Estrone supplier | CasNO.53-16-7

Name
1,3,5(10)-Estratrien-3-ol-17-one
EINECS 200-164-5
CAS No. 53-16-7
Article Data173
CAS DataBase
Density 1.164 g/cm³
Solubility water: 0.03 g/L
Melting Point 258-261 ºC
Formula C₁₈H₂₂O₂
Boiling Point 445.2 ºC at 760 mmHg
Molecular Weight 270.371
Flash Point 189.7 ºC
Transport Information
Appearance crystalline solid
Safety 53-45
Risk Codes 45-60-61
Molecular Structure
Hazard Symbols T
Synonyms delta-1,3,5-estratrien-3-beta-ol-17-one;Hormestrin;Oestrin;delta-1,3,5-oestratrien-3-beta-ol-17-one;Estrona [Spanish];CMC_13458;Ovifollin;Wynestron;component of Mal-O-Fem;Cristallovar;Menagen;Estrusol;hydroxyestrones;Ketohydroxyoestrin;.delta.-1,3, 5-Oestratrien-3.beta.-ol-17-one;Folipex;3-Hydroxy-17-keto-estra-1,3,5-triene;Disynformon;3-Hydroxy-oestra-1,3, 5(10)-trien-17-one;Estrone-A;Destrone;Ovex (tablets);Estrol;Follicunodis;
PSA 37.30000
LogP 3.81740

Synthetic route

: 50-28-2
estradiol

: 53-16-7
Estrone

Conditions

Conditions	Yield
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In tert-butyl alcohol at 130℃; for 20h;	100%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In tert-butyl alcohol for 20h; Reflux;	100%
With polystyrene-supported(cathecholato) oxoRe cat. act by iPrOH; dimethyl sulfoxide In toluene for 4h; Heating; Dean-Stark apparatus;	98%

: 493001-46-0
R-estradiol

: 75-65-0
tert-butyl alcohol

: 53-16-7
Estrone

Conditions

Conditions	Yield
	100%

: 901-93-9
estrone acetate

: 53-16-7
Estrone

Conditions

Conditions	Yield
With methanol; zinc	98%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 27℃; for 72h;	94%
With lipase from Candida cylindracea; octanol In various solvent(s) at 37℃; for 144h;	90%
With sodium hydroxide In methanol; water for 0.25h;

: 92803-51-5
17-oxo-1,3,5(10)-estratrien-3-yl 2-(trimethylsilyl)ethyl butanedioate

: 53-16-7
Estrone

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 27℃; for 24h;	97%

: 5189-96-8
10β-hydroxy-19-norandrost-4-ene-3,17-dione

: 53-16-7
Estrone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In diethyl ether Ambient temperature;	96%
With toluene-4-sulfonic acid In diethyl ether Ambient temperature; Yield given;
With acetic acid In chloroform-d1

: 1422954-71-9
C23H34O3Si

: 53-16-7
Estrone

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 2h;	95%

: 1624-62-0
estrone 3-methyl ether

: 53-16-7
Estrone

Conditions

Conditions	Yield
With aluminium trichloride; sodium iodide In dichloromethane; acetonitrile for 5.5h; Heating;	93%
Stage #1: estrone 3-methyl ether With aluminum (III) chloride; sodium iodide In dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: With hydrogenchloride; water In dichloromethane Inert atmosphere;	92%
With boron tribromide at -30 - 0℃; for 2.5h;	88%

: 95282-98-7
19-acetoxyandrosta-1,4-diene-3,17-dione

: 53-16-7
Estrone

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; for 0.05h;	90%
With sodium hydroxide In methanol at 20℃; for 2h;	76%
With potassium hydroxide In methanol at 20℃; for 2h;	50.1%

(polystyrene resin Novabiochem)-C6H4(C6H5)2CNHSO2O-3-estrone: (polystyrene resin Novabiochem)-C6H4(C6H5)2CNHSO2O-3-estrone

