Conditions | Yield |
---|---|
With sodium tetrahydroborate In water; dimethyl sulfoxide at 60℃; for 4.5h; High pressure; Green chemistry; | 99.9% |
With borane-ammonia complex; copper cobaltite In methanol; water at 50℃; under 1125.11 Torr; for 5h; Catalytic behavior; Reagent/catalyst; Pressure; Concentration; Sealed tube; | 98% |
With hydrogen In ethanol at 99.84℃; under 22502.3 Torr; Autoclave; | 81% |
Conditions | Yield |
---|---|
With borane-ammonia complex In methanol; water at 20℃; for 0.0833333h; | 99% |
With ammonia borane; Pd/MIL-101 In methanol; water at 20℃; for 0.025h; | 99% |
With sodium tetrahydroborate In methanol; water at 20℃; for 0.0666667h; Sealed tube; Green chemistry; | 99% |
Conditions | Yield |
---|---|
With hydrogen In ethanol at 109.84℃; under 18751.9 Torr; for 7.5h; Autoclave; Green chemistry; chemoselective reaction; | 99% |
Conditions | Yield |
---|---|
Stage #1: propiononitrile In methanol; water at 20℃; for 0.0833333h; Stage #2: With ammonia borane In methanol; water at 20℃; | 98% |
Conditions | Yield |
---|---|
With hydrogen In para-xylene; isopropyl alcohol at 25℃; under 760.051 Torr; for 2h; Catalytic behavior; Reagent/catalyst; | A 6% B 94% |
Pt-Rh catalysts Product distribution; electrochemical reduction; | |
With sulfuric acid; palladium Product distribution; electrocatalytic hydrogenation, oth. catalysts; | |
With 5% Pd/SiO2; hydrogen In isopropyl alcohol at 20℃; under 750.075 Torr; for 2h; | A 9 %Spectr. B 91 %Spectr. |
(R/S)-2-(ethylamino)-1-phenylethanol
A
2-hydroxy-1-phenylpropylamine
B
formaldehyd
C
benzaldehyde
D
ethylamine
E
acetaldehyde
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 1.9% B 67% C 75% D 79% E 10% |
N-ethyl-N-hydroxy-ethanamine
A
formaldehyd
B
N-Ethylmethylamine
C
ethylamine
D
acetaldehyde
Conditions | Yield |
---|---|
With phosphorus pentachloride In toluene at 18 - 20℃; Mechanism; Product distribution; object of study: Stieglitz rearrangement (prototype); | A n/a B 1.4% C 76% D n/a |
{(C2H5NH2)2BH2}(1+)*{SC2H5}(1-)={(C2H5NH2)2BH2}{SC2H5}
A
N,N',N''-triethylborazine
B
ethylamine
C
ethylamine borane complex
D
ethanethiol
Conditions | Yield |
---|---|
In neat (no solvent) pyrolysis;; | A 20% B n/a C 36% D 75% |
In neat (no solvent) |
2-(Diethylamino)ethanol
A
formaldehyd
B
ethylamine
C
acetaldehyde
D
diethylamine
E
2-(Ethylamino)ethanol
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 5% B 1.6% C 72% D 20% E 73% |
N,N'-diethylurea
sodium p-toluenesulfonamide
A
N-(ethylcarbamoyl)-4-methylbenzenesulfonamide
B
ethylamine
Conditions | Yield |
---|---|
at 145℃; for 5h; Product distribution; other time;; | A 71.6% B n/a |
at 145℃; for 5h; | A 71.6% B n/a |
2-Diethylamino-pentan-3-ol
A
ethylamine
B
acetaldehyde
C
propionaldehyde
2-Ethylamino-pentan-3-ol
E
diethylamine
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A n/a B 70% C 36% D n/a E 46% |
2-(ethylamino)-2-methylpropanol hydrochloride
A
formaldehyd
B
ethylamine
C
2-Amino-2-methyl-1-propanol
D
acetaldehyde
E
acetone
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 50% B 44% C 14% D 26% E 66% |
2-(ethylamino)-2-methylpropanol hydrochloride
A
formaldehyd
B
ethylamine
C
2-Amino-2-methyl-1-propanol
D
acetone
Conditions | Yield |
---|---|
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given; | A 50% B 44% C 14% D 66% |
Conditions | Yield |
---|---|
With ammonium formate; zinc In methanol for 0.05h; Heating; | 62% |
With ammonium amalgam | |
With ammonium formate; magnesium In methanol at 20℃; for 0.666667h; |
1-diethylamino-butan-2-ol
A
formaldehyd
B
1-ethylamino-butan-2-ol
C
ethylamine
D
acetaldehyde
E
propionaldehyde
F
diethylamine
