Ethylbromoacetate supplier

Name
Ethyl bromoacetate
EINECS 203-290-9
CAS No. 105-36-2
Article Data92
CAS DataBase
Density 1.501 g/cm³
Solubility Insoluble in water, soluble in ethanol, benzene, diethyl ether
Melting Point -38 °C
Formula C₄H₇BrO₂
Boiling Point 168.499 °C at 760 mmHg
Molecular Weight 167.002
Flash Point 47.778 °C
Transport Information UN 1603 6.1/PG 2
Appearance colourless to light yellow liquid
Safety 26-45-7/9-1/2
Risk Codes 26/27/28
Molecular Structure
Hazard Symbols T+
Synonyms Acetic acid, 2-bromo-, ethyl ester;a-Bromoacetic acid ethyl ester;Aceticacid, bromo-, ethyl ester (6CI,8CI,9CI);(Ethoxycarbonyl)methyl bromide;2-Bromoacetic acid ethyl ester;Bromoacetic acid ethyl ester;Ethyl bromacetate;Ethyl bromoethanoate;Ethyl monobromoacetate;Ethyl a-bromoacetate;Aceticacid, 2-bromo-, ethyl ester;
PSA 26.30000
LogP 0.94440

Synthetic route

: 64-17-5
ethanol

: 64-19-7
acetic acid

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With bromine; phosphorus tribromide for 0.5h; Hell-Volhard-Zelinsky reaction; Heating;	100%
With phosphorus tribromide 1.) r.t., 5 min; reflux, 3 h, 2.) r.t., overnight; Yield given. Multistep reaction;

: 64-17-5
ethanol

: 79-08-3
bromoacetic acid

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With thionyl chloride In diethyl ether at 0 - 20℃;	95%
With sulfuric acid for 24h; Reflux;	85%
at 100℃;

: 103514-71-2
C10H25N3O2PS(1+)

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With bromide In N,N-dimethyl-formamide	95%

: 623-73-4
diazoacetic acid ethyl ester

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With 1-bromo-butane; [HB(3,5-(CF3)2Pz)3]Ag(THF)	78%
With chloroform; hydrogen bromide

: 109-92-2
ethyl vinyl ether

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With tetraethylammonium bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dichloromethane at 20℃; for 0.166667h; regioselective reaction;	65%

: 64-17-5
ethanol

: 598-21-0
2-Bromoacetyl bromide

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
Stage #1: ethanol With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 2-Bromoacetyl bromide In dichloromethane at 0 - 25℃; for 5h;	42%

: 227945-00-8
diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium

A: diethyl 2-amino-6-[(2-oxo-2-ethoxy-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate

B: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
	A 24% B n/a

: 5292-43-3
bromoacetic acid tert-butyl ester

: 6873-86-5, 111289-37-3, 116560-14-6
(+)-(S)-isopropyl-p-toluenesulphinamide

A: 105-36-2
ethyl bromoacetate

B /PBBPD039-1840/: /PBBPD039-1840/

Conditions

Conditions	Yield
With n-butyllithium Product distribution; 1.) THF, -30 deg C, 15 min, 2.) THF, 0 deg C, 5 h; further temperatures; further alkylating agents; regio and stereochemistry of alkylation;	A 3% B n/a

...Expand

: 13094-51-4
bromoacetic anhydride

: 64-17-5
ethanol

: 105-36-2
ethyl bromoacetate

: 623-73-4
diazoacetic acid ethyl ester

: 74-96-4
ethyl bromide

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
bei der Einwirkung von UV-Licht;

: 623-73-4
diazoacetic acid ethyl ester

: 507-19-7
t-butyl bromide

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
Photolysis;

: 74-96-4
ethyl bromide

: 5349-28-0
thiocyanato-acetic acid ethyl ester

A: 542-90-5
ethyl isothiocyanate

B: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
at 120℃;

