Imidazo[1,2-a]pyridine supplier

Name
Imidazo[1,2-a]pyridine
EINECS
CAS No. 274-76-0
Article Data48
CAS DataBase
Density 1.142 g/cm³
Solubility
Melting Point
Formula C₇H₆N₂
Boiling Point 103oC (1 mmHg)
Molecular Weight 118.138
Flash Point 113oC
Transport Information
Appearance
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3a-Diazaindene;1-Azaindolizine;Pyridino[1',2':1,2]glyoxaline;Pyrimidazole;
PSA 17.30000
LogP 1.33430

Synthetic route

: 504-29-0
2-aminopyridine

: 107-20-0
2-chloroethanal

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
at 70℃;	100%
With sodium hydrogencarbonate In ethanol for 2h; Heating;	90%
In water; butan-1-ol at 130℃; for 12h;	90%

: 6200-60-8
imidazo[1,2-a]pyridine-3-carboxylic acid

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With C46H48N6O5Pd; potassium acetate In N,N-dimethyl acetamide at 160℃; for 24h; Inert atmosphere;	99%

: 4926-47-0
3-bromoimidazo[1,2-a]pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 25℃; for 2h; Inert atmosphere;	83%

: 7,7-(3-Oxa-1,5-pentanediyl)-7,8-dihydroimidazo<1,2-a>pyrazinium perchlorate

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 2h; Heating;	72%

: 504-29-0
2-aminopyridine

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Stage #1: Bromoacetaldehyde diethyl acetal With hydrogenchloride In ethanol for 1.5h; Reflux; Stage #2: 2-aminopyridine With sodium hydrogencarbonate at 20℃; for 2h; pH=Ca. 7;	62.2%
Stage #1: Bromoacetaldehyde diethyl acetal With hydrogenchloride In water at 80℃; for 0.5h; Stage #2: 2-aminopyridine With sodium hydrogencarbonate In water at 20℃; for 2h; pH=7;	55.9%
With sodium carbonate In 1,4-dioxane; water for 22h; Cyclization; Tschitschibabin reaction; Heating;	19%

: 69214-12-6
3,5-dibromoimidazo<1,2-a>pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 12h; Heating;	34%
With hydrazine hydrate In ethanol for 12h; Product distribution; Heating; various solvents and reaction conditions;

: 111753-05-0
5-bromo-3-nitroimidazo<1,2-a>pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 0.5h; Heating;	20%
With hydrazine hydrate In ethanol for 0.5h; Product distribution; Heating; various solvents and reaction conditions;

: 1072-98-6
5-chloro-2-pyridylamine

: 1526-73-4
3-chloro-2-hydroxy-naphthalene-1,4-dione

A: 274-76-0
imidazo[1,2-a]pyridine

B: 192654-05-0
2-chloro-6,11-dihydro-6,11-dioxo-naphtho-[2',3':4,5]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium bicarbonate; sodium chloride In 1,2-dimethoxyethane; dichloromethane; water	A n/a B 4%

...Expand

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 19798-80-2
2-Amino-4-chloropyridine

A: 274-76-0
imidazo[1,2-a]pyridine

B: 192654-11-8
10-chloro-5,6-dihydro-5,6-dioxonaphtho-[1',2':4,5]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
In methanol; glycerol	A n/a B 2%

...Expand

1,2-dihydro-1,2-dioxo-4-sulfonate of potassium naphthalene: 1,2-dihydro-1,2-dioxo-4-sulfonate of potassium naphthalene

: 21717-96-4
2-amino-5-fluoropyridine

A: 274-76-0
imidazo[1,2-a]pyridine

B 5,6-Dihydro-5,6-dioxo-5-fluoro-naphtho[1',2':4,5]imidazo[1,2-a] pyridine: 5,6-Dihydro-5,6-dioxo-5-fluoro-naphtho[1',2':4,5]imidazo[1,2-a] pyridine

Conditions

Conditions	Yield
In water	A n/a B 2%

...Expand

: 504-29-0
2-aminopyridine

: 7252-83-7
1-bromo-2,2-dimethoxyethane

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
at 150 - 160℃; im Rohr;
Stage #1: 2-aminopyridine; 1-bromo-2,2-dimethoxyethane With hydrogenchloride In 1,4-dioxane; water Reflux; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water for 22h; Reflux;
Stage #1: 2-aminopyridine; 1-bromo-2,2-dimethoxyethane With hydrogenchloride In 1,4-dioxane; water Reflux; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water for 22h; Reflux;
Stage #1: 2-aminopyridine; 1-bromo-2,2-dimethoxyethane With hydrogenchloride In water Reflux; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water for 22h; Reflux;
Stage #1: 2-aminopyridine; 1-bromo-2,2-dimethoxyethane With hydrogenchloride In 1,4-dioxane; water Reflux; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water for 22h; Reflux;

