Product Name

  • Name

    Prednisolone

  • EINECS 200-021-7
  • CAS No. 50-24-8
  • Article Data60
  • CAS DataBase
  • Density 1.31 g/cm3
  • Solubility 2.225g/L(25 oC)
  • Melting Point 240 °C (dec.)(lit.)
  • Formula C21H28O5
  • Boiling Point 570.6 °C at 760 mmHg
  • Molecular Weight 360.45
  • Flash Point 313 °C
  • Transport Information
  • Appearance Crystalline Solid
  • Safety 22-45-36/37/39-26-16
  • Risk Codes 22-34-11
  • Molecular Structure Molecular Structure of 50-24-8 (Prednisolone)
  • Hazard Symbols HarmfulXn, CorrosiveC, FlammableF
  • Synonyms Predonin;Supercortisol;Codelcortone;Prestwick_404;Precortancyl;Cortalone;Dydeltrone;Fernisolone;Meti-Derm;Donisolone;K 1557;Paracortol;Cotogesic;Paracotol;Precortilon;Sterolone;Delcortol;Rolisone;Precortalon;Hydrodeltalone;Delta-Ef-Cortelan;Delta-cortef (TN);component of Ataraxoid;Prenolone;Cordrol;Hydeltra;(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Meticortelone;Deltacortenol;Sterane;Delta F;Precortisyl;Ulacort;Meticortelone;Sterolone;Deltisilone;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-;Decortin H;1-Dehydrohydrocortisone;Prednis;Pregna-1,4-diene-3,20-dione,11,17,21- trihydroxy-,(11a)-;Predonine;Lentosone;1, 2-Dehydrohydrocortisone;Hydroretrocortin;Deltacortril;Di-Adreson F;Derpo PD;Deltahydrocortisone;Dexa-Cortidelt Hostacortin H;Hostacortin H;Scherisolon;Hydrodeltisone;Metacortandralone;Ultracortene-H;Ultracorten H;Fernisolone P;
  • PSA 94.83000
  • LogP 1.55760

Synthetic route

methanol
67-56-1

methanol

prednisolone 21-acetate
52-21-1

prednisolone 21-acetate

A

prednisolon
50-24-8

prednisolon

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution;A n/a
B 100%
HYDROCORTISONE
50-23-7

HYDROCORTISONE

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With Rhodococcus coprophilus DSM 43347 In dimethyl sulfoxide at 30℃; for 24h; Reagent/catalyst; Green chemistry; regiospecific reaction;97%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane for 4h; Reflux;83.33%
With potassium phosphate buffer In methanol at 30℃; free and the urethane prepolymer-entrapped acetone-dried cells of Arthrobacter simplex; effect of gel hydrophobicity; effect of electron acceptors and solvents;
With 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium smegmatis mc2155; phenazine methosulfate In dimethyl sulfoxide at 30℃; for 16h; pH=8; Catalytic behavior; Kinetics; Solvent; Reagent/catalyst; Enzymatic reaction;
methanol
67-56-1

methanol

prednisolone 21-isobutyrate

prednisolone 21-isobutyrate

A

prednisolon
50-24-8

prednisolon

B

Methyl isobutyrate
547-63-7

Methyl isobutyrate

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution;A n/a
B 96%
prednisolone 21-acetate
52-21-1

prednisolone 21-acetate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With water; potassium carbonate; sodium hydroxide In methanol at 0 - 10℃; for 2h; Inert atmosphere;92.5%
With methanol; triethylamine for 14h; Ambient temperature;49%
With potassium hydroxide
Stage #1: prednisolone 21-acetate With water; sodium hydroxide In methanol; dichloromethane at 0 - 30℃; for 2.5h; Inert atmosphere;
Stage #2: With acetic acid In methanol; dichloromethane at -12 - -5℃; for 1h; pH=6 - 7; Reagent/catalyst; Reflux;
15.8 g
prednisolone 11β,21-diacetate
98523-85-4

prednisolone 11β,21-diacetate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With di(n-butyl)tin oxide In methanol for 2.5h; Heating;91%
21-<<(6-carboxy-3-cyclohexen-1-yl)carbonyl>oxy>-11β,17α-dihydroxypregna-1,4-diene-3,20-dione