...Expand

: 22118-09-8
2-bromoacetyl chloride

: 64-17-5
ethanol

: 105-36-2
ethyl bromoacetate

: 60-29-7
diethyl ether

: 506-68-3
bromocyane

: 2644-21-5
ethyl N,N-diethylglycinate

A: N-ethyl-N-cyano-glycine ethyl ester

B: 617-83-4
Diethylcyanamide

C: 105-36-2
ethyl bromoacetate

...Expand

: 506-68-3
bromocyane

: 2644-21-5
ethyl N,N-diethylglycinate

: 105-36-2
ethyl bromoacetate

: 506-96-7
Acetyl bromide

: 817-95-8
ethyl 2-ethoxyethanoate

A: 74-96-4
ethyl bromide

B: 623-86-9
acetoxy-acetic acid ethyl ester

C: 141-78-6
ethyl acetate

D: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
at 190℃;

...Expand

: 593-92-0
vinylidene dibromide

: 64-17-5
ethanol

: 105-36-2
ethyl bromoacetate

: 24298-33-7
1-ethoxy-1,2-dibromo-ethene

A: 74-96-4
ethyl bromide

B: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With ethanol

: 64-17-5
ethanol

: 861797-08-2
bromo-acetic acid-(1-bromo-ethyl ester)

A: 105-57-7
diethyl acetal

B: 74-96-4
ethyl bromide

C: 105-36-2
ethyl bromoacetate

D: 123-73-9
crotonaldehyde

...Expand

: 64-17-5
ethanol

: 2,2,3,4-tetrabromo-butyraldehyde

A: 74-96-4
ethyl bromide

B: 105-36-2
ethyl bromoacetate

C: 2032-35-1
Bromoacetaldehyde diethyl acetal

D: 17157-48-1
bromoacetaldehyde

...Expand

: 79-28-7
1,1,2,2-tetrabromoethene

: 141-52-6
sodium ethanolate

A: 70442-46-5
3,4-dibromobut-3-en-2-ol

B: 105-36-2
ethyl bromoacetate

...Expand

: 623-50-7
ethyl 2-hydroxyacetate

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With phosphorus pentabromide
With phosphorus tribromide In dichloromethane for 0.5h; Cooling with ice;

: 108-24-7
acetic anhydride

: 64-19-7
acetic acid

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With pyridine; bromine durch folgende Veresterung mit Aethanol in Gegenwart von konz. H2SO4 in siedendem Benzol;

: antimony (V)-triethylate dibromide

A: 74-96-4
ethyl bromide

B: 60-29-7
diethyl ether

C: 64-17-5
ethanol

D: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
at 130 - 135℃;

...Expand

: 64-19-7
acetic acid

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With phosphorus; bromine Abdestillieren des ueberschuessigen Broms und Giessen des Reaktionsprodukts in Alkohol;
With bromine; acetic anhydride at 100℃; und Behandlung des Reaktionsprodukts mit Alkohol auf dem Wasserbad;

: 75-36-5
acetyl chloride

: 105-36-2
ethyl bromoacetate

Conditions

Conditions	Yield
With phosphorus; bromine bei der Einw. von absol. Aethanol auf das Reaktionsgemisch;

: 623-73-4
diazoacetic acid ethyl ester

: 4784-77-4, 39616-19-8, 29576-14-5
(E)-1-Bromo-2-butene

A: 105-36-2
ethyl bromoacetate

B: 79357-22-5
Ethyl 2-bromo-3-methyl-4-pentenoate

: 79357-25-8
Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate

: 79390-68-4
Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate

Conditions

Conditions	Yield
dirhodium tetraacetate at 4℃; Yield given. Yields of byproduct given;

...Expand

: 681-94-7
ethyl 2-(tributylstannyl)acetate

: 98-86-2
acetophenone

A: 141-78-6
ethyl acetate

B: 105-36-2
ethyl bromoacetate

C: 70-11-1
α-bromoacetophenone

Conditions

Conditions	Yield
With tributyltin iodide; bromine Product distribution; 1.) DMSO, 75 deg C, 36 h;	A 82 % Chromat. B 10 % Chromat. C 75 % Chromat.

