Ethylene Glycol Mono-tert-butyl Ether supplier

Name
Ethylene Glycol Mono-tert-butyl Ether
EINECS 242-826-6
CAS No. 7580-85-0
Article Data20
CAS DataBase
Density 0.898 g/cm³
Solubility Completely miscible in water
Melting Point
Formula C₆H₁₄O₂
Boiling Point 144 °C at 760 mmHg
Molecular Weight 118.176
Flash Point 47.3 °C
Transport Information UN 3271
Appearance
Safety 26-36/37/39
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols
Synonyms Ethanol,2-(1,1-dimethylethoxy)-;Ethanol,2-tert-butoxy- (6CI,7CI,8CI);2-(1,1-Dimethylethoxy)ethanol;2-tert-Butoxyethanol;2-tert-Butoxyethyl alcohol;Ethylene glycolmono-tert-butyl ether;Ethylene glycol tert-butyl ether;Swasolve ETB;tert-Butyl 2-hydroxyethyl ether;tert-Butyl Cellosolve;2-(tert-butoxy)ethanol;
PSA 29.46000
LogP 0.79380

Synthetic route

: 75-21-8
oxirane

: 75-65-0
tert-butyl alcohol

: 7580-85-0
tert-butyl glycidyl ether

Conditions

Conditions	Yield
With K-MgO/γ-alumina In tetrahydrofuran at 50℃; for 5h; Temperature;	97.3%
With hydro silicate
With hydro silicate

: 109-65-9
1-bromo-butane

: 75-65-0
tert-butyl alcohol

: 7580-85-0
tert-butyl glycidyl ether

Conditions

Conditions	Yield
Stage #1: 1-bromo-butane With 1-methyl-1H-imidazole at 80℃; for 3h; Stage #2: With imidazolyl sodium In methanol at 20℃; for 6h; Stage #3: tert-butyl alcohol at 30 - 50℃; Temperature;	94.2%

: 3984-22-3
2-vinyl-1,3-dioxolane

: 75-65-0
tert-butyl alcohol

A: 7580-85-0
tert-butyl glycidyl ether

B: 26547-47-7
Ethylene glycol di-tert-butyl diether

C: 107378-68-7
2-(2-tert-butoxyethyl)-1,3-dioxolane

Conditions

Conditions	Yield
With sulfuric acid for 5h; Heating;	A 8.5% B 2% C 6 g

...Expand

: 507-19-7
t-butyl bromide

: 107-21-1
ethylene glycol

: 7580-85-0
tert-butyl glycidyl ether

: 107-21-1
ethylene glycol

: 115-11-7
isobutene

A: 7580-85-0
tert-butyl glycidyl ether

B: 26547-47-7
Ethylene glycol di-tert-butyl diether

Conditions

Conditions	Yield
With hydrogenchloride at 75℃;
With sulfuric acid at 75℃;
With hydrogenchloride at 75℃;
With sulfuric acid at 75℃;

...Expand

: 4544-20-1
2-ethoxy-1,3-dioxolane

: 13058-24-7
tert-butoxytrimethylsilane

A: 1825-62-3
ethyl trimethylsilyl ether

B: 7580-85-0
tert-butyl glycidyl ether

C: 129345-72-8
1-tert-butoxy-2-trimethylsiloxy ethane

D: 129345-71-7
1-formyloxy-2-tert-butoxy ethane

Conditions

Conditions	Yield
at 16 - 20℃; for 1h; Further byproducts given;

...Expand

: 7580-85-0
tert-butyl glycidyl ether

: 124-63-0
methanesulfonyl chloride

: 2-(tert-butoxy)ethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In tert-butyl methyl ether at 0 - 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0℃; for 2h;
With sodium hydrogencarbonate; triethylamine In dichloromethane

: 108-31-6
maleic anhydride

: 7580-85-0
tert-butyl glycidyl ether

: 7580-82-7
Bis-(2-t-butoxyethyl)-maleat

Conditions

Conditions	Yield
With KC105A strong acid catalyst In toluene at 115℃; for 5h; Temperature; Inert atmosphere; Flow reactor;	99.5%

: 2224-15-9
ethylene glycol diglycidyl ether

: 7580-85-0
tert-butyl glycidyl ether

: C14H28O6

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at 80℃; for 3h;	99.3%

: 75-15-0
carbon disulfide

: 7580-85-0
tert-butyl glycidyl ether

: 100-44-7
benzyl chloride

: O-tert-butoxyethyl-S-benzylxanthate

Conditions

Conditions	Yield
Stage #1: carbon disulfide; tert-butyl glycidyl ether With sodium hydroxide In water at 25℃; for 2h; Stage #2: benzyl chloride In water at 75℃; for 4h;	98.2%

...Expand

: 7580-85-0
tert-butyl glycidyl ether

: 403-01-0
methyl 3-fluoro-4-hydroxybenzoate

: C14H19FO4

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 1h;	98%

: 1191-99-7
2,3-dihydro-2H-furan

: 7580-85-0
tert-butyl glycidyl ether

: 2-(2-tert-butoxyethoxy)tetrahydrofuran

Conditions

Conditions	Yield
With copper(I) triflate In Petroleum ether for 2h; Reagent/catalyst; Solvent; Time; Reflux;	96%