: 53-16-7
Estrone

Conditions

Conditions	Yield
With diethylamine In ethanol; dichloromethane at 55 - 60℃; for 8h; Hydrolysis;	90%

: 90850-47-8
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-17-one

: 53-16-7
Estrone

Conditions

Conditions	Yield
With sodium methylate In N,N-dimethyl-formamide at 20℃; for 2h; Product distribution; regeneration reactions of the parent compound from different perfluoroaryl derivatives to the alcohols; other educts and products, different times, temperatures and mol ratios of the educts;	87%

: 194094-44-5
19-tert-butyldimethylsilyloxy-androsta-1,4-diene-3,17-dione

: 53-16-7
Estrone

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 2h;	85.9%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h;

: 84882-46-2
4β,5-epoxy-5β-androstane-3,17,19-trione

A: 53-16-7
Estrone

B: 84882-49-5
4β,5-dihydroxy-5α-androstane-3,17,19-trione 4,19-hemiacetal

Conditions

Conditions	Yield
With perchloric acid In tetrahydrofuran; water for 72h;	A 3% B 82%

: (8R,9S,13S,14S)-13-Methyl-3-[1-(2-trimethylsilanyl-ethoxy)-ethoxy]-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one

: 53-16-7
Estrone

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 45℃; for 20h;	82%

: 50-28-2
estradiol

: 107-21-1
ethylene glycol

A: 53-16-7
Estrone

B: 900-83-4
(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

Conditions

Conditions	Yield
With dimethyl sulfoxide; [ReOCl3(PPh3)2] In toluene for 5h; Heating;	A 18% B 82%

...Expand

: 858-98-0
3-benzyloxyestra-1,3,5(10)-trien-17-one

: 53-16-7
Estrone

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran; methanol at 40℃; for 12h;	81%
With palladium on activated charcoal; hydrogen In methanol at 40℃; for 12h;	81%

: 124522-65-2
2α-acetoxy-19-oxoandrost-4-ene-3,17-dione

: 53-16-7
Estrone

Conditions

Conditions	Yield
With potassium hydrogencarbonate In methanol; water for 2h; Ambient temperature; further reagents;	80%

: 76251-10-0
3,17-dioxo-4β,5-epoxy-5β-androstan-19-oic acid

A: 53-16-7
Estrone

B: 76251-11-1, 76251-12-2
(8R,9S,13S,14S)-3-Hydroxy-13-methyl-2,3,6,7,8,9,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-4,17-dione

Conditions

Conditions	Yield
In decalin for 2.5h; Heating;	A 9% B 79%

: 843-81-2
3β-Hydroxy-19-norandrosta-1(10),5-dien-17-one

: 53-16-7
Estrone

Conditions

Conditions	Yield
With 1-Methyl-4-piperidone; aluminum isopropoxide In toluene for 4h; Heating;	77%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 53-16-7
Estrone

Conditions

Conditions	Yield
With iodine; triethylphosphine In toluene at 120℃; for 10h; Concentration; Solvent; Reagent/catalyst; Temperature;	72%
With mineral oil at 530℃; in ein mit Glasperlen beschicktes Rohr;
at 325℃; unter vermindertem Druck;
at 325℃;

: 60788-62-7
2,4-dibromo-3-hydroxy-13β-estra-1,3,5(10)-trien-17-one

A: 53-16-7
Estrone

B: 1630-82-6
4-bromo-3-hydroxyestra-1,3,5(10)-trien-17-one

Conditions

Conditions	Yield
With formic acid; palladium on activated charcoal In N,N-dimethyl-formamide for 1.75h; Heating;	A 20% B 70%
With formic acid; palladium on activated charcoal In N,N-dimethyl-formamide for 1.75h; Heating; variation in time and temperature;	A 20% B 70%
With hydrogen; palladium on activated charcoal In ethanol Ambient temperature; Yield given;