...Expand

: 358-98-5
1,2-dibromo-1-fluoro-ethene

: 141-52-6
sodium ethanolate

A: 105-36-2
ethyl bromoacetate

B: (E)-1,2-Dibromo-1-ethoxy-ethene

C: (E)-2-Bromo-1-ethoxy-1-fluoro-ethene

D: (Z)-2-Bromo-1-ethoxy-1-fluoro-ethene

Conditions

Conditions	Yield
In ethanol Further byproducts given. Yields of byproduct given;	A 7 % Spectr. B 20 % Spectr. C n/a D n/a

...Expand

: 623-73-4
diazoacetic acid ethyl ester

: 67-66-3
chloroform

: 10035-10-6, 12258-64-9
hydrogen bromide

: 105-36-2
ethyl bromoacetate

...Expand

: 110-91-8
morpholine

: 105-36-2
ethyl bromoacetate

: 3235-82-3
N-morpholylacetic acid ethyl ester

Conditions

Conditions	Yield
In benzene for 0.5h; Reflux;	100%
In toluene for 8h;	92%
In benzene for 0.5h; Alkylation; Heating;	91%

: 123-08-0
4-hydroxy-benzaldehyde

: 105-36-2
ethyl bromoacetate

: 51264-69-8
ethyl 2-(4-formylphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Reflux;	100%
Stage #1: 4-hydroxy-benzaldehyde With potassium carbonate; sodium iodide In acetonitrile for 0.5h; Heating; Stage #2: ethyl bromoacetate In acetonitrile for 18h; Heating;	98%
With potassium carbonate In acetone at 20℃; for 2h;	95%

: 121-33-5
vanillin

: 105-36-2
ethyl bromoacetate

: 51264-70-1
ethyl 2-(4-formyl-2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 14h; Reflux; Inert atmosphere;	100%
With potassium carbonate In acetone for 4h; Reflux; Inert atmosphere;	98%
With potassium carbonate In acetone for 14h; Reflux;	96%

: 105-36-2
ethyl bromoacetate

: 611-70-1
phenyl isopropyl ketone

: 92301-37-6
(+/-)-Ethyl 3-hydroxy-4-methyl-3-phenylpentanoate

Conditions

Conditions	Yield
With iodine; zinc In 1,4-dioxane for 0.583333h; Reformatsky reaction; ultrasound irradiation;	100%
	86%
With zinc; benzene

: 105-36-2
ethyl bromoacetate

: 122-52-1
triethyl phosphite

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

Conditions

Conditions	Yield
at 60 - 80℃; for 0.5h; Arbusov reaction;	100%
at 150℃; for 3h;	99%
for 0.0333333h; Michaelis-Arbuzov reaction; microwave irradiation;	98%

: 2782-91-4
1,1,3,3-tetramethyl-2-thiourea

: 105-36-2
ethyl bromoacetate

: 2-(2-ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In acetone

: 105-36-2
ethyl bromoacetate

: 765-30-0
Cyclopropylamine

: 71922-62-8
[(cyclopropyl)amino]acetic acid ethyl ester

Conditions

Conditions	Yield
In ethanol for 1h;	100%
With triethylamine In diethyl ether at 20℃;	100%
In ethanol at 0 - 20℃; for 18h;	99%

: 105-36-2
ethyl bromoacetate

: 637-81-0
ethyl-2-azidoacetate

Conditions

Conditions	Yield
With sodium azide In water; acetone at 20℃; for 0.5h;	100%
With sodium azide In water; acetone at 20℃; for 24h;	100%
With sodium azide In water; acetone at 0 - 63℃; for 4h;	100%

: 105-36-2
ethyl bromoacetate

: 999-17-7
ethyl 2-nitrooxyacetate

Conditions

Conditions	Yield
With silver nitrate In acetonitrile at 20℃; for 12h;	100%
With trinitromethane; silver(l) oxide In acetonitrile