21-<<(6-carboxy-3-cyclohexen-1-yl)carbonyl>oxy>-11β,17α-dihydroxypregna-1,4-diene-3,20-dione

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With methanol; triethylamine for 0.166667h; Ambient temperature; Irradiation;90%
prednisolone 21-[hydrogen (cyclohex-3-ene-1,2-dicarboxylate)]

prednisolone 21-[hydrogen (cyclohex-3-ene-1,2-dicarboxylate)]

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With methanol; triethylamine at 20℃; under 8250660 Torr; for 168h; Product distribution; Further Variations:; Reagents; Pressures;81%
methanol
67-56-1

methanol

prednisolone 21-trimethylacetate
1107-99-9

prednisolone 21-trimethylacetate

A

prednisolon
50-24-8

prednisolon

B

Methyl pivalate
598-98-1

Methyl pivalate

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution; Further Variations:; Reagents; Pressures;A n/a
B 78%
methanol
67-56-1

methanol

prednisolone 11β-acetate
104687-90-3

prednisolone 11β-acetate

A

prednisolon
50-24-8

prednisolon

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 168h; Product distribution; Further Variations:; Reagents; Pressures;A 76%
B n/a
HYDROCORTISONE
50-23-7

HYDROCORTISONE

A

prednisolon
50-24-8

prednisolon

B

11β,17α,20β,21-tetrahydroxy-1,4-pregnadiene-3-one
15847-24-2

11β,17α,20β,21-tetrahydroxy-1,4-pregnadiene-3-one

Conditions
ConditionsYield
With Rhodococcus erythropholis DSM 43188 In dimethyl sulfoxide at 30℃; for 72h; Green chemistry; regiospecific reaction;A 37%
B 40%
prednisolone 21-trimethylacetate
1107-99-9

prednisolone 21-trimethylacetate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With Curvularia lunata In water at 30℃; for 72h; Yield given;
prednisolone hemisuccinate
2920-86-7

prednisolone hemisuccinate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With methanol; triethylamine for 0.0833333h; Ambient temperature; Irradiation;67 % Chromat.
11β,17,21-trihydroxy-pregna-4-ene-3,20-dione

11β,17,21-trihydroxy-pregna-4-ene-3,20-dione

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With didymella lycopersicin
With corynebacterium simplex
With corynebacterium simplex
11β,17,21-tris-trifluoroacetoxy-5α-pregnane-3,20-dione

11β,17,21-tris-trifluoroacetoxy-5α-pregnane-3,20-dione

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; bromine
prednisolone hemisuccinate
2920-86-7

prednisolone hemisuccinate

A

prednisolon
50-24-8

prednisolon

B

succinic acid
110-15-6

succinic acid

C

prednisolone 17-hemisuccinate

prednisolone 17-hemisuccinate

Conditions
ConditionsYield
With phosphate buffer In N,N-dimethyl-formamide at 37℃; Kinetics;
prednisolone 21-hemisuccinate/β-cyclodextrin amide conjugate

prednisolone 21-hemisuccinate/β-cyclodextrin amide conjugate

A

prednisolon
50-24-8

prednisolon

B

mono(6-deoxy-6-succimino)-β-cyclodextrin

mono(6-deoxy-6-succimino)-β-cyclodextrin

Conditions
ConditionsYield
With phosphate buffer In N,N-dimethyl-formamide at 25℃; Kinetics;
oxone

oxone

11β,17α-dihydroxy-20-phenoxypregna-1,4,20-trien-3-one

11β,17α-dihydroxy-20-phenoxypregna-1,4,20-trien-3-one

Oxone

Oxone

ethylene glycol
107-21-1

ethylene glycol

A

prednisolon
50-24-8

prednisolon

B

prednisolone 21-acetate
52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With potassium hydroxide; sodium hydroxide In tetrahydrofuran; PO4; dichloromethane; water; acetone
C29H37NO6

C29H37NO6

A

2-oxoindole
59-48-3

2-oxoindole

B

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With water at 37℃; pH=7.4 - 8; Kinetics;
C30H39NO6
1154703-42-0

C30H39NO6

A

3,4-dihydro-2(1H)-quinolone
553-03-7

3,4-dihydro-2(1H)-quinolone

B

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With water at 37℃; pH=7.4 - 9; Kinetics;
C29H33NO8
1426535-35-4