: 58534-72-8
estrone-3′-hemisuccinate

: 53-16-7
Estrone

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 27℃; for 32h;	66%

: (3aS,3bR,9bS,11aS)‐11a‐methyl‐7‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH‐cyclopenta[a]phenanthren‐1‐one

: 53-16-7
Estrone

Conditions

Conditions	Yield
With [Rh2(bpy)2(μ-OAc)2(OAc)2]; oxygen; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide under 760.051 Torr; for 24h; Irradiation;	63%

: 76920-48-4
17-oxo-estra-1,3,5(10)-trien-3-yl Se-phenyl selenocarbonate

A: 53-16-7
Estrone

B: estrone formate

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In xylene at 144℃;	A 62% B 18%

: 145164-84-7
estradiol

: 53-16-7
Estrone

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; aluminum isopropoxide; benzaldehyde In 2-methyltetrahydrofuran at 20℃; for 4h; Oppenauer Oxidation; Inert atmosphere;	58%

: C20H26O3

A: 53-16-7
Estrone

B: 1225-03-2
3-Hydroxy-9β-estra-1,3,5(10)-trien-17-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20 - 25℃; for 0.5h; Inert atmosphere;	A 56% B 32%

: 843-81-2
3β-Hydroxy-19-norandrosta-1(10),5-dien-17-one

A: 53-16-7
Estrone

B: 116202-05-2
17-Oxo-19-norandrost-1(10),5-dien-3β-yl trifluoroacetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; dimethyl sulfoxide at -78℃;	A 53% B 20%

: 843-81-2
3β-Hydroxy-19-norandrosta-1(10),5-dien-17-one

: 407-25-0
trifluoroacetic anhydride

A: 53-16-7
Estrone

B: 116202-05-2
17-Oxo-19-norandrost-1(10),5-dien-3β-yl trifluoroacetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; dimethyl sulfoxide at -78℃;	A 53% B 20%

...Expand

: C18H24O3

A: 53-16-7
Estrone

B: 5189-96-8
10β-hydroxy-19-norandrost-4-ene-3,17-dione

Conditions

Conditions	Yield
With acetic acid for 1.33333h; Heating;	A 18% B 50%

: 84882-46-2
4β,5-epoxy-5β-androstane-3,17,19-trione

A: 53-16-7
Estrone

B: A-nor-5β-androstane-3,17,19-trione

C: 84882-49-5
4β,5-dihydroxy-5α-androstane-3,17,19-trione 4,19-hemiacetal

D: 4-hydroxyandrost-4-ene-3,17,19-trione

Conditions

Conditions	Yield
With perchloric acid In tetrahydrofuran for 24h;	A 8% B 7% C 17% D 49%
With perchloric acid In tetrahydrofuran for 24h; Product distribution; reaction in the presence of H2SO4; acid- and base-catalysed reactions of 4β,5β- and 4α,5α-epoxyandrostane-3,17,19-triones;	A 8% B 7% C 17% D 49%

...Expand

: 53-16-7
Estrone

: 5982-51-4
3-hydroxy-estra-1,3,5(10)-trien-17-one oxime

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In ethanol; water for 6h; Reflux; Inert atmosphere;	100%
With pyridine; hydroxylamine hydrochloride In ethanol for 6h; Reflux;	100%
With hydroxylamine hydrochloride In pyridine; ethanol	99%

: 53-16-7
Estrone

: 7628-02-6
17β-hydrazoestra-1,3,5(10)-trien-3-ol

Conditions

Conditions	Yield
With triethylamine; hydrazine In ethanol; water	100%
With triethylamine; hydrazine In ethanol for 3h; Reflux;	96%
With hydrazine hydrate In ethanol at 45℃; for 2h;	95%
With hydrazine
With hydrazine In butan-1-ol; diethylene glycol for 1h; Reflux;

: 53-16-7
Estrone

: 3282-30-2
pivaloyl chloride

: 4003-22-9
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl pivalate

Conditions

Conditions	Yield
With triethylamine In chloroform	100%
With dmap; triethylamine In dichloromethane at 0℃; for 0.3h; Inert atmosphere;	96%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Sealed tube;	87%

