Glyoxylic Acid Monohydrate supplier

Name
Glyoxylic acid monohydrate
EINECS 206-058-5
CAS No. 563-96-2
Article Data6
CAS DataBase
Density 1.33 g/mL at 20 °C
Solubility water: 0.1 g/mL, clear
Melting Point 49-52 °C(lit.)
Formula C₂H₄O₄
Boiling Point 300.934 °C at 760 mmHg
Molecular Weight 92.0514
Flash Point 150.027 °C
Transport Information UN 3265 8/PG 2
Appearance white to light yellow crystalline powder
Safety 26-36/37/39-45-37/39-24-27
Risk Codes 34-43-41
Molecular Structure
Hazard Symbols C,Xi
Synonyms 2,2-dihydroxyacetate;Glyoxylic acid 1-hydrate;
PSA 63.60000
LogP -0.79440

Synthetic route

: 298-12-4
Glyoxilic acid

: 563-96-2
2,2-dihydroxyacetic acid

Conditions

Conditions	Yield
at 25℃; Kinetics; in wss. Loesungen vom pH 8.27 bis pH 9.97;
With water In water-d2 at 20℃;

: 298-12-4
Glyoxilic acid

: 98480-38-7
(4S,5S)-4,5-Dihydroxy-[1,3]dioxolane-2-carboxylic acid

B: (2,2-Dihydroxy-acetoxy)-hydroxy-acetic acid

C: 98453-07-7, 98453-08-8
(Carboxy-hydroxy-methoxy)-hydroxy-acetic acid

D: 563-96-2
2,2-dihydroxyacetic acid

Conditions

Conditions	Yield
With water at 45℃; Product distribution; effect of the concentration;

...Expand

: 7664-93-9
sulfuric acid

: 7732-18-5
water

: 298-12-4
Glyoxilic acid

: 563-96-2
2,2-dihydroxyacetic acid

Conditions

Conditions	Yield
at 25℃; Kinetics;

...Expand

: 60-35-5
acetamide

: 563-96-2
2,2-dihydroxyacetic acid

: 63327-49-1
N-acetyl-α-hydroxyglycine

Conditions

Conditions	Yield
In acetone for 20h; Heating;	100%
In acetone

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 563-96-2
2,2-dihydroxyacetic acid

: 117379-73-4
2-Hydroxy-4-(2-hydroxy-4-methoxy-phenyl)-4-oxo-butyric acid

Conditions

Conditions	Yield
at 95℃; under 50 Torr; for 3h;	100%

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 563-96-2
2,2-dihydroxyacetic acid

: 1069-48-3, 7685-44-1
rac-allylglycine

Conditions

Conditions	Yield
Stage #1: 2,2-dihydroxyacetic acid With ammonium hydroxide In ethanol at 20℃; for 0.5h; Stage #2: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In ethanol at 20℃; for 3h;	100%

: 621-84-1
O-benzyl carbamate

: 563-96-2
2,2-dihydroxyacetic acid

: 79002-45-2
N-benzyloxycarbonyl-glycine

Conditions

Conditions	Yield
In toluene at 40℃;	100%
In toluene at 40℃; for 3.5h;	100%
In toluene at 40℃; for 3.5h; Large scale reaction;	96%
In diethyl ether at 20℃; for 10h;

: 83-33-0
inden-1-one

: 563-96-2
2,2-dihydroxyacetic acid

: 114915-75-2
1-oxoindan-Δ2,α-acetic acid

Conditions

Conditions	Yield
With sulfuric acid Inert atmosphere;	100%

: 563-96-2
2,2-dihydroxyacetic acid

A: 144-62-7
oxalic acid

B: 298-12-4
Glyoxilic acid

Conditions

Conditions	Yield
With oxygen; ethylenediamine; Flavin mononucleotide In water at 15℃; under 4350.3 Torr; for 77h; glycolate oxidase, Aspergillus niger catalase, pH 8-9;	A 0.2% B 99.8%

: 626-62-0
1-iodocyclohexane

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 563-96-2
2,2-dihydroxyacetic acid

