Product Name

  • Name

    MALONIC ACID DISODIUM SALT

  • EINECS 205-514-0
  • CAS No. 141-95-7
  • Article Data4
  • CAS DataBase
  • Density 2.08 g/cm3
  • Solubility 1 M at 20 °C, clear, colorless in water
  • Melting Point
  • Formula C3H2Na2O4
  • Boiling Point 386.8 °C at 760 mmHg
  • Molecular Weight 148.026
  • Flash Point 201.9 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 22-24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 141-95-7 (MALONIC ACID DISODIUM SALT)
  • Hazard Symbols
  • Synonyms Malonicacid, disodium salt (8CI);Propanedioic acid, disodium salt (9CI);Disodiummalonate;Sodium malonate;
  • PSA 80.26000
  • LogP -3.12370

Synthetic route

malonic acid
141-82-2

malonic acid

sodium hydroxide
1310-73-2

sodium hydroxide

sodium malonate
141-95-7

sodium malonate

Conditions
ConditionsYield
In water neutralization reaction with stoich. amt. at pH 6-7;
sodium α-sodium acetate

sodium α-sodium acetate

carbon dioxide
124-38-9

carbon dioxide

sodium malonate
141-95-7

sodium malonate

Na2[Cu(malonate)2(H2O)2]

Na2[Cu(malonate)2(H2O)2]

thiosemicarbazide
79-19-6

thiosemicarbazide

A

C2H10CuN6S2(2+)*C3H2O4(2-)

C2H10CuN6S2(2+)*C3H2O4(2-)

B

sodium malonate
141-95-7

sodium malonate

Conditions
ConditionsYield
In water
...Expand
sodium malonate
141-95-7

sodium malonate

benzoyl chloride
98-88-4

benzoyl chloride

A

benzoic acid anhydride
93-97-0

benzoic acid anhydride

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With Pyridine 1-oxide hydrochloride In dichloromethane; water at 18℃; Rate constant;A 13%
B 87%
...Expand
1,4-pyrazine
290-37-9

1,4-pyrazine

cadmium(II) nitrate tetrhydrate

cadmium(II) nitrate tetrhydrate

sodium malonate
141-95-7

sodium malonate

[Cd(μ-malonato)(μ-pyrazine)0.5(H2O)](n)

[Cd(μ-malonato)(μ-pyrazine)0.5(H2O)](n)

Conditions
ConditionsYield
With tetramethylammonium chloride In water a soln. of Cd salt reated with a soln. of sodium malonate, stirred for 10 min, an aq. mixt. of pyrazine and tetramethylammonium chloride added slowly; filtered, crystd. for 1 wk in an open atmosphere, sepd., washed (H2O), dried; elem. anal.;85%
...Expand
(η5-cyclopentadienyl)(dicarbonyl){(2R,5S,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-ethoxy-5,6-dihydro-2H-pyran-5-yl}molybdenum

(η5-cyclopentadienyl)(dicarbonyl){(2R,5S,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-ethoxy-5,6-dihydro-2H-pyran-5-yl}molybdenum

sodium malonate
141-95-7

sodium malonate

(η5-cyclopentadienyl)(dicarbonyl){(2R,3R,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-(1,3-dioxo-1,3-dimethoxy-2-propyl)-5,6-dihydro-2H-pyran-5-yl}molybdenum

(η5-cyclopentadienyl)(dicarbonyl){(2R,3R,6S)-(3,4,5-η)-2-(acetoxymethyl)-6-(1,3-dioxo-1,3-dimethoxy-2-propyl)-5,6-dihydro-2H-pyran-5-yl}molybdenum

Conditions
ConditionsYield
In tetrahydrofuran under Ar; addn. of freshly prepared sodium malonate in THF to suspn. of Mo-complex in THF (molar ratio 3:1, stirred, 0°C), stirred (15 min, 0°C), quenched (satd. NH4Cl soln.); extn. (CH2Cl2, three times), drying (over Na2SO4), filtration, concn., flash chromy. (1:1 degassed hexanes/ethyl acetate), recrystn. (degassed hexanes/CH2Cl2); elem. anal.;82%
trans-bis(acetonitrile)palladium(II) chloride
21264-30-2, 14592-56-4, 90243-59-7

trans-bis(acetonitrile)palladium(II) chloride

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

sodium cis-dichloromalonatopalladate(II) dihydrate

sodium cis-dichloromalonatopalladate(II) dihydrate

Conditions
ConditionsYield
at 20℃;82%
...Expand
1,2-bis(4'-pyridyl)ethane
4916-57-8

