Product Name

  • Name

    Enrofloxacin

  • EINECS 618-911-2
  • CAS No. 93106-60-6
  • Article Data17
  • CAS DataBase
  • Density 1.385 g/cm3
  • Solubility Soluble in chloroform. Slightly soluble in water. Also soluble in dilute KOH
  • Melting Point 225 °C
  • Formula C19H22FN3O3
  • Boiling Point 560.5 °C at 760 mmHg
  • Molecular Weight 359.4
  • Flash Point 292.8 °C
  • Transport Information
  • Appearance Pale yellow crystals
  • Safety 26-36/37
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 93106-60-6 (Enrofloxacin)
  • Hazard Symbols IrritantXi
  • Synonyms 1-Cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid;Alsir;BAY-Vp 2674;Baytril;Biofloxavet;CFPQ;Enrocin;Enrofan;Enrogil;Enroxil;N-Ethylciprofloxacin;N'-Ethylciprofloxacin;3-Quinolinecarboxylicacid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-;
  • PSA 65.78000
  • LogP 2.31850

Synthetic route

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
86393-33-1

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.316667h; Solvent; Temperature; Reagent/catalyst; Reflux;97%
at 150℃; for 0.416667h; Microwave irradiation;93%
With aluminum tri-bromide In ethanol at 75℃; for 4h; Reagent/catalyst; Solvent; Temperature;92%
1-cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt

1-cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
With aluminum (III) chloride In i-Amyl alcohol at 140℃; for 8h; Temperature;91.8%
ditrimethylsilyl N-cyclopropyl-3-(4-ethyl-1-piperazinyl)anilinomethylenemalonate
131776-44-8

ditrimethylsilyl N-cyclopropyl-3-(4-ethyl-1-piperazinyl)anilinomethylenemalonate

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
90%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
86393-33-1

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

A

7-chloro-1-cyclopropyl-6-(4-ethyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-chloro-1-cyclopropyl-6-(4-ethyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

B

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
In water for 13h; Heating;A n/a
B 89%
ethyl bromide
74-96-4

ethyl bromide

ciprofloxacin hydrochloride
93107-08-5

ciprofloxacin hydrochloride

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium iodide In water; acetonitrile at 20℃; for 12h;70%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

ethyl 2,4,5-trifluorobenzoylacetate
98349-24-7

ethyl 2,4,5-trifluorobenzoylacetate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

Cyclopropylamine
765-30-0

Cyclopropylamine

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Yield given. Multistep reaction;
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate
86483-51-4

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic anhydride / 2 h / Heating
2: 92 percent / ethanol / 1 h / Ambient temperature
3: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
4: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
5: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester
86483-53-6

3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
2: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
3: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate
86483-54-7

ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
2: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C.
2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
3: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating
4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
Multi-step reaction with 7 steps
1: Mg/ethanol, CCl4 / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature
2: p-toluenesulfonic acid / H2O / 5 h / Heating
3: acetic anhydride / 2 h / Heating
4: 92 percent / ethanol / 1 h / Ambient temperature
5: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
6: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
7: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tributyl-amine / 1 h / 70 °C
1.2: 15 °C / 1520.1 Torr
2.1: cesium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 125 - 130 °C
2.2: 8 h / 85 °C
View Scheme
3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-methylester
105392-26-5

3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-methylester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
2: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating
3: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester
104599-90-8

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating
2: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
diethyl 2,4-dichloro-5-fluoro-benzoyl-malonate
86483-50-3

diethyl 2,4-dichloro-5-fluoro-benzoyl-malonate

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: p-toluenesulfonic acid / H2O / 5 h / Heating
2: acetic anhydride / 2 h / Heating
3: 92 percent / ethanol / 1 h / Ambient temperature
4: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
5: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
6: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
3-(Cyclopropylamino)acrylsaeure-methylester
72396-25-9

3-(Cyclopropylamino)acrylsaeure-methylester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C.
2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
3: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating
4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester
86483-52-5

