(2,4,6-trimethylphenylsulfonylamino)-1-phenylethylphosphonate

Conditions

Conditions	Yield
With sodium carbonate; hydroquinidine In toluene at -20℃; for 60h; Pudovik reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 119-65-3
isoquinoline

: 4712-55-4
diphenyl hydrogen phosphite

: 28479-22-3
2-chloro-4-isocyanato-1-methylbenzene

: 1229062-04-7
diphenyl {2-{[(3-chloro-4-methylphenyl)amino]carbonyl}-1,2-dihydroisoquinolin-1-yl}phosphonate

Conditions

Conditions	Yield
at 20℃; for 0.0666667h;	99%

...Expand

: N-(2-furylmethylidene)-2-methylaniline

: 4712-55-4
diphenyl hydrogen phosphite

: 1378426-62-0
diphenyl (2-furyl)(2-methylphenylamino)methylphosphonate

Conditions

Conditions	Yield
With trifluoroacetic acid In acetonitrile at 20 - 80℃; for 72h;	99%

: 13060-72-5
furfurylidene-p-toluidine

: 4712-55-4
diphenyl hydrogen phosphite

: 1378426-66-4
diphenyl (2-furyl)(4-methylphenylamino)methylphosphonate

Conditions

Conditions	Yield
With trifluoroacetic acid In acetonitrile at 20 - 80℃; for 72h;	99%

Diphenyl Phosphite Specification

This chemical is called Phosphonic acid, diphenyl ester, and it can also be named as Diphenyl phosphonate. With the molecular formula of C₁₂H₁₁O₃P, its molecular weight is 234.19. The CAS registry number of this chemical is 4712-55-4. Additionally, its product categories are Organic Building Blocks; Organic Phosphates/Phosphites; Phosphorus Compounds.

Other characteristics of the Phosphonic acid, diphenyl ester can be summarised as followings: (1)ACD/LogP: 0.91; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 28; (6)ACD/BCF (pH 7.4): 28; (7)ACD/KOC (pH 5.5): 373; (8)ACD/KOC (pH 7.4): 373; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 59 Å²; (13)Flash Point: 178.834 °C; (14)Enthalpy of Vaporization: 56.918 kJ/mol; (15)Boiling Point: 348.233 °C at 760 mmHg; (16)Vapour Pressure: 0 mmHg at 25°C.

Production method of this chemical: The Phosphonic acid, diphenyl ester could be obtained by the reactant of phenol. This reaction needs the reagent of (Et₂N)₂P(O)H.

Uses of this chemical: The phenyl H-phosphonate ammonium salt could be obtained by the reactant of Phosphonic acid, diphenyl ester. This reaction needs the reagent of pyridine, aq. NH₃, and the solvent of H₂O. The yield is 89 %.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to respiratory system and skin. It's harmful if swallowed. It has risk of serious damage to the eyes.Wear eye / face protection if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.InChI:InChI=1/C12H11O3P/c13-16(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h1-10,16H
2.Smiles: P(Oc1ccccc1)(=O)Oc1ccccc1

Product Name

Diphenyl Phosphite

Synthetic route

Diphenyl Phosphite Specification

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