1,2-bis(4'-pyridyl)ethane

sodium malonate
141-95-7

sodium malonate

Cu(NO3)2.3H2O

Cu(NO3)2.3H2O

polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2

polymer, [{Cu3(malonate)2{1,2-bis(4-pyridyl)ethane}3(H2O)2}(NO3)2(H2O)2]n, 3D open framework, organic-inorganic hybrid; monomer(s): disodium malonate; 1,2-bis(4-pyridyl)ethane; Cu(NO3)2

Conditions
ConditionsYield
Stage #1: sodium malonate; Cu(NO3)2.3H2O In methanol; water for 0.5h;
Stage #2: 1,2-bis(4'-pyridyl)ethane In methanol; water for 4h; Heating; Further stages.;		80%
...Expand
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

[Mn(II)2(malonate)(1,10-phenanthroline)3(H2O)2Cl]Cl

[Mn(II)2(malonate)(1,10-phenanthroline)3(H2O)2Cl]Cl

Conditions
ConditionsYield
In methanol; water aq. soln. of malonate was added dropwise to MeOH soln. of Mn salt with stirring for 30 min, to this mixt. MeOH soln. of phenanthroline was addedslowly and stirred for 2 h, then refluxed for 6 h; mixt. was cooled, filtered, filtrate was kept in CaCl2-desiccator for several days, ppt. was filtered off, washed and dried; elem. anal.;80%
...Expand
4,4'-bipyridine
553-26-4

4,4'-bipyridine

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

sodium malonate
141-95-7

sodium malonate

[Mn2(malonate)2(H2O)2(4,4'-bipyridine)]n

[Mn2(malonate)2(H2O)2(4,4'-bipyridine)]n

Conditions
ConditionsYield
In methanol; water soln. MnCl2*4H2O in MeOH was allowed to react with aq. soln. disodium malonate for 20 min, MeOH soln. 4,4'-bipy was added and stirred for 2 h; soln. was filtered and evapd. slowly, crystals were filtered off, washedwith 2-propanol and dried; elem. anal.;80%
...Expand
1,2-bis(4'-pyridyl)ethane
4916-57-8

1,2-bis(4'-pyridyl)ethane

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

sodium malonate
141-95-7

sodium malonate

[(Cu3(malonate)2(1,2-bis(4-pyridyl)ethane)3(H2O)2)(NO3)2(H2O)2]n

[(Cu3(malonate)2(1,2-bis(4-pyridyl)ethane)3(H2O)2)(NO3)2(H2O)2]n

Conditions
ConditionsYield
In methanol; water aq. soln. of malonate added dropwise to soln. of Cu salt in MeOH, stirring for 30 min, soln. of bipyridylethane in MeOH added slowly, heated under reflux for 4 h; cooled, filtered, filtrate kept in CaCl2 desiccator, after week ppt. wascollected, washed with isopropanol, dried; elem. anal.;80%
...Expand
{UO2(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(NO3)2}

{UO2(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(NO3)2}

sodium malonate
141-95-7

sodium malonate

{UO2(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(O2CCH2CO2)}

{UO2(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(O2CCH2CO2)}

Conditions
ConditionsYield
In acetone dissolving (UO2(C17H14N2O2)2(NO3)2) (1 mmol) in acetone; mixing with 50% aq. acetone soln. of sodium malonate (1 mmol); refluxing for 3 h; concg., cooling;; pptn.; collecting, washing repeatedly with hot 50% aq. acetone; drying in vac. over P2O5; elem. anal.;;76%
tributyltin chloride
1461-22-9

tributyltin chloride

sodium malonate
141-95-7

sodium malonate

(n-Bu)3SnO2CCH2CO2Sn(Bu-n)3

(n-Bu)3SnO2CCH2CO2Sn(Bu-n)3

Conditions
ConditionsYield
In ethanol under N2 atm. disodium dicarboxylate was added to EtOH soln. (n-Bu)3SnCland stirred for 15 h at 40°C; soln. was filtered and evapd., residue was recrystd. from EtOH; elem. anal.;75.5%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

diaqua(2,2'-bipyridine)malonatomanganese(II)

diaqua(2,2'-bipyridine)malonatomanganese(II)