2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / ethanol / 1 h / Ambient temperature
2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating
4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C
View Scheme
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester
86483-53-6

3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
Stage #1: 3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester With cesium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 125 - 130℃;
Stage #2: 4-ethylpiperazine With aluminum (III) chloride In ethanol at 85℃; for 8h; Solvent; Reagent/catalyst; Temperature;
48.7 g
enrofloxacin
93106-60-6

enrofloxacin

1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-quinolinoyl chloride
474022-78-1

1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-quinolinoyl chloride

Conditions
ConditionsYield
With thionyl chloride for 10h; Heating;95.1%
With thionyl chloride at 75℃; for 10h;
With thionyl chloride at 70℃;
C6H16Cl4Cu2N8O2

C6H16Cl4Cu2N8O2

enrofloxacin
93106-60-6

enrofloxacin

C22H29CuFN7O4(1+)*Cl(1-)

C22H29CuFN7O4(1+)*Cl(1-)

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 2h;88%
enrofloxacin
93106-60-6

enrofloxacin

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

1-cyclopropyl-6-fluoro-7-(4-ethylpiperazin-1-yl)-3-(1H-imidazole-1-formyl)-quinoline-4(1H)-one

1-cyclopropyl-6-fluoro-7-(4-ethylpiperazin-1-yl)-3-(1H-imidazole-1-formyl)-quinoline-4(1H)-one

Conditions
ConditionsYield
In acetonitrile Solvent; Reflux;86.4%
enrofloxacin
93106-60-6

enrofloxacin

C38H50CaF2N6O10

C38H50CaF2N6O10

Conditions
ConditionsYield
With water; calcium hydroxide In methanol at 40℃; for 8h; Temperature; Solvent;85%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

[Ni(enx)2(1,10-phenantroline)]

[Ni(enx)2(1,10-phenantroline)]

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 2h; pH=7;85%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

[Co(enx)2(1,10-phenantroline)]

[Co(enx)2(1,10-phenantroline)]

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 2h; pH=7;82%
8-quinolinol
148-24-3

8-quinolinol

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

[Ni(enx)2(1,10-phenantroline)(Q)]

[Ni(enx)2(1,10-phenantroline)(Q)]

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 2h; pH=7; Reflux;80%
8-quinolinol
148-24-3

8-quinolinol

cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

C28H27CoFN4O4*H2O

C28H27CoFN4O4*H2O

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 1h; pH=7; Reflux;80%
8-quinolinol
148-24-3

8-quinolinol

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

C28H27FN4NiO4*H2O

C28H27FN4NiO4*H2O

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 1h; pH=7; Reflux;78%
vanadium(V) oxychloride
7727-18-6

vanadium(V) oxychloride

enrofloxacin
93106-60-6

enrofloxacin

o-toluidine
95-53-4

o-toluidine

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]4-(4-amino-3-methylphenyl)-2-methylanilineoxo vanadium chloride monohydrate

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]4-(4-amino-3-methylphenyl)-2-methylanilineoxo vanadium chloride monohydrate

Conditions
ConditionsYield
Stage #1: vanadium(V) oxychloride; enrofloxacin With sodium hydroxide In ethanol at 20℃; for 1h;
Stage #2: o-toluidine In ethanol at 20℃; for 72h;
77%
zinc(II) perchlorate

zinc(II) perchlorate

enrofloxacin
93106-60-6

enrofloxacin

C57H63F3N9O9Zn(1-)

C57H63F3N9O9Zn(1-)

Conditions
ConditionsYield
With ammonium hydroxide In methanol; water for 0.166667h;77%
1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

enrofloxacin
93106-60-6

enrofloxacin

3-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one
1381763-39-8

3-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 20℃;76%
enrofloxacin
93106-60-6

enrofloxacin

isopropylamine
75-31-0

isopropylamine

1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-1,4-dihydro-4-oxo-N-(propan-2-yl)quinoline-3-carboxamide