: 110-87-2
3,4-dihydro-2H-pyran

: 53-16-7
Estrone

: 7103-48-2
3-tetrahydropyranyloxy-1,3,5(10)-estratrien-17-one

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; for 18h;	100%
With pyridinium p-toluenesulfonate In dichloromethane at 21℃; for 20h;	100%
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; for 18h;	100%

: 358-23-6
trifluoromethylsulfonic anhydride

: 53-16-7
Estrone

: 92817-04-4
estrone triflate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With pyridine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0℃; for 1h;	99%

: 53-16-7
Estrone

: 107-21-1
ethylene glycol

: 900-83-4
(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%
With trimethyl orthoformate In toluene; acetonitrile at 20℃;	99%
With toluene-4-sulfonic acid In benzene for 13h; Heating;	94%

: 53-16-7
Estrone

: 124-63-0
methanesulfonyl chloride

: 3381-23-5
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl methanesulfonate

Conditions

Conditions	Yield
With pyridine Ambient temperature;	100%
In dichloromethane Heating;	92%
With triethylamine In dichloromethane for 3h;	91%
With triethylamine In dichloromethane 0 deg C to r.t., 24 h;	88%
With pyridine at 0 - 25℃;

: 53-16-7
Estrone

: 21286-54-4, 39262-22-1
D-camphor-10-sulfonyl chloride

: estrone-3-((+)-10-camphor)sulfonate

Conditions

Conditions	Yield
With pyridine Ambient temperature;	100%

: 53-16-7
Estrone

: 645-88-5
aminooxyacetic acid

: 16218-61-4
2-({(E)-[(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-ylidene]amino}oxy)acetic acid

Conditions

Conditions	Yield
With pyridine at 20℃; for 17h;	100%

: 13154-24-0
triisopropylsilyl chloride

: 53-16-7
Estrone

: (8R,9S,13S,14S)-13-Methyl-3-triisopropylsilanyloxy-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide Inert atmosphere;	100%

: 53-16-7
Estrone

: 106-93-4
ethylene dibromide

: 191155-58-5
3-(2’-bromoethoxy)estra-1,3,5(10)-trien-17-one

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water Reflux;	100%
With sodium hydroxide In tetrahydrofuran; water Reflux;	84%

: 53-16-7
Estrone

: 98-88-4
benzoyl chloride

: 2393-53-5
estrone 3-benzoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20 - 30℃;	100%
With pyridine at 25℃;	95%
With pyridine for 2h; Inert atmosphere;	94%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 53-16-7
Estrone

: methyl 4-((((8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)methyl)benzoate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 48h; Schlenk technique; Inert atmosphere; Reflux;	100%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 48h; Schlenk technique; Inert atmosphere; Reflux;	100%

Br(CH2)2OCH3: Br(CH2)2OCH3

: 53-16-7
Estrone

: 243638-26-8
3-(2'-Methoxyethoxy)-1,3,5(10)-estratrien-17-one

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile	99.4%

: 421-83-0
trifluoromethane sulfonyl chloride

: 53-16-7
Estrone

: 92817-04-4
estrone triflate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.25h; Inert atmosphere;	99%
With triethylamine	91%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	82%

: 53-16-7
Estrone

: 56588-58-0
16,16-di-deuterium-estra-1,3,5(10)-triene-17-one

Conditions

Conditions	Yield
With [D]-sodium hydroxide In deuteromethanol; water-d2 for 24h; Reflux; Inert atmosphere;	99%
With deuteriated sodium hydroxide In deuteromethanol; water-d2 at 60℃; for 24h;
With deuteromethanol; sodium methylate

: 53-16-7
Estrone

: 540-63-6
ethane-1,2-dithiol

: 14485-61-1
C20H26OS2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	99%
With toluene-4-sulfonic acid In toluene Reflux;