: 504-29-0
2-aminopyridine

: 17157-48-1
bromoacetaldehyde

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
at 200 - 210℃; im Rohr;
In ethanol Heating;

: 85102-38-1
2-Morpholinomethyl-1-(2-propynyl)-imidazole

A: 274-76-0
imidazo[1,2-a]pyridine

B: 7,7-(3-Oxa-1,5-pentanediyl)-7,8-dihydroimidazo<1,2-a>pyrazinium perchlorate

Conditions

Conditions	Yield
With perchloric acid; water 1.) MeOH, 5 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
With perchloric acid; water In methanol Mechanism; Product distribution;
With perchloric acid; water 1.) MeOH, 50 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

: 74149-50-1
1H-imidazo<1,2-a>pyridinium-8-carboxylate

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
at 250 - 270℃; for 4h;

2,3-dihydro-imidazole<1,2-α>pyridine: 2,3-dihydro-imidazole<1,2-α>pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With water; sodium hydrogencarbonate; potassium hexacyanoferrate(III)
With lead(IV) acetate; benzene

: 19798-81-3
2-Amino-6-bromopyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 79 percent / ethanol / 6 h / Heating 2: 90 percent / fuming nitric acid, conc. sulphuric acid 3: hydrazine hydrate / ethanol / 0.5 h / Heating; various solvents and reaction conditions View Scheme
Multi-step reaction with 3 steps 1: 79 percent / ethanol / 6 h / Heating 2: 80 percent / N-bromosuccinimide / CH2Cl2; CHCl3 / Ambient temperature 3: hydrazine hydrate / ethanol / 12 h / Heating; various solvents and reaction conditions View Scheme

: 69214-09-1
5-bromoimidazo<1,2-a>pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / fuming nitric acid, conc. sulphuric acid 2: hydrazine hydrate / ethanol / 0.5 h / Heating; various solvents and reaction conditions View Scheme
Multi-step reaction with 2 steps 1: 80 percent / N-bromosuccinimide / CH2Cl2; CHCl3 / Ambient temperature 2: hydrazine hydrate / ethanol / 12 h / Heating; various solvents and reaction conditions View Scheme

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 3.8 g / 0.08 h / 130 °C 2: 1.) aq. sodium hydroxide, 2.) aq. HCl / 1.) reflux, 3 - 4 h, 2.) heating, 10 min 3: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 4: 4 h / 250 - 270 °C View Scheme
Multi-step reaction with 5 steps 1: 3.8 g / 0.08 h / 130 °C 2: 8.3 g / aq. sodium hydroxide, hydrogen peroxide / ethanol / 1 h / 50 °C 3: 1.) aq. HCl, 2.) aq. sodium nitrite / 1.) 50 deg C, 1 h, 2.) 30 min, reflux 4: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 5: 4 h / 250 - 270 °C View Scheme
Multi-step reaction with 5 steps 1: 3.8 g / 0.08 h / 130 °C 2: 4.2 g / Ba(OH)2*8H2O / H2O / 4 h / Heating 3: 1.7 g / aq. HCl / H2O / 0.25 h / Heating 4: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 5: 4 h / 250 - 270 °C View Scheme

: 74149-49-8
N-(3-carboxy-2-pyridyl)aminoacetaldehyde

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 2: 4 h / 250 - 270 °C View Scheme

: 74149-44-3
N-(3-cyano-2-pyridyl)aminoacetaldehyde dimethyl acetal

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) aq. sodium hydroxide, 2.) aq. HCl / 1.) reflux, 3 - 4 h, 2.) heating, 10 min 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme
Multi-step reaction with 4 steps 1: 8.3 g / aq. sodium hydroxide, hydrogen peroxide / ethanol / 1 h / 50 °C 2: 1.) aq. HCl, 2.) aq. sodium nitrite / 1.) 50 deg C, 1 h, 2.) 30 min, reflux 3: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 4: 4 h / 250 - 270 °C View Scheme
Multi-step reaction with 4 steps 1: 4.2 g / Ba(OH)2*8H2O / H2O / 4 h / Heating 2: 1.7 g / aq. HCl / H2O / 0.25 h / Heating 3: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 4: 4 h / 250 - 270 °C View Scheme