: 98-01-1
furfural

: 105-36-2
ethyl bromoacetate

: 623-20-1
ethyl (E)-3-(2-furyl)prop-2-enoate

Conditions

Conditions	Yield
With triphenyl phosphite; potassium carbonate; (BrBu2Te)2O In toluene at 80℃; for 42h; Wittig-type olefination;	100%
With lithium hydroxide; triphenylphosphine; lithium chloride In water Wittig reaction; Heating;	99%
With lithium hydroxide; triphenylphosphine; lithium chloride In water for 0.25h; Wittig reaction; Heating;	97%

: 487-89-8
Indole-3-carboxaldehyde

: 105-36-2
ethyl bromoacetate

: 27065-94-7
(3-formylindol-1-yl)acetic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 15 - 20℃; for 16.5h;	100%
Stage #1: Indole-3-carboxaldehyde With sodium hydride In N,N-dimethyl-formamide Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With sodium hydride In DMF (N,N-dimethyl-formamide) at 15 - 20℃; for 16.5h;	100%

: 91-56-5
indole-2,3-dione

: 105-36-2
ethyl bromoacetate

: 41042-21-1
(1-ethoxycarbonylmethyl)isatin

Conditions

Conditions	Yield
Stage #1: indole-2,3-dione With calcium hydride In N,N-dimethyl-formamide at 100℃; for 1h; Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 100℃; for 4h;	100%
Stage #1: indole-2,3-dione With aluminum oxide; potassium fluoride In acetonitrile for 0.0833333h; Stage #2: ethyl bromoacetate In acetonitrile for 21h; Reflux;	97%
With KF-Celite In 2-methyltetrahydrofuran for 4h; Reflux; chemoselective reaction;	93%

: 104-88-1
4-chlorobenzaldehyde

: 105-36-2
ethyl bromoacetate

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

Conditions

Conditions	Yield
With triphenyl phosphite; poly(ethylene glycol) di(2-(n-butyltelluro)ethyl) ether; potassium carbonate In toluene at 80℃;	100%
Stage #1: ethyl bromoacetate With triphenyl phosphite; PEG-Te-Bu In toluene at 80℃; for 0.166667h; Stage #2: With potassium carbonate In toluene for 0.0166667h; Stage #3: 4-chlorobenzaldehyde In toluene for 7h; Wittig-type olefination; Further stages.;	98%
With N1,N3,N5-tris(4-(diphenylarsino)phenyl)benzene-1,3,5-tricarboxamide; potassium carbonate In neat (no solvent) at 80℃; for 0.5h; Wittig Olefination; stereoselective reaction;	96%

: 555-16-8
4-nitrobenzaldehdye

: 105-36-2
ethyl bromoacetate

: 24393-61-1
ethyl (E)-3-(4-nitrophenyl)-2-propenoate

Conditions

Conditions	Yield
With polyethyleneimine supported triphenylphosphine In chloroform at 65℃; Wittig Olefination; Inert atmosphere;	100%
With Rasta resin-PPh3-NBniPr2 In dichloromethane at 20℃; for 19h; Wittig reaction; Molecular sieve; optical yield given as %de;	99%
With triphenylphosphine; nanocrystalline aerogel prepared MgO In N,N-dimethyl-formamide at 20℃; for 3h; Wittig reaction;	98%

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 105-36-2
ethyl bromoacetate

: 10539-50-1
diethyl 2-benzoylsuccinate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol cooling;	100%
With potassium carbonate; sodium iodide at 65℃; for 2h;	63%
With sodium hydride 1.) THF, RT, 2.) THF, RT, 1 h; Yield given. Multistep reaction;
With potassium carbonate In acetone for 20h; Reflux;

: 100-52-7
benzaldehyde

: 105-36-2
ethyl bromoacetate

: 4192-77-2
ethyl cinnamate

Conditions

Conditions	Yield
With triphenyl phosphite; potassium carbonate; (BrBu2Te)2O In toluene at 80℃; for 36h; Wittig-type olefination;	100%
Stage #1: ethyl bromoacetate With triphenyl phosphite; PEG-Te-Bu In toluene at 80℃; for 0.166667h; Stage #2: With potassium carbonate In toluene for 0.0166667h; Stage #3: benzaldehyde In toluene for 18h; Further stages.;	98%
With triphenyl phosphite; poly(ethylene glycol) di(2-(n-butyltelluro)ethyl) ether; potassium carbonate In toluene at 80℃;	98%