: 53-16-7
Estrone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 57711-40-7
3-(O-tert-butyl(dimethyl)silyl)estrone

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1h;	99%
With 1H-imidazole	99%
With 1H-imidazole In DMF (N,N-dimethyl-formamide) at 20℃;	98%

: 53-16-7
Estrone

: 74-88-4
methyl iodide

: 1624-62-0
estrone 3-methyl ether

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In dichloromethane at 70℃; for 3h;	99%
With potassium carbonate In N,N-dimethyl-formamide Heating;	98%
With potassium carbonate In N,N-dimethyl-formamide 1) reflux, 2 h, 2) r.t., 5 d;	97%

: 53-16-7
Estrone

: 100-39-0
benzyl bromide

: 858-98-0
3-benzyloxyestra-1,3,5(10)-trien-17-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 24h; Heating;	99%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 24h; Heating;	99%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water for 24h; Heating / reflux;	99%

: 53-16-7
Estrone

: 2921-14-4, 7776-18-3, 20295-82-3
(aminooxy)acetic acid hemihydrochloride

: 16218-61-4
2-({(E)-[(8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-ylidene]amino}oxy)acetic acid

Conditions

Conditions	Yield
With pyridine at 23℃; for 16h;	99%

: 108-22-5
Isopropenyl acetate

: 53-16-7
Estrone

: 901-93-9
estrone acetate

Conditions

Conditions	Yield
With iron(III) trifluoromethanesulfonate at 20℃; for 5h; Schlenk technique;	99%
With iodine at 85 - 90℃; for 0.0833333h;	96%
With iodine at 90℃;

: 288-32-4
1H-imidazole

: 53-16-7
Estrone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 3-tert-butyldimethylsilyloxy-estra-1,3,5(10)-triene-17-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	99%
In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide	94%

...Expand

: 288-32-4
1H-imidazole

: 53-16-7
Estrone

: 18162-48-6
tert-butyldimethylsilyl chloride

A: 3-tert-butyldimethylsilyloxy-estra-1,3,5(10)-triene-17-one

B [17(20)E]-Carbethoxymethylideneestra-1,3,5(10)-trieno-[3,2,e]-1',2',3'-oxathiazine-2,2'-dioxide: [17(20)E]-Carbethoxymethylideneestra-1,3,5(10)-trieno-[3,2,e]-1',2',3'-oxathiazine-2,2'-dioxide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	A 99% B n/a

...Expand

: 53-16-7
Estrone

: 1021878-04-5
C18H19(2)H3O2

Conditions

Conditions	Yield
With hydrogen; water-d2; palladium on activated charcoal at 20℃; for 72h;	99%

: 53-16-7
Estrone

: 56310-18-0
di-tert-butylchlorosilane

: 1315577-32-2
C26H40O3Si

Conditions

Conditions	Yield
Stage #1: Estrone; di-tert-butylchlorosilane With 1H-imidazole In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With N-Bromosuccinimide In dichloromethane Stage #3: With water; sodium hydroxide In dichloromethane; N,N-dimethyl-formamide at 20℃;	99%

: 53-16-7
Estrone

: 616-38-6
carbonic acid dimethyl ester

: 1624-62-0
estrone 3-methyl ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 16h;	99%

Estrone Chemical Properties

Molecular Structure of Estrone (CAS NO.53-16-7):

Molecular Formula: C₁₈H₂₂O₂
Molecular Weight: 270.3661
IUPAC Name: (8R,9S,13S,14S)-3-Hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
CAS NO: 53-16-7
EINECS: 200-164-5
Classification Code: Drug / Therapeutic Agent ; Estrogen ; Estrogens ; Hormone ; Hormones ; Hormones, Hormone Substitutes, and Hormone Antagonists ; Human Data ; Mutation data ; Natural Product ; Reproductive Effect ; Tumor data
Melting point: 258-260 °C
Index of Refraction: 1.587
Molar Refractivity: 78.04 cm³
Molar Volume: 232.1 cm³
Surface Tension: 46 dyne/cm
Density: 1.164 g/cm³
Flash Point: 189.7 °C
Enthalpy of Vaporization: 73.02 kJ/mol
Boiling Point: 445.2 °C at 760 mmHg
Vapour Pressure: 1.54E-08 mmHg at 25 °C
alpha :158 °(c=1, dioxane)
refractive index: 165 °(C=1, Dioxane)
Water Solubility: 0.03 g/L
Product Categories: Steroids; Various Metabolites and Impurities; 17-Ketosteroids; Biochemistry; Hydroxyketosteroids; Metabolites & Impurities