: 2-(benzyloxyamino)-2-cyclohexylethanoic acid

Conditions

Conditions	Yield
Stage #1: O-benzylhydoxylamine hydrochloride; 2,2-dihydroxyacetic acid In water at 20℃; for 3h; Condensation; Stage #2: Cyclohexyl iodide With triethyl borane In hexane; water at 20℃; for 1h; Addition; Further stages.;	99%

...Expand

: 538-32-9
benzylurea

: 298-12-4
Glyoxilic acid

: 563-96-2
2,2-dihydroxyacetic acid

A: 110668-56-9
1-benzyl-5-hydroxy-hydantoin

B: 1-benzyl-4-hydroxy-hydantoin

Conditions

Conditions	Yield
Stage #1: benzylurea; Glyoxilic acid; 2,2-dihydroxyacetic acid With acetic acid In water at 100℃; for 1h; Stage #2: With acetic acid In dichloromethane; water at 25℃; for 12h;	A 97.2% B 2.8%

...Expand

: 71397-61-0
4-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)semicarbazide

: 563-96-2
2,2-dihydroxyacetic acid

: 82206-54-0
Glyoxyilic acid (E)-4-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)semicarbazone

Conditions

Conditions	Yield
In methanol for 0.5h; Ambient temperature;	97%

: 75-30-9
2-iodo-propane

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 563-96-2
2,2-dihydroxyacetic acid

: 54837-19-3
2-(benzyloxyamino)-3-methylbutanoic acid

Conditions

Conditions	Yield
Stage #1: O-benzylhydoxylamine hydrochloride; 2,2-dihydroxyacetic acid In water at 20℃; for 3h; Condensation; Stage #2: 2-iodo-propane With triethyl borane In hexane; water at 20℃; for 1h; Addition; Further stages.;	97%

...Expand

: 1556-18-9
cyclopentyl iodide

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 563-96-2
2,2-dihydroxyacetic acid

: 2-(benzyloxyamino)-2-cyclopentylacetic acid

Conditions

Conditions	Yield
Stage #1: O-benzylhydoxylamine hydrochloride; 2,2-dihydroxyacetic acid In water at 20℃; for 3h; Condensation; Stage #2: cyclopentyl iodide With triethyl borane In hexane; water at 20℃; for 1h; Addition; Further stages.;	97%

...Expand

: 106-49-0
p-toluidine

: 829-85-6
diphenylphosphane

: 563-96-2
2,2-dihydroxyacetic acid

A: 1221419-06-2
α-(diphenylphosphanyl)-N-(p-tolyl)glycine

B: 1221419-10-8
N-tolylammonium (diphenylphosphanyl)glycolate

Conditions

Conditions	Yield
In diethyl ether Inert atmosphere;	A 97% B n/a

...Expand

: 140133-91-1
1,2-bishydroxylamino-2-methyl-1-phenylpropane

: 563-96-2
2,2-dihydroxyacetic acid

: 1,3-dihydroxy-4,4-dimethyl-5-phenylimidazolidine-2-carboxylic acid

Conditions

Conditions	Yield
In ethanol at 20℃; for 2h; Cyclization;	95%

: 513-48-4, 52152-71-3
2-butyl iodide

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 563-96-2
2,2-dihydroxyacetic acid

: 115220-56-9
α-N-benzyloxyamino-γ-methylpentanoic acid

Conditions

Conditions	Yield
Stage #1: O-benzylhydoxylamine hydrochloride; 2,2-dihydroxyacetic acid In water at 20℃; for 3h; Condensation; Stage #2: 2-butyl iodide With triethyl borane In hexane; water at 20℃; for 1h; Addition; Further stages.;	95%

...Expand

: 106-95-6
allyl bromide

: 563-96-2
2,2-dihydroxyacetic acid

: 67951-43-3
2-hydroxypent-4-enoic acid

Conditions

Conditions	Yield
With bismuth(III) chloride; zinc	95%

: dimethyl 2-ferrocenyl-2-oxoethylphosphonate

: 563-96-2
2,2-dihydroxyacetic acid

: (E)-4-ferrocenyl-4-oxobut-2-enoic acid

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.333333h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;	95%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Horner-Wadsworth-Emmons Olefination; stereoselective reaction;	95%