1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-1,4-dihydro-4-oxo-N-(propan-2-yl)quinoline-3-carboxamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃;76%
vanadium(V) oxychloride
7727-18-6

vanadium(V) oxychloride

enrofloxacin
93106-60-6

enrofloxacin

triethylamine
121-44-8

triethylamine

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]N,N-diethylethanamineoxo vanadium chloride hexahydrate

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]N,N-diethylethanamineoxo vanadium chloride hexahydrate

Conditions
ConditionsYield
Stage #1: vanadium(V) oxychloride; enrofloxacin With sodium hydroxide In ethanol at 20℃; for 1h;
Stage #2: triethylamine In ethanol at 20℃; for 72h;
76%
bis(acetylacetonato)dioxidomolybdenum(VI)

bis(acetylacetonato)dioxidomolybdenum(VI)

enrofloxacin
93106-60-6

enrofloxacin

MoO2(1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate)2

MoO2(1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate)2

Conditions
ConditionsYield
With potassium hydroxide In methanol a MeOH soln. of 2 equiv. of F-compd. deprotonated with 2 equiv. of KOH was added to the Mo-compd. soln. in MeOH, reflux for 2.5 h; soln. was filtered and left to slowly evaporate for a few days, crystalswere filtered off, washed with MeOH and dried, elem. anal.;75%
manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

enrofloxacin
93106-60-6

enrofloxacin

Mn(1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato)2(H2O)2
1030834-09-3

Mn(1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato)2(H2O)2

Conditions
ConditionsYield
With potassium hydroxide In methanol a soln. of ligand deprotonated with KOH, added to a soln. of Mn salt, refluxed for 2 h; filtered, crystd. for days, filtered, washed (MeOH), dried; elem. anal.;75%
zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

(4S)-4-isopropyl-N-[(4R)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-N-(4-vinylbenzyl)-4,5-dihydro-1,3-oxazol-2-amine

(4S)-4-isopropyl-N-[(4R)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]-N-(4-vinylbenzyl)-4,5-dihydro-1,3-oxazol-2-amine

water
7732-18-5

water

enrofloxacin
93106-60-6

enrofloxacin

C40H50FN6O5Zn(1+)*NO3(1-)

C40H50FN6O5Zn(1+)*NO3(1-)

Conditions
ConditionsYield
With sodium hydroxide In acetonitrile75%
C20H28Cl4Cu2N8O2

C20H28Cl4Cu2N8O2

enrofloxacin
93106-60-6

enrofloxacin

C29H35CuFN7O4(1+)*Cl(1-)

C29H35CuFN7O4(1+)*Cl(1-)

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 2h;74.1%
vanadium(V) oxychloride
7727-18-6

vanadium(V) oxychloride

enrofloxacin
93106-60-6

enrofloxacin

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]N,N-dimethylformamideoxo vanadium chloride pentahydrate

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]N,N-dimethylformamideoxo vanadium chloride pentahydrate

Conditions
ConditionsYield
Stage #1: vanadium(V) oxychloride; enrofloxacin With sodium hydroxide In ethanol at 20℃; for 1h;
Stage #2: N,N-dimethyl-formamide In ethanol at 20℃; for 72h;
74%
pyridine
110-86-1

pyridine

vanadium(V) oxychloride
7727-18-6

vanadium(V) oxychloride

enrofloxacin
93106-60-6

enrofloxacin

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]pyridineoxo vanadium chloride tetrahydrate

bis[1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato]pyridineoxo vanadium chloride tetrahydrate

Conditions
ConditionsYield
Stage #1: vanadium(V) oxychloride; enrofloxacin With sodium hydroxide In ethanol at 20℃; for 1h;
Stage #2: pyridine In ethanol at 20℃; for 72h;
73%
boron trifluoride diethyl etherate
109-63-7

boron trifluoride diethyl etherate

enrofloxacin
93106-60-6

enrofloxacin

difluoroboron complexes of enrofloxacin

difluoroboron complexes of enrofloxacin

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide for 24h; Reflux;71%
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

enrofloxacin
93106-60-6

enrofloxacin

Co(1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato)2(H2O)2
1030834-12-8