: 74149-47-6
N-(3-carboxamido-2-pyridyl)aminoacetaldehyde dimethyl acetal

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) aq. HCl, 2.) aq. sodium nitrite / 1.) 50 deg C, 1 h, 2.) 30 min, reflux 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme

: 74149-46-5
N-(3-carboxy-2-pyridyl)aminoacetaldehyde dimethyl acetal

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.7 g / aq. HCl / H2O / 0.25 h / Heating 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme

: 85102-38-1
2-Morpholinomethyl-1-(2-propynyl)-imidazole

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) water, 2.) HClO4 / 1.) MeOH, 50 deg C, 2 h 2: 72 percent / aq. NaOH / methanol / 2 h / Heating View Scheme

: 504-29-0
2-aminopyridine

aqueous chloroacetaldehyde: aqueous chloroacetaldehyde

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With ammonia In methanol

: 109-09-1
2-chloropyridine

: 1072-98-6
5-chloro-2-pyridylamine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With trichlorophosphate

: 288-36-8
1,2,3-triazole

: 109-04-6
2-bromo-pyridine

: 274-76-0
imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
at 160℃; for 14h;

: 274-76-0
imidazo[1,2-a]pyridine

: 104-92-7
1-bromo-4-methoxy-benzene

: 1338248-76-2
3-(4-methoxylphenyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With C27H22N4O2Pd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Catalytic behavior; Schlenk technique; Inert atmosphere;	100%
With palladium 10% on activated carbon; potassium acetate In i-Amyl alcohol at 150℃; for 16h; Inert atmosphere; Green chemistry;	93%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	80%

: 274-76-0
imidazo[1,2-a]pyridine

: 623-00-7
4-bromobenzenecarbonitrile

: 59182-08-0
4-(imidazo[1,2-a]pyridin-3-yl)benzonitrile

Conditions

Conditions	Yield
With C27H22N4O2Pd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Catalytic behavior; Schlenk technique; Inert atmosphere;	100%
With sodium acetate In N,N-dimethyl acetamide at 166℃; for 12h; Inert atmosphere; Sonication; regioselective reaction;	95%
With palladium 10% on activated carbon; potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; Solvent; Inert atmosphere;	94%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	80%

: 274-76-0
imidazo[1,2-a]pyridine

: 99-90-1
para-bromoacetophenone

: 59182-04-6
1-(4-(imidazo[1,2-a]pyridin-3-yl)phenyl)ethan-1-one

Conditions

Conditions	Yield
With C26H22Cl2FN3OPd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Heck Reaction; Schlenk technique; Inert atmosphere;	100%
With C27H22N4O2Pd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Catalytic behavior; Schlenk technique; Inert atmosphere;	100%
With palladium 10% on activated carbon; potassium acetate In i-Amyl alcohol at 150℃; for 16h; Inert atmosphere; Green chemistry;	96%
With sodium acetate In N,N-dimethyl acetamide at 166℃; for 12h; Inert atmosphere; Sonication; regioselective reaction;	94%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	92%

: 274-76-0
imidazo[1,2-a]pyridine

: 108-86-1
bromobenzene

: 92961-15-4
3-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide Inert atmosphere; Schlenk technique;	100%
With C26H22Cl2FN3OPd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Reagent/catalyst; Heck Reaction; Schlenk technique; Inert atmosphere;	99%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	58%
With potassium acetate; palladium diacetate In N,N-dimethyl-formamide at 160℃; for 1h; Microwave irradiation; Inert atmosphere;	58%

: 274-76-0
imidazo[1,2-a]pyridine

: 17534-15-5
1,2-benzenedithiole

: imidazolium[1,2-a]pyridine benzene 1-thiol 2-thiolate

Conditions

Conditions	Yield
at 5 - 8℃; Inert atmosphere; Glovebox; Sealed tube; Sonication; Green chemistry;	100%

: 274-76-0
imidazo[1,2-a]pyridine

: 2398-37-0
3-methoxyphenyl bromide

: 1338248-69-3
3-(3-methoxyphenyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With C27H22N4O2Pd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Catalytic behavior; Schlenk technique; Inert atmosphere;	100%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	53%

: 274-76-0
imidazo[1,2-a]pyridine

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 2,3-bis((4-tert-butylphenyl)thio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sulfur; copper(l) iodide; potassium tert-butylate In acetic acid; N,N-dimethyl-formamide at 130℃; for 24h; Sealed tube;	99%