: 98-86-2
acetophenone

: 563-96-2
2,2-dihydroxyacetic acid

: 65245-10-5
2-hydroxy-4-oxo-4-phenyl-butyric acid

Conditions

Conditions	Yield
With indium(III) chloride at 30℃; for 72h; sonication;	94%

: 109-89-7
diethylamine

: 829-85-6
diphenylphosphane

: 563-96-2
2,2-dihydroxyacetic acid

: 1384754-29-3
diethylammonium diphenylphosphinoglycolate

Conditions

Conditions	Yield
Stage #1: diethylamine; 2,2-dihydroxyacetic acid In diethyl ether Inert atmosphere; Stage #2: diphenylphosphane In tetrahydrofuran Heating; Inert atmosphere;	94%

...Expand

: (S)-dimethyl 4,8-dimethyl-2-oxonon-7-enylphosphonate

: 563-96-2
2,2-dihydroxyacetic acid

: (S,E)-6,10-dimethyl-4-oxoundeca-2,9-dienoic acid

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at -20℃; for 1h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;	93%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Horner-Wadsworth-Emmons Olefination; stereoselective reaction;	93%

: 95-14-7
1,2,3-Benzotriazole

: 55-21-0
benzamide

: 563-96-2
2,2-dihydroxyacetic acid

: 125453-17-0
2-(1H-benzotriazol-1-yl)-2-(benzoylamino)acetic acid

Conditions

Conditions	Yield
In toluene for 3h; Heating;	92%

...Expand

: 75-64-9
tert-butylamine

: 829-85-6
diphenylphosphane

: 563-96-2
2,2-dihydroxyacetic acid

: 843664-57-3
tert-butylamino(diphenylphosphanyl)acetic acid

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 24h;	92%

...Expand

: 141-43-5
ethanolamine

: 620634-44-8
2-(1-azulenyl)-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane

: 563-96-2
2,2-dihydroxyacetic acid

: 2-(azulen-1-yl)-N-(2-hydroxyethyl)glycine

Conditions

Conditions	Yield
In methanol at 20℃; for 3h; Petasis Reaction; Inert atmosphere;	92%

...Expand

: 60-35-5
acetamide

: 104-93-8
4-Methylanisole

: 563-96-2
2,2-dihydroxyacetic acid

: Acetylamino-(2-methoxy-5-methyl-phenyl)-acetic acid

Conditions

Conditions	Yield
With sulfuric acid In formic acid for 72h; Ambient temperature;	91%

...Expand

: 110-89-4
piperidine

: 620634-44-8
2-(1-azulenyl)-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane

: 563-96-2
2,2-dihydroxyacetic acid

: 2-(azulen-1-yl)-2-(piperidin-1-yl)acetic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 4h; Petasis Reaction; Inert atmosphere;	91%

...Expand

: 563-96-2
2,2-dihydroxyacetic acid

: 4746-62-7
2-amino-2-hydroxyacetic acid

Conditions

Conditions	Yield
With ammonium acetate In water at 0℃; for 2.75h;	90.3%
With ammonia

: 110-91-8
morpholine

: 563-96-2
2,2-dihydroxyacetic acid

: 78920-08-8
morpholinohydroxyethanoic acid

Conditions

Conditions	Yield
In ethanol at 4℃; for 3h;	90%

: 6065-82-3
Ethyl diethoxyacetate

: 563-96-2
2,2-dihydroxyacetic acid

: 924-44-7
glyoxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: Ethyl diethoxyacetate; 2,2-dihydroxyacetic acid With toluene-4-sulfonic acid at 90℃; for 27h; Stage #2: With phosphorus pentoxide at 90 - 100℃; for 2h;	90%