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 17% B 59% C 3% D 60% E 18% F 32% |
Conditions | Yield |
---|---|
With K2CO3; THF In tetrahydrofuran Irradiation (UV/VIS); Et2NNO and K2CO3 added to soln. of Mo complex in THF, heated under reflux under N2 with W-light irrdn. for 4 h; filtered hot, cooled to room temp., crystals recrystd. from THF; elem. anal.; | A n/a B 60% C n/a D n/a |
1,6-diethyl-2,5-dithiobiurea
A
ethylamine
B
4-ethyl-[1,2,4]triazolidine-3,5-dithione
Conditions | Yield |
---|---|
With sodium hydroxide In water Heating; | A n/a B 56% |
1-Ethoxy-3-ethylamino-propan-2-ol
A
formaldehyd
B
ethylamine
C
acetaldehyde
Conditions | Yield |
---|---|
With chlorine dioxide In water for 1h; Product distribution; Ambient temperature; | A 4% B 55% C 53% |
1-Cyclohexyloxy-3-ethylamino-propan-2-ol
A
formaldehyd
B
ethylamine
C
acetaldehyde
D
cyclohexanol
Conditions | Yield |
---|---|
With chlorine dioxide In water for 1h; Product distribution; Ambient temperature; | A 5% B 54% C 55% D 18% |
1-ethylamino-3-phenoxy-propan-2-ol
A
formaldehyd
B
ethylamine
C
acetaldehyde
D
phenol
Conditions | Yield |
---|---|
With chlorine dioxide In water for 1h; Product distribution; Ambient temperature; | A 3% B 49% C 50% D 30% |
ethanol
1-dodecyl alcohol
acetonitrile
A
dodecane
B
ethane
C
N-n-dodecyl-ethylamine
D
diethyllaurylamine
E
ethylamine
F
triethylamine
Conditions | Yield |
---|---|
With hydrogen; aluminum oxide; copper at 240℃; under 7600 Torr; Product distribution; other catalyst and composition; | A n/a B n/a C 15% D 30% E n/a F 50% |
2-(Ethylamino)ethanol
A
formaldehyd
B
ethylamine
C
ethanolamine
D
acetaldehyde
Conditions | Yield |
---|---|
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given; | A 14% B 43% C 45% D 44% |
2-(Ethylamino)ethanol
A
formaldehyd
B
ethylamine
C
ethanolamine
D
acetaldehyde
E
Glycolaldehyde
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 14% B 43% C 45% D 44% E n/a |
1-ethyl-6-tolyl-2,5-dithiobiurea
A
2-(4'-methylphenylamino)-Δ2-1,3,4-thiadiazoline-5-thione
B
p-toluidine
C
ethylamine
D
4-ethyl-[1,2,4]triazolidine-3,5-dithione
Conditions | Yield |
---|---|
With sodium hydroxide In water Heating; | A 44% B n/a C n/a D 31% |
1-(ethylamino)-2-methylpropan-2-ol
A
ethylamine
B
1-Amino-2-methyl-propan-2-ol
C
acetaldehyde
D
acetone
Conditions | Yield |
---|---|
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given; | A 35% B 18% C 34% D 43% |
1-(ethylamino)-2-methylpropan-2-ol
A
formaldehyd
B
ethylamine
C
1-Amino-2-methyl-propan-2-ol
D
acetaldehyde
E
acetone
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 18% B 35% C 18% D 34% E 43% |
1-ethyl-6-(4'-ethoxyphenyl)-2,5-dithiobiurea
A
2-(4'-ethoxyphenylamino)-Δ2-1,3,4-thiadiazoline-5-thione
B
ethylamine
C
4-Ethoxyaniline
D
4-ethyl-[1,2,4]triazolidine-3,5-dithione
Conditions | Yield |
---|---|
With sodium hydroxide In water Heating; | A 41% B n/a C n/a D 32% |
1-ethyl-6-(4'-methoxyphenyl)-2,5-dithiobiurea
A
2-(4'-methoxyphenylamino)-Δ2-1,3,4-thiadiazoline-5-thione
B
4-methoxy-aniline
C
ethylamine
D
4-ethyl-[1,2,4]triazolidine-3,5-dithione
Conditions | Yield |
---|---|
With sodium hydroxide In water Heating; | A 40% B n/a C n/a D 34% |
1-ethyl-6-phenyl-2,5-dithiobiurea
A
ethylamine
B
aniline
C
5-phenylamino-3H-[1,3,4]thiadiazole-2-thione
D
4-ethyl-[1,2,4]triazolidine-3,5-dithione
Conditions | Yield |
---|---|
With sodium hydroxide In water Heating; | A n/a B n/a C 38% D 33% |
Conditions | Yield |
---|---|
at 20℃; under 600.048 - 750.06 Torr; Addition; soid-gas reaction; ring cleavage; | 100% |
With water |
Conditions | Yield |
---|---|