C29H33NO8

A

2-oxoindole
59-48-3

2-oxoindole

B

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With sodium dithionite In acetonitrile
C29H33NO8
1426535-35-4

C29H33NO8

A

1,3-dihydro-1-hydroxyindole-2-one
18108-55-9

1,3-dihydro-1-hydroxyindole-2-one

B

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With Clostridium perfringens; brain heart infusion medium In dimethyl sulfoxide at 37℃; for 24h; pH=7.4; Enzymatic reaction;
C30H35NO8
1426535-37-6

C30H35NO8

A

3,4-dihydro-2(1H)-quinolone
553-03-7

3,4-dihydro-2(1H)-quinolone

B

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With sodium dithionite In acetonitrile
C30H35NO8
1426535-37-6

C30H35NO8

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
With Clostridium perfringens; brain heart infusion medium In dimethyl sulfoxide at 37℃; for 24h; pH=7.4; Enzymatic reaction;
hydrocortisone acetate
50-03-3

hydrocortisone acetate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methylate / methanol / 0.5 h / 20 °C
2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 4 h / Reflux
View Scheme
prednicarbate
73771-04-7

prednicarbate

A

prednisolon
50-24-8

prednisolon

B

4-(4-hydroxybenzyl)-2-(3-methylbut-2-enyl)phenyl methyl carbonate

4-(4-hydroxybenzyl)-2-(3-methylbut-2-enyl)phenyl methyl carbonate

C

Prednisolone 17-ethylcarbonate
104286-02-4

Prednisolone 17-ethylcarbonate

Conditions
ConditionsYield
With water In acetone at 25 - 28℃; for 336h; Microbiological reaction;
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate
4380-55-6

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / acetone; water / 0.5 h / 0 - 5 °C
1.2: 0 - 5 °C
2.1: zinc; chromium(VI) oxide; mercaptoacetic acid / acetone; dimethyl sulfoxide / 15 - 20 °C
2.2: 1 h
2.3: 0.33 h
3.1: sodium hydroxide; potassium carbonate; water / methanol / 2 h / 0 - 10 °C / Inert atmosphere
View Scheme
(10S,13S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
10184-69-7

(10S,13S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one

prednisolon
50-24-8

prednisolon

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap / chloroform / 0.17 h
1.2: 10 - 20 °C
2.1: sulfuric acid / acetone; water / 0.5 h / 0 - 5 °C
2.2: 0 - 5 °C
3.1: zinc; chromium(VI) oxide; mercaptoacetic acid / acetone; dimethyl sulfoxide / 15 - 20 °C
3.2: 1 h
3.3: 0.33 h
4.1: sodium hydroxide; potassium carbonate; water / methanol / 2 h / 0 - 10 °C / Inert atmosphere
View Scheme
prednisolon
50-24-8

prednisolon

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid
37927-29-0

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0 02,7. 011,15]heptadeca-3,6-diene-14-carboxylic acid

Conditions
ConditionsYield
With periodic acid In tetrahydrofuran; methanol at 20℃; for 2h;100%
With sodium periodate; sulfuric acid In methanol; water at 20℃; for 16h; Inert atmosphere;98.8%
With sodium periodate In methanol; water for 0.5h; Heating; Large scale;97%
prednisolon
50-24-8

prednisolon

diethyl dicarbonate
1609-47-8

diethyl dicarbonate

Prednisolone 21-ethylcarbonate

Prednisolone 21-ethylcarbonate

Conditions
ConditionsYield
In acetone for 0.5h; Heating;100%
prednisolon
50-24-8

prednisolon

acetic anhydride
108-24-7

acetic anhydride

prednisolone 21-acetate
52-21-1

prednisolone 21-acetate

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 40℃; for 0.5h; Inert atmosphere;99.8%
With pyridine98%
With pyridine
With dmap at 60 - 65℃; for 6h; Time;55.1 g
With sodium acetate In tetrahydrofuran; acetone at 40℃; for 3h; Reagent/catalyst; Inert atmosphere;
prednisolon
50-24-8

prednisolon

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-mesylate
35410-28-7

11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-mesylate

Conditions
ConditionsYield
With pyridine for 0.5h;99.2%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;91%
prednisolon
50-24-8

prednisolon

trimethyl 3-(methoxycarbonyl)orthopropionate
71235-00-2

trimethyl 3-(methoxycarbonyl)orthopropionate

11β-hydroxy-17α,21-(1-methoxy-3-methoxycarbonylpropylidenedioxy)-1,4-pregnadiene-3,20-dione
102113-12-2

