Iminodibenzylcarbonyl chloride supplier

Name
Iminodibenzylcarbonyl chloride
EINECS 251-756-5
CAS No. 33948-19-5
Article Data10
CAS DataBase
Density 1.282 g/cm³
Solubility
Melting Point 121-124 °C(lit.)
Formula C₁₅H₁₂ClNO
Boiling Point 397.5 °C at 760 mmHg
Molecular Weight 257.719
Flash Point 194.2 °C
Transport Information UN 3261 8/PG 2
Appearance white to yellowish powder
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 5-(Chlorocarbonyl)-10,11-dihydrodibenzazepine;5-Chlorocarbonyl-10,11-dihydro-5H-dibenz[b,f]azepine;
PSA 20.31000
LogP 4.34710

Synthetic route

: 75-44-5
phosgene

: 494-19-9
9,10-dihydrodibenzazepine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

Conditions

Conditions	Yield
In toluene at 90 - 95℃; for 3.5h;	90%
With sodium hydroxide In chlorobenzene at 100 - 115℃; for 4h;	80%
With toluene
With toluene

: 109-72-8, 29786-93-4
n-butyllithium

: 150332-87-9
6-fluoro-3-[1-(3-hydroxypropyl)-4-piperidinyl]-1,2-benzisoxazole

A: 1-[3-((10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)carbonyloxy)propyl]-4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine, oxalate

B: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

Conditions

Conditions	Yield
In hexane

...Expand

: 494-19-9
9,10-dihydrodibenzazepine

: 32315-10-9
bis(trichloromethyl) carbonate

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

Conditions

Conditions	Yield
With pyridine In 1,2-dichloro-ethane at 75℃; for 3h; Inert atmosphere;
With sodium hydroxide In chlorobenzene at 100 - 115℃; for 4.5h;
In chlorobenzene at 110℃; for 5h; Temperature;
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 12.5h;

: 951010-97-2
5,10-bis(2-nitrobenzenesulfonyl)-5,10-diaza-1,14-tetradecanediamine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: C39H47N7O9S2

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 19h;	95%
In dichloromethane at 20℃;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With sodium bromate; N-benzyl-N,N,N-triethylammonium chloride; bromine; dibenzoyl peroxide In chlorobenzene at 92 - 97℃; for 8.5h; Temperature; Reagent/catalyst;	90.5%
Multi-step reaction with 2 steps 1: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C 2: chlorobenzene / 2 h / 150 - 155 °C View Scheme
With bromine In chlorobenzene at 80℃; for 6h; Temperature; Inert atmosphere;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 494-19-9
9,10-dihydrodibenzazepine

Conditions

Conditions	Yield
In acetonitrile electrolysis (Et4NClO4, Hg-dropelectrode);	90%

: 73579-08-5
Methyl-(1-methyl-[4]piperidyl)-amin

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: N-methyl-N-(1-methylpiperodin-4-yl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h; Heating;	90%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 3564-73-6
10,11-Dihydrocarbamazepin

Conditions

Conditions	Yield
With ammonia In methanol; water at 57 - 59℃; for 1.5h;	85.35%
With ethanol; ammonia
With ethanol; ammonia

: 123-75-1
pyrrolidine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 294194-09-5
(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(pyrrolidin-1-yl)methanone

Conditions

Conditions	Yield
With triethylamine In benzene	85%

: 92-54-6
4-phenyl-1-piperazine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1250430-98-8
(11,12-dihydro-5H-dibenzo[b,f]azepin-5-yl)(4-phenylpiperazin-1-yl)methanone

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane	83%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 2450-71-7
Propargylamine

: 127025-48-3
N-(prop-2-ynyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 24h; Reflux;	76%

: 2759-28-6
1-phenylmethylpiperazine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 5-[(4-benzylpiperazin-1-yl)carbonyl]-10,11-dihydro-5H-dibenzo[b,f]azepine

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h; Heating;	75%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1949-55-9
methyl 3,5-diaminobenzoate

: 175085-87-7
N,N'-bis(iminodibenzyl-5-carbonyl)-3,5-diaminobenzoic methyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 24h; Heating;	72%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 2-propynyl 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oate

: (6bS,8aS,11R,12bS,14aR)-4,6b,8a,11,12b,14a-hexamethyl-2-oxo-11-((prop-2-yn-1-yloxy)carbonyl)-2,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14a-tetradecahydropicen-3-yl 10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxylate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 25℃; for 12h;	62%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 7524-52-9, 26988-71-6, 5619-09-0, 14907-27-8, 41222-70-2, 67557-19-1, 109492-62-8
(S)-tryptophan methyl ester hydrochloride