at 20℃; under 600.048 - 750.06 Torr; Addition; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Solid phase reaction; gas-solid reaction; | 100% |
With water | |
In ethanol at 50℃; | |
In tetrahydrofuran; ethanol at 20℃; for 12h; Inert atmosphere; | |
In ethanol at 20℃; for 12h; |
1,4-dibromo-2-nitrobenzene
ethylamine
(4-bromo-2-nitrophenyl)ethylamine
Conditions | Yield |
---|---|
In water at 100℃; for 24h; Sealed vessel; | 100% |
Conditions | Yield |
---|---|
With magnesium sulfate In dichloromethane; water at 24.84℃; for 4h; | 100% |
In diethyl ether for 2h; | 74% |
Conditions | Yield |
---|---|
100% |
methyl (3S)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate
ethylamine
Conditions | Yield |
---|---|
In water at -10℃; for 1h; | 100% |
N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine
ethylamine
1-[1-Ethylamino-4-(2,2,2-trifluoro-acetyl)-naphthalen-2-yl]-2,2,2-trifluoro-ethanone
Conditions | Yield |
---|---|
In water; acetonitrile for 2h; Ambient temperature; | 100% |
ethylamine
ethyl 4-formyl-2-hydroxybenzoate
4-[(Z)-Ethyliminomethyl]-2-hydroxy-benzoic acid ethyl ester
Conditions | Yield |
---|---|
for 0.333333h; | 100% |
ethylamine
1-Methyl-6-methylsulfanyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
6-Ethylamino-1-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
Conditions | Yield |
---|---|
In acetonitrile for 0.0833333h; Ambient temperature; | 100% |
ethylamine
Conditions | Yield |
---|---|
In diethyl ether Heating; | 100% |
ethylamine
Conditions | Yield |
---|---|
In diethyl ether Heating; | 100% |
ethylamine
Conditions | Yield |
---|---|
In diethyl ether Heating; | 100% |
ethylamine
ethylammonium nitrate
Conditions | Yield |
---|---|
With nitric acid In water at 10℃; pH=7.3; | 100% |
With nitric acid In water for 1h; pH=7.3; Cooling with ice; | 100% |
With acide nitrique at 0℃; |
1-diethylamino-2,4-dinitronaphthalene
ethylamine
A
N-ethyl-2,4-dinitro-1-naphthylamine
B
diethylamine
Conditions | Yield |
---|---|
In water at 30℃; for 1h; | A 100% B n/a |
ethylamine
tetraethyl ethylenebisbenzoyloxymalonate
Conditions | Yield |
---|---|
In methanol at 20℃; for 72h; | 100% |
3,4-bis(diphenylmethylene)-1,2-cyclobutanedione
ethylamine
Conditions | Yield |
---|---|
With bromine In tetrachloromethane for 0.5h; Ambient temperature; | 100% |
ethylamine
N,N-dimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine
Conditions | Yield |
---|---|
With water In acetonitrile for 1h; Ambient temperature; | 100% |
With water In acetonitrile at 20℃; for 1h; Substitution; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 50℃; for 22h; | 100% |
In tetrahydrofuran at 20℃; Acylation; | |
With ammonia In methanol at 20℃; |
Conditions | Yield |
---|---|
at 80℃; under 600.048 - 750.06 Torr; Addition; soid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 20℃; under 600.048 - 750.06 Torr; Addition; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 20℃; under 600.048 - 750.06 Torr; Substitution; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
under 750.06 Torr; Condensation; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 0℃; under 150.012 Torr; Addition; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 0℃; under 187.515 Torr; Solid phase reaction; gas-solid reaction; | 100% |
With calcium oxide In ethanol; water at 20℃; for 2.5h; |
Conditions | Yield |
---|---|
at 20℃; under 600.048 Torr; for 24h; Addition; solid-gas reaction; ring cleavage; | 100% |
Conditions | Yield |
---|---|
at 0℃; under 375.03 Torr; Addition; solid-gas reaction; | 100% |
ethylamine
4-dimethylamino-benzaldehyde
4-[(ethylimino)methyl]-N,N-dimethylbenzeneamine