Co(1-cyclopropyl-7-(4-ethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylato)2(H2O)2

Conditions
ConditionsYield
With potassium hydroxide In methanol a soln. of ligand deprotonated with KOH, added to a soln. of Co salt, refluxed; filtered, crystd., filtered, washed (MeOH), dried; elem. anal.;70%
pyridine
110-86-1

pyridine

methanol
67-56-1

methanol

water
7732-18-5

water

enrofloxacin
93106-60-6

enrofloxacin

zinc(II) chloride
7646-85-7

zinc(II) chloride

bis(enrofloxacinato)bis(pyridine)zinc(II) hexahydrate monomethanolate

bis(enrofloxacinato)bis(pyridine)zinc(II) hexahydrate monomethanolate

Conditions
ConditionsYield
With KOH In methanol KOH added to MeOH soln. of enrofloxacin; added to MeOH soln. of ZnCl2; pyridine added; crystd. by slow evapn. after 10 d; elem. anal.;70%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

enrofloxacin
93106-60-6

enrofloxacin

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn(erx)(bipy)Cl]
1426910-55-5

[Zn(erx)(bipy)Cl]

Conditions
ConditionsYield
Stage #1: enrofloxacin With potassium hydroxide In methanol at 20℃; for 0.333333h;
Stage #2: [2,2]bipyridinyl; zinc(II) chloride In methanol
70%
methanol
67-56-1

methanol

1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

enrofloxacin
93106-60-6

enrofloxacin

[Mn(enrofloxacinato)2(1,10-phenanthroline)]*1.5MeOH*H2O

[Mn(enrofloxacinato)2(1,10-phenanthroline)]*1.5MeOH*H2O

Conditions
ConditionsYield
Stage #1: methanol; enrofloxacin With potassium hydroxide for 0.5h;
Stage #2: methanol; 1,10-Phenanthroline; manganese(II) chloride tetrahydrate for 1h;
70%

Enrofloxacin Chemical Properties


IUPAC Name: 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid
Molecular Weight: 359.394683 [g/mol]
Molecular Formula: C19H22FN3O3
XLogP3: -0.2
H-Bond Donor: 1
H-Bond Acceptor: 7 
Index of Refraction: 1.634
Molar Refractivity: 92.8 cm3
Molar Volume: 259.3 cm3
Surface Tension: 62 dyne/cm
Density: 1.385 g/cm3
Flash Point: 292.8 °C
Enthalpy of Vaporization: 88.7 kJ/mol
Boiling Point: 560.5 °C at 760 mmHg
Vapour Pressure: 2.13E-13 mmHg at 25 °C
Water Solubility: 3400 mg/L at 25 °C
Appearance: Pale Yellow Crystals
Melting Point: 225 °C
Classification Code of Enrofloxacin (CAS NO.93106-60-6): Antibacterial [veterinary]; Antineoplastic agents; Drug / Therapeutic Agent; Mutation data
Product Categories: Antibiotics for Research and Experimental Use; Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries

Enrofloxacin Uses

 Enrofloxacin (CAS NO.93106-60-6) is widely used in the treatment of human disease. It is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration dependent, with susceptible bacteria cell death occurring within 20-30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication.

Enrofloxacin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 200mg/kg (200mg/kg)   VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
mouse LD50 oral 4336mg/kg (4336mg/kg)   VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
rabbit LD50 oral 500mg/kg (500mg/kg)   VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
rat LD50 oral 5gm/kg (5000mg/kg)   VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.

Enrofloxacin Safety Profile

 Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS of Enrofloxacin (CAS NO.93106-60-6): VB1993650

Enrofloxacin Specification

 Enrofloxacin (CAS NO.93106-60-6), its Synonyms are 1,4-Dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid ; 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ; BAY VP 2674 ; Enrofloxacine ; Enrofloxacino ; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo- ; 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- .

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