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 7580-85-0
tert-butyl glycidyl ether

: 91505-31-6
(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

Conditions

Conditions	Yield
Stage #1: 5-Chlorothiophene-2-carboxylic acid With oxalyl dichloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 0 - 20℃; for 2h; Stage #2: tert-butyl glycidyl ether With triethylamine In tetrahydrofuran at 0 - 20℃; for 2h;	95.56%

: 7580-85-0
tert-butyl glycidyl ether

: 3454-29-3
1,1,1-trimethylolpropane triglycidyl ether

: C21H40O8

Conditions

Conditions	Yield
With Amberlyst-15 resin at 80℃; for 4h;	95.5%

: 2075-46-9
4-nitro-1H-pyrazole

: 7580-85-0
tert-butyl glycidyl ether

: 1-(2-(tert-butoxy)ethyl)-4-nitro-1H-pyrazole

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 2h;	95%

: cyclohexane-1,4-dimethanole diglycidyl ether

: 7580-85-0
tert-butyl glycidyl ether

: C20H38O6

Conditions

Conditions	Yield
With Amberlyst-15 resin at 80℃; for 4h;	94.3%

: 2425-79-8
1,4-Butanediol diglycidyl ether

: 7580-85-0
tert-butyl glycidyl ether

: C16H32O6

Conditions

Conditions	Yield
With tin(IV) chloride at 80℃; for 5h; Reagent/catalyst;	94.1%

: 63676-19-7
[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone

: 7580-85-0
tert-butyl glycidyl ether

: 1972-28-7
diethylazodicarboxylate

: 220655-20-9
[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][(4-t-butoxyethoxy)phenyl]methanone

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran	94%

...Expand

: 7580-85-0
tert-butyl glycidyl ether

: 4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

: N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium hydroxide In toluene at 55℃;	91.8%
With sodium hydroxide

: 7580-85-0
tert-butyl glycidyl ether

: 4489-34-3
4,6-dichloro-2-(methylsulfonyl)pyrimidine

: 2-(2-(tert-butoxy)ethoxy)-4,6-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: tert-butyl glycidyl ether With sodium hydride In tetrahydrofuran for 1h; Inert atmosphere; Cooling with ice; Stage #2: 4,6-dichloro-2-(methylsulfonyl)pyrimidine In tetrahydrofuran Inert atmosphere;	91%

: 7580-85-0
tert-butyl glycidyl ether

: 98-59-9
p-toluenesulfonyl chloride

: 108366-80-9
2-(tert-butoxy)ethyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 0 - 5℃; for 2h;	90%
With sodium hydroxide In tetrahydrofuran	90%
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;	61%
With triethylamine In dichloromethane at 0 - 20℃; for 17.5h;

: 7580-85-0
tert-butyl glycidyl ether

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 1177447-87-8
4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine

Conditions

Conditions	Yield
With sodium hydroxide In toluene at 55℃; for 2h;	90%
With potassium carbonate; tetrabutylammomium bromide In toluene at 100 - 110℃; for 9h;

: 33252-28-7
6-chloronicotinonitrile

: 7580-85-0
tert-butyl glycidyl ether

: 6-(2-tert-butoxy-ethoxy)-nicotinonitrile

Conditions

Conditions	Yield
Stage #1: tert-butyl glycidyl ether With lithium hexamethyldisilazane In tetrahydrofuran for 0.5h; Stage #2: 6-chloronicotinonitrile In tetrahydrofuran at 70℃; for 9h; Further stages.;	87%

: 7580-85-0
tert-butyl glycidyl ether

: 1393813-42-7
N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

: 1393813-43-8
N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide

Conditions

Conditions	Yield
Stage #1: N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide With potassium tert-butylate In toluene at 20℃; for 0.0833333h; Stage #2: tert-butyl glycidyl ether In toluene at 85℃; for 2h; Stage #3: With titanium tetrachloride In toluene at 35℃; for 20h;	86%

: 7580-85-0
tert-butyl glycidyl ether

: 1,8-bis(benzyloxy)-9,10-anthraquinone-3-carbonyl chloride

: 1,8-bis(benzyloxy)-9,10-anthraquinone-O-(2-(tert-butoxy)ethyl)-3-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;	85%

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 7580-85-0
tert-butyl glycidyl ether

: 91505-31-6
(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran 1) r.t., 1 h, 2) reflux, 10 min;	80%

: 7580-85-0
tert-butyl glycidyl ether

: 1173068-83-1
tert-butyl 4-(3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate

: 1173068-84-2
tert-butyl 4-(3-(2-tert-butoxyethoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; potassium fluoride on basic alumina In toluene at 120℃; for 40h;	68%

: 7580-85-0
tert-butyl glycidyl ether

: 815632-47-4
5-bromo-1,3-dimethoxy-2-nitrobenzene

: 5-(2-(tert-butoxy)ethoxy)-1,3-dimethoxy-2-nitrobenzene

Conditions

Conditions	Yield
With 5-di(1-adamantylphosphino)-1-(1,3,5-triphenyl-1H-pyrazol-4-yl)-1H-pyrazole; palladium diacetate; caesium carbonate at 80℃; Inert atmosphere; Schlenk technique;	68%

