Hypoxanthine supplier | CasNO.68-94-0

Name
6-Hydroxypurine
EINECS 200-697-3
CAS No. 68-94-0
Article Data148
CAS DataBase
Density 1.892 g/cm³
Solubility practically insoluble in water
Melting Point 250 °C
Formula C₅H₄N₄O
Boiling Point 533.428 °C at 760 mmHg
Molecular Weight 136.113
Flash Point 276.407 °C
Transport Information
Appearance White to off-white powder
Safety 22-24/25-37/39-26-36
Risk Codes 36/37/38-22-40
Molecular Structure
Hazard Symbols Xn
Synonyms Sarcine;9H-Purin-6-ol (VAN);Hypoxanthine enol;3,7-dihydropurin-6-one;3,5-dihydropurin-6-one;Hypoxanthine (VAN) (8CI);3H-Purin-6-ol;9H-Purin-6(1H)-one;1,9-Dihydro-purin-6-one;Sarkine;Hyp;Purin-6(3H)-one;25991-09-7;HX;Sarkin;Purine-6-ol;Purin-6(1H)-one;6H-Purin-6-one, 1,7-dihydro-;6(1H)-purinone;1,7-Dihydro-6H-purin-6-one;6H-Purin-6-one,1,7-dihydro-;39464-15-8;Purin-6-ol;9H-purin-6-ol;6-Hydroxypurine;6-Hydroxypurine (Hypoxanthine);
PSA 74.43000
LogP -0.35380

Synthetic route

: 64-18-6
formic acid

: 4316-98-7
6-chloro-4,5-diaminopyrimidine

A: 64194-58-7
6-amino-5-formylamino-3H-pyrimidin-4-one

B: 68-94-0
1,7-dihydro-6H-purin-6-one

...Expand

: 69-93-2
uric Acid

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

A: 68-94-0
1,7-dihydro-6H-purin-6-one

B: 69-89-6
xanthin

Conditions

Conditions	Yield
With water at 180 - 200℃;

...Expand

: 64-18-6
formic acid

: 7132-71-0
5-amino-3-β-D-ribofuranosyl-3H-imidazole-4-carboxylic acid amide

: 108-24-7
acetic anhydride

A: 5627-15-6, 5627-18-9, 10280-01-0, 10280-02-1, 19895-30-8
7-β-D-ribofuranosyl-1,7-dihydro-purin-6-one

B: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
und Erwaermen des Reaktionsprodukts mit wss.KHCO3;

...Expand

: 52502-66-6, 102783-18-6, 120568-21-0
5,6-diamino-3H-pyrimidin-4-one; sulfate

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With formic acid

: 108-24-7
acetic anhydride

: 16014-63-4
aminomalonamamidine dihydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 68-94-0
1,7-dihydro-6H-purin-6-one

...Expand

: 52502-66-6, 102783-18-6, 120568-21-0
5,6-diamino-3H-pyrimidin-4-one; sulfate

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 7501-32-8
N-(5-amino-6-chloropyrimidin-4-yl)formamide

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 21214-07-3
[5']inosinic acid

A: 3615-55-2, 7591-07-3, 13137-52-5, 66768-39-6, 69881-36-3, 69881-39-6, 136376-80-2, 136376-83-5, 136376-85-7, 136376-88-0, 136376-89-1, 4300-28-1
D-ribose 5-phosphate

B: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
zeitlicher Verlauf der Hydrolyse.Hydrolysis;

: 73-24-5
7H-purin-6-ylamine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
durch Enzymwirkung; z. B. durch faulenden Pankreasextrakt unter Luftabschluss;
durch Faeulnisbakterien;
durch Schweinemilzferment;

: 631-61-8
ammonium acetate

: 122-51-0
orthoformic acid triethyl ester

: 90877-70-6, 4977-62-2
ethyl 2-acetamido-2-cyanoacetate

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With ammonia at 180℃;