Conditions
ConditionsYield
In methanol; water aq. soln. of malonate was added dropwise to MeOH soln. of Mn salt with stirring for 30 min, to this mixt. MeOH soln. of bipyridine was added, mixt. was refluxed for 2 h; mixt. was cooled, filtered, filtrate was kept in CaCl2-desiccator for several days; elem. anal.;75%
...Expand
manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

sodium malonate
141-95-7

sodium malonate

manganese(II) malonate dihydrate

manganese(II) malonate dihydrate

Conditions
ConditionsYield
In methanol; water soln. MnCl2*4H2O in MeOH was allowed to react with aq. soln. disodium malonate at reflux temp. for 24 h; soln. was cooled, filtered, and evapd. slowly, crystals were filtered off, washed with 2-propanol and dried; elem. anal.;75%
methanol
67-56-1

methanol

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

water
7732-18-5

water

trans-1,2-bis(pyridin-4-yl)ethene
13362-78-2

trans-1,2-bis(pyridin-4-yl)ethene

sodium malonate
141-95-7

sodium malonate

[Mn2(malonate)2(trans-1,2-bis(4-pyridyl)ethylene)(H2O)2]*0.5(trans-1,2-bis(4-pyridyl)ethylene)*0.5CH3OH

[Mn2(malonate)2(trans-1,2-bis(4-pyridyl)ethylene)(H2O)2]*0.5(trans-1,2-bis(4-pyridyl)ethylene)*0.5CH3OH

Conditions
ConditionsYield
In methanol; water aq. soln. of disodium malonate (1 mmol) added dropwise to aq. soln. of MnCl2*4H2O (1 mmol) with stirring, methanolic soln. of ligand added; stirred for 1 h, filtered, crystd., elem. anal.;75%
...Expand
dichloro(diphenyl-1,6-di(2-pyridyl)-2,5-diazahexane)cobalt(III) perchlorate dihydrate

dichloro(diphenyl-1,6-di(2-pyridyl)-2,5-diazahexane)cobalt(III) perchlorate dihydrate

sodium malonate
141-95-7

sodium malonate

(diphenyl-1,6-di(2-pyridyl)-2,5-diazahexane)malonatocobalt(III) perchlorate*3H2O

(diphenyl-1,6-di(2-pyridyl)-2,5-diazahexane)malonatocobalt(III) perchlorate*3H2O

Conditions
ConditionsYield
With water In water addn. of malonate to soln. of Co compd. (stirring),; crystn. (several h), filtered off, washing (water), drying (air); elem. anal.;74%
{Th(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(NO3)4}

{Th(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(NO3)4}

sodium malonate
141-95-7

sodium malonate

{Th(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(O2CCH2CO2)2}

{Th(4-benzoyl-3-methyl-1-phenylpyrazole-5-one)2(O2CCH2CO2)2}

Conditions
ConditionsYield
In acetone dissolving (Th(C17H14N2O2)2(NO3)4) (1 mmol) in acetone; mixing with 50% aq. acetone soln. of sodium malonate (2 mmol); refluxing for 3 h; concg., cooling;; pptn.; collecting, washing repeatedly with hot 50% aq. acetone; drying in vac. over P2O5; elem. anal.;;71%
C11H15Cl2FN2O2Pt

C11H15Cl2FN2O2Pt

sodium malonate
141-95-7

sodium malonate

C14H17FN2O6Pt

C14H17FN2O6Pt

Conditions
ConditionsYield
Stage #1: C11H15Cl2FN2O2Pt With silver nitrate In water at 50 - 60℃; for 24h; Darkness;
Stage #2: sodium malonate In water at 20℃;		70.3%
tetra(thiourea)zinc chloride

tetra(thiourea)zinc chloride

sodium malonate
141-95-7

sodium malonate

[Zn(tu)2(μ-mal)]
273214-99-6, 322411-00-7

[Zn(tu)2(μ-mal)]

Conditions
ConditionsYield
In water filtration; elem. anal.;70%
copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

hexamethylenetetramine
100-97-0

hexamethylenetetramine

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

[Cu4(malonato)4(hexamethylenetetramine)]*7H2O

[Cu4(malonato)4(hexamethylenetetramine)]*7H2O

Conditions
ConditionsYield
In water aq. soln. of urotropine added dropwise to aq. soln. of Cu salt (molar ratio 1:1) with stirring for 5 min; aq. soln. of disodium malonate (1 equiv.) added dropwise; filtered; filtrate kept over CaCl2 in a desiccator for a few d; crystalscollected; elem. anal.;70%
...Expand
methylene chloride
74-87-3

methylene chloride

sodium malonate
141-95-7

sodium malonate

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

Conditions
ConditionsYield
tetrahexylammonium bromide at 125℃; for 4h;67%
tetrabutylammomium bromide at 125℃; for 5h;64%
tetrabutylammomium bromide at 100℃; for 4h;58%
cis-dichloro[(1R,2R)-N1-benzyl-1,2-diaminocyclohexane-N,N']platinum(II)

cis-dichloro[(1R,2R)-N1-benzyl-1,2-diaminocyclohexane-N,N']platinum(II)

sodium malonate
141-95-7

sodium malonate

silver nitrate

silver nitrate

[(1R,2R)-N1-benzyl-1,2-cyclohexanediamine-N,N'](malonato-O,O')platinum(II)

