Ethyl (s)-2-chloro propionate supplier

Name
Ethyl (s)-2-chloro propionate
EINECS
CAS No. 74497-15-7
Article Data9
CAS DataBase
Density 1.081 g/cm³
Solubility
Melting Point
Formula C₅H₉ClO₂
Boiling Point 149 °C at 760 mmHg
Molecular Weight 136.578
Flash Point 49.5 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Propanoicacid, 2-chloro-, ethyl ester, (S)-;(-)-Ethyl 2-chloropropionate;(S)-2-Chloropropionic acid ethyl ester;Ethyl (S)-2-chloropropionate;Ethyl L-a-chloropropionate;
PSA 26.30000
LogP 1.17680

Synthetic route

: 7699-00-5
(R)-Ethyl lactate

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 3.5h; Ambient temperature;	32%
With pyridine; thionyl chloride at 60℃;
With quinoline; thionyl chloride at 60℃;

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
With pyridine; thionyl chloride

: 114983-33-4
O-chlorosulfinyl-D-lactic acid ethyl ester

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
bei der Destillation;

: 7699-00-5
(R)-Ethyl lactate

: 98-59-9
p-toluenesulfonyl chloride

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
With pyridine

: 687-47-8
(S)-Ethyl lactate

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B: 42411-39-2
(R)-ethyl 2-chloropropanoate

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 3h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With calcium fluoride; thionyl chloride In neat (no solvent) at 70 - 170℃; for 13h; Reagent/catalyst; Overall yield = 74 %;	A n/a B n/a
With calcium fluoride; thionyl chloride In neat (no solvent) at 70 - 170℃; for 17h; Overall yield = 60 %;	A n/a B n/a

: 7719-09-7
thionyl chloride

: 7699-00-5
(R)-Ethyl lactate

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
at 60℃; in Gegenwart von tertiaeren Basen;

: 110-86-1
pyridine

: 7699-00-5
(R)-Ethyl lactate

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 74497-15-7
(+)-ethyl 2-chloropropionate

...Expand

: 91-22-5
quinoline

: 7699-00-5
(R)-Ethyl lactate

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 74497-15-7
(+)-ethyl 2-chloropropionate

...Expand

: 7699-00-5
(R)-Ethyl lactate

: 121-69-7
N,N-dimethyl-aniline

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 74497-15-7
(+)-ethyl 2-chloropropionate

...Expand

D(+)-chlorosulfinyllactic acid ethyl ester: D(+)-chlorosulfinyllactic acid ethyl ester

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
unter Destillieren;
With pyridine; diethyl ether

D(+)-p-toluenesulfinyllactic acid ethyl ester: D(+)-p-toluenesulfinyllactic acid ethyl ester

: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
With chlorine

: 628-13-7
pyridine hydrochloride

d(+)-p-toluene-sulfonyl-lactic acid ethyl ester: d(+)-p-toluene-sulfonyl-lactic acid ethyl ester

: 74497-15-7
(+)-ethyl 2-chloropropionate

D(+)-p-toluenesulfinyllactic acid ethyl ester: D(+)-p-toluenesulfinyllactic acid ethyl ester

A: 687-47-8
(S)-Ethyl lactate

B: 74497-15-7
(+)-ethyl 2-chloropropionate

Conditions

Conditions	Yield
With hypochloric acid

D-ethyl lactate: D-ethyl lactate

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B: D-phosphoric acid bis-(1-ethoxycarbonyl-ethyl ester)

Conditions

Conditions	Yield
With phosphorus trichloride at -10℃;

: 7699-00-5
(R)-Ethyl lactate

PCl3 (0.33 mol): PCl3 (0.33 mol)

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B: D-phosphoric acid bis-(1-ethoxycarbonyl-ethyl ester)

Conditions

Conditions	Yield
at -10℃;

...Expand

: 110-86-1
pyridine

: 7699-00-5
(R)-Ethyl lactate

: 98-59-9
p-toluenesulfonyl chloride

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B d(+)-p-toluenesulfonyl-lactic acid ethyl ester: d(+)-p-toluenesulfonyl-lactic acid ethyl ester

Conditions

Conditions	Yield
in der Waerme;
bei laengerer Einw.;

...Expand

: 110-86-1
pyridine

: 60-29-7
diethyl ether

: 114983-33-4
O-chlorosulfinyl-D-lactic acid ethyl ester

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B N-<1-ethoxycarbonyl-ethyl>-pyridinium picrate: N-<1-ethoxycarbonyl-ethyl>-pyridinium picrate