...Expand

: 67-66-3
chloroform

: furan-2,3,5(4H)-trione pyridine (1:1)

: 69-89-6
xanthin

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
at 60 - 70℃;

...Expand

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 69-89-6
xanthin

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
at 200℃;

: 69-89-6
xanthin

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With sodium hydroxide; chloroform at 60 - 70℃;
With garcinielliptone HA; xanthine oxidase In water at 25℃; for 0.0833333h; pH=7.5; Kinetics; Reagent/catalyst; Time; Concentration; aq. phosphate buffer; Enzymatic reaction;

: 58-61-7
adenosine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
mit Hilfe von Bacterium-coli;
Hydrolyse und Desaminierung bei der Einwirkung von Escherichia coli und anderen Bakterien.Hydrolysis;

: 58-63-9
Inosine

A: 532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7
D-Ribose

B: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With trisodium arsenate; nucleoside phosphorylase
With trisodium arsenate; nucleoside phosphorylase Ambient temperature;

: 58-63-9
Inosine

A: 18646-11-2, 19993-20-5, 21317-51-1, 27638-61-5, 50574-24-8, 51501-98-5, 72075-46-8, 98243-09-5, 119240-26-5, 14075-00-4
ribofuranose-1-phosphate

B: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With nucleoside phosphorylase
With Pi; nucleoside phosphorylase (enzyme) Rate constant;

1,7-dihydro-<1 or 3-15N>purin-6-one: 1,7-dihydro-<1 or 3-15N>purin-6-one

: 68-94-0
1,7-dihydro-6H-purin-6-one

1,7-dihydro-<4-14C>purin-6-one: 1,7-dihydro-<4-14C>purin-6-one

: 68-94-0
1,7-dihydro-6H-purin-6-one

1,7-dihydro-<8-14C>purin6-one: 1,7-dihydro-<8-14C>purin6-one

: 68-94-0
1,7-dihydro-6H-purin-6-one

2.8-dichloro-6-ethoxy-purine: 2.8-dichloro-6-ethoxy-purine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With phosphorous; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphonium iodide; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphorous; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphonium iodide; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;

2.8-dichloro-6-oxy-purine: 2.8-dichloro-6-oxy-purine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With phosphonium iodide; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphorous; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphorous; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;
With phosphonium iodide; hydrogen iodide at 25℃; durch nachfolgendes Erwaermen auf dem Wasserbad;

2-mercapto-adenine: 2-mercapto-adenine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With nitric acid

2-thio-xanthine: 2-thio-xanthine

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With nitric acid

: 3647-48-1
6-amino-3,7-dihydro-purine-2-thione

: 7697-37-2
nitric acid

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 2487-40-3
2-thioxanthine

: 7697-37-2
nitric acid

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

2-formylamino-malonomonoimidic acid diamide hydrochloride: 2-formylamino-malonomonoimidic acid diamide hydrochloride

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
at 185℃;

: 141-52-6
sodium ethanolate

5-amino-1(3)H-imidazole-4-carboxylic acid formylamide: 5-amino-1(3)H-imidazole-4-carboxylic acid formylamide

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
With ethanol
With potassium hydrogencarbonate

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

5-amino-1(3)H-imidazole-4-carboxylic acid: 5-amino-1(3)H-imidazole-4-carboxylic acid

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
at 185℃;

AMP: AMP

: 68-94-0
1,7-dihydro-6H-purin-6-one

Conditions

Conditions	Yield
mit Hilfe von Bacterium-coli;

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 6-chloropurine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; trichlorophosphate In dichloromethane; N,N-dimethyl-aniline	99%

: 617-89-0
furan-2-ylmethanamine

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 525-79-1
kinetin

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 72h;	90%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃; for 72h;	90 % Chromat.