: (2S)-2-[(10,11-dihydro-5H-dibenzo[b,f]azepin-5-ylcarbonyl)amino]-3-(1H-indol-3-yl)propionic acid methyl ester

Conditions

Conditions	Yield
With N-ethylmorpholine; In N,N-dimethyl-formamide at 0 - 40℃;	30.3%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 142-25-6
N,N',N'-trimethylenediamine

: 10,11-dihydro-dibenz[b,f]azepine-5-carboxylic acid-[(2-dimethylamino-ethyl)-methyl-amide]

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 33948-20-8
10-bromo-10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

Conditions

Conditions	Yield
With bromine In chlorobenzene at 145 - 150℃; for 1.5h;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 4353-32-6
NG-tosylargine

: Nα-(10,11-dihydroo-5H-dibenz[b.f]azepine-5-carbonyl)toluenesulfonyl-L-arginine

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane

: 71-44-3
Spermine

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: C25H37N5O

Conditions

Conditions	Yield
In dichloromethane at 20℃;

: 951010-96-1
C23H34N6O8S2

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: C38H45N7O9S2

Conditions

Conditions	Yield
In dichloromethane at 20℃;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 298-46-4
carbamazepin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C 2: chlorobenzene / 2 h / 150 - 155 °C 3: 25percent NH4OH / methanol / 5 h / 75 - 85 °C View Scheme

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: (S)-1-(10,11-Dihydro-5H-dibenz[b,f]azepine-5-carbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylic acid

Conditions

Conditions	Yield
	284 mg (24%)

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 100-46-9
benzylamine

: 10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid benzylamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 27h;

: 1131679-43-0
C17H22N2O3*ClH

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1131680-29-9
C32H33N3O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran

: 1131679-47-4
C17H22N2O3*ClH

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1131680-31-3
C32H33N3O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1676-31-9
10,11-Dihydro-dibenzo[b,f]azepine-5-carboxylic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In diethyl ether; ethanol for 0.5h; Schlenk technique; Inert atmosphere;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1417342-96-1
[ReBr(CO)3(H2BF)]

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrazine hydrate / diethyl ether; ethanol / 0.5 h / Schlenk technique; Inert atmosphere 2: toluene-4-sulfonic acid / toluene / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere 3: toluene / 5 h / Schlenk technique; Inert atmosphere; Reflux View Scheme

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 1417342-90-5
C22H19N3O2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrazine hydrate / diethyl ether; ethanol / 0.5 h / Schlenk technique; Inert atmosphere 2: toluene-4-sulfonic acid / toluene / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere View Scheme

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 56613-80-0
(R)-Phenylglycinol

: C23H22N2O2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 12h; Inert atmosphere;

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 56613-80-0
(R)-Phenylglycinol

: C33H43N3O6Si

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 12 h / 0 °C / Inert atmosphere 2: triethylamine / benzene / 72 h / 111 °C / Inert atmosphere View Scheme

Iminodibenzylcarbonyl chloride Chemical Properties

Molecular Structure:

Molecular Formula: C₁₅H₁₂ClNO
Molecular Weight: 257.7149
IUPAC Name: 5,6-Dihydrobenzo[b][1]benzazepine-11-carbonyl chloride
Synonyms of Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5): EINECS 251-756-5 ; 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carbonyl chloride
CAS NO: 33948-19-5
Product Categories: (intermediate of carbamazepine)
Melting point: 121-124 °C
Index of Refraction: 1.628
Molar Refractivity: 71.39 cm³
Molar Volume: 200.9 cm³
Surface Tension: 50.1 dyne/cm
Density: 1.282 g/cm³
Flash Point: 194.2 °C
Enthalpy of Vaporization: 64.79 kJ/mol
Boiling Point: 397.5 °C at 760 mmHg
Vapour Pressure: 1.58E-06 mmHg at 25°C

Iminodibenzylcarbonyl chloride Uses

Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5) is used as pharmaceutical intermediates.

Iminodibenzylcarbonyl chloride Safety Profile

Hazard Codes of Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5): Corrosive C
Risk Statements: 34
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III

Product Name

Iminodibenzylcarbonyl chloride

Synthetic route

Iminodibenzylcarbonyl chloride Chemical Properties

Iminodibenzylcarbonyl chloride Uses

Iminodibenzylcarbonyl chloride Safety Profile

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