: 73-22-3, 6912-86-3, 54-12-6, 153-94-6, 63148-28-7, 65556-72-1
L-tryptophan

: 563-96-2
2,2-dihydroxyacetic acid

: 59132-30-8
1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid

Conditions

Conditions	Yield
In sulfuric acid for 12h;	89%

: 615-13-4
2-indanone

: 563-96-2
2,2-dihydroxyacetic acid

: 318472-09-2
2-(2-oxo-indan-1-yl)-2-hydroxyacetic acid

Conditions

Conditions	Yield
for 0.133333h; microwave irradiation;	88.5%

: 5813-89-8
2-thiophenylcarboxamide

: 95-14-7
1,2,3-Benzotriazole

: 563-96-2
2,2-dihydroxyacetic acid

: 368870-43-3
benzotriazol-1-yl-[(thiophene-2-carbonyl)-amino]-acetic acid

Conditions

Conditions	Yield
In toluene for 3h; Heating;	88%

...Expand

Glyoxylic Acid Monohydrate Chemical Properties

Molecular Formula: C₂H₄O₄
Molecular Weight: 92.05
IUPAC Name: oxaldehydic acid hydrate
Synonyms: Dihydroxyacetic acid ; Formylformic acid ; Oxoethanoic acid ; Formylformic acid monohydrate ; Oxoethanoic acid monohydrate
Melting Point: 49-52 °C (lit.)
Boiling Point: 100°C (lit.)
Density of Glyoxylic acid monohydrate (563-96-2) : 1.33 g/mL at 20 °C
Refractive index: n20/D 1.414
Flash Point: >230 °F
Storage temp.: 2-8 °C
Sensitive: Hygroscopic
Enthalpy of Vaporization: 62.76 kJ/mol
Vapour Pressure: 0.000107 mmHg at 25 °C
Solubility of Glyoxylic acid monohydrate (563-96-2): H₂O: 0.1 g/mL, clear
Chemical Properties: Glyoxylic acid monohydrate (563-96-2) is a white to light yellow crystalline powder or chunks

Glyoxylic Acid Monohydrate Uses

In industrial field, Glyoxylic acid monohydrate (563-96-2) is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds.

Glyoxylic Acid Monohydrate Toxicity Data With Reference

Carcinogenicity: Glyoxylic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Water - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

Glyoxylic Acid Monohydrate Safety Profile

Hazard Codes: Corrosive C, Irritant Xi
Risk Statements: 34-43-41
34: Causes burns
43: May cause sensitization by skin contact
41: Risk of serious damage to eyes
Safety Statements: 26-36/37/39-45-37/39-24-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
37/39: Wear suitable gloves and eye/face protection
24: Avoid contact with skin
27: Take off immediately all contaminated clothing
RIDADR: UN 3265 8/PG 2
WGK Germany: 1
RTECS: MD4550000
F: 3: Hygroscopic
HazardClass: 8
PackingGroup: III

Glyoxylic Acid Monohydrate Standards and Recommendations

Assay: 98.0% min

Glyoxylic Acid Monohydrate Specification

Glyoxylic Acid Monohydrate, its cas register number is 563-96-2. It also can be called Dihydroxyacetic acid; Formylformic acid; Oxoethanoic acid, and its IUPAC name is (oxaldehydic acid hydrate. L-serine (CAS NO.56-45-1) is hygroscopic, it can absorbs moisture or water from the air. And it is incompatible with strong oxidizing agents,strong bases. L-serine's hazardous decomposition products are carbon monoxide, formaldehyde and carbon dioxide.Glyoxylic acid monohydrate (563-96-2) is a white to light yellow crystalline powder or chunks. In industrial field, Glyoxylic acid monohydrate (563-96-2) is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds. It should keep container tightly closed and keep container in a cool, well-ventilated area.

Product Name

Glyoxylic acid monohydrate

Synthetic route

Glyoxylic Acid Monohydrate Chemical Properties

Glyoxylic Acid Monohydrate Uses

Glyoxylic Acid Monohydrate Toxicity Data With Reference

Glyoxylic Acid Monohydrate Safety Profile

Glyoxylic Acid Monohydrate Standards and Recommendations

Glyoxylic Acid Monohydrate Specification

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