: 7580-85-0
tert-butyl glycidyl ether

: methyl 7-(benzyloxy)-1H-indole-5-carboxylate

: C16H21NO4

Conditions

Conditions	Yield
With triphenylphosphine at 20℃; for 2h;	68%

: 7580-85-0
tert-butyl glycidyl ether

: 91505-31-6
(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

: 91505-34-9
(2-(2-methyl-2-propoxy)-ethyl) 5-(2-(2-methyl-2-propoxy)-ethoxy)-thiophene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 65℃; for 1h;	65%
With sodium hydride In N,N-dimethyl-formamide at 20 - 65℃; for 1.5h; Inert atmosphere;	62.27%

: 7580-85-0
tert-butyl glycidyl ether

: methyl 5-formyl-4-hydroxy-2-methoxybenzoate

: methyl 4-(2-(tert-butoxy)ethoxy)-5-formyl-2-methoxybenzoate

Conditions

Conditions	Yield
With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 4h;	63%

: 7580-85-0
tert-butyl glycidyl ether

: methyl 5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

: methyl 2-(2-(tert-butoxy)ethyl)-5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 60℃; for 16h; Mitsunobu Displacement; Inert atmosphere;	61%

: 64-18-6
formic acid

: 7580-85-0
tert-butyl glycidyl ether

: 74338-98-0
3-(tert-butoxy)propane-1,2-diol

Conditions

Conditions	Yield
In water for 12h; Ambient temperature;	52%

: 7580-85-0
tert-butyl glycidyl ether

: 478010-54-7
2-chloro-4,6-dimethoxy-5-nitro-pyrimidine

: 918444-85-6
2-(2-tert-butoxyethoxy)-4,6-dimethoxy-5-nitropyrimidine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 0.25h;	50%
With sodium hydride In tetrahydrofuran at -41℃;

Ethylene Glycol Mono-tert-butyl Ether Specification

The Ethylene Glycol Mono-tert-butyl Ether is an organic compound with the formula C₆H₁₄O₂. Its IUPAC name is 2-[(2-methylpropan-2-yl)oxy]ethanol. With the CAS registry number 7580-85-0, it has the systematic name 2-tert-Butoxyethanol. It can be prepared by Isobutylene and ethylene glycol. Moreover, it belongs to the product categories Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols. However, it should be sealed in the cool and dry place.

Physical properties about Ethylene Glycol Mono-tert-butyl Ether are:
(1)ACD/LogP: 0.43; (2)ACD/LogD (pH 5.5): 0.43; (3)ACD/LogD (pH 7.4): 0.43; (4)ACD/BCF (pH 5.5): 1.25; (5)ACD/BCF (pH 7.4): 1.25; (6)ACD/KOC (pH 5.5): 40.87; (7)ACD/KOC (pH 7.4): 40.87; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 18.46 Å²; (12)Index of Refraction: 1.417; (13)Molar Refractivity: 33.09 cm³; (14)Molar Volume: 131.4 cm³; (15)Polarizability: 13.11×10^-24cm³; (16)Surface Tension: 27.9 dyne/cm; (17)Density: 0.898 g/cm³; (18)Flash Point: 47.3 °C; (19)Enthalpy of Vaporization: 44.4 kJ/mol; (20)Boiling Point: 144 °C at 760 mmHg; (21)Vapour Pressure: 2.08 mmHg at 25°C.

Uses of the Ethylene Glycol Mono-tert-butyl Ether:
It is high boiling point solvents for the paint and it's fiber wetting agents, plasticizers, organic synthesis intermediate. Besides, it can be used to produce 3-tert-butoxy-propane-1,2-diol at ambient temperature. It will need solvent H₂O and reaction time 12 hours. The yield is about 52 %.

Safety information of Ethylene Glycol Mono-tert-butyl Ether:
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. As it's flammable, keep it away from the sources of ignition.

You can still convert the following datas into molecular structure:
(1)SMILES: OCCOC(C)(C)C
(2)InChI: InChI=1/C6H14O2/c1-6(2,3)8-5-4-7/h7H,4-5H2,1-3H3
(3)InChIKey: BDLXTDLGTWNUFM-UHFFFAOYAJ
(4)Std. InChI: InChI=1S/C6H14O2/c1-6(2,3)8-5-4-7/h7H,4-5H2,1-3H3
(5)Std. InChIKey: BDLXTDLGTWNUFM-UHFFFAOYSA-N

The toxicity data of Ethylene Glycol Mono-tert-butyl Ether is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1328mg/kg (1328mg/kg)		Archives of Toxicology. Vol. 66, Pg. 368, 1992.
rat	LCLo	inhalation	2400ppm/5H (2400ppm)	BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: HEMATURIA	British Journal of Industrial Medicine. Vol. 27, Pg. 1, 1970.

Product Name

Ethylene Glycol Mono-tert-butyl Ether

Synthetic route

Ethylene Glycol Mono-tert-butyl Ether Specification

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