: 274-76-0
imidazo[1,2-a]pyridine

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 3-(p-tolylthio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; propylene glycol dimethyl ether dimer at 100℃; for 12h; Schlenk technique;	99%

: 274-76-0
imidazo[1,2-a]pyridine

: 1-benzyl-5-(2-bromophenyl)tetrazole

: 3-(2-(1-benzyltetrazol-5-yl)phenyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium pivalate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere; Schlenk technique;	98%

: 274-76-0
imidazo[1,2-a]pyridine

: 3-nitrosoimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With tert.-butylnitrite In acetonitrile at 70℃; for 0.25h; regioselective reaction;	97%

: 274-76-0
imidazo[1,2-a]pyridine

: 2052-07-5
2-Bromobiphenyl

: 3-([1,1'-biphenyl]-2-yl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate at 150℃; for 16h; Inert atmosphere; Schlenk technique;	96%

: 274-76-0
imidazo[1,2-a]pyridine

: 2-((difluoromethyl)thio)isoindoline-1,3-dione

: 3-[(difluoromethyl)thio]-imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sodium chloride In N,N-dimethyl-formamide at 80℃; for 16h; Schlenk technique; Inert atmosphere;	95%

: 274-76-0
imidazo[1,2-a]pyridine

: 1666-13-3
diphenyl diselenide

: 3-(phenylselanyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With potassium iodate; glycerol In neat (no solvent) at 110℃; for 3h; Inert atmosphere; Schlenk technique; regioselective reaction;	95%
With ammonium iodide In acetonitrile at 20℃; for 18h;	89%
With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 0.0833333h; regioselective reaction;	88%

: 274-76-0
imidazo[1,2-a]pyridine

: sodium S-(6-chloro-1H-indol-3-yl) thiosulfate

: 3-((6-chloro-1H-indol-3-yl)thio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 80℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere; regioselective reaction;	95%

: 274-76-0
imidazo[1,2-a]pyridine

: 407-14-7
1-bromo-4-(trifluoromethoxy)benzene

: 3-(4-(trifluoromethoxy)phenyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	95%

: 274-76-0
imidazo[1,2-a]pyridine

: 5332-24-1
3-bromoquinoline

: 1373494-56-4
3-(imidazo[1,2-a]pyridin-3-yl)quinoline

Conditions

Conditions	Yield
With palladium 10% on activated carbon; potassium acetate In i-Amyl alcohol at 150℃; for 16h; Inert atmosphere; Green chemistry;	94%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	73%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	61%

: 274-76-0
imidazo[1,2-a]pyridine

: 6952-59-6
3-cyanobromobenzene

: 1373494-46-2
3-(imidazo[1,2-a]pyridin-2-yl)benzonitrile

Conditions

Conditions	Yield
With sodium acetate In N,N-dimethyl acetamide at 166℃; for 12h; Inert atmosphere; Sonication; regioselective reaction;	94%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	93%

: 274-76-0
imidazo[1,2-a]pyridine

: 108-98-5
thiophenol

: 1609583-33-6
3-(phenylthio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
Stage #1: thiophenol With N-chloro-succinimide In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: imidazo[1,2-a]pyridine In dichloromethane at 20℃; for 0.5h; Inert atmosphere; regioselective reaction;	94%
With rose bengal In dimethyl sulfoxide for 6h; Irradiation; Molecular sieve; regioselective reaction;	85%
With 5-ethyl-10-(2-hydroxylethyl)-7,8-dimethylisoalloxazinium triflate; iodine; oxygen In acetonitrile at 50℃; under 760.051 Torr; for 16h; Green chemistry; chemoselective reaction;	70%

: 274-76-0
imidazo[1,2-a]pyridine

: sodium 4-bromobenzylsulfanesulfonate

: 3-((4-bromobenzyl)thio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 80℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere; regioselective reaction;	94%

: 274-76-0
imidazo[1,2-a]pyridine

: 76-02-8
Trichloroacetyl chloride

: 3-(trichloroacetyl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With dmap In tetrahydrofuran for 12h; Acetylation; Heating;	93%

: 274-76-0
imidazo[1,2-a]pyridine

: 591-50-4
iodobenzene

: 92961-15-4
3-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With palladium(II) complex with imidazolyl carbene ligandO; cesium acetate In N,N-dimethyl acetamide at 125℃; for 24h;	93%
With cobalt(II) chloride hexahydrate; potassium acetate In N,N-dimethyl-formamide at 150℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent;	92%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	65%