11β-hydroxy-17α,21-(1-methoxy-3-methoxycarbonylpropylidenedioxy)-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 4h; Heating;99%
prednisolon
50-24-8

prednisolon

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C25H34O6
137759-51-4

C25H34O6

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In benzene for 1h; Heating;97%
prednisolon
50-24-8

prednisolon

p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

prednisolone 21-[4'-(chloromethyl)benzoate]

prednisolone 21-[4'-(chloromethyl)benzoate]

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 18h;97%
prednisolon
50-24-8

prednisolon

chloroacetyl chloride
79-04-9

chloroacetyl chloride

prednisolone 21-chloroacetate
100931-13-3

prednisolone 21-chloroacetate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 18h;95%
succinic acid anhydride
108-30-5

succinic acid anhydride

prednisolon
50-24-8

prednisolon

prednisolone hemisuccinate
2920-86-7

prednisolone hemisuccinate

Conditions
ConditionsYield
With pyridine at 20℃; for 24h;92%
Stage #1: succinic acid anhydride; prednisolon With pyridine at 20℃; for 24h;
Stage #2: With hydrogenchloride In water Cooling with ice;
63%
prednisolon
50-24-8

prednisolon

orthocarbonic acid tetraethyl ester
78-09-1

orthocarbonic acid tetraethyl ester

prednisolone-17,21-diethylorthocarbonate
26129-79-3

prednisolone-17,21-diethylorthocarbonate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In 1,4-dioxane at 22℃; for 17h;90%
prednisolon
50-24-8

prednisolon

acetic anhydride
108-24-7

acetic anhydride

prednisolone 11β,21-diacetate
98523-85-4

prednisolone 11β,21-diacetate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 25℃; for 17h;90%
With pyridine; dmap at 20℃; for 0.5h;
prednisolon
50-24-8

prednisolon

C14H19NO4
1070955-54-2

C14H19NO4

3-(2-(tert-butoxycarbonylamino)phenyl)propionic acid 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl ester
1314005-13-4

3-(2-(tert-butoxycarbonylamino)phenyl)propionic acid 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 3h;90%
prednisolon
50-24-8

prednisolon

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

Prednisolone 21-ethylcarbonate

Prednisolone 21-ethylcarbonate

Conditions
ConditionsYield
With pyridine at 22℃; for 2h;88.3%
prednisolon
50-24-8

prednisolon

(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
898-84-0

(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

Conditions
ConditionsYield
In water; acetonitrile at 20℃; Electrochemical reaction;87%
With bithmuth(III) triflate hydrate In 1,4-dioxane at 80℃; chemoselective reaction;78%
With zinc(II) chloride In tetrahydrofuran for 8h; Reagent/catalyst; Reflux; Inert atmosphere;76%
prednisolon
50-24-8

prednisolon

m-sulfobenzoic acid, monosodium salt
17625-03-5

m-sulfobenzoic acid, monosodium salt

prednisolone sodium metasulfobenzoate

prednisolone sodium metasulfobenzoate

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 95℃; for 18h; Inert atmosphere;86%
prednisolon
50-24-8

prednisolon

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

prednisolone 21-palmitate

prednisolone 21-palmitate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Steglich Esterification; Inert atmosphere;85%
prednisolon
50-24-8

prednisolon

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

prednisolone 21-(4-nitrophenylcarbonate)
1422676-54-7

prednisolone 21-(4-nitrophenylcarbonate)

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 10h;84%
prednisolon
50-24-8

prednisolon

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

21-O-diphenylphosphorylprednisolone

21-O-diphenylphosphorylprednisolone

Conditions
ConditionsYield
With pyridine N-oxide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 20℃; for 2h; Inert atmosphere; chemoselective reaction;83%
prednisolon
50-24-8

prednisolon

4-bromobutyroyl chloride
927-58-2

4-bromobutyroyl chloride

prednisolone 21-(4'-bromobutyrate)

prednisolone 21-(4'-bromobutyrate)