Estrone Uses

Estrone (CAS NO.53-16-7) is mainly used as a metabolite of 17-Estradiol.

Estrone Consensus Reports

NTP 10th Report on Carcinogens. Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 , 1974,p. 123.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: )IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 343.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

Estrone Safety Profile

Hazard Codes of Estrone (CAS NO.53-16-7): Toxic T
Risk Statements: 45-60-61
R45: May cause cancer.
R60: May impair fertility.
R61: May cause harm to the unborn child.
Safety Statements: 53-45
S53: Avoid exposure - obtain special instructions before use.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: KG8575000
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A poison by intraperitoneal and subcutaneous routes. Human reproductive effects by implantation: spermatogenesis and impotence. Mutation data reported. A steroid drug for the treatment of menopause and ovariectomy symptoms. When heated to decomposition it emits acrid smoke and irritating fumes.

Estrone Specification

Synonyms of Estrone (CAS NO.53-16-7) are1,3,5(10)-Estratrien-3-ol-17-one ; 1,3,5(10)-Oestratrien-3-ol-17-one ; 3-08-00-01171 (Beilstein Handbook Reference) ; 3-Hydroxy-17-keto-estra-1,3,5-triene ; 3-Hydroxy-17-keto-oestra-1,3,5-triene ; 3-Hydroxy-oestra-1,3,5(10)-trien-17-one ; 3-Hydroxyestra-1,3,5(10)-trien-17-one ; 3-Hydroxyestra-1,3,5(10)-triene-17-one ; Aquacrine ; Crinovaryl ; Cristallovar ; Crystogen ; Destrone ; Disynformon ; E(sub 1) ; Endofolliculina ; Estra-1,3,5(10)-trien-17-one, 3-hydroxy- ; Estrogenic substance ; Estron ; Estrona ; Estrone-A ; Estronum ; Estrovarin ; Estrugenone ; Estrusol ; Fem-O-Gen ; Femestrone injection ; Femidyn ; Folikrin ; Folipex ; Folisan ; Follestrine ; Follestrol ; Follicular hormone ; Folliculin ; Folliculine ; Folliculine benzoate ; Follicunodis ; Glandubolin ; Hiestrone ; Hormestrin ; Hormofollin ; Hormovarine ; Kestrone ; Ketodestrin ; Ketohydroxy-estratriene ; Ketohydroxyestrin ; Ketohydroxyoestrin ; Kolpon ; Menagen ; Menformon ; Mestronaq ; Natural estrogenic substance-estrone ; Oestrin ; Oestroform ; Oestrone ; Oestronum ; Oestroperos ; Ovex (tablets) ; Ovifollin ; Perlatan ; Solliculin ; Theelin ; Thelestrin ; Thelykinin ; Thynestron ; Tokokin ; Unden ; Unden (pharmaceutical) ; Wynestron ; delta-1,3,5-Estratrien 3beta-ol-17-one ; delta-1,3,5-Oestratrien-3beta-ol-17-one ; delta-1,3,5-estratrien-3-beta-ol-17-one ; delta-1,3,5-oestratrien-3-beta-ol-17-one .

Product Name

1,3,5(10)-Estratrien-3-ol-17-one

Synthetic route

Estrone Chemical Properties

Estrone Uses

Estrone Consensus Reports

Estrone Safety Profile

Estrone Specification

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