: 274-76-0
imidazo[1,2-a]pyridine

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1373494-42-8
methyl 4-(imidazo[1,2-a]pyridin-3-yl)benzoate

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	93%

: 274-76-0
imidazo[1,2-a]pyridine

: 112-55-0
1-dodecylthiol

: C19H30N2S

Conditions

Conditions	Yield
With copper(l) iodide; oxygen In dimethyl sulfoxide at 100℃; regioselective reaction;	93%

: 274-76-0
imidazo[1,2-a]pyridine

: 937-30-4
4-ethylacetophenone

: 1-(4-ethylphenyl)-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,2-dione

Conditions

Conditions	Yield
With oxygen; copper diacetate; acetic acid In toluene at 140℃; for 12h; Schlenk technique; Sealed tube; regioselective reaction;	93%

: 274-76-0
imidazo[1,2-a]pyridine

: 352-34-1
4-fluoro-1-iodobenzene

: 2,3-bis((4-fluorophenyl)thio)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With sulfur; copper(l) iodide; potassium tert-butylate In acetic acid; N,N-dimethyl-formamide at 130℃; for 24h; Sealed tube;	93%

: 626-55-1
3-Bromopyridine

: 274-76-0
imidazo[1,2-a]pyridine

: 930113-28-3
3-(pyridin-3-yl)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	92%
With potassium carbonate; triphenylphosphine; palladium diacetate In 1,4-dioxane; ethanol at 130℃; for 1h; microwave irradiation;	90%

: 274-76-0
imidazo[1,2-a]pyridine

: 2042-37-7
o-cyanobromobenzene

: 1373494-50-8
2-(imidazo[1,2-a]pyridin-3-yl)benzonitrile

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;	92%
With palladium 10% on activated carbon; potassium acetate In pentan-1-ol at 150℃; for 16h; Solvent; Inert atmosphere; Green chemistry;	92%

: 274-76-0
imidazo[1,2-a]pyridine

: 108-90-7
chlorobenzene

: 92961-15-4
3-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; sodium t-butanolate In tetrahydrofuran at 120℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere;	92%
With NHC-Pd(II)-Im; sodium t-butanolate In tetrahydrofuran at 120℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere;	92%
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere;	54%

Imidazo[1,2-a]pyridine Specification

The Imidazo[1,2-a]pyridine is an organic compound with the formula C₇H₆N₂. The IUPAC name of this chemical is imidazo[1,2-a]pyridine. With the CAS registry number 274-76-0, it is also named as H-imidazo[1,2-a]pyridine. The product's categories are C7 and C8; Heterocyclic Building Blocks; Pyridines. Besides, it should be stored in a cool, dry place.

Physical properties about Imidazo[1,2-a]pyridine are: (1)ACD/LogP: 1.49; (2)ACD/LogD (pH 5.5): 0.193; (3)ACD/LogD (pH 7.4): 1.391; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 6.366; (6)ACD/KOC (pH 5.5): 7.795; (7)ACD/KOC (pH 7.4): 122.883; (8)#H bond acceptors: 2 ; (9)Polar Surface Area: 17.3 Å²; (10)Index of Refraction: 1.628; (11)Molar Refractivity: 36.713 cm³; (12)Molar Volume: 103.418 cm3; (13)Polarizability: 14.554×10^-24cm³; (14)Surface Tension: 45.705 dyne/cm; (15)Density: 1.142 g/cm³.

Preparation: this chemical can be prepared by pyridin-2-ylamine and chloroacetaldehyde. This reaction will need reagent sodium bicarbonate and solvent H₂O. The reaction time is 72 hours at ambient temperature.

Uses of Imidazo[1,2-a]pyridine: it can be used to produce 2,2,2-trichloro-1-imidazo[1,2-a]pyridin-3-yl-ethanol at ambient temperature. It will need solvent benzene. The yield is about 83%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: c1ccn2ccnc2c1
(2)InChI: InChI=1/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H
(3)InChIKey: UTCSSFWDNNEEBH-UHFFFAOYAA
(4)Std. InChI: InChI=1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H
(5)Std. InChIKey: UTCSSFWDNNEEBH-UHFFFAOYSA-N

Product Name

Imidazo[1,2-a]pyridine

Synthetic route

Imidazo[1,2-a]pyridine Specification

Related Products

Hot Products