: 120-80-9
benzene-1,2-diol

: 105-36-2
ethyl bromoacetate

: 52376-09-7
ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>acetate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 120h;	100%
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating;	95%
With potassium carbonate In N,N-dimethyl-formamide at 75 - 80℃; for 1.5h;	90%

: 104-94-9
4-methoxy-aniline

: 105-36-2
ethyl bromoacetate

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 16h;	100%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 18h;	100%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 16h;	100%

: 157432-87-6, 288302-11-4, 288302-12-5
5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

: 105-36-2
ethyl bromoacetate

: 121702-03-2, 133576-87-1, 97600-39-0, 145511-82-6, 145511-83-7
5,11,17,23-tetra-tert-butyl-[25,26,27,28-(ethylethanoate)oxy]-calix[4]arene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;	100%
With caesium carbonate In acetone at 56℃; for 1h;	100%
With potassium carbonate In acetone for 120h; Heating;	88%

: 76543-12-9
p-(tert-butyl)hexahomotrioxacalix[3]arene

: 105-36-2
ethyl bromoacetate

: 151782-37-5, 151852-34-5, 118859-91-9
7,15,23-tri-tert-butyl-25,26,27-tris(ethoxycarbonylmethoxy)-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix[3]arene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 56℃; for 6h;	100%
With sodium hydride In tetrahydrofuran at 67℃; distribution of cone and partial-cone conformers; other bases, solvents, temperatures and reaction times;
With potassium carbonate In acetone for 12h; Heating;

: 87307-95-7
1-methyl-4-(2-hydroxy-3-methoxyphenyl)-3-(3-oxo-3-ethoxypropyl)pyridinuim iodide

: 105-36-2
ethyl bromoacetate

: 87307-96-8
4-<2-(2-ethoxy-2-oxoethoxy)3-3-methoxyphenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 1h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 1h;

: 105-36-2
ethyl bromoacetate

: 108-98-5
thiophenol

: 7605-25-6
ethyl phenylsulfenylacetate

Conditions

Conditions	Yield
With pyridine In ethanol for 2h; Ambient temperature;	100%
With triethylamine In tetrahydrofuran at 20℃; for 4h;	99%
With 1-pentyl-3-methylimidazolium bromide at 25 - 30℃; for 0.166667h;	98%

: 105-36-2
ethyl bromoacetate

: 149-30-4
2-Mercaptobenzothiazole

: 24044-88-0
ethyl 2-(benzo[d]thiazol-2-ylthio)acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
With potassium carbonate In acetone for 3h; Heating;	95%
With potassium carbonate In acetonitrile at 20℃; for 3h; Inert atmosphere;	74%

: 105-36-2
ethyl bromoacetate

: 75930-92-6, 75948-26-4
(1aS,3aS,4R,8aR)-1a,4-Dimethyl-octahydro-1-oxa-cyclopropa[c]azulen-8-one

: 75930-94-8
((1aR,3aR,4S,7R,8aS)-1a,4-Dimethyl-8-oxo-octahydro-1-oxa-cyclopropa[c]azulen-7-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran	100%

: 105-36-2
ethyl bromoacetate

: 145162-27-2
2-((isopropylamino)methylene)malononitrile

: 145162-35-2
3-amino-4-cyan-1-(2-propyl)-pyrrol-2-carbonsaeureethylester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 5h;	100%
With sodium ethanolate; potassium carbonate 1.) DMF, 80 deg C, 30 min, 2.) DMF, ethanol, 60 deg C, 30 min; Yield given. Multistep reaction;

: 105-36-2
ethyl bromoacetate

: 603-35-0
triphenylphosphine

: 1530-45-6
(carbethoxymethyl)triphenylphosphonium bromide

Conditions

Conditions	Yield
In xylene for 0.00833333h; Heating; microwave irradiation;	100%
In ethyl acetate Reflux;	100%
In benzene at 20℃;	100%