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 4h;82%
prednisolon
50-24-8

prednisolon

3-(Chloromethyl)benzoyl chloride
63024-77-1

3-(Chloromethyl)benzoyl chloride

prednisolone 21-[3'-(chloromethyl)benzoate]

prednisolone 21-[3'-(chloromethyl)benzoate]

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 18h;82%
prednisolon
50-24-8

prednisolon

11β,21-Dihydroxy-pregn-1,4-diene-3,20-dione
13479-38-4

11β,21-Dihydroxy-pregn-1,4-diene-3,20-dione

Conditions
ConditionsYield
With trimethylsilyl iodide In acetonitrile for 1h; Ambient temperature;80%
prednisolon
50-24-8

prednisolon

Boc-His(Tos)-Gly-Lys(Z)-NHNH2

Boc-His(Tos)-Gly-Lys(Z)-NHNH2

2-amino-N-{[5-amino-1-(11,17-dihydroxy-17-hydroxyacetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-ylidene-hydrazinocarbonyl)-pentylcarbamoyl]-methyl}-3-(3H-imidazol-4-yl)-propionamide

2-amino-N-{[5-amino-1-(11,17-dihydroxy-17-hydroxyacetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-ylidene-hydrazinocarbonyl)-pentylcarbamoyl]-methyl}-3-(3H-imidazol-4-yl)-propionamide

Conditions
ConditionsYield
Stage #1: prednisolon; Boc-His(Tos)-Gly-Lys(Z)-NHNH2 With acetic acid In methanol at 20℃; for 48h; pH=2;
Stage #2: With dimethylsulfide; trifluorormethanesulfonic acid; trifluoroacetic acid at 0℃; for 2h;
80%
prednisolon
50-24-8

prednisolon

prednisolone 20-hydrazone
1315514-34-1

prednisolone 20-hydrazone

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 40℃; for 2h;80%

Hydrodeltalone Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Hydrodeltalone Specification

The Hydrodeltalone, with the CAS registry number 50-24-8, is also known as 11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione; 1,4-Pregnadiene-11b,17a,21-triol-3,20-dione. It belongs to the product categories of Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone.This chemical's molecular formula is C21H28O5 and molecular weight is 360.45.Its EINECS number is 200-021-7.What's more,Its systematic name is Prednisolone.It is Crystalline Solid.It is a glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Physical properties about Hydrodeltalone are:
(1)ACD/LogP: 1.635; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.64; (4)ACD/LogD (pH 7.4): 1.64; (5)ACD/BCF (pH 5.5): 10.29; (6)ACD/BCF (pH 7.4): 10.29; (7)ACD/KOC (pH 5.5): 184.65; (8)ACD/KOC (pH 7.4): 184.65; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.612; (13)Molar Refractivity: 95.481 cm3; (14)Molar Volume: 274.7 cm3; (15)Surface Tension: 60.7360000610352 dyne/cm; (16)Density: 1.312 g/cm3; (17)Flash Point: 312.953 °C; (18)Enthalpy of Vaporization: 98.3 kJ/mol; (19)Boiling Point: 570.629 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C;

You can still convert the following datas into molecular structure:
(1)SMILES:O=C\1\C=C/[C@]4(/C(=C/1)CC[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@@H]23)C)C;
(2)Std. InChI:InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;
(3)Std. InChIKey:OIGNJSKKLXVSLS-VWUMJDOOSA-N.

Safety Information of Hydrodeltalone:
The Hydrodeltalone is highly flammable.Keep it far away from sources of ignition - No smoking. It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.When you use it ,wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

The toxicity data of Prednisolone as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 9mg/kg/2W-I (9mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984.
mouse LD50 intraperitoneal 65mg/kg (65mg/kg)   Indian Drugs. Vol. 22, Pg. 529, 1985.
mouse LD50 intravenous 180mg/kg (180mg/kg)   Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982.
mouse LD50 oral 1680mg/kg (1680mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970.
mouse LD50 subcutaneous > 3500mg/kg (3500mg/kg)   Drugs in Japan Vol. 6, Pg. 710, 1982.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg)   Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat LD50 intravenous 120mg/kg (120mg/kg)   Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982.
rat LD50 subcutaneous 147mg/kg (147mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
women TDLo oral 14mg/kg/13D-I (14mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984.

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