[(1R,2R)-N1-benzyl-1,2-cyclohexanediamine-N,N'](malonato-O,O')platinum(II)

Conditions
ConditionsYield
Stage #1: cis-dichloro[(1R,2R)-N1-benzyl-1,2-diaminocyclohexane-N,N']platinum(II); silver nitrate In water at 38℃; for 12h;
Stage #2: sodium malonate In water at 35℃; for 12h; Darkness;		67%
...Expand
C11H15Cl2FN2O2Pt

C11H15Cl2FN2O2Pt

sodium malonate
141-95-7

sodium malonate

C14H17FN2O6Pt

C14H17FN2O6Pt

Conditions
ConditionsYield
Stage #1: C11H15Cl2FN2O2Pt With silver nitrate In water at 50 - 60℃; for 24h; Darkness;
Stage #2: sodium malonate In water at 20℃;		65.4%
zinc perchlorate

zinc perchlorate

N-(pyridin-4-yl)pyridine-3-carboxamide
64479-79-4

N-(pyridin-4-yl)pyridine-3-carboxamide

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

[Zn(N-(4-pyridyl)nicotinamide)2(malonate)(H2O)2]
1161745-38-5

[Zn(N-(4-pyridyl)nicotinamide)2(malonate)(H2O)2]

Conditions
ConditionsYield
In ethanol; water ethanolic soln. of N-(4-pyridyl)nicotinamide (0.5 mmol) added to aq. soln. of Zn(ClO4)2*6H2O (0.5 mmol); stirred (60°C, 30 min); soln. ofdisodium malonate (0.5 mmol) in H2O/EtOH (1:1, v/v) added; stirred (70. degree.C, 4 h); cooled to room temp.; filtered; evapd. partially on water bath; evapd. (room temp., 3 d); elem. anal.;63.9%
...Expand
C11H15Cl2FN2O2Pt

C11H15Cl2FN2O2Pt

sodium malonate
141-95-7

sodium malonate

C14H17FN2O6Pt

C14H17FN2O6Pt

Conditions
ConditionsYield
Stage #1: C11H15Cl2FN2O2Pt With silver nitrate In water at 50 - 60℃; for 24h; Darkness;
Stage #2: sodium malonate In water at 20℃;		63.8%
C11H16Cl2N2O2Pt

C11H16Cl2N2O2Pt

sodium malonate
141-95-7

sodium malonate

C14H18N2O6Pt

C14H18N2O6Pt

Conditions
ConditionsYield
Stage #1: C11H16Cl2N2O2Pt With silver nitrate In water at 50 - 60℃; for 24h; Darkness;
Stage #2: sodium malonate In water at 20℃;		62.5%
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

N-(pyridin-4-yl)pyridine-3-carboxamide
64479-79-4

N-(pyridin-4-yl)pyridine-3-carboxamide

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

[Co(N-(4-pyridyl)nicotinamide)2(malonate)(H2O)2]
1161745-35-2

[Co(N-(4-pyridyl)nicotinamide)2(malonate)(H2O)2]

Conditions
ConditionsYield
In ethanol; water ethanolic soln. of N-(4-pyridyl)nicotinamide (0.5 mmol) added to aq. soln. of Co(NO3)2*6H2O (0.5 mmol); stirred (60°C, 30 min); soln. of disodium malonate (0.5 mmol) in H2O/EtOH (1:1, v/v) added; stirred (70°C, 4 h); cooled to room temp.; filtered; evapd. partially on water bath; evapd. (room temp., 3 d); elem. anal.;60.6%
...Expand
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

hexamethylenetetramine
100-97-0

hexamethylenetetramine

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

2 Co-malonate * hexamethylenetetramine * dihydrate

2 Co-malonate * hexamethylenetetramine * dihydrate

Conditions
ConditionsYield
In methanol; water aq. soln. of urotropine added dropwise to MeOH soln. of Co salt with stirring; aq. soln. of disodium malonate (1 equiv.) added; elem. anal.;60%
...Expand
(N,N'-dicyclopentylethylenediamine)platinum diiodide monohydrate