: 105-36-2
ethyl bromoacetate

: 609-08-5
Diethyl methylmalonate

: 39994-45-1
triethyl propane-1,2,2-tricarboxylate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;	100%

: 105-36-2
ethyl bromoacetate

: 102612-39-5
2-<(4'-hydroxyphenyl)methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran

: 102612-26-0
2-<<4'-(carbethoxymethoxy)phenyl>methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran

Conditions

Conditions	Yield
With potassium carbonate In acetone for 0.5h; Heating;	100%
With potassium carbonate In hexane; acetone

: 105-36-2
ethyl bromoacetate

: 101508-94-5
3,5-dihydroxybenzoic acid benzyl ester

: 153444-36-1
benzyl 3,5-bis(ethoxycarbonylmethoxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4.5h; Heating;	100%

: 105-36-2
ethyl bromoacetate

: 156557-47-0
tert-butyl ((trans)-7-methyl-2-oxoazepan-3-yl)carbamate

: 156479-94-6
((3S,7S)-3-tert-Butoxycarbonylamino-7-methyl-2-oxo-azepan-1-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran for 0.5h; Ambient temperature;	100%

Ethylbromoacetate Consensus Reports

Reported in EPA TSCA Inventory.

Ethylbromoacetate Specification

The Ethylbromoacetate, with the CAS registry number 105-36-2, is also known as Bromoacetic acid ethyl ester. It belongs to the product categories of Pharmaceutical Intermediates; Organics; C2 to C5; Carbonyl Compounds; Esters. Its EINECS number is 203-290-9. This chemical's molecular formula is C₄H₇BrO₂ and molecular weight is 167.00. It is the ethyl ester of bromoacetic acid and is prepared in two steps from acetic acid. It is a lachrymator and has a fruity, pungent odor. What's more, its systematic name is Ethyl bromoacetate. Its classification code is Tumor data. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides, heat and fire. It is used in organic synthesis, and it is use to prepare war gas.

Physical properties of Ethylbromoacetate are: (1)ACD/LogP: 1.239; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.24; (4)ACD/LogD (pH 7.4): 1.24; (5)ACD/BCF (pH 5.5): 5.15; (6)ACD/BCF (pH 7.4): 5.15; (7)ACD/KOC (pH 5.5): 112.42; (8)ACD/KOC (pH 7.4): 112.42; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 26.3 Å²; (13)Index of Refraction: 1.453; (14)Molar Refractivity: 30.087 cm³; (15)Molar Volume: 111.226 cm³; (16)Polarizability: 11.927×10^-24cm³; (17)Surface Tension: 33.8 dyne/cm; (18)Density: 1.501 g/cm³; (19)Flash Point: 47.778 °C; (20)Enthalpy of Vaporization: 40.494 kJ/mol; (21)Boiling Point: 168.499 °C at 760 mmHg; (22)Vapour Pressure: 1.6 mmHg at 25°C.

Uses of Ethylbromoacetate: it can be used to produce (2-methylsulfanyl-ethylamino)-acetic acid ethyl ester at the ambient temperature. It will need solvent tetrahydrofuran with the reaction time of 2.5 hours. The yield is about 88%.

Ethylbromoacetate can be used to produce (2-methylsulfanyl-ethylamino)-acetic acid ethyl ester at the ambient temperature

When you are using this chemical, please be cautious about it as the following:
This chemical is very toxic by inhalation, in contact with skin and if swallowed. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You must keep the container tightly closed and in a well-ventilated place, and you should keep it locked up and out of the reach of children. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: BrCC(=O)OCC
(2)Std. InChI: InChI=1S/C4H7BrO2/c1-2-7-4(6)3-5/h2-3H2,1H3
(3)Std. InChIKey: PQJJJMRNHATNKG-UHFFFAOYSA-N

Product Name

Ethyl bromoacetate

Synthetic route

Ethylbromoacetate Consensus Reports

Ethylbromoacetate Specification

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