Conditions

Conditions	Yield
Behandeln das entstehende Produkt mit Pikrinsaeure in verduenntem Aethanol;

...Expand

: 7699-00-5
(R)-Ethyl lactate

A: 74497-15-7
(+)-ethyl 2-chloropropionate

B: 42411-39-2
(R)-ethyl 2-chloropropanoate

Conditions

Conditions	Yield
With pyridine; thionyl chloride at 20℃; Inert atmosphere; enantioselective reaction;	A n/a B n/a

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 76578-79-5
6-chloro-2-(4-hydroxyphenoxy)quinoxaline

: 76578-14-8
(R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid ethyl ester

Conditions

Conditions	Yield
With tetrabutylammomium bromide; triethylamine In toluene at 60℃; for 4h; Solvent; Temperature; Reflux;	95.1%

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 29617-66-1
(S)-2-chloropropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water	85%

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 100-46-9
benzylamine

: 119817-95-7
(S)-(-)-N-Benzyl-2-chloropropionamide

Conditions

Conditions	Yield
With aluminium trichloride for 22h;	70%

: 87-65-0
2,6-Dichlorophenol

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 383898-16-6
(-)-ethyl 2-(2,6-dichlorophenoxy)propionate

Conditions

Conditions	Yield
With potassium methanolate 1.) 2-butanone, 40 deg C, 1 h, 2.) 2-butanone, reflux, 48 h; Yield given. Multistep reaction;

: 4128-31-8
rac-octan-2-ol

: 74497-15-7
(+)-ethyl 2-chloropropionate

A: 6169-06-8
(S)-2-Octanol

B: 129974-86-3
(R)-1-Methylheptyl (L)-2-chloropropanoate

Conditions

Conditions	Yield
lipase CC In hexane Product distribution; lipase P;
lipase CC In hexane lipase P;
lipase CC In hexane Product distribution;
With CC lipase In hexane at 40℃;

...Expand

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 89-78-1
menthol

A: 89-78-1, 490-99-3, 491-01-0, 491-02-1, 1490-04-6, 2216-51-5, 2216-52-6, 3623-51-6, 3623-52-7, 3623-53-8, 15356-60-2, 15356-70-4, 20747-49-3, 20752-33-4, 20752-34-5, 23283-97-8, 64282-88-8
(3S)-3-methyl-6-(1-methylethyl)cyclohexanol

B: 55284-69-0, 130060-51-4, 130060-52-5, 130060-53-6
(1R)-Menthyl (L)-2-chloropropanoate

Conditions

Conditions	Yield
lipase CC In hexane Product distribution;
lipase CC In hexane Product distribution; lipase P;
lipase CC In hexane or lipase P;

...Expand

: (S)-1-(1-phenylpropyl)-biguanide

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 640997-22-4
ethyl (R)-2-(4-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
With sodium hydroxide In water	n/a

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 123-08-0
4-hydroxy-benzaldehyde

: C12H14O4

Conditions

Conditions	Yield
With sodium hydroxide In water	n/a

: 74497-15-7
(+)-ethyl 2-chloropropionate

: 123-31-9
hydroquinone

: 71301-98-9
(R)-2-(4-hydroxyphenoxy)propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In water Product distribution / selectivity;	n/a

Ethyl (s)-2-chloro propionate Specification

The CAS registry number of Ethyl (s)-2-chloro propionate is 74497-15-7. It belongs to the product category of Chiral Compounds. This chemical is also named as (S)-2-Chloropropanoic acid ethyl ester. In addition, its molecular formula is C₅H₉ClO₂ and molecular weight is 136.58. Its systematic name is called ethyl (2S)-2-chloropropanoate.

Physical properties about Ethyl (s)-2-chloro propionate are: (1)ACD/LogP: 1.29; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 3; (6)Index of Refraction: 1.417; (7)Molar Refractivity: 31.79 cm³; (8)Molar Volume: 126.3 cm³; (9)Surface Tension: 28.4 dyne/cm; (10)Density: 1.081 g/cm³; (11)Flash Point: 49.5 °C; (12)Enthalpy of Vaporization: 38.59 kJ/mol; (13)Boiling Point: 149 °C at 760 mmHg; (14)Vapour Pressure: 4.11 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl[C@H](C(=O)OCC)C
(2)InChI: InChI=1/C5H9ClO2/c1-3-8-5(7)4(2)6/h4H,3H2,1-2H3/t4-/m0/s1
(3)InChIKey: JEAVBVKAYUCPAQ-BYPYZUCNBB

Product Name

Ethyl (s)-2-chloro propionate

Synthetic route

Ethyl (s)-2-chloro propionate Specification

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