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Solid phase reaction; gas-solid reaction; | 100% |
ethylamine
1-isothiocyanatonaphthalene
1,1-dimethyl-3-naphthalene-1-yl-thiourea
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Addition; solid-gas reaction; | 100% |
Conditions | Yield |
---|---|
at 20℃; under 750.06 Torr; Solid phase reaction; gas-solid reaction; | 100% |
In methanol for 9h; Reflux; | 84% |
It is also produced by reductive amination of acetaldehyde.CH3CHO + NH3 + H2 → CH3CH2NH2 + H2O
Ethylamine can be prepared by several other routes, but those are not economical.
The IUPAC name of Monoethylamine is ethanamine. With the CAS registry number 75-04-7, it is also named as 1-Aminoethane. The product's categories are Pharmaceutical Intermediates; Refrigerants; Alkylamines; Monofunctional & alpha, omega-Bifunctional Alkanes; Monofunctional Alkanes; Amines (Low Boiling point); Gas Cylinders; Synthetic Organic Chemistry, and the other registry numbers are 43031-21-6; 85404-16-6; 85404-22-4. Besides, it is light yellow liquid, which should be sealed in a cool and dry place at 2-8 °C. In addition, its molecular formula is C2H7N and molecular weight is 45.08.
The other characteristics of this product can be summarized as: (1)EINECS: 200-834-7; (2)ACD/LogP: -0.13; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -3.23; (5)ACD/LogD (pH 7.4): -2.99; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 1; (11)#H bond donors: 2; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.372; (14)Molar Refractivity: 14.84 cm3; (15)Molar Volume: 65.2 cm3; (16)Surface Tension: 21.6 dyne/cm; (17)Density: 0.691 g/cm3; (18)Flash Point: -17 °C; (19)Melting Point: -81 °C; (20)Enthalpy of Vaporization: 26.17 kJ/mol; (21)Boiling Point: 14.2 °C at 760 mmHg; (22)Vapour Pressure: 1130 mmHg at 25 °C.
Preparation of Monoethylamine: this chemical can be prepared by the reaction of Ethanol with Ammonia in the presence of an oxide catalyst:
CH3CH2OH + NH3 → CH3CH2NH2 + H2O
Uses of Monoethylamine: this chemical can be be oxidized to form Acetaldehyde. It is a precursor to many herbicides including atrazine and simazine. And it is widely used in chemical industry and organic synthesis. Additionally, it can react with [1,3]Dioxolan-2-one to get Ethyl-carbamic acid-(2-hydroxy-ethyl ester).
This reaction will occur at temperature of 20 °C for 1 hour. The yield is 92 %.
When you are using this chemical, please be cautious about it as the following: it is extremely flammable that may form explosive peroxides. Please keep away from sources of ignition. It is also toxic by inhalation, in contact with skin and if swallowed, so please keep container tightly closed. Moreover, it is danger of very serious irreversible effects, and irritating to eyes and respiratory system. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing and gloves. Furthermore, please do not empty into drains. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCN
(2)InChI: InChI=1S/C2H7N/c1-2-3/h2-3H2,1H3
(3)InChIKey: QUSNBJAOOMFDIB-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LC50 | inhalation | 2300mg/m3 (2300mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
rabbit | LD50 | skin | 390uL/kg (0.39mL/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954. | |
rabbit | LDLo | intravenous | 350mg/kg (350mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935. | |
rat | LC50 | inhalation | 5540ppm/1H (5540ppm) | SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. OTS0538173, |
rat | LD50 | oral | 400mg/kg (400mg/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954. |
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