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 503173-75-9
13C5-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose

: 503173-78-2
[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)hypoxanthine

Conditions

Conditions	Yield
Stage #1: 1,7-dihydro-6H-purin-6-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Heating; Stage #2: 13C5-1′, 2 ′-di-O-acetyl-3 ′ ,5 ′-di-O-benzoyl-β-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate In dichloromethane for 2.5h; Heating;	86%

: copper(II) perchlorate hexahydrate

: 4097-89-6
2,2',2''-triaminotriethylamine

: 68-94-0
1,7-dihydro-6H-purin-6-one

: [(Cu(tris(2-aminoethyl)amine))2(hypoxanthinato)](ClO4)3

Conditions

Conditions	Yield
With NaOH In methanol; water an aq. soln. of hypoxanthine and a MeOH soln. of N(C2H4NH2)3 and Cu saltmixed, pH adjusted to 8-9 with NaOH soln.; crystd. at room temp. for 3 wk; elem. anal.;	81%

...Expand

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 88166-56-7
6-chloropurine methanesulfonate

Conditions

Conditions	Yield
With trichlorophosphate In methanesulfonic acid; dichloromethane; N,N-dimethyl-aniline	78%

: zinc perchlorate

: 4097-89-6
2,2',2''-triaminotriethylamine

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 1145782-16-6
[Zn(tris(2-aminoethyl)amine)(hypoxanthinato)]ClO4*H2O

Conditions

Conditions	Yield
With NaOH In methanol; water an aq. soln. of hypoxanthine and a MeOH soln. of N(C2H4NH2)3 and Zn saltmixed, pH adjusted to 8-9 with NaOH soln.; crystd. at room temp. for 3 wk; elem. anal.;	78%

...Expand

: cadmium(II) perchlorate hexahydrate

: 4097-89-6
2,2',2''-triaminotriethylamine

: 68-94-0
1,7-dihydro-6H-purin-6-one

: [(Cd(tris(2-aminoethyl)amine))2(hypoxanthinato)](ClO4)3*0.5H2O

Conditions

Conditions	Yield
With NaOH In methanol; water an aq. soln. of hypoxanthine and a MeOH soln. of N(C2H4NH2)3 and Cd saltmixed, pH adjusted to 8-9 with NaOH soln.; crystd. at room temp. for 1 mo; elem. anal.;	54%

...Expand

: 108-86-1
bromobenzene

: 68-94-0
1,7-dihydro-6H-purin-6-one

A: 6334-42-5
1,9-dihydro-9-phenyl-6H-purin-6-one

B: 62382-64-3
7-phenylhypoxanthine

Conditions

Conditions	Yield
With N4,N7-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; potassium hydroxide; copper(I) bromide In water; N,N-dimethyl-formamide at 120℃; for 32h; Inert atmosphere; Sealed tube; regioselective reaction;	A 48% B 11%

...Expand

: 591-50-4
iodobenzene

: 68-94-0
1,7-dihydro-6H-purin-6-one

A: 6334-42-5
1,9-dihydro-9-phenyl-6H-purin-6-one

B: 62382-64-3
7-phenylhypoxanthine

Conditions

Conditions	Yield
With N4,N7-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; potassium hydroxide; copper(I) bromide In water; N,N-dimethyl-formamide at 120℃; for 6h; Inert atmosphere; Sealed tube; regioselective reaction;	A 43% B 14%

...Expand

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 67-63-0
isopropyl alcohol

: 4C5H2N4O(2-)*4C3H8O*5Li(1+)*3H(1+)

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; lithium tert-butoxide In N,N-dimethyl-formamide at 100℃; for 72h;	31%

: 64-17-5
ethanol

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 4C5H2N4O(2-)*4C2H6O*5Li(1+)*3H(1+)

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; lithium tert-butoxide In N,N-dimethyl-formamide at 100℃; for 72h;	13%

: 2525-16-8
O-methylcaprolactim

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 33155-83-8
1,7-dimethylhypoxanthine