(N,N'-dicyclopentylethylenediamine)platinum diiodide monohydrate

sodium malonate
141-95-7

sodium malonate

(N,N'-dicyclopentylethylenediamine)platinum(II) malonate monohydrate

(N,N'-dicyclopentylethylenediamine)platinum(II) malonate monohydrate

Conditions
ConditionsYield
With AgNO3 In water byproducts: AgI; addn. of AgNO3 soln. to Pt complex suspension; stirring in the dark, 24h; filtration of AgI ppt.; addn. of sodium malonate soln.; pptn.; filtration; washing (water, ethanol, diethyl ether); drying over anhydrous CaCl2 (vac.); elem. anal.;60%
manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

hexamethylenetetramine
100-97-0

hexamethylenetetramine

water
7732-18-5

water

sodium malonate
141-95-7

sodium malonate

[bis(malonate)(hexamethylenetetramine)diaquadimanganese(II)]

[bis(malonate)(hexamethylenetetramine)diaquadimanganese(II)]

Conditions
ConditionsYield
In methanol; water byproducts: NaCl; to a soln. of Mn compd. (methanol) added dropwise an aq. soln. of amine (0.5 eqiv.), aq. malonate (1 equiv) added; elem. anal.;60%
...Expand
C42H62CoN6O5(1+)*NO3(1-)

C42H62CoN6O5(1+)*NO3(1-)

sodium malonate
141-95-7

sodium malonate

C45H64CoN5O6

C45H64CoN5O6

Conditions
ConditionsYield
In Isopropyl acetate; water; isopropyl alcohol57%
(HB(C3HN2(CH3)2)3)VOCl((CH3)2C3H2N2)*2CH3CN

(HB(C3HN2(CH3)2)3)VOCl((CH3)2C3H2N2)*2CH3CN

sodium malonate
141-95-7

sodium malonate

toluene
108-88-3

toluene

{VO((N2(CCH3)2CH)3BH)}2(HN2(CCH3)2CH)((O2C)2CH2)*2C6H5CH3

{VO((N2(CCH3)2CH)3BH)}2(HN2(CCH3)2CH)((O2C)2CH2)*2C6H5CH3

Conditions
ConditionsYield
In water; acetonitrile byproducts: sodium chloride; N2 atmosphere; dissolution of V-compd. in MeCN, addn. of soln. of org. compd. in H2O, stirring (ambient temp., 32 min); evapn. (vac.), crystn. (CH2Cl2), recrystn. (CH2Cl2/toluene 1:1 v:v); elem. anal.;55%
...Expand

Disodium malonate Chemical Properties

IUPAC Name: Disodium propanedioate (141-95-7)
Synonyms: Malonicacid,sodiumsalt ; Sodiumpropanedioate ; Sodium malonate ; Sodium malonite ; Propanedioic acid disodium salt ; Methanedicarboxylic acid disodium salt ; Malonic acid disodium salt ; Disodium malonate
Molecular Structure:  
Molecular Formula : C3H2Na2O4
Molecular Weight:  148.03
CAS :  141-95-7
EINECS:  205-514-0
Flash Point: 201.9 °C 
Enthalpy of Vaporization: 69.8 kJ/mol 
Boiling Point: 386.8 °C at 760 mmHg 
Vapour Pressure: 4.66E-07 mmHg at 25°C 
solubility  H2O: 1 M at 20 °C, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: Sodium malonate (141-95-7) is white crystalline powder
Solution:Soluble in water, insoluble in alcohol, ether and benzene.

Disodium malonate Uses

Sodium malonate (141-95-7) is used for raw material of pharmaceutical, dye and fragrance ; organic synthesis.

Disodium malonate Production

Derive by mixing malonic acid with sodium hydroxide solution; Industrial production often add chloroacetic acid with sodium cyanide to get cyanuric acid, and then through the role of liquid caustic soda sodium malonate. The chloroacetic acid dissolved in water at 15 ℃ below with saturated sodium carbonate solution  to pH7.0, and then adding sodium cyanide solution at 45 ℃, at 105-110 ℃ reaction to 30min, adding 45-55% sodium hydroxide,  reaction at the 100-105 ℃ 1.5h, concentrated solution of sodium malonic too dry to obtain Sodium malonate (141-95-7).

Disodium malonate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1550mg/kg (1550mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
mouse LD50 intravenous 2100mg/kg (2100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit LD50 intravenous 660mg/kg (660mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 461, 1949.
rabbit LDLo subcutaneous 1584mg/kg (1584mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

ENDOCRINE: HYPERGLYCEMIA		 Journal of Biological Chemistry. Vol. 161, Pg. 55, 1945.
rat LD50 intraperitoneal 1100mg/kg (1100mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965.

Disodium malonate Safety Profile

Safety Statements:  22-24/25
22: Sodium malonate (141-95-7) is harmful if swallowed
24/25:  Toxic in contact with skin and if swallowed
WGK Germany:  3
RTECS:  OO1750000

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