: 13414-33-0
7-ethoxy-3,4,5,6-tetrahydro-2H-azepine

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 113977-05-2
1,7-diethyl-1,7-dihydro-purin-6-one

: 305-80-6
4-diazobenzenesulfonic acid

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 4-(6-oxo-6,7-dihydro-1H-purin-8-ylazo)-benzenesulfonic acid

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 97-55-2, 7540-64-9, 99945-37-6, 130384-52-0
5-phosphoribosyl-1-pyrophosphate

: 21214-07-3
[5']inosinic acid

Conditions

Conditions	Yield
mit Hypoxanthin-phosphoribosyltransferase aus Hefe bzw.Rinderleber;

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 121-44-8
triethylamine

: 6284-24-8
6-diethylaminopurine

Conditions

Conditions	Yield
With trichlorophosphate

: 3615-55-2, 7591-07-3, 13137-52-5, 66768-39-6, 69881-36-3, 69881-39-6, 136376-80-2, 136376-83-5, 136376-85-7, 136376-88-0, 136376-89-1, 4300-28-1
D-ribose 5-phosphate

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 56-65-5
ATP

: 21214-07-3
[5']inosinic acid

Conditions

Conditions	Yield
mit Enzym-Praeparat aus Rinderleber bzw. aus Taubenleber;

...Expand

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 74-88-4
methyl iodide

: 1,7-dimethyl-1,7-dihydro-purin-6-one; sodium iodide compound

Conditions

Conditions	Yield
With sodium hydroxide

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 50-44-2
6H-purine-6-thione

Conditions

Conditions	Yield
With tetraphosphorus decasulfide; tetralin
With pyridine; tetraphosphorus decasulfide
Multi-step reaction with 2 steps 1: N,N-dimethyl-aniline; POCl3 2: ethanol View Scheme

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 69-93-2
uric Acid

Conditions

Conditions	Yield
With oxygen In various solvent(s) Kinetics; Km, Ki,slope, Vmax; xanthine oxidase;
With bovine spleen-extract; oxygen
With oxygen

: 68-94-0
1,7-dihydro-6H-purin-6-one

: 21214-07-3
[5']inosinic acid

Conditions

Conditions	Yield
With by means of cultures of a(n) bacillus subtilis-mutant

Hypoxanthine Chemical Properties

Product Name:6-Hydroxypurine
Synonyms:1,7-dihydro-6h-purin-6-on;6-Hydroxy-1H-purine;6-Oxopurine;1,7-Dihydro-6H-purine-6-one;3H-Purin-6-ol;4-Hydroxy-1H-purine;6-Hydropurine;6H-Purin-6-one, 1,7-dihydro-;
1,7-dihydro-6h-purin-6-on is the chemical compound with the formula C₅H₄N₄O.Its molecular weight is 136.11.It is white to off-white power.
Melting point:>300 °C(lit.)
storage temp.:2-8°C
solubility:1 M NaOH: 25 mg/mL
WATER Solubility:practically insoluble

Hypoxanthine Toxicity Data With Reference

ipr-mus LD50:750 mg/kg

NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 .

Hypoxanthine Consensus Reports

Reported in EPA TSCA Inventory.

Hypoxanthine Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Hypoxanthine's hazard Codes: Xn
Risk Statements:
20:Harmful by inhalation
40:Limited evidence of a carcinogenic effect
36/37/38: Irritating to eyes, respiratory system and skin
Hypoxanthine's safety Statements:
22:Do not breathe dust
26:In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36:Wear suitable protective clothing
24/25:Avoid contact with skin and eyes
37/39:Wear suitable gloves and eye/face protection
WGK Germany:3

Product Name

6-Hydroxypurine

Synthetic route

Hypoxanthine Chemical Properties

Hypoxanthine Toxicity Data With Reference

Hypoxanthine Consensus Reports

Hypoxanthine Safety Profile

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